Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOR211C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.399 | 5.82E-128 | YMR287C | DSS1 | hom | 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs |
0.397 | 7.70E-127 | YGR215W | RSM27 | hom | Mitochondrial ribosomal protein of the small subunit |
0.392 | 7.71E-124 | YDR462W | MRPL28 | hom | Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress |
0.383 | 1.96E-117 | YDR268W | MSW1 | hom | Mitochondrial tryptophanyl-tRNA synthetase |
0.380 | 1.56E-115 | YMR193W | MRPL24 | hom | Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene |
0.375 | 2.40E-112 | YMR098C | ATP25 | hom | Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene |
0.370 | 3.64E-109 | YDR079W | PET100 | hom | Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme |
0.368 | 5.23E-108 | YNL184C_p | YNL184C_p | hom | Protein of unknown function; expressed at both mRNA and protein levels |
0.364 | 7.35E-106 | YBR179C | FZO1 | hom | Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system |
0.364 | 1.05E-105 | YPR100W | MRPL51 | hom | Mitochondrial ribosomal protein of the large subunit |
0.363 | 3.49E-105 | YLL033W | IRC19 | hom | Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci |
0.360 | 2.59E-103 | YKL170W | MRPL38 | hom | Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress |
0.359 | 2.14E-102 | YNL252C | MRPL17 | hom | Mitochondrial ribosomal protein of the large subunit |
0.356 | 6.10E-101 | YDR298C | ATP5 | hom | Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated |
0.356 | 1.02E-100 | YGR102C | GTF1 | hom | Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria |