YOR233W / KIN4

Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR233W / KIN4

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-3.90|P-value:3.52E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:3.49|P-value:1.25E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.80|P-value:3.44E-5 ID:SGTC_389|Compound:tpck|FD-Score:5.51|P-value:4.57E-9 ID:SGTC_577|Compound:r071-0003|FD-Score:2.98|P-value:8.60E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:2.96|P-value:9.12E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.58|P-value:1.35E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:-3.44|P-value:2.33E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:4.16|P-value:6.86E-6 ID:SGTC_757|Compound:1066-0008|FD-Score:3.53|P-value:1.08E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.34|P-value:2.26E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:4.02|P-value:1.31E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:3.44|P-value:1.52E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:2.99|P-value:8.46E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.02|P-value:7.36E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.05|P-value:6.69E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.33|P-value:2.37E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.33|P-value:2.36E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.19|P-value:4.01E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.05|P-value:6.83E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.23|P-value:3.48E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-4.33|P-value:5.07E-6 ID:SGTC_1519|Compound:esterone|FD-Score:-3.29|P-value:4.21E-4 ID:SGTC_1628|Compound:st004252|FD-Score:2.99|P-value:8.44E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.30|P-value:2.65E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.05|P-value:6.70E-4 ID:SGTC_1839|Compound:st053978|FD-Score:4.75|P-value:3.50E-7 ID:SGTC_1977|Compound:st070720|FD-Score:-3.14|P-value:7.27E-4 ID:SGTC_1992|Compound:st073643|FD-Score:2.94|P-value:9.91E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.71|P-value:5.14E-5 ID:SGTC_2049|Compound:5262831|FD-Score:4.71|P-value:4.38E-7 ID:SGTC_2056|Compound:5235370|FD-Score:5.97|P-value:2.53E-10 ID:SGTC_2058|Compound:5236698|FD-Score:12.60|P-value:3.52E-39 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.37|P-value:2.04E-4 ID:SGTC_2174|Compound:5790901|FD-Score:4.07|P-value:1.02E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.39|P-value:2.90E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.38|P-value:1.94E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.07|P-value:6.21E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.61|P-value:7.17E-7 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.26|P-value:3.07E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.46|P-value:1.41E-4 ID:SGTC_2781|Compound:5567276|FD-Score:5.23|P-value:2.40E-8 ID:SGTC_2837|Compound:9008476|FD-Score:3.02|P-value:7.55E-4 ID:SGTC_2914|Compound:7968218|FD-Score:3.26|P-value:3.09E-4 ID:SGTC_3102|Compound:9121669|FD-Score:-4.06|P-value:1.73E-5 ID:SGTC_3173|Compound:9105693|FD-Score:2.99|P-value:8.18E-4 ID:SGTC_3238|Compound:9133470|FD-Score:-3.44|P-value:2.35E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.28|P-value:2.87E-4 ID:SGTC_3338|Compound:9144300|FD-Score:4.46|P-value:1.58E-6 ID:SGTC_3340|Compound:9146634|FD-Score:5.07|P-value:6.10E-8 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.90|P-value:3.52E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:3.49|P-value:1.25E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.80|P-value:3.44E-5 ID:SGTC_389|Compound:tpck|FD-Score:5.51|P-value:4.57E-9 ID:SGTC_577|Compound:r071-0003|FD-Score:2.98|P-value:8.60E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:2.96|P-value:9.12E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.58|P-value:1.35E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:-3.44|P-value:2.33E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:4.16|P-value:6.86E-6 ID:SGTC_757|Compound:1066-0008|FD-Score:3.53|P-value:1.08E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.34|P-value:2.26E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:4.02|P-value:1.31E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:3.44|P-value:1.52E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:2.99|P-value:8.46E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.02|P-value:7.36E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.05|P-value:6.69E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.33|P-value:2.37E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.33|P-value:2.36E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.19|P-value:4.01E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.05|P-value:6.83E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.23|P-value:3.48E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-4.33|P-value:5.07E-6 ID:SGTC_1519|Compound:esterone|FD-Score:-3.29|P-value:4.21E-4 ID:SGTC_1628|Compound:st004252|FD-Score:2.99|P-value:8.44E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.30|P-value:2.65E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.05|P-value:6.70E-4 ID:SGTC_1839|Compound:st053978|FD-Score:4.75|P-value:3.50E-7 ID:SGTC_1977|Compound:st070720|FD-Score:-3.14|P-value:7.27E-4 ID:SGTC_1992|Compound:st073643|FD-Score:2.94|P-value:9.91E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.71|P-value:5.14E-5 ID:SGTC_2049|Compound:5262831|FD-Score:4.71|P-value:4.38E-7 ID:SGTC_2056|Compound:5235370|FD-Score:5.97|P-value:2.53E-10 ID:SGTC_2058|Compound:5236698|FD-Score:12.60|P-value:3.52E-39 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.37|P-value:2.04E-4 ID:SGTC_2174|Compound:5790901|FD-Score:4.07|P-value:1.02E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.39|P-value:2.90E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.38|P-value:1.94E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.07|P-value:6.21E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.61|P-value:7.17E-7 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.26|P-value:3.07E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.46|P-value:1.41E-4 ID:SGTC_2781|Compound:5567276|FD-Score:5.23|P-value:2.40E-8 ID:SGTC_2837|Compound:9008476|FD-Score:3.02|P-value:7.55E-4 ID:SGTC_2914|Compound:7968218|FD-Score:3.26|P-value:3.09E-4 ID:SGTC_3102|Compound:9121669|FD-Score:-4.06|P-value:1.73E-5 ID:SGTC_3173|Compound:9105693|FD-Score:2.99|P-value:8.18E-4 ID:SGTC_3238|Compound:9133470|FD-Score:-3.44|P-value:2.35E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.28|P-value:2.87E-4 ID:SGTC_3338|Compound:9144300|FD-Score:4.46|P-value:1.58E-6 ID:SGTC_3340|Compound:9146634|FD-Score:5.07|P-value:6.10E-8

Top fitness defect scores for YOR233W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2058 5236698 12.60 133.0 µM 3.52E-39 3 1.46E-36
2 SGTC_2056 5235370 5.97 200.0 µM 2.53E-10 14 1.22E-9
3 SGTC_389 tpck 5.51 16.7 µM 4.57E-9 12 1.80E-8
4 SGTC_2781 5567276 5.23 71.4 µM 2.40E-8 21 8.43E-8
5 SGTC_3340 9146634 5.07 11.1 µM 6.10E-8 6 2.01E-7
6 SGTC_1839 st053978 4.75 48.0 µM 3.50E-7 8 1.02E-6
7 SGTC_2049 5262831 4.71 67.2 µM 4.38E-7 15 1.25E-6
8 SGTC_2566 crystal violet carbinol 4.61 226.0 nM 7.17E-7 24 1.98E-6
9 SGTC_3338 9144300 4.46 39.6 µM 1.58E-6 Golgi 21 4.14E-6
10 SGTC_751 0833-0568 4.16 350.0 µM 6.86E-6 15 1.62E-5
11 SGTC_2174 5790901 4.07 200.0 µM 1.02E-5 tubulin folding & SWR complex 34 2.34E-5
12 SGTC_771 0250-0039 4.02 27.3 µM 1.31E-5 11 2.96E-5
13 SGTC_341 1486-1430 3.80 230.0 µM 3.44E-5 27 7.24E-5
14 SGTC_2028 5153890 3.71 36.4 µM 5.14E-5 cell wall signaling 38 1.05E-4
15 SGTC_757 1066-0008 3.53 322.0 µM 1.08E-4 Golgi 31 2.10E-4
16 SGTC_245 methotrexate 3.49 289.6 µM 1.25E-4 54 2.40E-4
17 SGTC_2682 pyrogallin 3.46 40.0 µM 1.41E-4 copper-dependent oxidative stress 44 2.69E-4
18 SGTC_806 3966-4455 3.44 5.9 µM 1.52E-4 43 2.88E-4
19 SGTC_2399 5884133 3.38 200.0 µM 1.94E-4 cell wall signaling 103 3.62E-4
20 SGTC_2131 toluylene red 3.37 5.3 µM 2.04E-4 60S ribosome export 47 3.78E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 5.40E-19 YGR092W DBF2 hom Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis
0.140 4.63E-16 YOR247W SRL1 hom Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication
0.134 6.50E-15 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.117 1.34E-11 YOL073C YOL073C hom Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2
0.116 1.96E-11 YIL140W AXL2 hom Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate
0.115 2.58E-11 YDL015C TSC13 het Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress
0.113 5.48E-11 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.113 5.90E-11 YDR393W SHE9 hom Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex
0.111 1.01E-10 YBR047W_p FMP23_p hom Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.111 1.33E-10 YNL117W MLS1 hom Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic
0.101 4.79E-9 YJR133W XPT1 hom Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
0.097 1.83E-8 YPL191C_p YPL191C_p hom Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.096 2.24E-8 YER042W MXR1 hom Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan
0.094 4.63E-8 YHR130C_d YHR130C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094 5.37E-8 YGR087C PDC6 hom Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation