YOR206W / NOC2

Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR206W / NOC2

Click on Significant Values for Screen Details ID:SGTC_88|Compound:0180-0332|FD-Score:3.34|P-value:5.43E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.31|P-value:1.19E-5 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.78|P-value:6.85E-9 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.48|P-value:3.30E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.57|P-value:2.43E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.47|P-value:3.46E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.33|P-value:4.49E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:4.20|P-value:1.91E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:4.27|P-value:1.43E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:3.72|P-value:1.35E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:3.50|P-value:3.09E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.42|P-value:4.15E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:4.77|P-value:1.43E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.20|P-value:7.11E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.11|P-value:9.69E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:4.49|P-value:5.51E-6 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.72|P-value:1.37E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.17|P-value:9.91E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.30|P-value:6.27E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.62|P-value:1.99E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.69|P-value:1.50E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.64|P-value:1.81E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.18|P-value:9.53E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.35|P-value:5.30E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:-3.26|P-value:5.85E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:-3.87|P-value:5.81E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:5.26|P-value:1.22E-7 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.52|P-value:2.88E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-4.42|P-value:5.48E-6 ID:SGTC_1612|Compound:st002233|FD-Score:3.33|P-value:5.68E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-3.79|P-value:8.21E-5 ID:SGTC_1814|Compound:st052110|FD-Score:3.65|P-value:1.79E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.22|P-value:6.55E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.58|P-value:2.34E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-4.12|P-value:2.12E-5 ID:SGTC_1930|Compound:st074634|FD-Score:-3.78|P-value:8.50E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.79|P-value:1.03E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-3.56|P-value:1.97E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.44|P-value:3.80E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-4.55|P-value:3.10E-6 ID:SGTC_2312|Compound:7706453|FD-Score:3.85|P-value:8.14E-5 ID:SGTC_2315|Compound:7733312|FD-Score:3.95|P-value:5.59E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-4.94|P-value:4.68E-7 ID:SGTC_2377|Compound:9073351|FD-Score:-3.53|P-value:2.22E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-3.42|P-value:3.25E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.55|P-value:2.60E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.73|P-value:1.34E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.13|P-value:9.05E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.38|P-value:3.78E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.63|P-value:1.92E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.90|P-value:6.69E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.37|P-value:9.18E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.45|P-value:2.94E-4 ID:SGTC_2712|Compound:st079126|FD-Score:4.27|P-value:1.46E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.14|P-value:1.90E-5 ID:SGTC_2844|Compound:9010103|FD-Score:3.52|P-value:2.91E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.42|P-value:3.25E-4 ID:SGTC_2880|Compound:9042983|FD-Score:4.17|P-value:2.20E-5 ID:SGTC_2887|Compound:9044784|FD-Score:5.64|P-value:1.59E-8 ID:SGTC_2893|Compound:9048488|FD-Score:3.22|P-value:8.22E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-4.01|P-value:3.37E-5 ID:SGTC_2978|Compound:9011784|FD-Score:5.59|P-value:2.10E-8 ID:SGTC_2981|Compound:9013952|FD-Score:-3.86|P-value:6.05E-5 ID:SGTC_2993|Compound:9054257|FD-Score:6.10|P-value:1.04E-9 ID:SGTC_2995|Compound:9067767|FD-Score:3.68|P-value:1.58E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.53|P-value:2.16E-4 ID:SGTC_3071|Compound:9117417|FD-Score:4.44|P-value:6.73E-6 ID:SGTC_3126|Compound:9127922|FD-Score:4.07|P-value:3.38E-5 ID:SGTC_3170|Compound:9103054|FD-Score:3.39|P-value:4.59E-4 ID:SGTC_3247|Compound:9135149|FD-Score:-3.22|P-value:6.73E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.37|P-value:4.85E-4 ID:SGTC_3355|Compound:9151058|FD-Score:3.77|P-value:1.13E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.34|P-value:5.43E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.31|P-value:1.19E-5 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.78|P-value:6.85E-9 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.48|P-value:3.30E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.57|P-value:2.43E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.47|P-value:3.46E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.33|P-value:4.49E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:4.20|P-value:1.91E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:4.27|P-value:1.43E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:3.72|P-value:1.35E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:3.50|P-value:3.09E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.42|P-value:4.15E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:4.77|P-value:1.43E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.20|P-value:7.11E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.11|P-value:9.69E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:4.49|P-value:5.51E-6 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.72|P-value:1.37E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.17|P-value:9.91E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.30|P-value:6.27E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.62|P-value:1.99E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.69|P-value:1.50E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.64|P-value:1.81E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.18|P-value:9.53E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.35|P-value:5.30E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:-3.26|P-value:5.85E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:-3.87|P-value:5.81E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:5.26|P-value:1.22E-7 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.52|P-value:2.88E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-4.42|P-value:5.48E-6 ID:SGTC_1612|Compound:st002233|FD-Score:3.33|P-value:5.68E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-3.79|P-value:8.21E-5 ID:SGTC_1814|Compound:st052110|FD-Score:3.65|P-value:1.79E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.22|P-value:6.55E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.58|P-value:2.34E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-4.12|P-value:2.12E-5 ID:SGTC_1930|Compound:st074634|FD-Score:-3.78|P-value:8.50E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.79|P-value:1.03E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-3.56|P-value:1.97E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.44|P-value:3.80E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-4.55|P-value:3.10E-6 ID:SGTC_2312|Compound:7706453|FD-Score:3.85|P-value:8.14E-5 ID:SGTC_2315|Compound:7733312|FD-Score:3.95|P-value:5.59E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-4.94|P-value:4.68E-7 ID:SGTC_2377|Compound:9073351|FD-Score:-3.53|P-value:2.22E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-3.42|P-value:3.25E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.55|P-value:2.60E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.73|P-value:1.34E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.13|P-value:9.05E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.38|P-value:3.78E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.63|P-value:1.92E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.90|P-value:6.69E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.37|P-value:9.18E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.45|P-value:2.94E-4 ID:SGTC_2712|Compound:st079126|FD-Score:4.27|P-value:1.46E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.14|P-value:1.90E-5 ID:SGTC_2844|Compound:9010103|FD-Score:3.52|P-value:2.91E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.42|P-value:3.25E-4 ID:SGTC_2880|Compound:9042983|FD-Score:4.17|P-value:2.20E-5 ID:SGTC_2887|Compound:9044784|FD-Score:5.64|P-value:1.59E-8 ID:SGTC_2893|Compound:9048488|FD-Score:3.22|P-value:8.22E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-4.01|P-value:3.37E-5 ID:SGTC_2978|Compound:9011784|FD-Score:5.59|P-value:2.10E-8 ID:SGTC_2981|Compound:9013952|FD-Score:-3.86|P-value:6.05E-5 ID:SGTC_2993|Compound:9054257|FD-Score:6.10|P-value:1.04E-9 ID:SGTC_2995|Compound:9067767|FD-Score:3.68|P-value:1.58E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.53|P-value:2.16E-4 ID:SGTC_3071|Compound:9117417|FD-Score:4.44|P-value:6.73E-6 ID:SGTC_3126|Compound:9127922|FD-Score:4.07|P-value:3.38E-5 ID:SGTC_3170|Compound:9103054|FD-Score:3.39|P-value:4.59E-4 ID:SGTC_3247|Compound:9135149|FD-Score:-3.22|P-value:6.73E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.37|P-value:4.85E-4 ID:SGTC_3355|Compound:9151058|FD-Score:3.77|P-value:1.13E-4

Top fitness defect scores for YOR206W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2993 9054257 6.10 71.4 µM 1.04E-9 fatty acid desaturase (OLE1) 12 5.24E-10 0.01
2 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 5.78 4.6 µM 6.85E-9 heat shock/prefoldin 9 3.66E-9 0.07
3 SGTC_2887 9044784 5.64 58.4 µM 1.59E-8 fatty acid desaturase (OLE1) 8 8.73E-9 0.26
4 SGTC_2978 9011784 5.59 43.0 µM 2.10E-8 2 1.16E-8 0.90
5 SGTC_1360 1598-0022 5.26 39.8 µM 1.22E-7 ERG2 1 7.15E-8 0.78
6 SGTC_879 0831-1030 4.77 162.0 µM 1.43E-6 10 9.01E-7 0.07
7 SGTC_1074 carmofur 4.49 3.8 µM 5.51E-6 exosome 22 3.63E-6 0.08
8 SGTC_3071 9117417 4.44 49.5 µM 6.73E-6 fatty acid desaturase (OLE1) 8 4.47E-6 0.02
9 SGTC_2611 pyromycin 4.37 23.9 µM 9.18E-6 4 6.15E-6 0.50
10 SGTC_145 3737-0113 4.31 38.4 µM 1.19E-5 DNA intercalators 40 8.05E-6 0.09
11 SGTC_672 1441-0018 4.27 53.7 µM 1.43E-5 2 9.72E-6 0.20
12 SGTC_2712 st079126 4.27 47.7 µM 1.46E-5 2 9.92E-6 0.40
13 SGTC_610 4215-0184 4.20 155.0 µM 1.91E-5 exosome 20 1.31E-5 0.01
14 SGTC_2880 9042983 4.17 58.4 µM 2.20E-5 fatty acid desaturase (OLE1) 11 1.51E-5 0.20
15 SGTC_3126 9127922 4.07 49.5 µM 3.38E-5 fatty acid desaturase (OLE1) 28 2.36E-5 0.01
16 SGTC_2315 7733312 3.95 200.0 µM 5.59E-5 8 3.98E-5 0.14
17 SGTC_2569 tetrandrine 3.90 100.0 µM 6.69E-5 2 4.78E-5 0.07
18 SGTC_2312 7706453 3.85 155.7 µM 8.14E-5 14 5.86E-5 0.15
19 SGTC_2014 4013930 3.79 200.0 µM 1.03E-4 5 7.50E-5 0.22
20 SGTC_3355 9151058 3.77 44.0 µM 1.13E-4 RNA processing & uracil transport 4 8.24E-5 0.14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.215 2.09E-36 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.194 1.37E-29 YNL061W NOP2 het Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
0.192 3.05E-29 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.191 8.98E-29 YLR009W RLP24 het Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
0.182 2.07E-26 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.177 5.43E-25 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.170 3.03E-23 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.168 1.16E-22 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.164 1.24E-21 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.149 4.36E-18 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.149 5.08E-18 YCR035C RRP43 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress
0.148 7.06E-18 YBR190W_d YBR190W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
0.142 1.54E-16 YPL235W RVB2 het ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly
0.142 1.72E-16 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.141 1.88E-16 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria