YOR226C / ISU2

Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR226C / ISU2

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:3.80|P-value:4.25E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.21|P-value:4.74E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:5.03|P-value:1.04E-7 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.57|P-value:1.13E-4 ID:SGTC_230|Compound:MPP+|FD-Score:-3.34|P-value:2.87E-4 ID:SGTC_263|Compound:alizarin|FD-Score:4.50|P-value:1.72E-6 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.10|P-value:6.81E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:-3.08|P-value:7.58E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.47|P-value:1.93E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:4.37|P-value:3.21E-6 ID:SGTC_814|Compound:3342-0569|FD-Score:-3.71|P-value:6.63E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:-4.06|P-value:1.40E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:-3.91|P-value:2.77E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:3.76|P-value:5.21E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.50|P-value:1.49E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.57|P-value:1.13E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.41|P-value:2.23E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.58|P-value:1.09E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.51|P-value:1.61E-6 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.17|P-value:5.23E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-3.19|P-value:5.06E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.42|P-value:2.01E-4 ID:SGTC_1768|Compound:st044301|FD-Score:-3.42|P-value:2.14E-4 ID:SGTC_1772|Compound:st048439|FD-Score:4.73|P-value:5.26E-7 ID:SGTC_1794|Compound:st048918|FD-Score:5.26|P-value:2.82E-8 ID:SGTC_1852|Compound:st056254|FD-Score:4.88|P-value:2.31E-7 ID:SGTC_1871|Compound:st057448|FD-Score:3.38|P-value:2.40E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.77|P-value:4.85E-5 ID:SGTC_1978|Compound:st071761|FD-Score:-3.40|P-value:2.32E-4 ID:SGTC_2112|Compound:5488546|FD-Score:4.63|P-value:8.59E-7 ID:SGTC_2193|Compound:5925765|FD-Score:5.34|P-value:1.73E-8 ID:SGTC_2243|Compound:6634756|FD-Score:3.74|P-value:5.52E-5 ID:SGTC_2292|Compound:7671323|FD-Score:3.31|P-value:3.12E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.83|P-value:3.86E-5 ID:SGTC_2345|Compound:9052315|FD-Score:-3.73|P-value:5.98E-5 ID:SGTC_2360|Compound:9040895|FD-Score:3.39|P-value:2.32E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.16|P-value:5.41E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.04|P-value:8.31E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.49|P-value:1.54E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.02|P-value:9.33E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.07|P-value:7.80E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.19|P-value:4.87E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.11|P-value:6.80E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.18|P-value:5.00E-4 ID:SGTC_2848|Compound:9016370|FD-Score:4.35|P-value:3.44E-6 ID:SGTC_2908|Compound:7930301|FD-Score:-3.06|P-value:8.13E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.10|P-value:6.70E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.16|P-value:5.54E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.05|P-value:8.01E-4 ID:SGTC_3155|Compound:9099265|FD-Score:5.08|P-value:7.89E-8 ID:SGTC_3187|Compound:9109394|FD-Score:3.29|P-value:3.37E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.44|P-value:1.92E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.80|P-value:4.25E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.21|P-value:4.74E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:5.03|P-value:1.04E-7 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.57|P-value:1.13E-4 ID:SGTC_230|Compound:MPP+|FD-Score:-3.34|P-value:2.87E-4 ID:SGTC_263|Compound:alizarin|FD-Score:4.50|P-value:1.72E-6 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.10|P-value:6.81E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:-3.08|P-value:7.58E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.47|P-value:1.93E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:4.37|P-value:3.21E-6 ID:SGTC_814|Compound:3342-0569|FD-Score:-3.71|P-value:6.63E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:-4.06|P-value:1.40E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:-3.91|P-value:2.77E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:3.76|P-value:5.21E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.50|P-value:1.49E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.57|P-value:1.13E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.41|P-value:2.23E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.58|P-value:1.09E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.51|P-value:1.61E-6 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.17|P-value:5.23E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-3.19|P-value:5.06E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.42|P-value:2.01E-4 ID:SGTC_1768|Compound:st044301|FD-Score:-3.42|P-value:2.14E-4 ID:SGTC_1772|Compound:st048439|FD-Score:4.73|P-value:5.26E-7 ID:SGTC_1794|Compound:st048918|FD-Score:5.26|P-value:2.82E-8 ID:SGTC_1852|Compound:st056254|FD-Score:4.88|P-value:2.31E-7 ID:SGTC_1871|Compound:st057448|FD-Score:3.38|P-value:2.40E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.77|P-value:4.85E-5 ID:SGTC_1978|Compound:st071761|FD-Score:-3.40|P-value:2.32E-4 ID:SGTC_2112|Compound:5488546|FD-Score:4.63|P-value:8.59E-7 ID:SGTC_2193|Compound:5925765|FD-Score:5.34|P-value:1.73E-8 ID:SGTC_2243|Compound:6634756|FD-Score:3.74|P-value:5.52E-5 ID:SGTC_2292|Compound:7671323|FD-Score:3.31|P-value:3.12E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.83|P-value:3.86E-5 ID:SGTC_2345|Compound:9052315|FD-Score:-3.73|P-value:5.98E-5 ID:SGTC_2360|Compound:9040895|FD-Score:3.39|P-value:2.32E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.16|P-value:5.41E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.04|P-value:8.31E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.49|P-value:1.54E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.02|P-value:9.33E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.07|P-value:7.80E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.19|P-value:4.87E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.11|P-value:6.80E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.18|P-value:5.00E-4 ID:SGTC_2848|Compound:9016370|FD-Score:4.35|P-value:3.44E-6 ID:SGTC_2908|Compound:7930301|FD-Score:-3.06|P-value:8.13E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.10|P-value:6.70E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.16|P-value:5.54E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.05|P-value:8.01E-4 ID:SGTC_3155|Compound:9099265|FD-Score:5.08|P-value:7.89E-8 ID:SGTC_3187|Compound:9109394|FD-Score:3.29|P-value:3.37E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.44|P-value:1.92E-4

Top fitness defect scores for YOR226C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2193 5925765 5.34 200.0 µM 1.73E-8 2 4.60E-8
2 SGTC_1794 st048918 5.26 76.9 µM 2.82E-8 1 7.28E-8
3 SGTC_3155 9099265 5.08 49.5 µM 7.89E-8 9 1.92E-7
4 SGTC_161 4065-0411 5.03 162.2 µM 1.04E-7 39 2.48E-7
5 SGTC_1852 st056254 4.88 31.4 µM 2.31E-7 4 5.27E-7
6 SGTC_1772 st048439 4.73 82.2 µM 5.26E-7 20 1.14E-6
7 SGTC_2112 5488546 4.63 200.0 µM 8.59E-7 TSC3-RPN4 12 1.81E-6
8 SGTC_1132 3456-3614 4.51 2.5 µM 1.61E-6 tubulin folding & SWR complex 25 3.27E-6
9 SGTC_263 alizarin 4.50 107.9 µM 1.72E-6 iron homeostasis 43 3.47E-6
10 SGTC_495 decylubiquinone 4.47 155.0 µM 1.93E-6 copper-dependent oxidative stress 14 3.87E-6
11 SGTC_673 1082-0474 4.37 110.0 µM 3.21E-6 RSC complex & mRNA processing 47 6.25E-6
12 SGTC_2848 9016370 4.35 26.0 µM 3.44E-6 16 6.67E-6
13 SGTC_2307 7538926 3.83 6.3 µM 3.86E-5 46 6.50E-5
14 SGTC_39 0986-0283 3.80 58.4 µM 4.25E-5 calcium & mitochondrial duress 41 7.12E-5
15 SGTC_1956 st077085 3.77 54.0 µM 4.85E-5 23 8.06E-5
16 SGTC_894 0960-0238 3.76 55.9 µM 5.21E-5 14 8.61E-5
17 SGTC_2243 6634756 3.74 200.0 µM 5.52E-5 23 9.09E-5
18 SGTC_1128 3448-9350 3.58 235.0 µM 1.09E-4 31 1.73E-4
19 SGTC_1004 4084-0029 3.57 199.0 µM 1.13E-4 27 1.79E-4
20 SGTC_217 ketoconazole 3.57 989.0 nM 1.13E-4 ergosterol depletion effects on membrane 37 1.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 6.29E-10 YFR030W MET10 hom Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide
0.095 4.03E-8 YOL055C THI20 hom Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p
0.091 1.51E-7 YJL007C_d YJL007C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 5.43E-7 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.086 6.57E-7 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.081 2.54E-6 YOL150C_d YOL150C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 3.01E-6 YIR019C FLO11 hom GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required for the formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain
0.080 3.11E-6 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.077 8.59E-6 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.076 9.29E-6 YER022W SRB4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination
0.076 1.06E-5 YDR247W VHS1 hom Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
0.074 1.73E-5 YLR080W EMP46 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.074 1.97E-5 YLR451W LEU3 hom Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation
0.068 7.91E-5 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.068 7.99E-5 YGL259W_p YPS5_p hom Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p