YOR220W / RCN2

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR220W / RCN2

Click on Significant Values for Screen Details

Top fitness defect scores for YOR220W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1958 st076513 7.73 41.9 µM 8.52E-16 60S ribosome export 6 5.32E-15
2 SGTC_901 1112-0062 6.32 60.1 µM 3.82E-11 2 1.32E-10
3 SGTC_6 0844-0013 5.18 19.8 µM 4.89E-8 32 1.14E-7
4 SGTC_2942 9052777 5.08 62.2 µM 8.39E-8 9 1.89E-7
5 SGTC_2687 chenodiol 4.49 100.0 µM 1.85E-6 13 3.52E-6
6 SGTC_2766 oltipraz 4.40 83.9 µM 2.92E-6 heme requiring 18 5.43E-6
7 SGTC_3298 9116858 4.31 71.4 µM 4.49E-6 5 8.14E-6
8 SGTC_906 1165-0455 4.25 526.0 µM 6.12E-6 6 1.09E-5
9 SGTC_781 4335-2806 4.20 94.4 µM 7.60E-6 12 1.34E-5
10 SGTC_1844 rapamycin 3.90 4.0 nM 2.92E-5 161 4.79E-5
11 SGTC_1241 0364-0022 3.83 50.8 µM 3.97E-5 ERG2 35 6.40E-5
12 SGTC_1389 3405-0187 3.81 19.0 µM 4.29E-5 19 6.88E-5
13 SGTC_1608 st001473 3.72 40.5 µM 6.36E-5 43 1.00E-4
14 SGTC_3295 9122362 3.70 53.6 µM 6.81E-5 17 1.07E-4
15 SGTC_592 k241-0073 3.69 46.5 µM 7.11E-5 26 1.11E-4
16 SGTC_1842 st055362 3.64 61.2 µM 8.83E-5 20 1.36E-4
17 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.55 3.7 µM 1.26E-4 120 1.90E-4
18 SGTC_3210 9128157 3.54 49.5 µM 1.34E-4 68 2.03E-4
19 SGTC_552 k242-0005 3.49 476.0 µM 1.61E-4 33 2.40E-4
20 SGTC_1618 st003135 3.48 44.5 µM 1.70E-4 29 2.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.167 2.06E-22 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.141 2.82E-16 YLR421C RPN13 hom Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress
0.127 1.30E-13 YHL002W HSE1 hom Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
0.123 7.45E-13 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.120 3.35E-12 YDR197W CBS2 hom Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
0.117 1.29E-11 YDL028C MPS1 het Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p
0.115 2.09E-11 YIR010W DSN1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
0.114 3.24E-11 YEL072W RMD6 hom Protein required for sporulation
0.112 8.13E-11 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.110 2.03E-10 YIR043C YIR043C hom Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family
0.109 2.81E-10 YGR011W_d YGR011W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.108 2.98E-10 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.102 3.20E-9 YNL333W SNZ2 hom Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p
0.102 3.52E-9 YLR070C XYL2 hom Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect
0.100 5.52E-9 YDR100W TVP15 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p