YOR235W_d / IRC13

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR235W / IRC13

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-5.27|P-value:2.77E-6 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.90|P-value:4.26E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:3.87|P-value:4.67E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:3.74|P-value:7.00E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:6.23|P-value:4.80E-8 ID:SGTC_123|Compound:0083-0120|FD-Score:5.24|P-value:3.73E-6 ID:SGTC_280|Compound:3448-3607|FD-Score:-5.44|P-value:1.43E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:3.91|P-value:4.18E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:5.21|P-value:4.26E-6 ID:SGTC_617|Compound:3770-0098|FD-Score:4.11|P-value:2.23E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:4.65|P-value:3.55E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:3.80|P-value:5.79E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:6.45|P-value:1.67E-8 ID:SGTC_800|Compound:3448-7362|FD-Score:4.65|P-value:3.49E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:3.77|P-value:6.39E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:4.74|P-value:2.55E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:4.26|P-value:1.36E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.85|P-value:4.99E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.16|P-value:1.91E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.48|P-value:5.58E-5 ID:SGTC_1606|Compound:st000094|FD-Score:3.67|P-value:8.51E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.86|P-value:1.61E-5 ID:SGTC_1728|Compound:st035614|FD-Score:-4.09|P-value:2.13E-4 ID:SGTC_1753|Compound:st043925|FD-Score:-6.14|P-value:6.22E-8 ID:SGTC_1760|Compound:st045453|FD-Score:-5.67|P-value:5.17E-7 ID:SGTC_1846|Compound:st056244|FD-Score:3.80|P-value:5.91E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-3.60|P-value:9.56E-4 ID:SGTC_1901|Compound:st060216|FD-Score:5.50|P-value:1.26E-6 ID:SGTC_1914|Compound:st062367|FD-Score:6.18|P-value:6.15E-8 ID:SGTC_1919|Compound:st067113|FD-Score:-6.53|P-value:9.60E-9 ID:SGTC_2274|Compound:7947094|FD-Score:4.12|P-value:2.19E-4 ID:SGTC_2325|Compound:6158266|FD-Score:4.60|P-value:4.21E-5 ID:SGTC_2348|Compound:9022543|FD-Score:3.74|P-value:6.91E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.16|P-value:1.89E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.06|P-value:2.64E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-4.71|P-value:2.50E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.70|P-value:2.98E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.74|P-value:6.26E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.67|P-value:7.73E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.25|P-value:4.33E-8 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.97|P-value:3.07E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.41|P-value:8.20E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:5.13|P-value:5.80E-6 ID:SGTC_2746|Compound:daunorubicin|FD-Score:3.75|P-value:6.76E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.98|P-value:1.03E-5 ID:SGTC_2800|Compound:7887935|FD-Score:4.18|P-value:1.78E-4 ID:SGTC_2839|Compound:9003951|FD-Score:5.04|P-value:8.06E-6 ID:SGTC_2842|Compound:9000675|FD-Score:6.63|P-value:6.97E-9 ID:SGTC_2927|Compound:9011802|FD-Score:4.53|P-value:5.39E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-4.92|P-value:1.11E-5 ID:SGTC_2962|Compound:9082311|FD-Score:5.60|P-value:8.28E-7 ID:SGTC_3023|Compound:9089636|FD-Score:3.62|P-value:9.93E-4 ID:SGTC_3031|Compound:9088762|FD-Score:4.08|P-value:2.46E-4 ID:SGTC_3038|Compound:9091290|FD-Score:-3.83|P-value:4.79E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.90|P-value:4.34E-4 ID:SGTC_3264|Compound:9137442|FD-Score:5.64|P-value:7.10E-7 ID:SGTC_36|Compound:0335-0881|FD-Score:-5.27|P-value:2.77E-6 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.90|P-value:4.26E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:3.87|P-value:4.67E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:3.74|P-value:7.00E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:6.23|P-value:4.80E-8 ID:SGTC_123|Compound:0083-0120|FD-Score:5.24|P-value:3.73E-6 ID:SGTC_280|Compound:3448-3607|FD-Score:-5.44|P-value:1.43E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:3.91|P-value:4.18E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:5.21|P-value:4.26E-6 ID:SGTC_617|Compound:3770-0098|FD-Score:4.11|P-value:2.23E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:4.65|P-value:3.55E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:3.80|P-value:5.79E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:6.45|P-value:1.67E-8 ID:SGTC_800|Compound:3448-7362|FD-Score:4.65|P-value:3.49E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:3.77|P-value:6.39E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:4.74|P-value:2.55E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:4.26|P-value:1.36E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.85|P-value:4.99E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.16|P-value:1.91E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.48|P-value:5.58E-5 ID:SGTC_1606|Compound:st000094|FD-Score:3.67|P-value:8.51E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.86|P-value:1.61E-5 ID:SGTC_1728|Compound:st035614|FD-Score:-4.09|P-value:2.13E-4 ID:SGTC_1753|Compound:st043925|FD-Score:-6.14|P-value:6.22E-8 ID:SGTC_1760|Compound:st045453|FD-Score:-5.67|P-value:5.17E-7 ID:SGTC_1846|Compound:st056244|FD-Score:3.80|P-value:5.91E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-3.60|P-value:9.56E-4 ID:SGTC_1901|Compound:st060216|FD-Score:5.50|P-value:1.26E-6 ID:SGTC_1914|Compound:st062367|FD-Score:6.18|P-value:6.15E-8 ID:SGTC_1919|Compound:st067113|FD-Score:-6.53|P-value:9.60E-9 ID:SGTC_2274|Compound:7947094|FD-Score:4.12|P-value:2.19E-4 ID:SGTC_2325|Compound:6158266|FD-Score:4.60|P-value:4.21E-5 ID:SGTC_2348|Compound:9022543|FD-Score:3.74|P-value:6.91E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.16|P-value:1.89E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.06|P-value:2.64E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-4.71|P-value:2.50E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.70|P-value:2.98E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.74|P-value:6.26E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.67|P-value:7.73E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.25|P-value:4.33E-8 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.97|P-value:3.07E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.41|P-value:8.20E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:5.13|P-value:5.80E-6 ID:SGTC_2746|Compound:daunorubicin|FD-Score:3.75|P-value:6.76E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.98|P-value:1.03E-5 ID:SGTC_2800|Compound:7887935|FD-Score:4.18|P-value:1.78E-4 ID:SGTC_2839|Compound:9003951|FD-Score:5.04|P-value:8.06E-6 ID:SGTC_2842|Compound:9000675|FD-Score:6.63|P-value:6.97E-9 ID:SGTC_2927|Compound:9011802|FD-Score:4.53|P-value:5.39E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-4.92|P-value:1.11E-5 ID:SGTC_2962|Compound:9082311|FD-Score:5.60|P-value:8.28E-7 ID:SGTC_3023|Compound:9089636|FD-Score:3.62|P-value:9.93E-4 ID:SGTC_3031|Compound:9088762|FD-Score:4.08|P-value:2.46E-4 ID:SGTC_3038|Compound:9091290|FD-Score:-3.83|P-value:4.79E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.90|P-value:4.34E-4 ID:SGTC_3264|Compound:9137442|FD-Score:5.64|P-value:7.10E-7

Top fitness defect scores for YOR235W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2842 9000675 6.63 19.5 µM 6.97E-9 1 1.69E-11
2 SGTC_797 k781-0471 6.45 270.0 µM 1.67E-8 RPP1 & pyrimidine depletion 2 5.50E-11
3 SGTC_2688 kanamycin b 6.25 96.7 µM 4.33E-8 calcium & mitochondrial duress 140 1.99E-10
4 SGTC_118 0083-0097 6.23 135.3 µM 4.80E-8 translation 18 2.29E-10
5 SGTC_1914 st062367 6.18 72.6 µM 6.15E-8 3 3.19E-10
6 SGTC_3264 9137442 5.64 49.5 µM 7.10E-7 2 8.66E-9
7 SGTC_2962 9082311 5.60 13.2 µM 8.28E-7 5 1.07E-8
8 SGTC_1901 st060216 5.50 58.6 µM 1.26E-6 10 1.87E-8
9 SGTC_123 0083-0120 5.24 66.7 µM 3.73E-6 26 8.10E-8
10 SGTC_454 lyso-paf C-16 5.21 6.7 µM 4.26E-6 2 9.69E-8
11 SGTC_2739 tacrine 5.13 100.9 µM 5.80E-6 heme requiring 4 1.47E-7
12 SGTC_2839 9003951 5.04 26.0 µM 8.06E-6 5 2.29E-7
13 SGTC_2798 7813637 4.98 45.5 µM 1.03E-5 10 3.19E-7
14 SGTC_1723 st034307 4.86 2.5 µM 1.61E-5 mitochondrial processes 13 5.78E-7
15 SGTC_830 4076-0286 4.74 57.8 µM 2.55E-5 translation 36 1.08E-6
16 SGTC_2526 patulin 4.70 37.6 µM 2.98E-5 55 1.33E-6
17 SGTC_800 3448-7362 4.65 155.0 µM 3.49E-5 translation 107 1.64E-6
18 SGTC_701 4424-0219 4.65 185.0 µM 3.55E-5 calcium & mitochondrial duress 11 1.68E-6
19 SGTC_2325 6158266 4.60 200.0 µM 4.21E-5 14 2.12E-6
20 SGTC_2927 9011802 4.53 47.9 µM 5.39E-5 15 2.95E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 2.95E-16 YLR264W RPS28B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.133 9.90E-15 YDL061C RPS29B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication
0.132 1.84E-14 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.121 1.91E-12 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.117 1.32E-11 YLR058C SHM2 hom Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
0.116 2.08E-11 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.114 4.35E-11 YLR264C-A_p YLR264C-A_p hom Putative protein of unknown function
0.109 2.12E-10 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.109 2.69E-10 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.108 3.80E-10 YGR118W RPS23A hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.106 6.71E-10 YML031W NDC1 het Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
0.105 9.74E-10 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.103 1.99E-9 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.103 2.61E-9 YER131W RPS26B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication
0.102 3.40E-9 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog