YOR213C / SAS5

Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR213C / SAS5

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:3.63|P-value:2.70E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:9.35|P-value:1.06E-19 ID:SGTC_40|Compound:0327-0103|FD-Score:4.21|P-value:2.90E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.89|P-value:7.99E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:3.81|P-value:1.39E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:18.40|P-value:3.46E-71 ID:SGTC_137|Compound:0438-0332|FD-Score:3.69|P-value:2.12E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.44|P-value:1.09E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:-3.15|P-value:9.32E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.25|P-value:9.73E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:3.86|P-value:1.15E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.52|P-value:4.00E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:4.04|P-value:5.68E-5 ID:SGTC_569|Compound:4130-2812|FD-Score:3.53|P-value:3.75E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.86|P-value:7.29E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:4.19|P-value:3.08E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:4.09|P-value:4.54E-5 ID:SGTC_775|Compound:4577-0580|FD-Score:3.41|P-value:5.78E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.39|P-value:6.23E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:4.67|P-value:3.95E-6 ID:SGTC_976|Compound:1348-1067|FD-Score:4.74|P-value:2.77E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:3.25|P-value:9.99E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.88|P-value:1.06E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:5.70|P-value:2.30E-8 ID:SGTC_1194|Compound:1488-0194|FD-Score:6.20|P-value:1.29E-9 ID:SGTC_1201|Compound:1889-3372|FD-Score:-7.01|P-value:3.81E-12 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.93|P-value:8.65E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:13.70|P-value:3.59E-40 ID:SGTC_1213|Compound:1315-0166|FD-Score:10.40|P-value:5.88E-24 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.38|P-value:6.41E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.89|P-value:1.01E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-4.62|P-value:2.87E-6 ID:SGTC_1567|Compound:st069303|FD-Score:-3.87|P-value:7.02E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:-4.62|P-value:2.87E-6 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.39|P-value:4.16E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.36|P-value:1.50E-5 ID:SGTC_1827|Compound:berberine|FD-Score:4.84|P-value:1.74E-6 ID:SGTC_1829|Compound:berberine|FD-Score:4.04|P-value:5.55E-5 ID:SGTC_1909|Compound:st060837|FD-Score:4.22|P-value:2.71E-5 ID:SGTC_1910|Compound:st062352|FD-Score:4.94|P-value:1.09E-6 ID:SGTC_1913|Compound:st060213|FD-Score:3.79|P-value:1.47E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.36|P-value:6.93E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.32|P-value:7.88E-4 ID:SGTC_2117|Compound:5521686|FD-Score:5.53|P-value:5.51E-8 ID:SGTC_2118|Compound:5526350|FD-Score:-3.38|P-value:4.35E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.53|P-value:3.87E-4 ID:SGTC_2120|Compound:5538279|FD-Score:4.13|P-value:3.96E-5 ID:SGTC_2123|Compound:5259487|FD-Score:4.31|P-value:1.90E-5 ID:SGTC_2296|Compound:7971656|FD-Score:-3.61|P-value:1.90E-4 ID:SGTC_2342|Compound:7990637|FD-Score:4.45|P-value:1.05E-5 ID:SGTC_2348|Compound:9022543|FD-Score:-3.35|P-value:4.84E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.33|P-value:7.55E-4 ID:SGTC_2479|Compound:5617353|FD-Score:-3.71|P-value:1.31E-4 ID:SGTC_2511|Compound:berberine|FD-Score:4.84|P-value:1.76E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.59|P-value:3.07E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.41|P-value:5.68E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.48|P-value:9.24E-6 ID:SGTC_2671|Compound:danthron|FD-Score:3.27|P-value:9.07E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.30|P-value:8.40E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.70|P-value:2.03E-4 ID:SGTC_2783|Compound:7738165|FD-Score:4.09|P-value:4.57E-5 ID:SGTC_2811|Compound:7967822|FD-Score:6.08|P-value:2.67E-9 ID:SGTC_2857|Compound:9024691|FD-Score:6.23|P-value:1.10E-9 ID:SGTC_2947|Compound:9072639|FD-Score:-3.63|P-value:1.75E-4 ID:SGTC_3104|Compound:9120930|FD-Score:4.42|P-value:1.20E-5 ID:SGTC_3124|Compound:9127567|FD-Score:3.48|P-value:4.56E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-3.22|P-value:7.48E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.94|P-value:8.52E-5 ID:SGTC_3201|Compound:9113999|FD-Score:5.12|P-value:4.66E-7 ID:SGTC_3211|Compound:9128781|FD-Score:6.89|P-value:1.76E-11 ID:SGTC_31|Compound:0508-1974|FD-Score:3.63|P-value:2.70E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:9.35|P-value:1.06E-19 ID:SGTC_40|Compound:0327-0103|FD-Score:4.21|P-value:2.90E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.89|P-value:7.99E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:3.81|P-value:1.39E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:18.40|P-value:3.46E-71 ID:SGTC_137|Compound:0438-0332|FD-Score:3.69|P-value:2.12E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.44|P-value:1.09E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:-3.15|P-value:9.32E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.25|P-value:9.73E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:3.86|P-value:1.15E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.52|P-value:4.00E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:4.04|P-value:5.68E-5 ID:SGTC_569|Compound:4130-2812|FD-Score:3.53|P-value:3.75E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.86|P-value:7.29E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:4.19|P-value:3.08E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:4.09|P-value:4.54E-5 ID:SGTC_775|Compound:4577-0580|FD-Score:3.41|P-value:5.78E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.39|P-value:6.23E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:4.67|P-value:3.95E-6 ID:SGTC_976|Compound:1348-1067|FD-Score:4.74|P-value:2.77E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:3.25|P-value:9.99E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.88|P-value:1.06E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:5.70|P-value:2.30E-8 ID:SGTC_1194|Compound:1488-0194|FD-Score:6.20|P-value:1.29E-9 ID:SGTC_1201|Compound:1889-3372|FD-Score:-7.01|P-value:3.81E-12 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.93|P-value:8.65E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:13.70|P-value:3.59E-40 ID:SGTC_1213|Compound:1315-0166|FD-Score:10.40|P-value:5.88E-24 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.38|P-value:6.41E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.89|P-value:1.01E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-4.62|P-value:2.87E-6 ID:SGTC_1567|Compound:st069303|FD-Score:-3.87|P-value:7.02E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:-4.62|P-value:2.87E-6 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.39|P-value:4.16E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.36|P-value:1.50E-5 ID:SGTC_1827|Compound:berberine|FD-Score:4.84|P-value:1.74E-6 ID:SGTC_1829|Compound:berberine|FD-Score:4.04|P-value:5.55E-5 ID:SGTC_1909|Compound:st060837|FD-Score:4.22|P-value:2.71E-5 ID:SGTC_1910|Compound:st062352|FD-Score:4.94|P-value:1.09E-6 ID:SGTC_1913|Compound:st060213|FD-Score:3.79|P-value:1.47E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.36|P-value:6.93E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.32|P-value:7.88E-4 ID:SGTC_2117|Compound:5521686|FD-Score:5.53|P-value:5.51E-8 ID:SGTC_2118|Compound:5526350|FD-Score:-3.38|P-value:4.35E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.53|P-value:3.87E-4 ID:SGTC_2120|Compound:5538279|FD-Score:4.13|P-value:3.96E-5 ID:SGTC_2123|Compound:5259487|FD-Score:4.31|P-value:1.90E-5 ID:SGTC_2296|Compound:7971656|FD-Score:-3.61|P-value:1.90E-4 ID:SGTC_2342|Compound:7990637|FD-Score:4.45|P-value:1.05E-5 ID:SGTC_2348|Compound:9022543|FD-Score:-3.35|P-value:4.84E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.33|P-value:7.55E-4 ID:SGTC_2479|Compound:5617353|FD-Score:-3.71|P-value:1.31E-4 ID:SGTC_2511|Compound:berberine|FD-Score:4.84|P-value:1.76E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.59|P-value:3.07E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.41|P-value:5.68E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.48|P-value:9.24E-6 ID:SGTC_2671|Compound:danthron|FD-Score:3.27|P-value:9.07E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.30|P-value:8.40E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.70|P-value:2.03E-4 ID:SGTC_2783|Compound:7738165|FD-Score:4.09|P-value:4.57E-5 ID:SGTC_2811|Compound:7967822|FD-Score:6.08|P-value:2.67E-9 ID:SGTC_2857|Compound:9024691|FD-Score:6.23|P-value:1.10E-9 ID:SGTC_2947|Compound:9072639|FD-Score:-3.63|P-value:1.75E-4 ID:SGTC_3104|Compound:9120930|FD-Score:4.42|P-value:1.20E-5 ID:SGTC_3124|Compound:9127567|FD-Score:3.48|P-value:4.56E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-3.22|P-value:7.48E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.94|P-value:8.52E-5 ID:SGTC_3201|Compound:9113999|FD-Score:5.12|P-value:4.66E-7 ID:SGTC_3211|Compound:9128781|FD-Score:6.89|P-value:1.76E-11

Top fitness defect scores for YOR213C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_67 0335-0847 18.40 266.0 µM 3.46E-71 ubiquinone biosynthesis & proteasome 6 4.38E-76
2 SGTC_1205 4161-2785 13.70 76.0 µM 3.59E-40 1 5.78E-43
3 SGTC_1213 1315-0166 10.40 115.0 µM 5.88E-24 1 1.24E-25
4 SGTC_36 0335-0881 9.35 14.2 µM 1.06E-19 ubiquinone biosynthesis & proteasome 22 4.40E-21
5 SGTC_3211 9128781 6.89 49.5 µM 1.76E-11 14 2.79E-12
6 SGTC_2857 9024691 6.23 58.4 µM 1.10E-9 3 2.36E-10
7 SGTC_1194 1488-0194 6.20 225.0 µM 1.29E-9 4 2.78E-10
8 SGTC_2811 7967822 6.08 32.5 µM 2.67E-9 5 6.10E-10
9 SGTC_1121 fusaric acid 5.70 630.5 nM 2.30E-8 13 6.12E-9
10 SGTC_2117 5521686 5.53 200.0 µM 5.51E-8 3 1.56E-8
11 SGTC_3201 9113999 5.12 49.5 µM 4.66E-7 12 1.55E-7
12 SGTC_1910 st062352 4.94 60.4 µM 1.09E-6 12 3.84E-7
13 SGTC_1827 berberine 4.84 7.2 µM 1.74E-6 60S ribosome export 9 6.37E-7
14 SGTC_2511 berberine 4.84 10.5 µM 1.76E-6 60S ribosome export 10 6.45E-7
15 SGTC_976 1348-1067 4.74 47.6 µM 2.77E-6 60S ribosome export 13 1.05E-6
16 SGTC_862 0452-0056 4.67 10.2 µM 3.95E-6 azole & statin 24 1.53E-6
17 SGTC_2626 ethyl orsellinate 4.48 100.0 µM 9.24E-6 24 3.82E-6
18 SGTC_2342 7990637 4.45 118.9 µM 1.05E-5 RNA processing & uracil transport 21 4.38E-6
19 SGTC_158 k038-0087 4.44 26.4 µM 1.09E-5 ubiquinone biosynthesis & proteasome 109 4.55E-6
20 SGTC_3104 9120930 4.42 49.5 µM 1.20E-5 5 5.05E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.321 1.95E-81 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.317 4.46E-79 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.296 5.61E-69 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.287 8.10E-65 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.270 4.81E-57 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.241 9.50E-46 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.240 3.60E-45 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.214 4.54E-36 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.209 2.54E-34 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.204 7.55E-33 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.200 1.34E-31 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.192 4.03E-29 YPL153C RAD53 het Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
0.190 1.44E-28 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.187 1.11E-27 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.186 2.00E-27 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery