YOR210W / RPB10

RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR210W / RPB10

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:4.76|P-value:4.51E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:4.00|P-value:5.11E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.10|P-value:1.29E-5 ID:SGTC_232|Compound:clozapine|FD-Score:3.90|P-value:6.69E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.94|P-value:6.00E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:5.27|P-value:7.48E-6 ID:SGTC_251|Compound:melphalan|FD-Score:3.97|P-value:5.50E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:-3.91|P-value:6.29E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:7.25|P-value:1.26E-9 ID:SGTC_362|Compound:0310-0100|FD-Score:5.31|P-value:6.27E-6 ID:SGTC_430|Compound:0958-0115|FD-Score:-4.67|P-value:5.88E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:3.98|P-value:5.33E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:4.92|P-value:2.67E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:6.63|P-value:2.52E-8 ID:SGTC_620|Compound:0109-0052|FD-Score:4.21|P-value:2.69E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.84|P-value:8.07E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:4.24|P-value:2.47E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:4.53|P-value:9.83E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:6.39|P-value:7.33E-8 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.83|P-value:8.22E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:4.05|P-value:4.32E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:-4.01|P-value:4.73E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-4.48|P-value:1.09E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.50|P-value:1.08E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.76|P-value:9.96E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.54|P-value:9.52E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.95|P-value:5.89E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:6.85|P-value:8.92E-9 ID:SGTC_1226|Compound:3909-7979|FD-Score:-5.46|P-value:3.40E-6 ID:SGTC_1299|Compound:1079-1439|FD-Score:5.29|P-value:6.75E-6 ID:SGTC_1319|Compound:1306-0155|FD-Score:5.73|P-value:1.26E-6 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.30|P-value:2.04E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.90|P-value:6.82E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.51|P-value:1.04E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-5.04|P-value:1.58E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.58|P-value:8.41E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:5.32|P-value:6.13E-6 ID:SGTC_1581|Compound:himbacine|FD-Score:-4.31|P-value:1.89E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.59|P-value:7.53E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-4.91|P-value:2.57E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:-4.68|P-value:5.61E-5 ID:SGTC_1712|Compound:st032288|FD-Score:6.35|P-value:8.71E-8 ID:SGTC_1716|Compound:st033144|FD-Score:-4.30|P-value:1.92E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.85|P-value:7.77E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-3.97|P-value:5.24E-4 ID:SGTC_1862|Compound:st057513|FD-Score:4.77|P-value:4.40E-5 ID:SGTC_1970|Compound:st070122|FD-Score:-3.80|P-value:8.58E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.10|P-value:3.76E-4 ID:SGTC_2109|Compound:5483026|FD-Score:6.11|P-value:2.52E-7 ID:SGTC_2172|Compound:5754775|FD-Score:4.56|P-value:8.92E-5 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:4.06|P-value:4.30E-4 ID:SGTC_2229|Compound:7354935|FD-Score:3.76|P-value:9.97E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-4.43|P-value:1.30E-4 ID:SGTC_2358|Compound:9037157|FD-Score:4.97|P-value:2.23E-5 ID:SGTC_2381|Compound:9035592|FD-Score:4.65|P-value:6.71E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:5.00|P-value:1.99E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:5.50|P-value:3.09E-6 ID:SGTC_2526|Compound:patulin|FD-Score:4.07|P-value:4.09E-4 ID:SGTC_2534|Compound:helenine|FD-Score:7.55|P-value:2.65E-10 ID:SGTC_2549|Compound:cedrol|FD-Score:4.15|P-value:3.30E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.84|P-value:7.69E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.79|P-value:9.38E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.36|P-value:1.60E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-4.89|P-value:2.74E-5 ID:SGTC_2947|Compound:9072639|FD-Score:7.32|P-value:8.61E-10 ID:SGTC_2948|Compound:9070189|FD-Score:-4.22|P-value:2.50E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.77|P-value:4.44E-5 ID:SGTC_3031|Compound:9088762|FD-Score:4.62|P-value:7.41E-5 ID:SGTC_3032|Compound:9089427|FD-Score:-5.34|P-value:5.19E-6 ID:SGTC_3095|Compound:9117207|FD-Score:-4.20|P-value:2.67E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-4.03|P-value:4.37E-4 ID:SGTC_3278|Compound:9139605|FD-Score:4.00|P-value:5.03E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-4.88|P-value:2.81E-5 ID:SGTC_3282|Compound:9108498|FD-Score:8.13|P-value:1.15E-11 ID:SGTC_3286|Compound:9117135|FD-Score:4.23|P-value:2.54E-4 ID:SGTC_3287|Compound:9117173|FD-Score:-4.87|P-value:2.94E-5 ID:SGTC_3346|Compound:9158254|FD-Score:4.15|P-value:3.29E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:4.76|P-value:4.51E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:4.00|P-value:5.11E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.10|P-value:1.29E-5 ID:SGTC_232|Compound:clozapine|FD-Score:3.90|P-value:6.69E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.94|P-value:6.00E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:5.27|P-value:7.48E-6 ID:SGTC_251|Compound:melphalan|FD-Score:3.97|P-value:5.50E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:-3.91|P-value:6.29E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:7.25|P-value:1.26E-9 ID:SGTC_362|Compound:0310-0100|FD-Score:5.31|P-value:6.27E-6 ID:SGTC_430|Compound:0958-0115|FD-Score:-4.67|P-value:5.88E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:3.98|P-value:5.33E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:4.92|P-value:2.67E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:6.63|P-value:2.52E-8 ID:SGTC_620|Compound:0109-0052|FD-Score:4.21|P-value:2.69E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.84|P-value:8.07E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:4.24|P-value:2.47E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:4.53|P-value:9.83E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:6.39|P-value:7.33E-8 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.83|P-value:8.22E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:4.05|P-value:4.32E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:-4.01|P-value:4.73E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-4.48|P-value:1.09E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.50|P-value:1.08E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.76|P-value:9.96E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.54|P-value:9.52E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.95|P-value:5.89E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:6.85|P-value:8.92E-9 ID:SGTC_1226|Compound:3909-7979|FD-Score:-5.46|P-value:3.40E-6 ID:SGTC_1299|Compound:1079-1439|FD-Score:5.29|P-value:6.75E-6 ID:SGTC_1319|Compound:1306-0155|FD-Score:5.73|P-value:1.26E-6 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.30|P-value:2.04E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.90|P-value:6.82E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.51|P-value:1.04E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-5.04|P-value:1.58E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.58|P-value:8.41E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:5.32|P-value:6.13E-6 ID:SGTC_1581|Compound:himbacine|FD-Score:-4.31|P-value:1.89E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.59|P-value:7.53E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-4.91|P-value:2.57E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:-4.68|P-value:5.61E-5 ID:SGTC_1712|Compound:st032288|FD-Score:6.35|P-value:8.71E-8 ID:SGTC_1716|Compound:st033144|FD-Score:-4.30|P-value:1.92E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.85|P-value:7.77E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-3.97|P-value:5.24E-4 ID:SGTC_1862|Compound:st057513|FD-Score:4.77|P-value:4.40E-5 ID:SGTC_1970|Compound:st070122|FD-Score:-3.80|P-value:8.58E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.10|P-value:3.76E-4 ID:SGTC_2109|Compound:5483026|FD-Score:6.11|P-value:2.52E-7 ID:SGTC_2172|Compound:5754775|FD-Score:4.56|P-value:8.92E-5 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:4.06|P-value:4.30E-4 ID:SGTC_2229|Compound:7354935|FD-Score:3.76|P-value:9.97E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-4.43|P-value:1.30E-4 ID:SGTC_2358|Compound:9037157|FD-Score:4.97|P-value:2.23E-5 ID:SGTC_2381|Compound:9035592|FD-Score:4.65|P-value:6.71E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:5.00|P-value:1.99E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:5.50|P-value:3.09E-6 ID:SGTC_2526|Compound:patulin|FD-Score:4.07|P-value:4.09E-4 ID:SGTC_2534|Compound:helenine|FD-Score:7.55|P-value:2.65E-10 ID:SGTC_2549|Compound:cedrol|FD-Score:4.15|P-value:3.30E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.84|P-value:7.69E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.79|P-value:9.38E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.36|P-value:1.60E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-4.89|P-value:2.74E-5 ID:SGTC_2947|Compound:9072639|FD-Score:7.32|P-value:8.61E-10 ID:SGTC_2948|Compound:9070189|FD-Score:-4.22|P-value:2.50E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.77|P-value:4.44E-5 ID:SGTC_3031|Compound:9088762|FD-Score:4.62|P-value:7.41E-5 ID:SGTC_3032|Compound:9089427|FD-Score:-5.34|P-value:5.19E-6 ID:SGTC_3095|Compound:9117207|FD-Score:-4.20|P-value:2.67E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-4.03|P-value:4.37E-4 ID:SGTC_3278|Compound:9139605|FD-Score:4.00|P-value:5.03E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-4.88|P-value:2.81E-5 ID:SGTC_3282|Compound:9108498|FD-Score:8.13|P-value:1.15E-11 ID:SGTC_3286|Compound:9117135|FD-Score:4.23|P-value:2.54E-4 ID:SGTC_3287|Compound:9117173|FD-Score:-4.87|P-value:2.94E-5 ID:SGTC_3346|Compound:9158254|FD-Score:4.15|P-value:3.29E-4

Top fitness defect scores for YOR210W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3282 9108498 8.13 15.5 µM 1.15E-11 2 2.17E-16 0.57
2 SGTC_2534 helenine 7.55 20.1 µM 2.65E-10 RSC complex & mRNA processing 7 2.16E-14 0.22
3 SGTC_2947 9072639 7.32 7.7 µM 8.61E-10 tubulin folding & SWR complex 2 1.21E-13 1.24
4 SGTC_351 caspofungin 7.25 25.0 nM 1.26E-9 cell wall 8 2.12E-13 0.53
5 SGTC_1178 0988-0033 6.85 191.0 µM 8.92E-9 1 3.72E-12 1.41
6 SGTC_611 3453-1652 6.63 23.7 µM 2.52E-8 7 1.70E-11 0.56
7 SGTC_839 0122-0028 6.39 230.0 µM 7.33E-8 RSC complex & mRNA processing 8 8.11E-11 0.05
8 SGTC_1712 st032288 6.35 53.4 µM 8.71E-8 calcium & mitochondrial duress 11 1.04E-10 0.51
9 SGTC_2109 5483026 6.11 200.0 µM 2.52E-7 RSC complex & mRNA processing 18 4.93E-10 0.04
10 SGTC_1319 1306-0155 5.73 43.7 µM 1.26E-6 2 5.17E-9 0.03
11 SGTC_2497 7-hydroxyflavone 5.50 100.0 µM 3.09E-6 2 1.91E-8 0.83
12 SGTC_1544 7-methoxy-4-methylcoumarin 5.32 105.0 µM 6.13E-6 2 5.19E-8 0.80
13 SGTC_362 0310-0100 5.31 9.0 µM 6.27E-6 RPP1 & pyrimidine depletion 4 5.36E-8 0.17
14 SGTC_1299 1079-1439 5.29 3.7 µM 6.75E-6 TSC3-RPN4 1 5.97E-8 1.11
15 SGTC_246 cycloheximide 5.27 667.0 µM 7.48E-6 5 6.93E-8 0.07
16 SGTC_2495 cafestol 5.00 54.5 µM 1.99E-5 Golgi 4 2.88E-7 0.35
17 SGTC_2358 9037157 4.97 4.0 µM 2.23E-5 8 3.39E-7 0.03
18 SGTC_605 1315-0399 4.92 119.0 µM 2.67E-5 Golgi 4 4.42E-7 0.08
19 SGTC_1862 st057513 4.77 3.8 µM 4.40E-5 2 9.12E-7 0.42
20 SGTC_2952 9073731 4.77 13.8 µM 4.44E-5 tubulin folding & SWR complex 9 9.24E-7 0.42

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 7.56E-22 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.141 1.99E-16 YDR404C RPB7 het RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
0.141 2.96E-16 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.121 2.19E-12 YDL150W RPC53 het RNA polymerase III subunit C53
0.120 3.35E-12 YBR154C RPB5 het RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
0.120 3.53E-12 YOL005C RPB11 het RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
0.119 5.01E-12 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.111 1.19E-10 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.111 1.30E-10 YDR324C UTP4 het Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
0.110 1.73E-10 YNL178W RPS3 het Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.110 2.03E-10 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.109 2.15E-10 YMR185W RTP1 het Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene
0.109 2.73E-10 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.108 3.81E-10 YDR398W UTP5 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.108 4.12E-10 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein