YOR234C / RPL33B

Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR234C / RPL33B

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:3.99|P-value:1.01E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.67|P-value:4.76E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-6.95|P-value:1.38E-10 ID:SGTC_139|Compound:0099-0334|FD-Score:3.42|P-value:6.83E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.51|P-value:2.34E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:3.52|P-value:4.99E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:4.64|P-value:8.03E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.69|P-value:4.51E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.76|P-value:2.26E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-4.44|P-value:2.98E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.77|P-value:2.19E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.47|P-value:8.95E-4 ID:SGTC_1847|Compound:st056231|FD-Score:4.54|P-value:1.22E-5 ID:SGTC_1849|Compound:st056239|FD-Score:3.65|P-value:3.28E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-4.41|P-value:3.36E-5 ID:SGTC_2116|Compound:5511452|FD-Score:3.46|P-value:6.06E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.40|P-value:7.47E-4 ID:SGTC_2364|Compound:9055074|FD-Score:4.59|P-value:9.77E-6 ID:SGTC_2391|Compound:6285546|FD-Score:3.59|P-value:4.02E-4 ID:SGTC_2430|Compound:5571206|FD-Score:-3.62|P-value:5.67E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-4.11|P-value:1.06E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-6.25|P-value:6.91E-9 ID:SGTC_2867|Compound:9039098|FD-Score:4.80|P-value:4.01E-6 ID:SGTC_2874|Compound:9043904|FD-Score:-6.84|P-value:2.65E-10 ID:SGTC_2878|Compound:9043973|FD-Score:-5.79|P-value:7.72E-8 ID:SGTC_2898|Compound:9056270|FD-Score:-3.75|P-value:3.66E-4 ID:SGTC_3036|Compound:9090181|FD-Score:3.58|P-value:4.05E-4 ID:SGTC_3148|Compound:9097893|FD-Score:6.72|P-value:2.40E-10 ID:SGTC_3152|Compound:9099253|FD-Score:-4.98|P-value:3.28E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:3.99|P-value:1.01E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.67|P-value:4.76E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-6.95|P-value:1.38E-10 ID:SGTC_139|Compound:0099-0334|FD-Score:3.42|P-value:6.83E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.51|P-value:2.34E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:3.52|P-value:4.99E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:4.64|P-value:8.03E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.69|P-value:4.51E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.76|P-value:2.26E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-4.44|P-value:2.98E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.77|P-value:2.19E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.47|P-value:8.95E-4 ID:SGTC_1847|Compound:st056231|FD-Score:4.54|P-value:1.22E-5 ID:SGTC_1849|Compound:st056239|FD-Score:3.65|P-value:3.28E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-4.41|P-value:3.36E-5 ID:SGTC_2116|Compound:5511452|FD-Score:3.46|P-value:6.06E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.40|P-value:7.47E-4 ID:SGTC_2364|Compound:9055074|FD-Score:4.59|P-value:9.77E-6 ID:SGTC_2391|Compound:6285546|FD-Score:3.59|P-value:4.02E-4 ID:SGTC_2430|Compound:5571206|FD-Score:-3.62|P-value:5.67E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-4.11|P-value:1.06E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-6.25|P-value:6.91E-9 ID:SGTC_2867|Compound:9039098|FD-Score:4.80|P-value:4.01E-6 ID:SGTC_2874|Compound:9043904|FD-Score:-6.84|P-value:2.65E-10 ID:SGTC_2878|Compound:9043973|FD-Score:-5.79|P-value:7.72E-8 ID:SGTC_2898|Compound:9056270|FD-Score:-3.75|P-value:3.66E-4 ID:SGTC_3036|Compound:9090181|FD-Score:3.58|P-value:4.05E-4 ID:SGTC_3148|Compound:9097893|FD-Score:6.72|P-value:2.40E-10 ID:SGTC_3152|Compound:9099253|FD-Score:-4.98|P-value:3.28E-6

Top fitness defect scores for YOR234C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3148 9097893 6.72 49.5 µM 2.40E-10 11 9.01E-12
2 SGTC_2867 9039098 4.80 71.4 µM 4.01E-6 iron homeostasis 18 7.90E-7
3 SGTC_782 0083-0095 4.64 30.5 µM 8.03E-6 15 1.77E-6
4 SGTC_2364 9055074 4.59 200.0 µM 9.77E-6 11 2.23E-6
5 SGTC_1847 st056231 4.54 15.0 µM 1.22E-5 21 2.88E-6
6 SGTC_52 0329-0193 3.99 875.0 nM 1.01E-4 TSC3-RPN4 29 3.37E-5
7 SGTC_1789 tunicamycin 3.77 25.0 nM 2.19E-4 unfolded protein response 58 8.27E-5
8 SGTC_1167 k781-0610 3.76 148.0 µM 2.26E-4 RNA processing & uracil transport 33 8.57E-5
9 SGTC_1849 st056239 3.65 19.2 µM 3.28E-4 RPP1 & pyrimidine depletion 34 1.32E-4
10 SGTC_2391 6285546 3.59 200.0 µM 4.02E-4 26 1.67E-4
11 SGTC_3036 9090181 3.58 49.5 µM 4.05E-4 9 1.69E-4
12 SGTC_364 0083-0097 3.52 67.7 µM 4.99E-4 40 2.14E-4
13 SGTC_2116 5511452 3.46 16.9 µM 6.06E-4 26 2.69E-4
14 SGTC_139 0099-0334 3.42 718.6 µM 6.83E-4 57 3.09E-4
15 SGTC_2357 9067248 3.40 200.0 µM 7.47E-4 40 3.42E-4
16 SGTC_1222 0366-0074 3.29 1.2 µM 0.00103 TSC3-RPN4 37 4.98E-4
17 SGTC_2042 p-Dimethylaminoacetophenone 3.21 200.0 µM 0.00131 47 6.57E-4
18 SGTC_1770 st043884 3.19 66.3 µM 0.00142 40 7.18E-4
19 SGTC_1857 st056007 3.17 79.3 µM 0.00150 24 7.64E-4
20 SGTC_691 1548-0686 3.11 185.0 µM 0.00178 81 9.30E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.179 1.56E-25 YBR196C-A_p YBR196C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.168 2.14E-22 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.161 7.48E-21 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.149 4.92E-18 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.144 6.03E-17 YMR114C YMR114C hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
0.137 2.27E-15 YCR007C_p YCR007C_p hom Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
0.136 2.41E-15 YPL125W KAP120 hom Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
0.132 2.07E-14 YBR084C-A RPL19A hom Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication
0.131 2.69E-14 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.127 1.77E-13 YNL047C SLM2 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication
0.121 1.62E-12 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.121 2.11E-12 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.120 3.41E-12 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.120 4.33E-12 YOR092W ECM3 hom Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication
0.119 4.92E-12 YGR295C COS6 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins