YOR230W / WTM1

Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR230W / WTM1

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:-4.89|P-value:2.73E-6 ID:SGTC_909|Compound:3448-9333|FD-Score:-4.73|P-value:5.63E-6 ID:SGTC_941|Compound:3237-0776|FD-Score:3.55|P-value:3.07E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:-3.53|P-value:5.58E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:-3.36|P-value:9.73E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.31|P-value:6.82E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.51|P-value:3.41E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:5.57|P-value:4.67E-8 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.94|P-value:1.03E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.43|P-value:7.61E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.21|P-value:9.50E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.76|P-value:1.45E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.45|P-value:4.27E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.60|P-value:2.51E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-4.77|P-value:4.62E-6 ID:SGTC_2081|Compound:5214970|FD-Score:-4.25|P-value:4.05E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:4.06|P-value:4.61E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.02|P-value:5.43E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.38|P-value:9.00E-4 ID:SGTC_2696|Compound:st077691|FD-Score:-4.86|P-value:3.11E-6 ID:SGTC_2785|Compound:7756463|FD-Score:3.52|P-value:3.32E-4 ID:SGTC_3010|Compound:9080089|FD-Score:7.20|P-value:2.99E-12 ID:SGTC_3195|Compound:9113082|FD-Score:3.57|P-value:2.86E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.82|P-value:1.14E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.77|P-value:1.36E-4 ID:SGTC_3220|Compound:9131269|FD-Score:-3.98|P-value:1.14E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:-4.89|P-value:2.73E-6 ID:SGTC_909|Compound:3448-9333|FD-Score:-4.73|P-value:5.63E-6 ID:SGTC_941|Compound:3237-0776|FD-Score:3.55|P-value:3.07E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:-3.53|P-value:5.58E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:-3.36|P-value:9.73E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.31|P-value:6.82E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.51|P-value:3.41E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:5.57|P-value:4.67E-8 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.94|P-value:1.03E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.43|P-value:7.61E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.21|P-value:9.50E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.76|P-value:1.45E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.45|P-value:4.27E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.60|P-value:2.51E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-4.77|P-value:4.62E-6 ID:SGTC_2081|Compound:5214970|FD-Score:-4.25|P-value:4.05E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:4.06|P-value:4.61E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.02|P-value:5.43E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.38|P-value:9.00E-4 ID:SGTC_2696|Compound:st077691|FD-Score:-4.86|P-value:3.11E-6 ID:SGTC_2785|Compound:7756463|FD-Score:3.52|P-value:3.32E-4 ID:SGTC_3010|Compound:9080089|FD-Score:7.20|P-value:2.99E-12 ID:SGTC_3195|Compound:9113082|FD-Score:3.57|P-value:2.86E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.82|P-value:1.14E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.77|P-value:1.36E-4 ID:SGTC_3220|Compound:9131269|FD-Score:-3.98|P-value:1.14E-4

Top fitness defect scores for YOR230W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3010 9080089 7.20 71.4 µM 2.99E-12 1 2.98E-13
2 SGTC_1272 0839-0021 5.57 27.0 µM 4.67E-8 6 1.27E-8
3 SGTC_1445 4239-0156 4.94 97.7 µM 1.03E-6 7 3.81E-7
4 SGTC_2543 pimpinellin 4.06 60.7 µM 4.61E-5 Golgi 13 2.47E-5
5 SGTC_2594 a-mangostin 4.02 100.0 µM 5.43E-5 31 2.96E-5
6 SGTC_3202 9113761 3.82 49.5 µM 1.14E-4 50 6.66E-5
7 SGTC_3207 9114163 3.77 49.5 µM 1.36E-4 36 8.08E-5
8 SGTC_1762 st045503 3.76 25.5 µM 1.45E-4 33 8.66E-5
9 SGTC_2069 5228469 3.60 200.0 µM 2.51E-4 22 1.57E-4
10 SGTC_3195 9113082 3.57 49.5 µM 2.86E-4 28 1.81E-4
11 SGTC_941 3237-0776 3.55 460.0 µM 3.07E-4 29 1.96E-4
12 SGTC_2785 7756463 3.52 72.7 µM 3.32E-4 42 2.14E-4
13 SGTC_1246 0422-0085 3.51 105.0 µM 3.41E-4 51 2.20E-4
14 SGTC_2004 4023728 3.45 41.9 µM 4.27E-4 44 2.81E-4
15 SGTC_1171 0368-0077 3.31 21.4 µM 6.82E-4 33 4.67E-4
16 SGTC_1564 D-Arginine 3.21 115.0 µM 9.50E-4 57 6.71E-4
17 SGTC_66 0109-0187 3.14 42.4 µM 0.00118 64 8.47E-4
18 SGTC_2547 epiafzelechin trimethyl ether 3.09 100.0 µM 0.00137 13 0.00100
19 SGTC_973 1325-0077 3.00 65.9 µM 0.00179 44 0.00133
20 SGTC_2078 5212016 2.97 200.0 µM 0.00198 60S ribosome export 39 0.00149

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 3.62E-10 YHR123W EPT1 hom sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication
0.101 5.12E-9 YLR176C RFX1 hom Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins
0.093 6.48E-8 YBR080C SEC18 het ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF
0.093 6.68E-8 YPR185W ATG13 hom Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling
0.092 9.04E-8 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.091 1.42E-7 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.090 1.82E-7 YPL225W YPL225W hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.090 2.07E-7 YMR284W YKU70 hom Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
0.088 3.12E-7 YLR017W MEU1 hom Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression
0.084 9.84E-7 YOL027C MDM38 hom Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome
0.084 9.95E-7 YMR278W PGM3 hom Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential
0.079 4.22E-6 YKR079C TRZ1 het tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2
0.078 5.80E-6 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.078 6.05E-6 YCL040W GLK1 hom Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication
0.077 7.44E-6 YBR113W_d YBR113W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8