YOR221C / MCT1

Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR221C / MCT1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:6.88|P-value:1.04E-10 ID:SGTC_36|Compound:0335-0881|FD-Score:7.55|P-value:1.48E-12 ID:SGTC_59|Compound:0330-0160|FD-Score:4.37|P-value:3.02E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:4.36|P-value:3.21E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:8.08|P-value:3.68E-14 ID:SGTC_86|Compound:0417-1630|FD-Score:3.79|P-value:2.61E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.03|P-value:1.88E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:4.02|P-value:1.15E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.79|P-value:2.67E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:6.35|P-value:2.36E-9 ID:SGTC_236|Compound:1509-0011|FD-Score:9.04|P-value:2.76E-17 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.80|P-value:2.56E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:4.40|P-value:2.71E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-4.72|P-value:3.48E-6 ID:SGTC_625|Compound:k213-0058|FD-Score:4.79|P-value:5.45E-6 ID:SGTC_628|Compound:1636-0253|FD-Score:3.66|P-value:4.14E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.01|P-value:9.67E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:5.52|P-value:1.85E-7 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.35|P-value:6.61E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.72|P-value:3.36E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.30|P-value:2.46E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:3.66|P-value:4.06E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:5.92|P-value:2.35E-8 ID:SGTC_976|Compound:1348-1067|FD-Score:3.69|P-value:3.74E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.47|P-value:2.07E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:4.62|P-value:1.11E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:4.21|P-value:5.73E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.93|P-value:1.61E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:4.45|P-value:2.24E-5 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.62|P-value:4.72E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.10|P-value:8.74E-5 ID:SGTC_1635|Compound:st007035|FD-Score:5.39|P-value:3.50E-7 ID:SGTC_1653|Compound:st012112|FD-Score:4.58|P-value:1.30E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-4.14|P-value:3.90E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.40|P-value:9.58E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.39|P-value:9.93E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.89|P-value:1.85E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.55|P-value:1.48E-5 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.44|P-value:8.34E-4 ID:SGTC_1975|Compound:st070967|FD-Score:-3.23|P-value:9.71E-4 ID:SGTC_2012|Compound:4023501|FD-Score:5.83|P-value:3.75E-8 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.43|P-value:8.80E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:5.46|P-value:2.45E-7 ID:SGTC_2593|Compound:nobiletin|FD-Score:-4.07|P-value:5.20E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.17|P-value:6.56E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.42|P-value:2.50E-5 ID:SGTC_2704|Compound:st078022|FD-Score:-3.44|P-value:4.98E-4 ID:SGTC_2709|Compound:st078560|FD-Score:4.13|P-value:7.71E-5 ID:SGTC_2744|Compound:captopril|FD-Score:4.13|P-value:7.70E-5 ID:SGTC_2884|Compound:9058502|FD-Score:5.04|P-value:1.80E-6 ID:SGTC_2885|Compound:9057732|FD-Score:3.86|P-value:2.08E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.29|P-value:8.13E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.50|P-value:3.99E-4 ID:SGTC_2917|Compound:7979103|FD-Score:4.36|P-value:3.12E-5 ID:SGTC_2929|Compound:9013348|FD-Score:4.72|P-value:7.17E-6 ID:SGTC_2963|Compound:9082507|FD-Score:-4.25|P-value:2.57E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-4.26|P-value:2.43E-5 ID:SGTC_2994|Compound:9053520|FD-Score:4.00|P-value:1.26E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-4.84|P-value:2.05E-6 ID:SGTC_3112|Compound:9123419|FD-Score:3.90|P-value:1.79E-4 ID:SGTC_3171|Compound:9103192|FD-Score:4.45|P-value:2.17E-5 ID:SGTC_3216|Compound:9129716|FD-Score:3.43|P-value:8.71E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:6.88|P-value:1.04E-10 ID:SGTC_36|Compound:0335-0881|FD-Score:7.55|P-value:1.48E-12 ID:SGTC_59|Compound:0330-0160|FD-Score:4.37|P-value:3.02E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:4.36|P-value:3.21E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:8.08|P-value:3.68E-14 ID:SGTC_86|Compound:0417-1630|FD-Score:3.79|P-value:2.61E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.03|P-value:1.88E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:4.02|P-value:1.15E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.79|P-value:2.67E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:6.35|P-value:2.36E-9 ID:SGTC_236|Compound:1509-0011|FD-Score:9.04|P-value:2.76E-17 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.80|P-value:2.56E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:4.40|P-value:2.71E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-4.72|P-value:3.48E-6 ID:SGTC_625|Compound:k213-0058|FD-Score:4.79|P-value:5.45E-6 ID:SGTC_628|Compound:1636-0253|FD-Score:3.66|P-value:4.14E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.01|P-value:9.67E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:5.52|P-value:1.85E-7 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.35|P-value:6.61E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.72|P-value:3.36E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.30|P-value:2.46E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:3.66|P-value:4.06E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:5.92|P-value:2.35E-8 ID:SGTC_976|Compound:1348-1067|FD-Score:3.69|P-value:3.74E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.47|P-value:2.07E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:4.62|P-value:1.11E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:4.21|P-value:5.73E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.93|P-value:1.61E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:4.45|P-value:2.24E-5 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.62|P-value:4.72E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.10|P-value:8.74E-5 ID:SGTC_1635|Compound:st007035|FD-Score:5.39|P-value:3.50E-7 ID:SGTC_1653|Compound:st012112|FD-Score:4.58|P-value:1.30E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-4.14|P-value:3.90E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.40|P-value:9.58E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.39|P-value:9.93E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.89|P-value:1.85E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.55|P-value:1.48E-5 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.44|P-value:8.34E-4 ID:SGTC_1975|Compound:st070967|FD-Score:-3.23|P-value:9.71E-4 ID:SGTC_2012|Compound:4023501|FD-Score:5.83|P-value:3.75E-8 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.43|P-value:8.80E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:5.46|P-value:2.45E-7 ID:SGTC_2593|Compound:nobiletin|FD-Score:-4.07|P-value:5.20E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.17|P-value:6.56E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.42|P-value:2.50E-5 ID:SGTC_2704|Compound:st078022|FD-Score:-3.44|P-value:4.98E-4 ID:SGTC_2709|Compound:st078560|FD-Score:4.13|P-value:7.71E-5 ID:SGTC_2744|Compound:captopril|FD-Score:4.13|P-value:7.70E-5 ID:SGTC_2884|Compound:9058502|FD-Score:5.04|P-value:1.80E-6 ID:SGTC_2885|Compound:9057732|FD-Score:3.86|P-value:2.08E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.29|P-value:8.13E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.50|P-value:3.99E-4 ID:SGTC_2917|Compound:7979103|FD-Score:4.36|P-value:3.12E-5 ID:SGTC_2929|Compound:9013348|FD-Score:4.72|P-value:7.17E-6 ID:SGTC_2963|Compound:9082507|FD-Score:-4.25|P-value:2.57E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-4.26|P-value:2.43E-5 ID:SGTC_2994|Compound:9053520|FD-Score:4.00|P-value:1.26E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-4.84|P-value:2.05E-6 ID:SGTC_3112|Compound:9123419|FD-Score:3.90|P-value:1.79E-4 ID:SGTC_3171|Compound:9103192|FD-Score:4.45|P-value:2.17E-5 ID:SGTC_3216|Compound:9129716|FD-Score:3.43|P-value:8.71E-4

Top fitness defect scores for YOR221C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 9.04 5.3 µM 2.76E-17 217 7.91E-20
2 SGTC_67 0335-0847 8.08 266.0 µM 3.68E-14 ubiquinone biosynthesis & proteasome 39 3.15E-16
3 SGTC_36 0335-0881 7.55 14.2 µM 1.48E-12 ubiquinone biosynthesis & proteasome 40 2.23E-14
4 SGTC_7 0192-1582 6.88 4.2 µM 1.04E-10 16 3.02E-12
5 SGTC_227 fluconazole 6.35 33.5 µM 2.36E-9 azole & statin 37 1.10E-10
6 SGTC_969 1313-0238 5.92 134.0 µM 2.35E-8 mitochondrial processes 5 1.57E-9
7 SGTC_2012 4023501 5.83 200.0 µM 3.75E-8 7 2.69E-9
8 SGTC_778 3456-2434 5.52 196.0 µM 1.85E-7 mitochondrial response to ROS 30 1.70E-8
9 SGTC_2532 xanthone 5.46 78.9 µM 2.45E-7 12 2.35E-8
10 SGTC_1635 st007035 5.39 42.4 µM 3.50E-7 153 3.55E-8
11 SGTC_2884 9058502 5.04 52.0 µM 1.80E-6 12 2.36E-7
12 SGTC_116 0155-0182 5.03 31.8 µM 1.88E-6 mitochondrial response to ROS 40 2.47E-7
13 SGTC_625 k213-0058 4.79 121.0 µM 5.45E-6 translation 64 8.47E-7
14 SGTC_2929 9013348 4.72 24.6 µM 7.17E-6 10 1.16E-6
15 SGTC_1123 mangostin 4.62 811.3 nM 1.11E-5 mitochondrial response to ROS 21 1.94E-6
16 SGTC_1653 st012112 4.58 65.0 µM 1.30E-5 3 2.32E-6
17 SGTC_1877 wortmannin 4.55 25.0 µM 1.48E-5 77 2.69E-6
18 SGTC_1103 duloxetine 4.47 36.1 µM 2.07E-5 17 3.96E-6
19 SGTC_3171 9103192 4.45 49.5 µM 2.17E-5 2 4.20E-6
20 SGTC_1442 4112-3290 4.45 3.0 µM 2.24E-5 4 4.34E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.372 7.16E-111 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.339 9.31E-91 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.337 4.54E-90 YLR239C LIP2 hom Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups
0.331 2.23E-86 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.323 3.23E-82 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.317 3.49E-79 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.315 2.01E-78 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.305 3.04E-73 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.294 9.45E-68 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.292 5.00E-67 YOR196C LIP5 hom Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase
0.288 5.65E-65 YJL046W AIM22 hom Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss
0.277 5.03E-60 YFL018C LPD1 hom Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
0.272 6.53E-58 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.267 8.61E-56 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.267 7.20E-56 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis