HIPHOP chemogenomics database

YOR211C / MGM1

Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy

Zygosity: Homozygous strain

fixedexpanded
Profile for YOR211C / MGM1

Click on Significant Values for Screen Details

Top fitness defect scores for YOR211C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	10.20	5.3 µM	1.22E-26		191	8.15E-25
2	SGTC_1514	1189-1591	8.94	158.0 µM	7.88E-21		2	1.98E-19
3	SGTC_1353	1498-1206	7.71	8.1 µM	5.79E-16	mitochondrial response to ROS	4	6.43E-15
4	SGTC_173	1273-0061	6.97	2.7 µM	2.25E-13	mitochondrial stress	88	1.62E-12
5	SGTC_275	trichlorophene	5.94	5.7 µM	3.27E-10	mitochondrial stress	123	1.39E-9
6	SGTC_778	3456-2434	5.71	196.0 µM	1.45E-9	mitochondrial response to ROS	26	5.52E-9
7	SGTC_2829	7992743	5.10	58.4 µM	5.72E-8		14	1.68E-7
8	SGTC_918	glabranin	5.05	770.7 nM	7.51E-8		8	2.16E-7
9	SGTC_1742	st038235	4.91	28.9 µM	1.70E-7	mitochondrial stress	80	4.60E-7
10	SGTC_2041	5107442	4.69	45.3 µM	5.41E-7	RSC complex & mRNA processing	14	1.35E-6
11	SGTC_1087	pterostilbene	4.61	9.1 µM	8.46E-7		15	2.04E-6
12	SGTC_116	0155-0182	4.52	31.8 µM	1.30E-6	mitochondrial response to ROS	53	3.03E-6
13	SGTC_691	1548-0686	4.16	185.0 µM	7.85E-6		27	1.62E-5
14	SGTC_63	0099-0242	4.10	26.7 µM	1.00E-5	mitochondrial stress	82	2.03E-5
15	SGTC_1989	st071868	4.06	50.2 µM	1.23E-5		12	2.46E-5
16	SGTC_2688	kanamycin b	3.92	96.7 µM	2.37E-5	calcium & mitochondrial duress	375	4.52E-5
17	SGTC_141	0443-0274	3.91	32.3 µM	2.44E-5	mitochondrial response to ROS	42	4.64E-5
18	SGTC_625	k213-0058	3.90	121.0 µM	2.52E-5	translation	109	4.78E-5
19	SGTC_2321	7390090	3.87	138.8 µM	2.90E-5		30	5.45E-5
20	SGTC_310	1273-0058	3.75	1.1 µM	4.80E-5	mitochondrial stress	256	8.71E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.399	5.82E-128	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.397	7.70E-127	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.392	7.71E-124	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.383	1.96E-117	YDR268W	MSW1	hom	Mitochondrial tryptophanyl-tRNA synthetase
0.380	1.56E-115	YMR193W	MRPL24	hom	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.375	2.40E-112	YMR098C	ATP25	hom	Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.370	3.64E-109	YDR079W	PET100	hom	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.368	5.23E-108	YNL184C_p	YNL184C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.364	7.35E-106	YBR179C	FZO1	hom	Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.364	1.05E-105	YPR100W	MRPL51	hom	Mitochondrial ribosomal protein of the large subunit
0.363	3.49E-105	YLL033W	IRC19	hom	Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.360	2.59E-103	YKL170W	MRPL38	hom	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.359	2.14E-102	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.356	6.10E-101	YDR298C	ATP5	hom	Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.356	1.02E-100	YGR102C	GTF1	hom	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria