YOR214C_p

Putative protein of unknown function; YOR214C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR214C / YOR214C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.47|P-value:1.27E-6 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.44|P-value:1.28E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.63|P-value:6.96E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.97|P-value:1.49E-5 ID:SGTC_584|Compound:0986-0246|FD-Score:-3.49|P-value:1.04E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:4.28|P-value:3.34E-6 ID:SGTC_766|Compound:1391-0721|FD-Score:-2.99|P-value:7.19E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.22|P-value:3.61E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:4.99|P-value:7.56E-8 ID:SGTC_912|Compound:3474-0017|FD-Score:3.30|P-value:2.63E-4 ID:SGTC_917|Compound:harmaline|FD-Score:4.46|P-value:1.35E-6 ID:SGTC_972|Compound:1319-0219|FD-Score:4.34|P-value:2.55E-6 ID:SGTC_983|Compound:1491-0821|FD-Score:4.13|P-value:7.11E-6 ID:SGTC_1111|Compound:tnp00062|FD-Score:2.99|P-value:8.60E-4 ID:SGTC_1771|Compound:st048882|FD-Score:-3.88|P-value:1.81E-5 ID:SGTC_2032|Compound:5185112|FD-Score:-2.99|P-value:7.31E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.32|P-value:2.07E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.24|P-value:3.33E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.48|P-value:1.30E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.05|P-value:6.86E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.07|P-value:5.28E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.00|P-value:8.29E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.69|P-value:5.34E-5 ID:SGTC_3227|Compound:9130768|FD-Score:3.31|P-value:2.55E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.47|P-value:1.27E-6 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.44|P-value:1.28E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.63|P-value:6.96E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.97|P-value:1.49E-5 ID:SGTC_584|Compound:0986-0246|FD-Score:-3.49|P-value:1.04E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:4.28|P-value:3.34E-6 ID:SGTC_766|Compound:1391-0721|FD-Score:-2.99|P-value:7.19E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.22|P-value:3.61E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:4.99|P-value:7.56E-8 ID:SGTC_912|Compound:3474-0017|FD-Score:3.30|P-value:2.63E-4 ID:SGTC_917|Compound:harmaline|FD-Score:4.46|P-value:1.35E-6 ID:SGTC_972|Compound:1319-0219|FD-Score:4.34|P-value:2.55E-6 ID:SGTC_983|Compound:1491-0821|FD-Score:4.13|P-value:7.11E-6 ID:SGTC_1111|Compound:tnp00062|FD-Score:2.99|P-value:8.60E-4 ID:SGTC_1771|Compound:st048882|FD-Score:-3.88|P-value:1.81E-5 ID:SGTC_2032|Compound:5185112|FD-Score:-2.99|P-value:7.31E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.32|P-value:2.07E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.24|P-value:3.33E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.48|P-value:1.30E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.05|P-value:6.86E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.07|P-value:5.28E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.00|P-value:8.29E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.69|P-value:5.34E-5 ID:SGTC_3227|Compound:9130768|FD-Score:3.31|P-value:2.55E-4

Top fitness defect scores for YOR214C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_909 3448-9333 4.99 149.0 µM 7.56E-8 6 3.00E-7
2 SGTC_6 0844-0013 4.47 19.8 µM 1.27E-6 53 3.83E-6
3 SGTC_917 harmaline 4.46 728.1 nM 1.35E-6 ergosterol biosynthesis 15 4.06E-6
4 SGTC_972 1319-0219 4.34 195.0 µM 2.55E-6 15 7.19E-6
5 SGTC_605 1315-0399 4.28 119.0 µM 3.34E-6 Golgi 19 9.16E-6
6 SGTC_983 1491-0821 4.13 12.2 µM 7.11E-6 14 1.81E-5
7 SGTC_402 epigallocatechin gallate 3.97 10.0 µM 1.49E-5 24 3.54E-5
8 SGTC_2984 9022109 3.69 39.0 µM 5.34E-5 10 1.12E-4
9 SGTC_399 oxolinic acid 3.63 75.0 µM 6.96E-5 13 1.43E-4
10 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.48 3.7 µM 1.30E-4 131 2.52E-4
11 SGTC_3227 9130768 3.31 49.5 µM 2.55E-4 15 4.64E-4
12 SGTC_912 3474-0017 3.30 2.2 µM 2.63E-4 45 4.78E-4
13 SGTC_2116 5511452 3.24 16.9 µM 3.33E-4 38 5.90E-4
14 SGTC_814 3342-0569 3.22 96.0 µM 3.61E-4 50 6.36E-4
15 SGTC_2712 st079126 3.05 47.7 µM 6.86E-4 50 0.00114
16 SGTC_2956 9076196 3.00 2.5 µM 8.29E-4 72 0.00135
17 SGTC_1111 tnp00062 2.99 510.7 nM 8.60E-4 36 0.00140
18 SGTC_2058 5236698 2.82 133.0 µM 0.00156 88 0.00241
19 SGTC_1879 gemcitabine 2.82 100.0 µM 0.00157 73 0.00241
20 SGTC_248 streptozotocin 2.81 5.2 mM 0.00159 DNA damage response 73 0.00244

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.17E-28 YMR191W SPG5 hom Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.190 1.21E-28 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.157 5.86E-20 YPL004C LSP1 hom Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family
0.152 7.65E-19 YJL110C GZF3 hom GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication
0.151 1.25E-18 YLR255C_d YLR255C_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.146 1.67E-17 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.143 8.86E-17 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.140 3.18E-16 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.137 1.57E-15 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.132 1.95E-14 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.129 5.91E-14 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.129 6.10E-14 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.129 8.44E-14 YDL239C ADY3 hom Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication
0.127 1.34E-13 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.127 1.62E-13 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1