RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YOR224C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.155 | 1.75E-19 | YDL150W | RPC53 | het | RNA polymerase III subunit C53 |
0.154 | 2.80E-19 | YOR116C | RPO31 | het | RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 |
0.138 | 9.42E-16 | YHL015W | RPS20 | het | Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10 |
0.131 | 2.87E-14 | YOR157C | PUP1 | het | Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z |
0.124 | 6.40E-13 | YPL237W | SUI3 | het | Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding |
0.124 | 7.75E-13 | YPL142C_d | YPL142C_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit |
0.122 | 1.46E-12 | YOR319W | HSH49 | het | U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) |
0.121 | 2.10E-12 | YML031W | NDC1 | het | Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1 |
0.120 | 3.89E-12 | YBR154C | RPB5 | het | RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation |
0.117 | 1.31E-11 | YOR340C | RPA43 | het | RNA polymerase I subunit A43 |
0.115 | 2.78E-11 | YOL040C | RPS15 | het | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19 |
0.114 | 3.72E-11 | YDR225W | HTA1 | hom | Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p |
0.107 | 5.65E-10 | YDR429C | TIF35 | het | eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation |
0.106 | 6.70E-10 | YPR136C_d | YPR136C_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9 |
0.105 | 9.56E-10 | YER025W | GCD11 | het | Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met |