YOR205C / GEP3

Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1)

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR205C / GEP3

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:6.85|P-value:1.11E-11 ID:SGTC_19|Compound:0279-0214|FD-Score:3.49|P-value:3.04E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.67|P-value:1.60E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.36|P-value:7.97E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:3.63|P-value:1.84E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.22|P-value:7.67E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.00|P-value:4.23E-12 ID:SGTC_211|Compound:3455-0679|FD-Score:4.15|P-value:2.40E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:8.20|P-value:6.37E-16 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.21|P-value:1.85E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.59|P-value:3.51E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:5.08|P-value:3.40E-7 ID:SGTC_330|Compound:1488-0319|FD-Score:3.26|P-value:6.78E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:5.86|P-value:5.20E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.07|P-value:2.59E-9 ID:SGTC_458|Compound:nppb|FD-Score:3.74|P-value:1.19E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:4.16|P-value:2.29E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:4.10|P-value:2.93E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:4.50|P-value:5.13E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:3.30|P-value:5.91E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:5.61|P-value:2.06E-8 ID:SGTC_832|Compound:4083-0019|FD-Score:4.66|P-value:2.48E-6 ID:SGTC_894|Compound:0960-0238|FD-Score:3.55|P-value:2.40E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.23|P-value:1.69E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:3.27|P-value:6.53E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:5.73|P-value:1.09E-8 ID:SGTC_1052|Compound:3253-3998|FD-Score:5.45|P-value:4.82E-8 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.60|P-value:2.84E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.72|P-value:1.33E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.33|P-value:5.34E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.23|P-value:1.72E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.25|P-value:7.01E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:4.56|P-value:3.99E-6 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.58|P-value:2.23E-4 ID:SGTC_1622|Compound:st003707|FD-Score:9.48|P-value:1.22E-20 ID:SGTC_1623|Compound:st003709|FD-Score:3.73|P-value:1.25E-4 ID:SGTC_1624|Compound:st003710|FD-Score:5.80|P-value:7.37E-9 ID:SGTC_1627|Compound:st003713|FD-Score:6.37|P-value:2.42E-10 ID:SGTC_1727|Compound:st034309|FD-Score:3.30|P-value:5.92E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-4.15|P-value:3.41E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.18|P-value:8.72E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.67|P-value:1.54E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.25|P-value:9.52E-4 ID:SGTC_1904|Compound:st060225|FD-Score:3.65|P-value:1.72E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.44|P-value:6.66E-6 ID:SGTC_2010|Compound:4012422|FD-Score:3.92|P-value:6.04E-5 ID:SGTC_2037|Compound:5169046|FD-Score:3.36|P-value:4.81E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.88|P-value:6.97E-5 ID:SGTC_2231|Compound:micatex|FD-Score:4.00|P-value:4.35E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.50|P-value:5.26E-6 ID:SGTC_2328|Compound:6201408|FD-Score:-3.60|P-value:2.83E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.25|P-value:6.86E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.98|P-value:4.75E-5 ID:SGTC_2403|Compound:6032726|FD-Score:3.58|P-value:2.21E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:4.43|P-value:7.24E-6 ID:SGTC_2673|Compound:kobusone|FD-Score:3.30|P-value:5.78E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.48|P-value:3.19E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.66|P-value:2.27E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.05|P-value:5.97E-7 ID:SGTC_2980|Compound:9014342|FD-Score:4.06|P-value:3.44E-5 ID:SGTC_3104|Compound:9120930|FD-Score:3.77|P-value:1.08E-4 ID:SGTC_3115|Compound:9123671|FD-Score:3.90|P-value:6.54E-5 ID:SGTC_3117|Compound:9124945|FD-Score:3.20|P-value:8.18E-4 ID:SGTC_3157|Compound:9099274|FD-Score:5.31|P-value:1.03E-7 ID:SGTC_3158|Compound:9100007|FD-Score:3.67|P-value:1.55E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.91|P-value:6.36E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.71|P-value:1.37E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:6.85|P-value:1.11E-11 ID:SGTC_19|Compound:0279-0214|FD-Score:3.49|P-value:3.04E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.67|P-value:1.60E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.36|P-value:7.97E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:3.63|P-value:1.84E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.22|P-value:7.67E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.00|P-value:4.23E-12 ID:SGTC_211|Compound:3455-0679|FD-Score:4.15|P-value:2.40E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:8.20|P-value:6.37E-16 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.21|P-value:1.85E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.59|P-value:3.51E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:5.08|P-value:3.40E-7 ID:SGTC_330|Compound:1488-0319|FD-Score:3.26|P-value:6.78E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:5.86|P-value:5.20E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.07|P-value:2.59E-9 ID:SGTC_458|Compound:nppb|FD-Score:3.74|P-value:1.19E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:4.16|P-value:2.29E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:4.10|P-value:2.93E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:4.50|P-value:5.13E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:3.30|P-value:5.91E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:5.61|P-value:2.06E-8 ID:SGTC_832|Compound:4083-0019|FD-Score:4.66|P-value:2.48E-6 ID:SGTC_894|Compound:0960-0238|FD-Score:3.55|P-value:2.40E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.23|P-value:1.69E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:3.27|P-value:6.53E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:5.73|P-value:1.09E-8 ID:SGTC_1052|Compound:3253-3998|FD-Score:5.45|P-value:4.82E-8 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.60|P-value:2.84E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.72|P-value:1.33E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.33|P-value:5.34E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.23|P-value:1.72E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.25|P-value:7.01E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:4.56|P-value:3.99E-6 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.58|P-value:2.23E-4 ID:SGTC_1622|Compound:st003707|FD-Score:9.48|P-value:1.22E-20 ID:SGTC_1623|Compound:st003709|FD-Score:3.73|P-value:1.25E-4 ID:SGTC_1624|Compound:st003710|FD-Score:5.80|P-value:7.37E-9 ID:SGTC_1627|Compound:st003713|FD-Score:6.37|P-value:2.42E-10 ID:SGTC_1727|Compound:st034309|FD-Score:3.30|P-value:5.92E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-4.15|P-value:3.41E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.18|P-value:8.72E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.67|P-value:1.54E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.25|P-value:9.52E-4 ID:SGTC_1904|Compound:st060225|FD-Score:3.65|P-value:1.72E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.44|P-value:6.66E-6 ID:SGTC_2010|Compound:4012422|FD-Score:3.92|P-value:6.04E-5 ID:SGTC_2037|Compound:5169046|FD-Score:3.36|P-value:4.81E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.88|P-value:6.97E-5 ID:SGTC_2231|Compound:micatex|FD-Score:4.00|P-value:4.35E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.50|P-value:5.26E-6 ID:SGTC_2328|Compound:6201408|FD-Score:-3.60|P-value:2.83E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.25|P-value:6.86E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.98|P-value:4.75E-5 ID:SGTC_2403|Compound:6032726|FD-Score:3.58|P-value:2.21E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:4.43|P-value:7.24E-6 ID:SGTC_2673|Compound:kobusone|FD-Score:3.30|P-value:5.78E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.48|P-value:3.19E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.66|P-value:2.27E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.05|P-value:5.97E-7 ID:SGTC_2980|Compound:9014342|FD-Score:4.06|P-value:3.44E-5 ID:SGTC_3104|Compound:9120930|FD-Score:3.77|P-value:1.08E-4 ID:SGTC_3115|Compound:9123671|FD-Score:3.90|P-value:6.54E-5 ID:SGTC_3117|Compound:9124945|FD-Score:3.20|P-value:8.18E-4 ID:SGTC_3157|Compound:9099274|FD-Score:5.31|P-value:1.03E-7 ID:SGTC_3158|Compound:9100007|FD-Score:3.67|P-value:1.55E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.91|P-value:6.36E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.71|P-value:1.37E-4

Top fitness defect scores for YOR205C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1622 st003707 9.48 19.4 µM 1.22E-20 calcium & mitochondrial duress 5 1.22E-21
2 SGTC_236 1509-0011 8.20 5.3 µM 6.37E-16 244 1.19E-16
3 SGTC_173 1273-0061 7.00 2.7 µM 4.23E-12 mitochondrial stress 86 1.30E-12
4 SGTC_10 0279-0212 6.85 42.6 µM 1.11E-11 TRP & mitochondrial translation 15 3.58E-12
5 SGTC_1627 st003713 6.37 25.6 µM 2.42E-10 calcium & mitochondrial duress 25 9.29E-11
6 SGTC_385 1494-0393 5.86 12.4 µM 5.20E-9 1 2.35E-9
7 SGTC_1624 st003710 5.80 6.2 µM 7.37E-9 calcium & mitochondrial duress 16 3.40E-9
8 SGTC_1051 3253-3903 5.73 78.0 µM 1.09E-8 3 5.15E-9
9 SGTC_831 k061-1017 5.61 217.0 µM 2.06E-8 translation 14 1.01E-8
10 SGTC_1052 3253-3998 5.45 198.0 µM 4.82E-8 3 2.46E-8
11 SGTC_63 0099-0242 5.36 26.7 µM 7.97E-8 mitochondrial stress 44 4.18E-8
12 SGTC_3157 9099274 5.31 49.5 µM 1.03E-7 4 5.48E-8
13 SGTC_314 1671-0008 5.08 2.7 µM 3.40E-7 19 1.92E-7
14 SGTC_832 4083-0019 4.66 164.0 µM 2.48E-6 translation 54 1.56E-6
15 SGTC_310 1273-0058 4.59 1.1 µM 3.51E-6 mitochondrial stress 203 2.25E-6
16 SGTC_1329 1447-1697 4.56 50.6 µM 3.99E-6 9 2.57E-6
17 SGTC_727 3032-0951 4.50 202.0 µM 5.13E-6 20 3.34E-6
18 SGTC_2232 chlorophetanol 4.50 41.5 µM 5.26E-6 TRP & mitochondrial translation 99 3.43E-6
19 SGTC_1921 5740136 4.44 50.0 µM 6.66E-6 TRP & mitochondrial translation 42 4.40E-6
20 SGTC_2622 2-methoxyxanthone 4.43 59.9 µM 7.24E-6 9 4.80E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.387 2.00E-120 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.373 1.25E-110 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.372 1.71E-110 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.369 6.64E-109 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.366 1.22E-106 YPR099C_d YPR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W
0.364 8.02E-106 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.364 1.73E-105 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.362 1.14E-104 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.359 1.12E-102 YPL029W SUV3 hom ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron
0.355 1.93E-100 YDL056W MBP1 hom Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
0.355 2.17E-100 YEL050C RML2 hom Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
0.353 2.94E-99 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.347 1.54E-95 YGR219W_d YGR219W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
0.345 1.15E-94 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.338 1.97E-90 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress