YOR209C / NPT1

Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR209C / NPT1

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:4.92|P-value:8.19E-6 ID:SGTC_51|Compound:1013-0126|FD-Score:5.50|P-value:6.94E-7 ID:SGTC_78|Compound:0336-0123|FD-Score:3.76|P-value:5.51E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.58|P-value:3.17E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.51|P-value:1.35E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:9.35|P-value:5.23E-17 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.68|P-value:2.81E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.41|P-value:5.99E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:5.02|P-value:5.52E-6 ID:SGTC_394|Compound:menadione|FD-Score:3.98|P-value:2.69E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.63|P-value:8.41E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.68|P-value:7.05E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.84|P-value:4.30E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:4.16|P-value:1.45E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.82|P-value:4.56E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:6.15|P-value:3.07E-8 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.06|P-value:2.04E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.71|P-value:6.48E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.72|P-value:2.46E-7 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.63|P-value:8.45E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:6.95|P-value:4.24E-10 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.15|P-value:1.50E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.90|P-value:9.12E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:3.77|P-value:5.38E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.09|P-value:1.86E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:8.62|P-value:1.04E-14 ID:SGTC_1684|Compound:st024538|FD-Score:4.02|P-value:2.40E-4 ID:SGTC_1685|Compound:st024049|FD-Score:4.47|P-value:4.86E-5 ID:SGTC_1705|Compound:st027868|FD-Score:6.61|P-value:2.82E-9 ID:SGTC_1720|Compound:st037298|FD-Score:3.69|P-value:6.83E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.91|P-value:3.44E-4 ID:SGTC_1834|Compound:st055981|FD-Score:4.26|P-value:1.05E-4 ID:SGTC_1847|Compound:st056231|FD-Score:4.42|P-value:5.78E-5 ID:SGTC_1927|Compound:st060202|FD-Score:4.19|P-value:1.33E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.79|P-value:5.05E-4 ID:SGTC_1959|Compound:st077091|FD-Score:4.46|P-value:4.99E-5 ID:SGTC_1984|Compound:st072354|FD-Score:5.38|P-value:1.16E-6 ID:SGTC_2029|Compound:5175081|FD-Score:4.25|P-value:1.09E-4 ID:SGTC_2089|Compound:5281248|FD-Score:4.77|P-value:1.50E-5 ID:SGTC_2156|Compound:5649887|FD-Score:3.73|P-value:6.05E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.70|P-value:6.69E-4 ID:SGTC_2259|Compound:7964009|FD-Score:7.38|P-value:3.43E-11 ID:SGTC_2306|Compound:7482397|FD-Score:4.54|P-value:3.63E-5 ID:SGTC_2456|Compound:5770359|FD-Score:5.05|P-value:4.83E-6 ID:SGTC_2488|Compound:5268135|FD-Score:7.09|P-value:1.91E-10 ID:SGTC_2507|Compound:purpurin|FD-Score:4.21|P-value:1.23E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:5.23|P-value:2.30E-6 ID:SGTC_2570|Compound:licareol|FD-Score:3.77|P-value:5.38E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:11.50|P-value:8.30E-25 ID:SGTC_2681|Compound:menadione|FD-Score:5.74|P-value:2.21E-7 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.67|P-value:7.44E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.94|P-value:3.10E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.91|P-value:3.44E-4 ID:SGTC_2965|Compound:9082772|FD-Score:6.87|P-value:6.47E-10 ID:SGTC_3002|Compound:9075603|FD-Score:3.65|P-value:7.73E-4 ID:SGTC_3062|Compound:9077494|FD-Score:4.95|P-value:7.38E-6 ID:SGTC_3107|Compound:9121808|FD-Score:-4.21|P-value:4.25E-5 ID:SGTC_3136|Compound:9095672|FD-Score:4.22|P-value:1.18E-4 ID:SGTC_3140|Compound:9094243|FD-Score:5.92|P-value:9.50E-8 ID:SGTC_3150|Compound:9097574|FD-Score:3.78|P-value:5.19E-4 ID:SGTC_3165|Compound:9101544|FD-Score:4.47|P-value:4.77E-5 ID:SGTC_3282|Compound:9108498|FD-Score:4.54|P-value:3.64E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:4.92|P-value:8.19E-6 ID:SGTC_51|Compound:1013-0126|FD-Score:5.50|P-value:6.94E-7 ID:SGTC_78|Compound:0336-0123|FD-Score:3.76|P-value:5.51E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.58|P-value:3.17E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.51|P-value:1.35E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:9.35|P-value:5.23E-17 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.68|P-value:2.81E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.41|P-value:5.99E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:5.02|P-value:5.52E-6 ID:SGTC_394|Compound:menadione|FD-Score:3.98|P-value:2.69E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.63|P-value:8.41E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.68|P-value:7.05E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.84|P-value:4.30E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:4.16|P-value:1.45E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.82|P-value:4.56E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:6.15|P-value:3.07E-8 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.06|P-value:2.04E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.71|P-value:6.48E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.72|P-value:2.46E-7 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.63|P-value:8.45E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:6.95|P-value:4.24E-10 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.15|P-value:1.50E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.90|P-value:9.12E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:3.77|P-value:5.38E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.09|P-value:1.86E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:8.62|P-value:1.04E-14 ID:SGTC_1684|Compound:st024538|FD-Score:4.02|P-value:2.40E-4 ID:SGTC_1685|Compound:st024049|FD-Score:4.47|P-value:4.86E-5 ID:SGTC_1705|Compound:st027868|FD-Score:6.61|P-value:2.82E-9 ID:SGTC_1720|Compound:st037298|FD-Score:3.69|P-value:6.83E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.91|P-value:3.44E-4 ID:SGTC_1834|Compound:st055981|FD-Score:4.26|P-value:1.05E-4 ID:SGTC_1847|Compound:st056231|FD-Score:4.42|P-value:5.78E-5 ID:SGTC_1927|Compound:st060202|FD-Score:4.19|P-value:1.33E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.79|P-value:5.05E-4 ID:SGTC_1959|Compound:st077091|FD-Score:4.46|P-value:4.99E-5 ID:SGTC_1984|Compound:st072354|FD-Score:5.38|P-value:1.16E-6 ID:SGTC_2029|Compound:5175081|FD-Score:4.25|P-value:1.09E-4 ID:SGTC_2089|Compound:5281248|FD-Score:4.77|P-value:1.50E-5 ID:SGTC_2156|Compound:5649887|FD-Score:3.73|P-value:6.05E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.70|P-value:6.69E-4 ID:SGTC_2259|Compound:7964009|FD-Score:7.38|P-value:3.43E-11 ID:SGTC_2306|Compound:7482397|FD-Score:4.54|P-value:3.63E-5 ID:SGTC_2456|Compound:5770359|FD-Score:5.05|P-value:4.83E-6 ID:SGTC_2488|Compound:5268135|FD-Score:7.09|P-value:1.91E-10 ID:SGTC_2507|Compound:purpurin|FD-Score:4.21|P-value:1.23E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:5.23|P-value:2.30E-6 ID:SGTC_2570|Compound:licareol|FD-Score:3.77|P-value:5.38E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:11.50|P-value:8.30E-25 ID:SGTC_2681|Compound:menadione|FD-Score:5.74|P-value:2.21E-7 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.67|P-value:7.44E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.94|P-value:3.10E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.91|P-value:3.44E-4 ID:SGTC_2965|Compound:9082772|FD-Score:6.87|P-value:6.47E-10 ID:SGTC_3002|Compound:9075603|FD-Score:3.65|P-value:7.73E-4 ID:SGTC_3062|Compound:9077494|FD-Score:4.95|P-value:7.38E-6 ID:SGTC_3107|Compound:9121808|FD-Score:-4.21|P-value:4.25E-5 ID:SGTC_3136|Compound:9095672|FD-Score:4.22|P-value:1.18E-4 ID:SGTC_3140|Compound:9094243|FD-Score:5.92|P-value:9.50E-8 ID:SGTC_3150|Compound:9097574|FD-Score:3.78|P-value:5.19E-4 ID:SGTC_3165|Compound:9101544|FD-Score:4.47|P-value:4.77E-5 ID:SGTC_3282|Compound:9108498|FD-Score:4.54|P-value:3.64E-5

Top fitness defect scores for YOR209C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2575 plumbagin 11.50 510.0 nM 8.30E-25 superoxide 4 8.71E-31
2 SGTC_141 0443-0274 9.35 32.3 µM 5.23E-17 mitochondrial response to ROS 7 4.43E-21
3 SGTC_1556 plumbagin 8.62 1.5 µM 1.04E-14 superoxide 6 3.25E-18
4 SGTC_2259 7964009 7.38 200.0 µM 3.43E-11 superoxide 8 7.96E-14
5 SGTC_2488 5268135 7.09 45.7 µM 1.91E-10 16 6.77E-13
6 SGTC_1192 1488-0095 6.95 21.4 µM 4.24E-10 2 1.84E-12
7 SGTC_2965 9082772 6.87 38.6 µM 6.47E-10 mitochondrial response to ROS 8 3.12E-12
8 SGTC_1705 st027868 6.61 56.3 µM 2.82E-9 1 1.97E-11
9 SGTC_1001 4048-4355 6.15 44.4 µM 3.07E-8 copper-dependent oxidative stress 10 3.88E-10
10 SGTC_3140 9094243 5.92 49.5 µM 9.50E-8 6 1.60E-9
11 SGTC_2681 menadione 5.74 3.2 µM 2.21E-7 superoxide 11 4.61E-9
12 SGTC_1083 didemethylchlorpromazine sulfoxide 5.72 707.4 nM 2.46E-7 redox potentiating 31 5.27E-9
13 SGTC_51 1013-0126 5.50 23.4 µM 6.94E-7 17 1.93E-8
14 SGTC_1984 st072354 5.38 53.1 µM 1.16E-6 2 3.68E-8
15 SGTC_2552 juarezic acid 5.23 87.0 µM 2.30E-6 TSC3-RPN4 10 8.65E-8
16 SGTC_2456 5770359 5.05 74.5 µM 4.83E-6 6 2.19E-7
17 SGTC_372 0155-0182 5.02 15.9 µM 5.52E-6 mitochondrial response to ROS 15 2.59E-7
18 SGTC_3062 9077494 4.95 49.5 µM 7.38E-6 mitochondrial response to ROS 22 3.74E-7
19 SGTC_19 0279-0214 4.92 38.4 µM 8.19E-6 TRP & mitochondrial translation 21 4.26E-7
20 SGTC_1371 2421-0008 4.90 32.7 µM 9.12E-6 mitochondrial processes 16 4.87E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.247 1.58E-47 YMR038C CCS1 hom Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress
0.224 1.71E-39 YJL120W_d YJL120W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
0.199 2.88E-31 YJR104C SOD1 hom Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
0.160 1.31E-20 YML007W YAP1 hom Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.149 4.78E-18 YJL121C RPE1 hom D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
0.146 1.72E-17 YPR074C TKL1 hom Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
0.146 2.37E-17 YHR206W SKN7 hom Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; SKN7 has a paralog, HMS2, that arose from the whole genome duplication
0.136 2.77E-15 YNL241C ZWF1 hom Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress
0.136 3.24E-15 YPR124W CTR1 hom High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress
0.128 1.11E-13 YGL167C PMR1 hom High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
0.127 1.39E-13 YLR188W MDL1 hom Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress
0.125 3.11E-13 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.123 1.02E-12 YPR123C_d YPR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR
0.120 3.12E-12 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.117 8.52E-12 YPL047W SGF11 hom Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation