HIPHOP chemogenomics database

YOR221C / MCT1

Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling

Zygosity: Homozygous strain

fixedexpanded
Profile for YOR221C / MCT1

Click on Significant Values for Screen Details

Top fitness defect scores for YOR221C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	9.04	5.3 µM	2.76E-17		217	7.91E-20
2	SGTC_67	0335-0847	8.08	266.0 µM	3.68E-14	ubiquinone biosynthesis & proteasome	39	3.15E-16
3	SGTC_36	0335-0881	7.55	14.2 µM	1.48E-12	ubiquinone biosynthesis & proteasome	40	2.23E-14
4	SGTC_7	0192-1582	6.88	4.2 µM	1.04E-10		16	3.02E-12
5	SGTC_227	fluconazole	6.35	33.5 µM	2.36E-9	azole & statin	37	1.10E-10
6	SGTC_969	1313-0238	5.92	134.0 µM	2.35E-8	mitochondrial processes	5	1.57E-9
7	SGTC_2012	4023501	5.83	200.0 µM	3.75E-8		7	2.69E-9
8	SGTC_778	3456-2434	5.52	196.0 µM	1.85E-7	mitochondrial response to ROS	30	1.70E-8
9	SGTC_2532	xanthone	5.46	78.9 µM	2.45E-7		12	2.35E-8
10	SGTC_1635	st007035	5.39	42.4 µM	3.50E-7		153	3.55E-8
11	SGTC_2884	9058502	5.04	52.0 µM	1.80E-6		12	2.36E-7
12	SGTC_116	0155-0182	5.03	31.8 µM	1.88E-6	mitochondrial response to ROS	40	2.47E-7
13	SGTC_625	k213-0058	4.79	121.0 µM	5.45E-6	translation	64	8.47E-7
14	SGTC_2929	9013348	4.72	24.6 µM	7.17E-6		10	1.16E-6
15	SGTC_1123	mangostin	4.62	811.3 nM	1.11E-5	mitochondrial response to ROS	21	1.94E-6
16	SGTC_1653	st012112	4.58	65.0 µM	1.30E-5		3	2.32E-6
17	SGTC_1877	wortmannin	4.55	25.0 µM	1.48E-5		77	2.69E-6
18	SGTC_1103	duloxetine	4.47	36.1 µM	2.07E-5		17	3.96E-6
19	SGTC_3171	9103192	4.45	49.5 µM	2.17E-5		2	4.20E-6
20	SGTC_1442	4112-3290	4.45	3.0 µM	2.24E-5		4	4.34E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.372	7.16E-111	YOR125C	CAT5	hom	Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.339	9.31E-91	YDR204W	COQ4	hom	Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.337	4.54E-90	YLR239C	LIP2	hom	Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups
0.331	2.23E-86	YOL096C	COQ3	hom	O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.323	3.23E-82	YNR042W_d	YNR042W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.317	3.49E-79	YDR148C	KGD2	hom	Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.315	2.01E-78	YLR201C	COQ9	hom	Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.305	3.04E-73	YGL119W	COQ8	hom	Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.294	9.45E-68	YNR041C	COQ2	hom	Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.292	5.00E-67	YOR196C	LIP5	hom	Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase
0.288	5.65E-65	YJL046W	AIM22	hom	Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss
0.277	5.03E-60	YFL018C	LPD1	hom	Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
0.272	6.53E-58	YPR024W	YME1	hom	Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.267	8.61E-56	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.267	7.20E-56	YBR003W	COQ1	hom	Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis