YOR217W / RFC1

Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR217W / RFC1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:4.09|P-value:9.60E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:5.56|P-value:1.86E-7 ID:SGTC_79|Compound:0052-0007|FD-Score:3.42|P-value:9.23E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.24|P-value:5.43E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:3.63|P-value:4.69E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:-5.46|P-value:2.30E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:4.71|P-value:8.58E-6 ID:SGTC_722|Compound:3534-0461|FD-Score:-3.34|P-value:9.98E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.52|P-value:6.78E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:4.61|P-value:1.28E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:6.63|P-value:6.72E-10 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.41|P-value:9.42E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.49|P-value:7.40E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.74|P-value:7.43E-6 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.03|P-value:1.19E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.68|P-value:3.94E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:-3.43|P-value:7.45E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.97|P-value:1.46E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:-3.41|P-value:7.89E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:6.30|P-value:4.27E-9 ID:SGTC_1246|Compound:0422-0085|FD-Score:-8.06|P-value:5.38E-14 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.78|P-value:2.33E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.99|P-value:1.40E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.75|P-value:3.17E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.40|P-value:9.70E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:-3.43|P-value:7.51E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.68|P-value:9.54E-6 ID:SGTC_1776|Compound:st049249|FD-Score:3.62|P-value:4.93E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.66|P-value:4.32E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-3.62|P-value:4.07E-4 ID:SGTC_2147|Compound:5545932|FD-Score:4.07|P-value:1.03E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-6.24|P-value:4.30E-9 ID:SGTC_2283|Compound:7944793|FD-Score:4.59|P-value:1.41E-5 ID:SGTC_2286|Compound:7945697|FD-Score:5.55|P-value:1.96E-7 ID:SGTC_2290|Compound:7904846|FD-Score:-6.73|P-value:2.69E-10 ID:SGTC_2389|Compound:9091542|FD-Score:4.63|P-value:1.21E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.62|P-value:4.80E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.70|P-value:3.74E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.71|P-value:3.61E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.58|P-value:5.46E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.21|P-value:6.27E-5 ID:SGTC_2939|Compound:9044578|FD-Score:3.57|P-value:5.68E-4 ID:SGTC_2944|Compound:9067346|FD-Score:4.99|P-value:2.56E-6 ID:SGTC_3025|Compound:9087895|FD-Score:3.59|P-value:5.40E-4 ID:SGTC_3033|Compound:9090887|FD-Score:4.00|P-value:1.32E-4 ID:SGTC_3126|Compound:9127922|FD-Score:6.39|P-value:2.54E-9 ID:SGTC_3142|Compound:9086498|FD-Score:-4.15|P-value:6.24E-5 ID:SGTC_3211|Compound:9128781|FD-Score:6.66|P-value:5.60E-10 ID:SGTC_3213|Compound:9129884|FD-Score:4.24|P-value:5.53E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:4.09|P-value:9.60E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:5.56|P-value:1.86E-7 ID:SGTC_79|Compound:0052-0007|FD-Score:3.42|P-value:9.23E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.24|P-value:5.43E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:3.63|P-value:4.69E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:-5.46|P-value:2.30E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:4.71|P-value:8.58E-6 ID:SGTC_722|Compound:3534-0461|FD-Score:-3.34|P-value:9.98E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.52|P-value:6.78E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:4.61|P-value:1.28E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:6.63|P-value:6.72E-10 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.41|P-value:9.42E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.49|P-value:7.40E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.74|P-value:7.43E-6 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.03|P-value:1.19E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.68|P-value:3.94E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:-3.43|P-value:7.45E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.97|P-value:1.46E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:-3.41|P-value:7.89E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:6.30|P-value:4.27E-9 ID:SGTC_1246|Compound:0422-0085|FD-Score:-8.06|P-value:5.38E-14 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.78|P-value:2.33E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.99|P-value:1.40E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.75|P-value:3.17E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.40|P-value:9.70E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:-3.43|P-value:7.51E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.68|P-value:9.54E-6 ID:SGTC_1776|Compound:st049249|FD-Score:3.62|P-value:4.93E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.66|P-value:4.32E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-3.62|P-value:4.07E-4 ID:SGTC_2147|Compound:5545932|FD-Score:4.07|P-value:1.03E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-6.24|P-value:4.30E-9 ID:SGTC_2283|Compound:7944793|FD-Score:4.59|P-value:1.41E-5 ID:SGTC_2286|Compound:7945697|FD-Score:5.55|P-value:1.96E-7 ID:SGTC_2290|Compound:7904846|FD-Score:-6.73|P-value:2.69E-10 ID:SGTC_2389|Compound:9091542|FD-Score:4.63|P-value:1.21E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.62|P-value:4.80E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.70|P-value:3.74E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.71|P-value:3.61E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.58|P-value:5.46E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.21|P-value:6.27E-5 ID:SGTC_2939|Compound:9044578|FD-Score:3.57|P-value:5.68E-4 ID:SGTC_2944|Compound:9067346|FD-Score:4.99|P-value:2.56E-6 ID:SGTC_3025|Compound:9087895|FD-Score:3.59|P-value:5.40E-4 ID:SGTC_3033|Compound:9090887|FD-Score:4.00|P-value:1.32E-4 ID:SGTC_3126|Compound:9127922|FD-Score:6.39|P-value:2.54E-9 ID:SGTC_3142|Compound:9086498|FD-Score:-4.15|P-value:6.24E-5 ID:SGTC_3211|Compound:9128781|FD-Score:6.66|P-value:5.60E-10 ID:SGTC_3213|Compound:9129884|FD-Score:4.24|P-value:5.53E-5

Top fitness defect scores for YOR217W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3211 9128781 6.66 49.5 µM 5.60E-10 2 1.36E-11 0.68
2 SGTC_977 1348-1378 6.63 135.0 µM 6.72E-10 1 1.69E-11 0.93
3 SGTC_3126 9127922 6.39 49.5 µM 2.54E-9 fatty acid desaturase (OLE1) 9 8.15E-11 0.52
4 SGTC_1239 0337-0584 6.30 35.4 µM 4.27E-9 unfolded protein response 14 1.51E-10 0.42
5 SGTC_21 0849-0113 5.56 23.0 µM 1.86E-7 2 1.33E-8 0.66
6 SGTC_2286 7945697 5.55 125.0 µM 1.96E-7 2 1.41E-8 0.15
7 SGTC_2944 9067346 4.99 25.6 µM 2.56E-6 5 2.96E-7 0.24
8 SGTC_1076 itraconazole 4.74 331.0 nM 7.43E-6 1 1.05E-6 0.53
9 SGTC_576 1073-0113 4.71 22.7 µM 8.58E-6 redox potentiating 32 1.24E-6 0.15
10 SGTC_1672 st016598 4.68 6.5 µM 9.54E-6 endomembrane recycling 14 1.41E-6 0.30
11 SGTC_2389 9091542 4.63 195.5 µM 1.21E-5 iron homeostasis 3 1.86E-6 0.17
12 SGTC_824 1304-0008 4.61 100.0 µM 1.28E-5 DNA damage response 5 1.98E-6 0.81
13 SGTC_2283 7944793 4.59 200.0 µM 1.41E-5 5 2.23E-6 0.42
14 SGTC_363 0455-0021 4.24 3.1 µM 5.43E-5 azole & statin 16 1.10E-5 0.14
15 SGTC_3213 9129884 4.24 49.5 µM 5.53E-5 1 1.13E-5 0.28
16 SGTC_2825 7998094 4.21 58.4 µM 6.27E-5 fatty acid desaturase (OLE1) 11 1.30E-5 0.22
17 SGTC_15 0266-0086 4.09 27.1 µM 9.60E-5 endomembrane recycling 11 2.16E-5 0.28
18 SGTC_2147 5545932 4.07 89.7 µM 1.03E-4 ergosterol biosynthesis 12 2.34E-5 0.12
19 SGTC_1080 nisoldipine 4.03 24.4 µM 1.19E-4 TSC3-RPN4 5 2.80E-5 0.39
20 SGTC_3033 9090887 4.00 49.5 µM 1.32E-4 fatty acid desaturase (OLE1) 14 3.15E-5 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.71E-13 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.114 3.56E-11 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.107 4.55E-10 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.101 4.70E-9 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.096 2.19E-8 YOR310C NOP58 het Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
0.094 4.61E-8 YCL034W LSB5 hom Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat
0.094 5.56E-8 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
0.093 7.02E-8 YIL054W_p YIL054W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.092 1.10E-7 YPL052W OAZ1 hom Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p
0.084 1.05E-6 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.081 2.55E-6 YIL156W UBP7 hom Ubiquitin-specific protease that cleaves ubiquitin-protein fusions
0.081 2.57E-6 YGR122C-A_d YGR122C-A_d hom Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
0.080 3.76E-6 YOR089C VPS21 hom Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication
0.079 4.92E-6 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.079 5.37E-6 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine