YOR204W / DED1

ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR204W / DED1

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:-4.78|P-value:5.37E-6 ID:SGTC_57|Compound:miconazole|FD-Score:4.11|P-value:7.10E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:3.95|P-value:1.26E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.49|P-value:6.68E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.45|P-value:7.61E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.63|P-value:3.87E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:-3.62|P-value:4.37E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:7.13|P-value:2.05E-11 ID:SGTC_227|Compound:fluconazole|FD-Score:3.65|P-value:3.54E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:5.31|P-value:4.31E-7 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.45|P-value:1.89E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.12|P-value:6.62E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:3.78|P-value:2.29E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.38|P-value:8.55E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.31|P-value:3.25E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:-4.20|P-value:5.67E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.56|P-value:4.89E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:-3.92|P-value:1.57E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:5.43|P-value:2.44E-7 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.54|P-value:5.68E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:5.15|P-value:9.33E-7 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.42|P-value:8.42E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.40|P-value:8.18E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.33|P-value:3.03E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.57|P-value:1.16E-5 ID:SGTC_1092|Compound:toremifene|FD-Score:3.65|P-value:3.55E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.86|P-value:3.34E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.78|P-value:5.41E-6 ID:SGTC_1378|Compound:2093-0007|FD-Score:7.10|P-value:2.56E-11 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.52|P-value:5.57E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.35|P-value:9.33E-4 ID:SGTC_2158|Compound:5657123|FD-Score:6.23|P-value:4.11E-9 ID:SGTC_2261|Compound:9010538|FD-Score:3.94|P-value:1.31E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-3.75|P-value:2.78E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.69|P-value:3.16E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.40|P-value:8.02E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.91|P-value:1.45E-4 ID:SGTC_2373|Compound:9071805|FD-Score:-3.60|P-value:4.62E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.34|P-value:9.69E-4 ID:SGTC_2404|Compound:5161160|FD-Score:4.52|P-value:1.44E-5 ID:SGTC_2470|Compound:5664817|FD-Score:3.43|P-value:7.33E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:5.11|P-value:1.12E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:6.00|P-value:1.40E-8 ID:SGTC_2709|Compound:st078560|FD-Score:4.00|P-value:1.07E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.77|P-value:2.34E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.94|P-value:2.34E-6 ID:SGTC_2831|Compound:7999036|FD-Score:4.18|P-value:5.38E-5 ID:SGTC_2921|Compound:7974240|FD-Score:5.21|P-value:7.13E-7 ID:SGTC_2926|Compound:9010726|FD-Score:4.50|P-value:1.54E-5 ID:SGTC_2932|Compound:9016711|FD-Score:3.93|P-value:1.35E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-5.08|P-value:1.48E-6 ID:SGTC_2950|Compound:9072895|FD-Score:6.81|P-value:1.43E-10 ID:SGTC_2994|Compound:9053520|FD-Score:4.00|P-value:1.07E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.37|P-value:8.97E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.81|P-value:2.09E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.95|P-value:2.24E-6 ID:SGTC_3339|Compound:9145883|FD-Score:3.73|P-value:2.69E-4 ID:SGTC_3351|Compound:9150312|FD-Score:4.55|P-value:1.26E-5 ID:SGTC_20|Compound:0481-0013|FD-Score:-4.78|P-value:5.37E-6 ID:SGTC_57|Compound:miconazole|FD-Score:4.11|P-value:7.10E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:3.95|P-value:1.26E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.49|P-value:6.68E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.45|P-value:7.61E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.63|P-value:3.87E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:-3.62|P-value:4.37E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:7.13|P-value:2.05E-11 ID:SGTC_227|Compound:fluconazole|FD-Score:3.65|P-value:3.54E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:5.31|P-value:4.31E-7 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.45|P-value:1.89E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.12|P-value:6.62E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:3.78|P-value:2.29E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.38|P-value:8.55E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.31|P-value:3.25E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:-4.20|P-value:5.67E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.56|P-value:4.89E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:-3.92|P-value:1.57E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:5.43|P-value:2.44E-7 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.54|P-value:5.68E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:5.15|P-value:9.33E-7 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.42|P-value:8.42E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.40|P-value:8.18E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.33|P-value:3.03E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.57|P-value:1.16E-5 ID:SGTC_1092|Compound:toremifene|FD-Score:3.65|P-value:3.55E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.86|P-value:3.34E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.78|P-value:5.41E-6 ID:SGTC_1378|Compound:2093-0007|FD-Score:7.10|P-value:2.56E-11 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.52|P-value:5.57E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.35|P-value:9.33E-4 ID:SGTC_2158|Compound:5657123|FD-Score:6.23|P-value:4.11E-9 ID:SGTC_2261|Compound:9010538|FD-Score:3.94|P-value:1.31E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-3.75|P-value:2.78E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.69|P-value:3.16E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.40|P-value:8.02E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.91|P-value:1.45E-4 ID:SGTC_2373|Compound:9071805|FD-Score:-3.60|P-value:4.62E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.34|P-value:9.69E-4 ID:SGTC_2404|Compound:5161160|FD-Score:4.52|P-value:1.44E-5 ID:SGTC_2470|Compound:5664817|FD-Score:3.43|P-value:7.33E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:5.11|P-value:1.12E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:6.00|P-value:1.40E-8 ID:SGTC_2709|Compound:st078560|FD-Score:4.00|P-value:1.07E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.77|P-value:2.34E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.94|P-value:2.34E-6 ID:SGTC_2831|Compound:7999036|FD-Score:4.18|P-value:5.38E-5 ID:SGTC_2921|Compound:7974240|FD-Score:5.21|P-value:7.13E-7 ID:SGTC_2926|Compound:9010726|FD-Score:4.50|P-value:1.54E-5 ID:SGTC_2932|Compound:9016711|FD-Score:3.93|P-value:1.35E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-5.08|P-value:1.48E-6 ID:SGTC_2950|Compound:9072895|FD-Score:6.81|P-value:1.43E-10 ID:SGTC_2994|Compound:9053520|FD-Score:4.00|P-value:1.07E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.37|P-value:8.97E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.81|P-value:2.09E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.95|P-value:2.24E-6 ID:SGTC_3339|Compound:9145883|FD-Score:3.73|P-value:2.69E-4 ID:SGTC_3351|Compound:9150312|FD-Score:4.55|P-value:1.26E-5

Top fitness defect scores for YOR204W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_217 ketoconazole 7.13 989.0 nM 2.05E-11 ergosterol depletion effects on membrane 2 4.90E-13 0.12
2 SGTC_1378 2093-0007 7.10 380.0 nM 2.56E-11 1 6.36E-13 2.53
3 SGTC_2950 9072895 6.81 21.5 µM 1.43E-10 1 4.71E-12 0.56
4 SGTC_2158 5657123 6.23 3.6 µM 4.11E-9 3 2.37E-10 0.17
5 SGTC_2612 dictamnine 6.00 15.5 µM 1.40E-8 RNA pol III & RNase P/MRP 18 9.87E-10 0.01
6 SGTC_689 0833-0039 5.43 98.0 µM 2.44E-7 ergosterol depletion effects on membrane 2 2.76E-8 0.73
7 SGTC_256 clotrimazole 5.31 625.0 nM 4.31E-7 ergosterol depletion effects on membrane 11 5.35E-8 0.03
8 SGTC_2921 7974240 5.21 10.7 µM 7.13E-7 6 9.62E-8 0.09
9 SGTC_932 2857-0803 5.15 154.0 µM 9.33E-7 3 1.31E-7 0.77
10 SGTC_2584 androsterone 5.11 48.7 µM 1.12E-6 cell wall 18 1.62E-7 0.04
11 SGTC_3304 9125678 4.95 46.1 µM 2.24E-6 24 3.65E-7 0.46
12 SGTC_2778 tioconazole 4.94 65.1 nM 2.34E-6 ergosterol depletion effects on membrane 19 3.82E-7 0.13
13 SGTC_1158 4092-0494 4.86 91.8 µM 3.34E-6 1 5.79E-7 0.42
14 SGTC_1080 nisoldipine 4.57 24.4 µM 1.16E-5 TSC3-RPN4 3 2.46E-6 0.41
15 SGTC_3351 9150312 4.55 21.6 µM 1.26E-5 cell wall 6 2.70E-6 0.25
16 SGTC_2404 5161160 4.52 200.0 µM 1.44E-5 6 3.16E-6 0.28
17 SGTC_2926 9010726 4.50 65.2 µM 1.54E-5 2 3.42E-6 0.17
18 SGTC_265 mycophenolic acid 4.45 32.9 µM 1.89E-5 RPP1 & pyrimidine depletion 4 4.35E-6 0.23
19 SGTC_1053 3366-3204 4.33 134.0 µM 3.03E-5 cell wall 5 7.50E-6 0.11
20 SGTC_576 1073-0113 4.31 22.7 µM 3.25E-5 redox potentiating 38 8.16E-6 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 3.88E-16 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.118 8.18E-12 YPL170W DAP1 hom Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
0.116 1.76E-11 YMR283C RIT1 hom 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA
0.116 1.89E-11 YCL031C RRP7 het Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress
0.106 7.52E-10 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.102 3.61E-9 YPR055W SEC8 het Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
0.099 8.37E-9 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.097 1.84E-8 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.095 3.36E-8 YBR102C EXO84 het Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate
0.091 1.42E-7 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.089 2.64E-7 YER008C SEC3 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress
0.088 3.37E-7 YNL311C SKP2 hom F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments
0.088 3.74E-7 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.087 4.47E-7 YNL278W CAF120 hom Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; CAF120 has a paralog, SKG3, that arose from the whole genome duplication
0.086 6.90E-7 YAR019C CDC15 het Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress