YOR211C / MGM1

Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR211C / MGM1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.05|P-value:7.75E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.30|P-value:3.03E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.10|P-value:1.00E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.40|P-value:2.07E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.52|P-value:1.30E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:3.91|P-value:2.44E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:6.97|P-value:2.25E-13 ID:SGTC_236|Compound:1509-0011|FD-Score:10.20|P-value:1.22E-26 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.94|P-value:3.27E-10 ID:SGTC_283|Compound:0987-0079|FD-Score:3.06|P-value:7.44E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.75|P-value:4.80E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.19|P-value:6.73E-6 ID:SGTC_426|Compound:0988-0037|FD-Score:3.04|P-value:7.89E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.35|P-value:1.33E-8 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.03|P-value:8.10E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.30|P-value:3.01E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.06|P-value:7.38E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.90|P-value:2.52E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:4.16|P-value:7.85E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:5.71|P-value:1.45E-9 ID:SGTC_791|Compound:1348-1292|FD-Score:3.27|P-value:3.35E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.21|P-value:4.19E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.63|P-value:8.13E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:3.73|P-value:5.28E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.14|P-value:5.52E-4 ID:SGTC_918|Compound:glabranin|FD-Score:5.05|P-value:7.51E-8 ID:SGTC_933|Compound:2914-0560|FD-Score:2.98|P-value:9.94E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.26|P-value:3.55E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.61|P-value:8.46E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.57|P-value:1.02E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.04|P-value:7.86E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.19|P-value:4.65E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:7.71|P-value:5.79E-16 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.20|P-value:4.48E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:8.94|P-value:7.88E-21 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.79|P-value:4.04E-5 ID:SGTC_1623|Compound:st003709|FD-Score:3.51|P-value:1.34E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.43|P-value:1.82E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.91|P-value:1.70E-7 ID:SGTC_1749|Compound:st037932|FD-Score:-3.72|P-value:5.52E-5 ID:SGTC_1776|Compound:st049249|FD-Score:3.46|P-value:1.60E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.84|P-value:2.45E-7 ID:SGTC_1834|Compound:st055981|FD-Score:3.37|P-value:2.27E-4 ID:SGTC_1989|Compound:st071868|FD-Score:4.06|P-value:1.23E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-3.23|P-value:3.88E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.69|P-value:5.41E-7 ID:SGTC_2067|Compound:5224629|FD-Score:-4.52|P-value:1.31E-6 ID:SGTC_2174|Compound:5790901|FD-Score:3.08|P-value:6.91E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.08|P-value:6.95E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-3.22|P-value:4.13E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.39|P-value:2.12E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.87|P-value:2.90E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.30|P-value:3.04E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.66|P-value:7.16E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:3.02|P-value:8.65E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.69|P-value:6.23E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.13|P-value:5.73E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.16|P-value:5.03E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.59|P-value:9.43E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.92|P-value:2.37E-5 ID:SGTC_2829|Compound:7992743|FD-Score:5.10|P-value:5.72E-8 ID:SGTC_2887|Compound:9044784|FD-Score:-3.51|P-value:1.35E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.94|P-value:3.38E-10 ID:SGTC_2910|Compound:7948405|FD-Score:3.38|P-value:2.22E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.30|P-value:2.99E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.51|P-value:1.31E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.18|P-value:4.80E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.41|P-value:1.95E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.05|P-value:7.75E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.30|P-value:3.03E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.10|P-value:1.00E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.40|P-value:2.07E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.52|P-value:1.30E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:3.91|P-value:2.44E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:6.97|P-value:2.25E-13 ID:SGTC_236|Compound:1509-0011|FD-Score:10.20|P-value:1.22E-26 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.94|P-value:3.27E-10 ID:SGTC_283|Compound:0987-0079|FD-Score:3.06|P-value:7.44E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.75|P-value:4.80E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.19|P-value:6.73E-6 ID:SGTC_426|Compound:0988-0037|FD-Score:3.04|P-value:7.89E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.35|P-value:1.33E-8 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.03|P-value:8.10E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.30|P-value:3.01E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.06|P-value:7.38E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.90|P-value:2.52E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:4.16|P-value:7.85E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:5.71|P-value:1.45E-9 ID:SGTC_791|Compound:1348-1292|FD-Score:3.27|P-value:3.35E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.21|P-value:4.19E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.63|P-value:8.13E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:3.73|P-value:5.28E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.14|P-value:5.52E-4 ID:SGTC_918|Compound:glabranin|FD-Score:5.05|P-value:7.51E-8 ID:SGTC_933|Compound:2914-0560|FD-Score:2.98|P-value:9.94E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.26|P-value:3.55E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.61|P-value:8.46E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.57|P-value:1.02E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.04|P-value:7.86E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.19|P-value:4.65E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:7.71|P-value:5.79E-16 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.20|P-value:4.48E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:8.94|P-value:7.88E-21 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.79|P-value:4.04E-5 ID:SGTC_1623|Compound:st003709|FD-Score:3.51|P-value:1.34E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.43|P-value:1.82E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.91|P-value:1.70E-7 ID:SGTC_1749|Compound:st037932|FD-Score:-3.72|P-value:5.52E-5 ID:SGTC_1776|Compound:st049249|FD-Score:3.46|P-value:1.60E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.84|P-value:2.45E-7 ID:SGTC_1834|Compound:st055981|FD-Score:3.37|P-value:2.27E-4 ID:SGTC_1989|Compound:st071868|FD-Score:4.06|P-value:1.23E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-3.23|P-value:3.88E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.69|P-value:5.41E-7 ID:SGTC_2067|Compound:5224629|FD-Score:-4.52|P-value:1.31E-6 ID:SGTC_2174|Compound:5790901|FD-Score:3.08|P-value:6.91E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.08|P-value:6.95E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-3.22|P-value:4.13E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.39|P-value:2.12E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.87|P-value:2.90E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.30|P-value:3.04E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.66|P-value:7.16E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:3.02|P-value:8.65E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.69|P-value:6.23E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.13|P-value:5.73E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.16|P-value:5.03E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.59|P-value:9.43E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.92|P-value:2.37E-5 ID:SGTC_2829|Compound:7992743|FD-Score:5.10|P-value:5.72E-8 ID:SGTC_2887|Compound:9044784|FD-Score:-3.51|P-value:1.35E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.94|P-value:3.38E-10 ID:SGTC_2910|Compound:7948405|FD-Score:3.38|P-value:2.22E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.30|P-value:2.99E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.51|P-value:1.31E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.18|P-value:4.80E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.41|P-value:1.95E-4

Top fitness defect scores for YOR211C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 10.20 5.3 µM 1.22E-26 191 8.15E-25
2 SGTC_1514 1189-1591 8.94 158.0 µM 7.88E-21 2 1.98E-19
3 SGTC_1353 1498-1206 7.71 8.1 µM 5.79E-16 mitochondrial response to ROS 4 6.43E-15
4 SGTC_173 1273-0061 6.97 2.7 µM 2.25E-13 mitochondrial stress 88 1.62E-12
5 SGTC_275 trichlorophene 5.94 5.7 µM 3.27E-10 mitochondrial stress 123 1.39E-9
6 SGTC_778 3456-2434 5.71 196.0 µM 1.45E-9 mitochondrial response to ROS 26 5.52E-9
7 SGTC_2829 7992743 5.10 58.4 µM 5.72E-8 14 1.68E-7
8 SGTC_918 glabranin 5.05 770.7 nM 7.51E-8 8 2.16E-7
9 SGTC_1742 st038235 4.91 28.9 µM 1.70E-7 mitochondrial stress 80 4.60E-7
10 SGTC_2041 5107442 4.69 45.3 µM 5.41E-7 RSC complex & mRNA processing 14 1.35E-6
11 SGTC_1087 pterostilbene 4.61 9.1 µM 8.46E-7 15 2.04E-6
12 SGTC_116 0155-0182 4.52 31.8 µM 1.30E-6 mitochondrial response to ROS 53 3.03E-6
13 SGTC_691 1548-0686 4.16 185.0 µM 7.85E-6 27 1.62E-5
14 SGTC_63 0099-0242 4.10 26.7 µM 1.00E-5 mitochondrial stress 82 2.03E-5
15 SGTC_1989 st071868 4.06 50.2 µM 1.23E-5 12 2.46E-5
16 SGTC_2688 kanamycin b 3.92 96.7 µM 2.37E-5 calcium & mitochondrial duress 375 4.52E-5
17 SGTC_141 0443-0274 3.91 32.3 µM 2.44E-5 mitochondrial response to ROS 42 4.64E-5
18 SGTC_625 k213-0058 3.90 121.0 µM 2.52E-5 translation 109 4.78E-5
19 SGTC_2321 7390090 3.87 138.8 µM 2.90E-5 30 5.45E-5
20 SGTC_310 1273-0058 3.75 1.1 µM 4.80E-5 mitochondrial stress 256 8.71E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.399 5.82E-128 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.397 7.70E-127 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.392 7.71E-124 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.383 1.96E-117 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.380 1.56E-115 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.375 2.40E-112 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.370 3.64E-109 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.368 5.23E-108 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.364 7.35E-106 YBR179C FZO1 hom Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.364 1.05E-105 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.363 3.49E-105 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.360 2.59E-103 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.359 2.14E-102 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.356 6.10E-101 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.356 1.02E-100 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria