YOR218C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR218C / YOR218C

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-3.17|P-value:1.33E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.51|P-value:2.73E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-2.88|P-value:4.52E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:-3.22|P-value:1.06E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-2.74|P-value:8.08E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.23|P-value:1.00E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-2.93|P-value:3.79E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-2.73|P-value:8.40E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-2.72|P-value:8.88E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.56|P-value:9.61E-8 ID:SGTC_735|Compound:3076-0345|FD-Score:-2.75|P-value:7.74E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.44|P-value:3.87E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.13|P-value:1.83E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.14|P-value:1.75E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.30|P-value:7.32E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:3.94|P-value:3.41E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:5.76|P-value:2.40E-11 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.33|P-value:6.35E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:2.78|P-value:7.65E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:2.90|P-value:4.79E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.95|P-value:3.24E-6 ID:SGTC_1323|Compound:1348-1351|FD-Score:2.92|P-value:4.34E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.75|P-value:8.30E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.37|P-value:5.26E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:2.79|P-value:7.55E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.12|P-value:1.68E-4 ID:SGTC_1765|Compound:st044815|FD-Score:-3.26|P-value:8.80E-5 ID:SGTC_1863|Compound:st057641|FD-Score:-3.59|P-value:1.88E-5 ID:SGTC_1866|Compound:st057638|FD-Score:-3.67|P-value:1.25E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:2.77|P-value:7.96E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-4.71|P-value:3.24E-8 ID:SGTC_2006|Compound:4011487|FD-Score:3.29|P-value:8.81E-5 ID:SGTC_2285|Compound:7945142|FD-Score:3.94|P-value:3.42E-6 ID:SGTC_2340|Compound:7987427|FD-Score:3.05|P-value:2.58E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.55|P-value:2.54E-5 ID:SGTC_2374|Compound:9071832|FD-Score:3.20|P-value:1.30E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:6.24|P-value:5.08E-13 ID:SGTC_2696|Compound:st077691|FD-Score:-2.90|P-value:4.29E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:2.87|P-value:5.49E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:5.19|P-value:1.56E-9 ID:SGTC_2816|Compound:7982706|FD-Score:4.46|P-value:1.79E-7 ID:SGTC_2826|Compound:7992541|FD-Score:-3.61|P-value:1.70E-5 ID:SGTC_2874|Compound:9043904|FD-Score:2.89|P-value:5.00E-4 ID:SGTC_2883|Compound:9059145|FD-Score:-2.79|P-value:6.52E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-4.72|P-value:2.95E-8 ID:SGTC_2893|Compound:9048488|FD-Score:3.00|P-value:3.11E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.43|P-value:4.72E-5 ID:SGTC_2916|Compound:7875993|FD-Score:-2.79|P-value:6.52E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.89|P-value:4.45E-6 ID:SGTC_2939|Compound:9044578|FD-Score:-4.02|P-value:1.89E-6 ID:SGTC_2965|Compound:9082772|FD-Score:-7.36|P-value:1.52E-17 ID:SGTC_3043|Compound:9092303|FD-Score:-2.95|P-value:3.48E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-4.25|P-value:5.14E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-2.93|P-value:3.78E-4 ID:SGTC_3109|Compound:9122853|FD-Score:2.95|P-value:3.82E-4 ID:SGTC_3118|Compound:9124250|FD-Score:-3.01|P-value:2.71E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-2.72|P-value:8.57E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-2.73|P-value:8.50E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.12|P-value:1.87E-4 ID:SGTC_3303|Compound:9125618|FD-Score:2.73|P-value:9.26E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.17|P-value:1.33E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.51|P-value:2.73E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-2.88|P-value:4.52E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:-3.22|P-value:1.06E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-2.74|P-value:8.08E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.23|P-value:1.00E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-2.93|P-value:3.79E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-2.73|P-value:8.40E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-2.72|P-value:8.88E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.56|P-value:9.61E-8 ID:SGTC_735|Compound:3076-0345|FD-Score:-2.75|P-value:7.74E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.44|P-value:3.87E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.13|P-value:1.83E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.14|P-value:1.75E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.30|P-value:7.32E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:3.94|P-value:3.41E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:5.76|P-value:2.40E-11 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.33|P-value:6.35E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:2.78|P-value:7.65E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:2.90|P-value:4.79E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.95|P-value:3.24E-6 ID:SGTC_1323|Compound:1348-1351|FD-Score:2.92|P-value:4.34E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.75|P-value:8.30E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.37|P-value:5.26E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:2.79|P-value:7.55E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.12|P-value:1.68E-4 ID:SGTC_1765|Compound:st044815|FD-Score:-3.26|P-value:8.80E-5 ID:SGTC_1863|Compound:st057641|FD-Score:-3.59|P-value:1.88E-5 ID:SGTC_1866|Compound:st057638|FD-Score:-3.67|P-value:1.25E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:2.77|P-value:7.96E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-4.71|P-value:3.24E-8 ID:SGTC_2006|Compound:4011487|FD-Score:3.29|P-value:8.81E-5 ID:SGTC_2285|Compound:7945142|FD-Score:3.94|P-value:3.42E-6 ID:SGTC_2340|Compound:7987427|FD-Score:3.05|P-value:2.58E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.55|P-value:2.54E-5 ID:SGTC_2374|Compound:9071832|FD-Score:3.20|P-value:1.30E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:6.24|P-value:5.08E-13 ID:SGTC_2696|Compound:st077691|FD-Score:-2.90|P-value:4.29E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:2.87|P-value:5.49E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:5.19|P-value:1.56E-9 ID:SGTC_2816|Compound:7982706|FD-Score:4.46|P-value:1.79E-7 ID:SGTC_2826|Compound:7992541|FD-Score:-3.61|P-value:1.70E-5 ID:SGTC_2874|Compound:9043904|FD-Score:2.89|P-value:5.00E-4 ID:SGTC_2883|Compound:9059145|FD-Score:-2.79|P-value:6.52E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-4.72|P-value:2.95E-8 ID:SGTC_2893|Compound:9048488|FD-Score:3.00|P-value:3.11E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.43|P-value:4.72E-5 ID:SGTC_2916|Compound:7875993|FD-Score:-2.79|P-value:6.52E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.89|P-value:4.45E-6 ID:SGTC_2939|Compound:9044578|FD-Score:-4.02|P-value:1.89E-6 ID:SGTC_2965|Compound:9082772|FD-Score:-7.36|P-value:1.52E-17 ID:SGTC_3043|Compound:9092303|FD-Score:-2.95|P-value:3.48E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-4.25|P-value:5.14E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-2.93|P-value:3.78E-4 ID:SGTC_3109|Compound:9122853|FD-Score:2.95|P-value:3.82E-4 ID:SGTC_3118|Compound:9124250|FD-Score:-3.01|P-value:2.71E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-2.72|P-value:8.57E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-2.73|P-value:8.50E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.12|P-value:1.87E-4 ID:SGTC_3303|Compound:9125618|FD-Score:2.73|P-value:9.26E-4

Top fitness defect scores for YOR218C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 6.24 3.7 µM 5.08E-13 1 2.17E-10 0.86
2 SGTC_949 1165-0505 5.76 146.0 µM 2.40E-11 1 4.22E-9 0.77
3 SGTC_2754 granisetron 5.19 64.0 µM 1.56E-9 3 1.05E-7 0.20
4 SGTC_534 k292-0788 4.56 63.4 µM 9.61E-8 mitochondrial processes 5 2.53E-6 0.04
5 SGTC_2816 7982706 4.46 58.4 µM 1.79E-7 azole & statin 4 4.09E-6 0.04
6 SGTC_1170 0310-0127 3.95 64.8 µM 3.24E-6 9 3.84E-5 0.14
7 SGTC_947 3447-0010 3.94 211.0 µM 3.41E-6 4 4.00E-5 0.21
8 SGTC_2285 7945142 3.94 200.0 µM 3.42E-6 9 4.01E-5 0.17
9 SGTC_2929 9013348 3.89 24.6 µM 4.45E-6 4 4.92E-5 0.05
10 SGTC_2371 9071574 3.55 200.0 µM 2.54E-5 4 1.90E-4 0.09
11 SGTC_2897 9048598 3.43 13.0 µM 4.72E-5 3 3.07E-4 0.30
12 SGTC_2006 4011487 3.29 200.0 µM 8.81E-5 endomembrane recycling 29 5.00E-4 0.08
13 SGTC_2374 9071832 3.20 200.0 µM 1.30E-4 endomembrane recycling 9 6.77E-4 6.70E-4
14 SGTC_915 methyl methanesulfonate (MMS) 3.14 110.0 mM 1.75E-4 DNA damage response 21 8.54E-4 0.01
15 SGTC_769 0302-0231 3.13 76.0 µM 1.83E-4 30 8.81E-4 0.04
16 SGTC_3223 9129970 3.12 49.5 µM 1.87E-4 15 8.96E-4 0.08
17 SGTC_2340 7987427 3.05 183.4 µM 2.58E-4 12 0.00115 0.01
18 SGTC_2893 9048488 3.00 26.0 µM 3.11E-4 fatty acid desaturase (OLE1) 22 0.00133 0.05
19 SGTC_3109 9122853 2.95 49.5 µM 3.82E-4 6 0.00157 0.05
20 SGTC_1323 1348-1351 2.92 11.2 µM 4.34E-4 10 0.00173 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 4.58E-17 YGR036C CAX4 hom Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
0.135 4.08E-15 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.132 1.67E-14 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.130 3.75E-14 YGL137W SEC27 het Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
0.130 5.08E-14 YKL196C YKT6 het Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
0.126 2.87E-13 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.125 3.44E-13 YFL046W_p FMP32_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.124 6.37E-13 YKL173W SNU114 het GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
0.114 3.15E-11 YGR251W NOP19 het Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes
0.114 3.36E-11 YMR308C PSE1 het Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
0.114 3.56E-11 YCR013C_d YCR013C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant
0.109 2.15E-10 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.109 2.22E-10 YJL156C SSY5 het Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p
0.109 2.92E-10 YHR019C DED81 het Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.105 8.94E-10 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing