YOR216C / RUD3

Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR216C / RUD3

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:4.28|P-value:8.33E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:6.09|P-value:4.31E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.98|P-value:9.31E-13 ID:SGTC_66|Compound:0109-0187|FD-Score:4.37|P-value:5.52E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:3.33|P-value:4.04E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.54|P-value:2.45E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:8.00|P-value:3.88E-16 ID:SGTC_137|Compound:0438-0332|FD-Score:4.21|P-value:1.12E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:3.33|P-value:3.99E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.39|P-value:3.03E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.62|P-value:1.36E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.11|P-value:8.84E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.24|P-value:5.64E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.89|P-value:4.15E-7 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.23|P-value:5.59E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.57|P-value:1.64E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.04|P-value:2.23E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:4.51|P-value:2.79E-6 ID:SGTC_577|Compound:r071-0003|FD-Score:3.48|P-value:2.30E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.22|P-value:1.05E-5 ID:SGTC_680|Compound:0417-1641|FD-Score:3.26|P-value:5.11E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:5.12|P-value:1.23E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:4.89|P-value:4.18E-7 ID:SGTC_825|Compound:1988-2224|FD-Score:3.83|P-value:5.78E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:4.51|P-value:2.83E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:3.13|P-value:8.22E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.31|P-value:4.32E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.47|P-value:2.36E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:4.26|P-value:8.94E-6 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.31|P-value:4.26E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.17|P-value:7.21E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.32|P-value:3.94E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:9.19|P-value:1.01E-20 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.91|P-value:4.06E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-5.49|P-value:1.48E-8 ID:SGTC_1611|Compound:st001856|FD-Score:3.13|P-value:8.29E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:6.19|P-value:2.28E-10 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.12|P-value:8.44E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.39|P-value:3.24E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-3.34|P-value:3.74E-4 ID:SGTC_2044|Compound:5102272|FD-Score:4.07|P-value:2.09E-5 ID:SGTC_2215|Compound:7188065|FD-Score:3.20|P-value:6.36E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.20|P-value:6.29E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.29|P-value:7.97E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.14|P-value:7.79E-4 ID:SGTC_2525|Compound:harmine|FD-Score:3.40|P-value:3.08E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.24|P-value:5.35E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.12|P-value:8.33E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.41|P-value:2.98E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.93|P-value:3.74E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:10.10|P-value:1.25E-24 ID:SGTC_2736|Compound:butenafine|FD-Score:4.71|P-value:1.07E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.09|P-value:8.95E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.06|P-value:1.75E-7 ID:SGTC_2808|Compound:7946468|FD-Score:3.45|P-value:2.58E-4 ID:SGTC_2810|Compound:7959871|FD-Score:5.20|P-value:8.11E-8 ID:SGTC_2811|Compound:7967822|FD-Score:3.18|P-value:6.93E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.98|P-value:3.11E-5 ID:SGTC_2835|Compound:9006588|FD-Score:3.31|P-value:4.38E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-4.60|P-value:1.70E-6 ID:SGTC_2922|Compound:7999257|FD-Score:-5.18|P-value:8.65E-8 ID:SGTC_2923|Compound:7992654|FD-Score:11.80|P-value:4.29E-33 ID:SGTC_2925|Compound:9010536|FD-Score:-3.83|P-value:5.41E-5 ID:SGTC_2927|Compound:9011802|FD-Score:5.88|P-value:1.57E-9 ID:SGTC_3103|Compound:9120822|FD-Score:3.59|P-value:1.50E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.84|P-value:5.09E-7 ID:SGTC_3137|Compound:9097352|FD-Score:-3.36|P-value:3.48E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.19|P-value:6.66E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.23|P-value:1.73E-10 ID:SGTC_3170|Compound:9103054|FD-Score:3.17|P-value:7.22E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.28|P-value:8.33E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:6.09|P-value:4.31E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.98|P-value:9.31E-13 ID:SGTC_66|Compound:0109-0187|FD-Score:4.37|P-value:5.52E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:3.33|P-value:4.04E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.54|P-value:2.45E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:8.00|P-value:3.88E-16 ID:SGTC_137|Compound:0438-0332|FD-Score:4.21|P-value:1.12E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:3.33|P-value:3.99E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.39|P-value:3.03E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.62|P-value:1.36E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.11|P-value:8.84E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.24|P-value:5.64E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.89|P-value:4.15E-7 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.23|P-value:5.59E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.57|P-value:1.64E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.04|P-value:2.23E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:4.51|P-value:2.79E-6 ID:SGTC_577|Compound:r071-0003|FD-Score:3.48|P-value:2.30E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.22|P-value:1.05E-5 ID:SGTC_680|Compound:0417-1641|FD-Score:3.26|P-value:5.11E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:5.12|P-value:1.23E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:4.89|P-value:4.18E-7 ID:SGTC_825|Compound:1988-2224|FD-Score:3.83|P-value:5.78E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:4.51|P-value:2.83E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:3.13|P-value:8.22E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.31|P-value:4.32E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.47|P-value:2.36E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:4.26|P-value:8.94E-6 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.31|P-value:4.26E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.17|P-value:7.21E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.32|P-value:3.94E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:9.19|P-value:1.01E-20 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.91|P-value:4.06E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-5.49|P-value:1.48E-8 ID:SGTC_1611|Compound:st001856|FD-Score:3.13|P-value:8.29E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:6.19|P-value:2.28E-10 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.12|P-value:8.44E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.39|P-value:3.24E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-3.34|P-value:3.74E-4 ID:SGTC_2044|Compound:5102272|FD-Score:4.07|P-value:2.09E-5 ID:SGTC_2215|Compound:7188065|FD-Score:3.20|P-value:6.36E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.20|P-value:6.29E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.29|P-value:7.97E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.14|P-value:7.79E-4 ID:SGTC_2525|Compound:harmine|FD-Score:3.40|P-value:3.08E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.24|P-value:5.35E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.12|P-value:8.33E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.41|P-value:2.98E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.93|P-value:3.74E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:10.10|P-value:1.25E-24 ID:SGTC_2736|Compound:butenafine|FD-Score:4.71|P-value:1.07E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.09|P-value:8.95E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.06|P-value:1.75E-7 ID:SGTC_2808|Compound:7946468|FD-Score:3.45|P-value:2.58E-4 ID:SGTC_2810|Compound:7959871|FD-Score:5.20|P-value:8.11E-8 ID:SGTC_2811|Compound:7967822|FD-Score:3.18|P-value:6.93E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.98|P-value:3.11E-5 ID:SGTC_2835|Compound:9006588|FD-Score:3.31|P-value:4.38E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-4.60|P-value:1.70E-6 ID:SGTC_2922|Compound:7999257|FD-Score:-5.18|P-value:8.65E-8 ID:SGTC_2923|Compound:7992654|FD-Score:11.80|P-value:4.29E-33 ID:SGTC_2925|Compound:9010536|FD-Score:-3.83|P-value:5.41E-5 ID:SGTC_2927|Compound:9011802|FD-Score:5.88|P-value:1.57E-9 ID:SGTC_3103|Compound:9120822|FD-Score:3.59|P-value:1.50E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.84|P-value:5.09E-7 ID:SGTC_3137|Compound:9097352|FD-Score:-3.36|P-value:3.48E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.19|P-value:6.66E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.23|P-value:1.73E-10 ID:SGTC_3170|Compound:9103054|FD-Score:3.17|P-value:7.22E-4

Top fitness defect scores for YOR216C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2923 7992654 11.80 58.1 µM 4.29E-33 Golgi 1 1.31E-32
2 SGTC_2688 kanamycin b 10.10 96.7 µM 1.25E-24 calcium & mitochondrial duress 25 2.80E-24
3 SGTC_1306 1185-0270 9.19 9.0 µM 1.01E-20 Golgi 13 1.97E-20
4 SGTC_124 0136-0217 8.00 7.1 µM 3.88E-16 mitochondrial stress 10 6.39E-16
5 SGTC_3152 9099253 6.23 49.5 µM 1.73E-10 NEO1-PIK1 54 2.33E-10
6 SGTC_1789 tunicamycin 6.19 25.0 nM 2.28E-10 unfolded protein response 16 3.05E-10
7 SGTC_22 0964-0034 6.09 14.5 µM 4.31E-10 unfolded protein response 17 5.72E-10
8 SGTC_2927 9011802 5.88 47.9 µM 1.57E-9 5 2.04E-9
9 SGTC_2810 7959871 5.20 45.5 µM 8.11E-8 copper-dependent oxidative stress 17 9.93E-8
10 SGTC_791 1348-1292 5.12 225.0 µM 1.23E-7 15 1.50E-7
11 SGTC_2776 terbinafine 5.06 19.9 µM 1.75E-7 cell wall signaling 33 2.12E-7
12 SGTC_363 0455-0021 4.89 3.1 µM 4.15E-7 azole & statin 43 4.96E-7
13 SGTC_800 3448-7362 4.89 155.0 µM 4.18E-7 translation 95 5.00E-7
14 SGTC_2736 butenafine 4.71 14.7 µM 1.07E-6 16 1.26E-6
15 SGTC_121 0557-0495 4.54 61.3 µM 2.45E-6 calcium & mitochondrial duress 41 2.86E-6
16 SGTC_531 3788-1495 4.51 174.0 µM 2.79E-6 unfolded protein response 14 3.24E-6
17 SGTC_871 0574-0004 4.51 149.0 µM 2.83E-6 34 3.29E-6
18 SGTC_66 0109-0187 4.37 42.4 µM 5.52E-6 30 6.35E-6
19 SGTC_2405 ticlatone 4.29 3.5 µM 7.97E-6 58 9.12E-6
20 SGTC_18 0111-0177 4.28 500.0 nM 8.33E-6 53 9.52E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.185 2.55E-27 YEL022W GEA2 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication
0.177 4.55E-25 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.166 3.85E-22 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.164 1.13E-21 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.147 1.29E-17 YOR008C-A_p YOR008C-A_p hom Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
0.138 7.88E-16 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.137 1.88E-15 YFL031W HAC1 hom Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress
0.130 3.74E-14 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.129 6.79E-14 YFR051C RET2 het Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.128 1.10E-13 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.128 1.17E-13 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.127 1.67E-13 YEL043W YEL043W hom Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold
0.127 1.78E-13 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.127 1.80E-13 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126 2.80E-13 YGR214W RPS0A hom Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;