YOR232W / MGE1

Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR232W / MGE1

Click on Significant Values for Screen Details ID:SGTC_103|Compound:0844-0104|FD-Score:8.41|P-value:3.57E-14 ID:SGTC_119|Compound:0121-0043|FD-Score:9.16|P-value:1.74E-16 ID:SGTC_124|Compound:0136-0217|FD-Score:8.76|P-value:3.10E-15 ID:SGTC_173|Compound:1273-0061|FD-Score:5.56|P-value:3.69E-7 ID:SGTC_288|Compound:1315-0019|FD-Score:-4.03|P-value:1.61E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.88|P-value:7.04E-6 ID:SGTC_426|Compound:0988-0037|FD-Score:3.80|P-value:3.58E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.90|P-value:6.62E-6 ID:SGTC_621|Compound:3584-0052|FD-Score:5.39|P-value:8.05E-7 ID:SGTC_733|Compound:4069-0007|FD-Score:9.13|P-value:2.19E-16 ID:SGTC_769|Compound:0302-0231|FD-Score:5.48|P-value:5.43E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.55|P-value:7.73E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.58|P-value:7.34E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.99|P-value:1.88E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:5.36|P-value:9.25E-7 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.81|P-value:3.37E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.21|P-value:9.13E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.83|P-value:3.25E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:5.37|P-value:8.78E-7 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.54|P-value:8.22E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:4.31|P-value:6.39E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:5.83|P-value:1.05E-7 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:5.11|P-value:2.75E-6 ID:SGTC_1941|Compound:st076221|FD-Score:3.72|P-value:4.72E-4 ID:SGTC_1945|Compound:st075991|FD-Score:4.25|P-value:7.88E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.96|P-value:2.11E-4 ID:SGTC_2050|Compound:5263056|FD-Score:7.49|P-value:1.31E-11 ID:SGTC_2051|Compound:5263410|FD-Score:4.05|P-value:1.58E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-4.15|P-value:1.09E-4 ID:SGTC_2279|Compound:7948423|FD-Score:5.02|P-value:4.00E-6 ID:SGTC_2301|Compound:7769476|FD-Score:3.56|P-value:7.73E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.70|P-value:5.01E-4 ID:SGTC_2445|Compound:5742597|FD-Score:-3.50|P-value:8.96E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.74|P-value:4.33E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.57|P-value:7.52E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:-3.66|P-value:5.47E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.80|P-value:3.63E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.94|P-value:2.31E-4 ID:SGTC_3032|Compound:9089427|FD-Score:4.09|P-value:1.39E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:-4.15|P-value:1.09E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.33|P-value:5.81E-5 ID:SGTC_3253|Compound:9135987|FD-Score:-3.70|P-value:4.91E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:8.41|P-value:3.57E-14 ID:SGTC_119|Compound:0121-0043|FD-Score:9.16|P-value:1.74E-16 ID:SGTC_124|Compound:0136-0217|FD-Score:8.76|P-value:3.10E-15 ID:SGTC_173|Compound:1273-0061|FD-Score:5.56|P-value:3.69E-7 ID:SGTC_288|Compound:1315-0019|FD-Score:-4.03|P-value:1.61E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.88|P-value:7.04E-6 ID:SGTC_426|Compound:0988-0037|FD-Score:3.80|P-value:3.58E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.90|P-value:6.62E-6 ID:SGTC_621|Compound:3584-0052|FD-Score:5.39|P-value:8.05E-7 ID:SGTC_733|Compound:4069-0007|FD-Score:9.13|P-value:2.19E-16 ID:SGTC_769|Compound:0302-0231|FD-Score:5.48|P-value:5.43E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.55|P-value:7.73E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.58|P-value:7.34E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.99|P-value:1.88E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:5.36|P-value:9.25E-7 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.81|P-value:3.37E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.21|P-value:9.13E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.83|P-value:3.25E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:5.37|P-value:8.78E-7 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.54|P-value:8.22E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:4.31|P-value:6.39E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:5.83|P-value:1.05E-7 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:5.11|P-value:2.75E-6 ID:SGTC_1941|Compound:st076221|FD-Score:3.72|P-value:4.72E-4 ID:SGTC_1945|Compound:st075991|FD-Score:4.25|P-value:7.88E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.96|P-value:2.11E-4 ID:SGTC_2050|Compound:5263056|FD-Score:7.49|P-value:1.31E-11 ID:SGTC_2051|Compound:5263410|FD-Score:4.05|P-value:1.58E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-4.15|P-value:1.09E-4 ID:SGTC_2279|Compound:7948423|FD-Score:5.02|P-value:4.00E-6 ID:SGTC_2301|Compound:7769476|FD-Score:3.56|P-value:7.73E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.70|P-value:5.01E-4 ID:SGTC_2445|Compound:5742597|FD-Score:-3.50|P-value:8.96E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.74|P-value:4.33E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.57|P-value:7.52E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:-3.66|P-value:5.47E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.80|P-value:3.63E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.94|P-value:2.31E-4 ID:SGTC_3032|Compound:9089427|FD-Score:4.09|P-value:1.39E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:-4.15|P-value:1.09E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.33|P-value:5.81E-5 ID:SGTC_3253|Compound:9135987|FD-Score:-3.70|P-value:4.91E-4

Top fitness defect scores for YOR232W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_119 0121-0043 9.16 24.8 µM 1.74E-16 mitochondrial stress 1 2.58E-20 1.04
2 SGTC_733 4069-0007 9.13 56.1 µM 2.19E-16 ERAD & cell cycle 3 3.43E-20 0.84
3 SGTC_124 0136-0217 8.76 7.1 µM 3.10E-15 mitochondrial stress 3 9.62E-19 1.60
4 SGTC_103 0844-0104 8.41 51.8 µM 3.57E-14 ERAD & cell cycle 12 2.08E-17 0.01
5 SGTC_2050 5263056 7.49 171.0 µM 1.31E-11 fatty acid desaturase (OLE1) 9 3.47E-14 0.68
6 SGTC_1787 fluconazole 5.83 80.0 µM 1.05E-7 iron homeostasis 2 2.74E-9 0.55
7 SGTC_173 1273-0061 5.56 2.7 µM 3.69E-7 mitochondrial stress 9 1.33E-8 0.03
8 SGTC_769 0302-0231 5.48 76.0 µM 5.43E-7 2 2.15E-8 0.09
9 SGTC_621 3584-0052 5.39 32.1 µM 8.05E-7 2 3.52E-8 0.86
10 SGTC_1347 1493-0251 5.37 600.0 nM 8.78E-7 mitochondrial response to ROS 1 3.92E-8 0.56
11 SGTC_1131 3454-3128 5.36 32.3 µM 9.25E-7 4 4.19E-8 0.34
12 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 5.11 14.9 µM 2.75E-6 2 1.64E-7 0.77
13 SGTC_2279 7948423 5.02 32.9 µM 4.00E-6 2 2.62E-7 0.25
14 SGTC_568 1193-0097 4.90 7.5 µM 6.62E-6 ERAD & cell cycle 18 4.91E-7 0.02
15 SGTC_365 0121-0052 4.88 13.6 µM 7.04E-6 mitochondrial response to ROS 4 5.31E-7 0.41
16 SGTC_3126 9127922 4.33 49.5 µM 5.81E-5 fatty acid desaturase (OLE1) 26 7.42E-6 0.03
17 SGTC_1578 josamycin 4.31 24.2 µM 6.39E-5 3 8.34E-6 0.43
18 SGTC_1945 st075991 4.25 56.6 µM 7.88E-5 60S ribosome export 6 1.08E-5 0.34
19 SGTC_1212 0520-0165 4.21 585.0 µM 9.13E-5 6 1.30E-5 0.49
20 SGTC_3032 9089427 4.09 49.5 µM 1.39E-4 60S ribosome export 3 2.20E-5 0.14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.236 1.57E-43 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.224 3.15E-39 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.184 5.69E-27 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.164 1.13E-21 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.161 6.35E-21 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.160 1.20E-20 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.154 3.05E-19 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.153 6.50E-19 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.149 3.55E-18 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.148 6.26E-18 YPL266W DIM1 het Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
0.148 7.87E-18 YOR109W INP53 hom Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
0.147 1.14E-17 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.145 2.75E-17 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.145 2.88E-17 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.143 9.66E-17 YAL051W OAF1 hom Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication