YOR228C

Protein of unknown function, localized to the mitochondrial outer membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR228C / YOR228C

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:3.15|P-value:8.26E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.86|P-value:5.40E-5 ID:SGTC_191|Compound:3914-0123|FD-Score:3.19|P-value:7.14E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.17|P-value:6.33E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.90|P-value:4.72E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:3.41|P-value:3.25E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:-3.51|P-value:1.83E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.30|P-value:4.85E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.13|P-value:8.61E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:5.33|P-value:4.31E-8 ID:SGTC_963|Compound:1269-2853|FD-Score:4.02|P-value:2.83E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:3.32|P-value:4.38E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.80|P-value:6.96E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:5.24|P-value:7.41E-8 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.17|P-value:7.51E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.09|P-value:9.81E-4 ID:SGTC_1666|Compound:st014829|FD-Score:4.57|P-value:2.32E-6 ID:SGTC_1682|Compound:st012968|FD-Score:8.26|P-value:5.08E-17 ID:SGTC_1697|Compound:st025554|FD-Score:3.31|P-value:4.55E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.55|P-value:1.93E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.17|P-value:7.55E-4 ID:SGTC_1979|Compound:st071809|FD-Score:3.29|P-value:4.95E-4 ID:SGTC_2013|Compound:4024628|FD-Score:4.31|P-value:7.67E-6 ID:SGTC_2113|Compound:5491891|FD-Score:3.99|P-value:3.21E-5 ID:SGTC_2116|Compound:5511452|FD-Score:-3.13|P-value:7.26E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.22|P-value:5.43E-4 ID:SGTC_2511|Compound:berberine|FD-Score:5.88|P-value:1.79E-9 ID:SGTC_2513|Compound:baicalein|FD-Score:5.65|P-value:7.02E-9 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.70|P-value:1.03E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:6.60|P-value:1.68E-11 ID:SGTC_2657|Compound:nystatin|FD-Score:3.22|P-value:6.29E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-3.09|P-value:8.48E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.65|P-value:1.57E-6 ID:SGTC_2844|Compound:9010103|FD-Score:3.25|P-value:5.72E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.19|P-value:7.07E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.55|P-value:1.92E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.22|P-value:6.35E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-3.07|P-value:8.86E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.37|P-value:3.05E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.67|P-value:1.18E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-3.34|P-value:3.42E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.49|P-value:2.35E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-4.02|P-value:2.30E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:3.15|P-value:8.26E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.86|P-value:5.40E-5 ID:SGTC_191|Compound:3914-0123|FD-Score:3.19|P-value:7.14E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.17|P-value:6.33E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.90|P-value:4.72E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:3.41|P-value:3.25E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:-3.51|P-value:1.83E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.30|P-value:4.85E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.13|P-value:8.61E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:5.33|P-value:4.31E-8 ID:SGTC_963|Compound:1269-2853|FD-Score:4.02|P-value:2.83E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:3.32|P-value:4.38E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.80|P-value:6.96E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:5.24|P-value:7.41E-8 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.17|P-value:7.51E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.09|P-value:9.81E-4 ID:SGTC_1666|Compound:st014829|FD-Score:4.57|P-value:2.32E-6 ID:SGTC_1682|Compound:st012968|FD-Score:8.26|P-value:5.08E-17 ID:SGTC_1697|Compound:st025554|FD-Score:3.31|P-value:4.55E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.55|P-value:1.93E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.17|P-value:7.55E-4 ID:SGTC_1979|Compound:st071809|FD-Score:3.29|P-value:4.95E-4 ID:SGTC_2013|Compound:4024628|FD-Score:4.31|P-value:7.67E-6 ID:SGTC_2113|Compound:5491891|FD-Score:3.99|P-value:3.21E-5 ID:SGTC_2116|Compound:5511452|FD-Score:-3.13|P-value:7.26E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.22|P-value:5.43E-4 ID:SGTC_2511|Compound:berberine|FD-Score:5.88|P-value:1.79E-9 ID:SGTC_2513|Compound:baicalein|FD-Score:5.65|P-value:7.02E-9 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.70|P-value:1.03E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:6.60|P-value:1.68E-11 ID:SGTC_2657|Compound:nystatin|FD-Score:3.22|P-value:6.29E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-3.09|P-value:8.48E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.65|P-value:1.57E-6 ID:SGTC_2844|Compound:9010103|FD-Score:3.25|P-value:5.72E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.19|P-value:7.07E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.55|P-value:1.92E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.22|P-value:6.35E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-3.07|P-value:8.86E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.37|P-value:3.05E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.67|P-value:1.18E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-3.34|P-value:3.42E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.49|P-value:2.35E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-4.02|P-value:2.30E-5

Top fitness defect scores for YOR228C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1682 st012968 8.26 530.0 nM 5.08E-17 1 7.40E-17
2 SGTC_2635 hydroquinidine 6.60 100.0 µM 1.68E-11 2 2.07E-11
3 SGTC_2511 berberine 5.88 10.5 µM 1.79E-9 60S ribosome export 5 2.08E-9
4 SGTC_2513 baicalein 5.65 25.6 µM 7.02E-9 calcium & mitochondrial duress 10 8.02E-9
5 SGTC_915 methyl methanesulfonate (MMS) 5.33 110.0 mM 4.31E-8 DNA damage response 16 4.81E-8
6 SGTC_1205 4161-2785 5.24 76.0 µM 7.41E-8 10 8.22E-8
7 SGTC_2790 5423970 4.65 71.4 µM 1.57E-6 endomembrane recycling 43 1.69E-6
8 SGTC_1666 st014829 4.57 29.0 µM 2.32E-6 calcium & mitochondrial duress 18 2.48E-6
9 SGTC_2013 4024628 4.31 200.0 µM 7.67E-6 34 8.08E-6
10 SGTC_963 1269-2853 4.02 151.0 µM 2.83E-5 22 2.94E-5
11 SGTC_2113 5491891 3.99 107.0 µM 3.21E-5 TSC3-RPN4 19 3.33E-5
12 SGTC_771 0250-0039 3.90 27.3 µM 4.72E-5 15 4.88E-5
13 SGTC_101 0490-5701 3.86 117.5 µM 5.40E-5 13 5.57E-5
14 SGTC_1013 4112-3890 3.80 241.0 µM 6.96E-5 TSC3-RPN4 36 7.16E-5
15 SGTC_2528 xanthyletin 3.70 44.8 µM 1.03E-4 29 1.06E-4
16 SGTC_3221 9128209 3.67 49.5 µM 1.18E-4 20 1.21E-4
17 SGTC_3054 9094397 3.55 49.5 µM 1.92E-4 fatty acid desaturase (OLE1) 45 1.96E-4
18 SGTC_1780 st038448 3.55 24.5 µM 1.93E-4 iron homeostasis 33 1.96E-4
19 SGTC_3304 9125678 3.49 46.1 µM 2.35E-4 72 2.39E-4
20 SGTC_874 0599-0792 3.41 117.0 µM 3.25E-4 48 3.30E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 3.66E-12 YNL285W_d YNL285W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.113 5.93E-11 YHR161C YAP1801 hom Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication
0.105 9.15E-10 YOR058C ASE1 hom Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress
0.096 2.19E-8 YBL097W BRN1 het Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission
0.092 1.08E-7 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.091 1.47E-7 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.090 1.52E-7 YOR213C SAS5 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
0.090 1.60E-7 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.090 1.95E-7 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.086 6.85E-7 YDL243C AAD4 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.082 2.26E-6 YDR216W ADR1 hom Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
0.081 2.30E-6 YNL203C_d YNL203C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.078 5.66E-6 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.078 5.66E-6 YMR068W AVO2 hom Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
0.078 6.36E-6 YPL188W POS5 hom Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress