YOR208W / PTP2

Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR208W / PTP2

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-3.90|P-value:1.94E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.96|P-value:1.53E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.92|P-value:1.82E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.28|P-value:2.74E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.20|P-value:3.77E-4 ID:SGTC_215|Compound:1287-0124|FD-Score:3.02|P-value:7.29E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.14|P-value:4.68E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.17|P-value:4.16E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:4.90|P-value:1.21E-7 ID:SGTC_842|Compound:0271-0008|FD-Score:3.45|P-value:1.42E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:-3.00|P-value:7.70E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.15|P-value:4.47E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.36|P-value:1.99E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.12|P-value:5.02E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.69|P-value:5.05E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.93|P-value:9.97E-4 ID:SGTC_1606|Compound:st000094|FD-Score:2.94|P-value:9.98E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.03|P-value:1.10E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-4.36|P-value:2.20E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.05|P-value:9.77E-6 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.88|P-value:2.21E-5 ID:SGTC_2034|Compound:5197015|FD-Score:6.31|P-value:1.55E-11 ID:SGTC_2038|Compound:4100038|FD-Score:-3.17|P-value:4.20E-4 ID:SGTC_2047|Compound:4141938|FD-Score:3.25|P-value:3.06E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.22|P-value:3.40E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-4.59|P-value:6.69E-7 ID:SGTC_2371|Compound:9071574|FD-Score:3.02|P-value:7.23E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.14|P-value:4.72E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.76|P-value:3.68E-5 ID:SGTC_2401|Compound:5128683|FD-Score:-3.69|P-value:5.09E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.05|P-value:6.70E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.26|P-value:3.02E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.23|P-value:3.32E-4 ID:SGTC_2811|Compound:7967822|FD-Score:4.38|P-value:2.01E-6 ID:SGTC_2832|Compound:7992762|FD-Score:-3.12|P-value:4.94E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.35|P-value:2.06E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.87|P-value:2.27E-5 ID:SGTC_3047|Compound:9092122|FD-Score:-3.38|P-value:1.83E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.31|P-value:2.44E-4 ID:SGTC_3161|Compound:9100388|FD-Score:3.33|P-value:2.26E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.68|P-value:5.27E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.90|P-value:1.94E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.96|P-value:1.53E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.92|P-value:1.82E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.28|P-value:2.74E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.20|P-value:3.77E-4 ID:SGTC_215|Compound:1287-0124|FD-Score:3.02|P-value:7.29E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.14|P-value:4.68E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.17|P-value:4.16E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:4.90|P-value:1.21E-7 ID:SGTC_842|Compound:0271-0008|FD-Score:3.45|P-value:1.42E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:-3.00|P-value:7.70E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.15|P-value:4.47E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.36|P-value:1.99E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.12|P-value:5.02E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.69|P-value:5.05E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.93|P-value:9.97E-4 ID:SGTC_1606|Compound:st000094|FD-Score:2.94|P-value:9.98E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.03|P-value:1.10E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-4.36|P-value:2.20E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.05|P-value:9.77E-6 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.88|P-value:2.21E-5 ID:SGTC_2034|Compound:5197015|FD-Score:6.31|P-value:1.55E-11 ID:SGTC_2038|Compound:4100038|FD-Score:-3.17|P-value:4.20E-4 ID:SGTC_2047|Compound:4141938|FD-Score:3.25|P-value:3.06E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.22|P-value:3.40E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-4.59|P-value:6.69E-7 ID:SGTC_2371|Compound:9071574|FD-Score:3.02|P-value:7.23E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.14|P-value:4.72E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.76|P-value:3.68E-5 ID:SGTC_2401|Compound:5128683|FD-Score:-3.69|P-value:5.09E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.05|P-value:6.70E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.26|P-value:3.02E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.23|P-value:3.32E-4 ID:SGTC_2811|Compound:7967822|FD-Score:4.38|P-value:2.01E-6 ID:SGTC_2832|Compound:7992762|FD-Score:-3.12|P-value:4.94E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.35|P-value:2.06E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.87|P-value:2.27E-5 ID:SGTC_3047|Compound:9092122|FD-Score:-3.38|P-value:1.83E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.31|P-value:2.44E-4 ID:SGTC_3161|Compound:9100388|FD-Score:3.33|P-value:2.26E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.68|P-value:5.27E-5

Top fitness defect scores for YOR208W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2034 5197015 6.31 53.1 µM 1.55E-11 SWF1 & branched chain AA biosynthesis 7 1.44E-10
2 SGTC_722 3534-0461 4.90 190.0 µM 1.21E-7 PDR1 19 4.74E-7
3 SGTC_2811 7967822 4.38 32.5 µM 2.01E-6 12 6.01E-6
4 SGTC_1679 4130-1276 4.03 6.7 µM 1.10E-5 Golgi 61 2.80E-5
5 SGTC_58 0957-0393 3.96 9.0 µM 1.53E-5 cell wall 371 3.78E-5
6 SGTC_69 0096-0274 3.92 206.7 µM 1.82E-5 mitochondrial processes 42 4.41E-5
7 SGTC_1951 sophoraflavanone G 3.88 9.2 µM 2.21E-5 RNA processing & uracil transport 24 5.27E-5
8 SGTC_2939 9044578 3.87 71.4 µM 2.27E-5 43 5.39E-5
9 SGTC_1458 k015-0034 3.69 6.3 µM 5.05E-5 20 1.11E-4
10 SGTC_3170 9103054 3.68 49.5 µM 5.27E-5 60S ribosome export 17 1.16E-4
11 SGTC_842 0271-0008 3.45 11.1 µM 1.42E-4 heme biosynthesis & mitochondrial translocase 31 2.85E-4
12 SGTC_964 1287-0107 3.36 19.4 µM 1.99E-4 cell wall 72 3.85E-4
13 SGTC_3161 9100388 3.33 49.5 µM 2.26E-4 iron homeostasis 17 4.34E-4
14 SGTC_3138 9097216 3.31 49.5 µM 2.44E-4 31 4.65E-4
15 SGTC_2739 tacrine 3.26 100.9 µM 3.02E-4 heme requiring 38 5.64E-4
16 SGTC_2047 4141938 3.25 200.0 µM 3.06E-4 19 5.70E-4
17 SGTC_2761 levamisole 3.23 97.9 µM 3.32E-4 40 6.14E-4
18 SGTC_151 3013-0144 3.20 2.3 µM 3.77E-4 iron homeostasis 57 6.89E-4
19 SGTC_958 1222-0007 3.15 33.0 µM 4.47E-4 56 8.04E-4
20 SGTC_362 0310-0100 3.14 9.0 µM 4.68E-4 RPP1 & pyrimidine depletion 76 8.38E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.170 3.48E-23 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.126 2.01E-13 YNL211C_p YNL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
0.122 1.15E-12 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.118 7.55E-12 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.118 7.63E-12 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.111 1.17E-10 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.109 2.38E-10 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.104 1.72E-9 YNL016W PUB1 hom Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress
0.103 1.97E-9 YML021C UNG1 hom Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
0.102 3.80E-9 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.101 4.36E-9 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.101 4.80E-9 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.100 6.44E-9 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.099 9.25E-9 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.097 1.54E-8 YOL036W_p YOL036W_p hom Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication