HIPHOP chemogenomics database
YOR222W / ODC2 
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YOR222W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.118 | 8.89E-12 | YPR088C | SRP54 | het | Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain |
| 0.104 | 1.85E-9 | YOL129W | VPS68 | hom | Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria |
| 0.103 | 2.18E-9 | YDR132C | YDR132C | hom | Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication |
| 0.100 | 7.72E-9 | YER101C | AST2 | hom | Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication |
| 0.096 | 2.79E-8 | YAR007C | RFA1 | het | Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination |
| 0.095 | 3.89E-8 | YML025C | YML6 | het | Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins |
| 0.092 | 8.55E-8 | YPL038W-A_p | YPL038W-A_p | hom | Putative protein of unknown function; identified by fungal homology and RT-PCR |
| 0.088 | 3.51E-7 | YDR033W | MRH1 | hom | Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication |
| 0.087 | 5.33E-7 | YPR072W | NOT5 | hom | Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation |
| 0.086 | 6.41E-7 | YAL068C | PAU8 | hom | Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions |
| 0.085 | 8.05E-7 | YMR269W | TMA23 | hom | Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan |
| 0.084 | 9.95E-7 | YER104W | RTT105 | het | Protein with a role in regulation of Ty1 transposition |
| 0.084 | 1.08E-6 | YDL159W-A_p | YDL159W-A_p | hom | Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species |
| 0.083 | 1.41E-6 | YKL120W | OAC1 | hom | Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family |
| 0.080 | 3.14E-6 | YGL038C | OCH1 | hom | Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins |