YOR236W / DFR1

Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR236W / DFR1

Click on Significant Values for Screen Details ID:SGTC_13|Compound:0199-0087|FD-Score:3.45|P-value:4.41E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:5.80|P-value:1.26E-8 ID:SGTC_22|Compound:0964-0034|FD-Score:10.80|P-value:2.12E-25 ID:SGTC_58|Compound:0957-0393|FD-Score:8.39|P-value:4.39E-16 ID:SGTC_93|Compound:0109-0045|FD-Score:3.44|P-value:4.52E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:12.50|P-value:2.75E-33 ID:SGTC_157|Compound:1348-1695|FD-Score:4.32|P-value:1.61E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:3.27|P-value:8.02E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.65|P-value:5.48E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:8.55|P-value:1.25E-16 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.29|P-value:7.49E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.78|P-value:1.35E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:9.97|P-value:6.71E-22 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.22|P-value:2.44E-5 ID:SGTC_249|Compound:wiskostatin|FD-Score:5.19|P-value:3.04E-7 ID:SGTC_268|Compound:camptothecin|FD-Score:5.63|P-value:3.24E-8 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.36|P-value:7.65E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.36|P-value:5.96E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:7.75|P-value:5.46E-14 ID:SGTC_354|Compound:2783-3500|FD-Score:7.28|P-value:1.41E-12 ID:SGTC_360|Compound:0957-0399|FD-Score:4.18|P-value:2.81E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:6.07|P-value:2.71E-9 ID:SGTC_426|Compound:0988-0037|FD-Score:3.48|P-value:3.96E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.67|P-value:2.60E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.19|P-value:1.41E-9 ID:SGTC_507|Compound:nimesulide|FD-Score:3.44|P-value:4.46E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.27|P-value:7.95E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.05|P-value:4.72E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:-4.30|P-value:2.39E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.95|P-value:6.99E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:7.26|P-value:1.69E-12 ID:SGTC_580|Compound:1123-0028|FD-Score:8.75|P-value:2.53E-17 ID:SGTC_584|Compound:0986-0246|FD-Score:5.88|P-value:8.29E-9 ID:SGTC_586|Compound:0957-0265|FD-Score:7.09|P-value:5.22E-12 ID:SGTC_629|Compound:3448-6466|FD-Score:3.35|P-value:6.06E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.94|P-value:7.44E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:13.00|P-value:7.41E-36 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.46|P-value:1.25E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:3.86|P-value:9.95E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.83|P-value:1.11E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:7.17|P-value:3.09E-12 ID:SGTC_770|Compound:0389-1121|FD-Score:4.49|P-value:7.76E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.66|P-value:5.08E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:7.92|P-value:1.59E-14 ID:SGTC_839|Compound:0122-0028|FD-Score:7.65|P-value:1.06E-13 ID:SGTC_852|Compound:0418-0143|FD-Score:-4.21|P-value:3.39E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:5.62|P-value:3.30E-8 ID:SGTC_871|Compound:0574-0004|FD-Score:9.12|P-value:1.19E-18 ID:SGTC_916|Compound:4466-0038|FD-Score:4.07|P-value:4.35E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:4.74|P-value:2.56E-6 ID:SGTC_964|Compound:1287-0107|FD-Score:5.22|P-value:2.60E-7 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.79|P-value:1.31E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.68|P-value:1.97E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:5.12|P-value:4.27E-7 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.19|P-value:2.70E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.92|P-value:1.05E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.38|P-value:1.23E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:-4.33|P-value:2.12E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.43|P-value:4.68E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.42|P-value:4.88E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.31|P-value:7.05E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:8.66|P-value:5.02E-17 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.26|P-value:2.76E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:8.72|P-value:3.09E-17 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.47|P-value:4.13E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:4.10|P-value:3.97E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.53|P-value:9.14E-6 ID:SGTC_1652|Compound:st011932|FD-Score:6.75|P-value:4.73E-11 ID:SGTC_1665|Compound:st014639|FD-Score:3.32|P-value:6.70E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.73|P-value:1.59E-4 ID:SGTC_1707|Compound:st032323|FD-Score:7.04|P-value:7.20E-12 ID:SGTC_1719|Compound:st032227|FD-Score:3.35|P-value:6.19E-4 ID:SGTC_1745|Compound:st081495|FD-Score:5.57|P-value:4.26E-8 ID:SGTC_1754|Compound:st042065|FD-Score:6.22|P-value:1.17E-9 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.51|P-value:4.60E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-4.42|P-value:1.44E-5 ID:SGTC_1800|Compound:st050079|FD-Score:4.07|P-value:4.34E-5 ID:SGTC_1818|Compound:st052136|FD-Score:7.63|P-value:1.22E-13 ID:SGTC_1915|Compound:st067105|FD-Score:5.54|P-value:5.19E-8 ID:SGTC_1930|Compound:st074634|FD-Score:3.50|P-value:3.63E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.52|P-value:6.90E-6 ID:SGTC_1959|Compound:st077091|FD-Score:5.60|P-value:3.64E-8 ID:SGTC_2025|Compound:5147754|FD-Score:3.58|P-value:2.77E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.78|P-value:1.32E-4 ID:SGTC_2107|Compound:5363541|FD-Score:4.86|P-value:1.48E-6 ID:SGTC_2109|Compound:5483026|FD-Score:13.30|P-value:1.99E-37 ID:SGTC_2111|Compound:5486399|FD-Score:3.63|P-value:2.31E-4 ID:SGTC_2186|Compound:6124449|FD-Score:5.36|P-value:1.32E-7 ID:SGTC_2187|Compound:6125751|FD-Score:4.31|P-value:1.66E-5 ID:SGTC_2192|Compound:5915882|FD-Score:8.98|P-value:3.92E-18 ID:SGTC_2229|Compound:7354935|FD-Score:7.05|P-value:6.65E-12 ID:SGTC_2275|Compound:7947463|FD-Score:3.89|P-value:8.92E-5 ID:SGTC_2277|Compound:7947813|FD-Score:3.32|P-value:6.72E-4 ID:SGTC_2291|Compound:7917025|FD-Score:6.88|P-value:2.04E-11 ID:SGTC_2329|Compound:6138490|FD-Score:4.44|P-value:9.68E-6 ID:SGTC_2361|Compound:9034121|FD-Score:4.02|P-value:5.29E-5 ID:SGTC_2474|Compound:5321570|FD-Score:3.68|P-value:1.97E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.27|P-value:8.00E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.00|P-value:7.79E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.31|P-value:7.05E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.05|P-value:4.80E-5 ID:SGTC_2708|Compound:st078559|FD-Score:3.60|P-value:2.59E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.66|P-value:3.64E-6 ID:SGTC_2890|Compound:9046729|FD-Score:5.37|P-value:1.23E-7 ID:SGTC_2912|Compound:7964298|FD-Score:8.01|P-value:7.81E-15 ID:SGTC_2997|Compound:9067075|FD-Score:3.36|P-value:5.91E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.58|P-value:2.80E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.35|P-value:7.97E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.74|P-value:1.57E-4 ID:SGTC_3347|Compound:9188721|FD-Score:9.46|P-value:6.19E-20 ID:SGTC_13|Compound:0199-0087|FD-Score:3.45|P-value:4.41E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:5.80|P-value:1.26E-8 ID:SGTC_22|Compound:0964-0034|FD-Score:10.80|P-value:2.12E-25 ID:SGTC_58|Compound:0957-0393|FD-Score:8.39|P-value:4.39E-16 ID:SGTC_93|Compound:0109-0045|FD-Score:3.44|P-value:4.52E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:12.50|P-value:2.75E-33 ID:SGTC_157|Compound:1348-1695|FD-Score:4.32|P-value:1.61E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:3.27|P-value:8.02E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.65|P-value:5.48E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:8.55|P-value:1.25E-16 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.29|P-value:7.49E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.78|P-value:1.35E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:9.97|P-value:6.71E-22 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.22|P-value:2.44E-5 ID:SGTC_249|Compound:wiskostatin|FD-Score:5.19|P-value:3.04E-7 ID:SGTC_268|Compound:camptothecin|FD-Score:5.63|P-value:3.24E-8 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.36|P-value:7.65E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.36|P-value:5.96E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:7.75|P-value:5.46E-14 ID:SGTC_354|Compound:2783-3500|FD-Score:7.28|P-value:1.41E-12 ID:SGTC_360|Compound:0957-0399|FD-Score:4.18|P-value:2.81E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:6.07|P-value:2.71E-9 ID:SGTC_426|Compound:0988-0037|FD-Score:3.48|P-value:3.96E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.67|P-value:2.60E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.19|P-value:1.41E-9 ID:SGTC_507|Compound:nimesulide|FD-Score:3.44|P-value:4.46E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.27|P-value:7.95E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.05|P-value:4.72E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:-4.30|P-value:2.39E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.95|P-value:6.99E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:7.26|P-value:1.69E-12 ID:SGTC_580|Compound:1123-0028|FD-Score:8.75|P-value:2.53E-17 ID:SGTC_584|Compound:0986-0246|FD-Score:5.88|P-value:8.29E-9 ID:SGTC_586|Compound:0957-0265|FD-Score:7.09|P-value:5.22E-12 ID:SGTC_629|Compound:3448-6466|FD-Score:3.35|P-value:6.06E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.94|P-value:7.44E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:13.00|P-value:7.41E-36 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.46|P-value:1.25E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:3.86|P-value:9.95E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.83|P-value:1.11E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:7.17|P-value:3.09E-12 ID:SGTC_770|Compound:0389-1121|FD-Score:4.49|P-value:7.76E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.66|P-value:5.08E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:7.92|P-value:1.59E-14 ID:SGTC_839|Compound:0122-0028|FD-Score:7.65|P-value:1.06E-13 ID:SGTC_852|Compound:0418-0143|FD-Score:-4.21|P-value:3.39E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:5.62|P-value:3.30E-8 ID:SGTC_871|Compound:0574-0004|FD-Score:9.12|P-value:1.19E-18 ID:SGTC_916|Compound:4466-0038|FD-Score:4.07|P-value:4.35E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:4.74|P-value:2.56E-6 ID:SGTC_964|Compound:1287-0107|FD-Score:5.22|P-value:2.60E-7 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.79|P-value:1.31E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.68|P-value:1.97E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:5.12|P-value:4.27E-7 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.19|P-value:2.70E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.92|P-value:1.05E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.38|P-value:1.23E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:-4.33|P-value:2.12E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.43|P-value:4.68E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.42|P-value:4.88E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.31|P-value:7.05E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:8.66|P-value:5.02E-17 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.26|P-value:2.76E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:8.72|P-value:3.09E-17 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.47|P-value:4.13E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:4.10|P-value:3.97E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.53|P-value:9.14E-6 ID:SGTC_1652|Compound:st011932|FD-Score:6.75|P-value:4.73E-11 ID:SGTC_1665|Compound:st014639|FD-Score:3.32|P-value:6.70E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.73|P-value:1.59E-4 ID:SGTC_1707|Compound:st032323|FD-Score:7.04|P-value:7.20E-12 ID:SGTC_1719|Compound:st032227|FD-Score:3.35|P-value:6.19E-4 ID:SGTC_1745|Compound:st081495|FD-Score:5.57|P-value:4.26E-8 ID:SGTC_1754|Compound:st042065|FD-Score:6.22|P-value:1.17E-9 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.51|P-value:4.60E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-4.42|P-value:1.44E-5 ID:SGTC_1800|Compound:st050079|FD-Score:4.07|P-value:4.34E-5 ID:SGTC_1818|Compound:st052136|FD-Score:7.63|P-value:1.22E-13 ID:SGTC_1915|Compound:st067105|FD-Score:5.54|P-value:5.19E-8 ID:SGTC_1930|Compound:st074634|FD-Score:3.50|P-value:3.63E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.52|P-value:6.90E-6 ID:SGTC_1959|Compound:st077091|FD-Score:5.60|P-value:3.64E-8 ID:SGTC_2025|Compound:5147754|FD-Score:3.58|P-value:2.77E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.78|P-value:1.32E-4 ID:SGTC_2107|Compound:5363541|FD-Score:4.86|P-value:1.48E-6 ID:SGTC_2109|Compound:5483026|FD-Score:13.30|P-value:1.99E-37 ID:SGTC_2111|Compound:5486399|FD-Score:3.63|P-value:2.31E-4 ID:SGTC_2186|Compound:6124449|FD-Score:5.36|P-value:1.32E-7 ID:SGTC_2187|Compound:6125751|FD-Score:4.31|P-value:1.66E-5 ID:SGTC_2192|Compound:5915882|FD-Score:8.98|P-value:3.92E-18 ID:SGTC_2229|Compound:7354935|FD-Score:7.05|P-value:6.65E-12 ID:SGTC_2275|Compound:7947463|FD-Score:3.89|P-value:8.92E-5 ID:SGTC_2277|Compound:7947813|FD-Score:3.32|P-value:6.72E-4 ID:SGTC_2291|Compound:7917025|FD-Score:6.88|P-value:2.04E-11 ID:SGTC_2329|Compound:6138490|FD-Score:4.44|P-value:9.68E-6 ID:SGTC_2361|Compound:9034121|FD-Score:4.02|P-value:5.29E-5 ID:SGTC_2474|Compound:5321570|FD-Score:3.68|P-value:1.97E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.27|P-value:8.00E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.00|P-value:7.79E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.31|P-value:7.05E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.05|P-value:4.80E-5 ID:SGTC_2708|Compound:st078559|FD-Score:3.60|P-value:2.59E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.66|P-value:3.64E-6 ID:SGTC_2890|Compound:9046729|FD-Score:5.37|P-value:1.23E-7 ID:SGTC_2912|Compound:7964298|FD-Score:8.01|P-value:7.81E-15 ID:SGTC_2997|Compound:9067075|FD-Score:3.36|P-value:5.91E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.58|P-value:2.80E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.35|P-value:7.97E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.74|P-value:1.57E-4 ID:SGTC_3347|Compound:9188721|FD-Score:9.46|P-value:6.19E-20

Top fitness defect scores for YOR236W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2109 5483026 13.30 200.0 µM 1.99E-37 RSC complex & mRNA processing 4 1.12E-40 0.24
2 SGTC_673 1082-0474 13.00 110.0 µM 7.41E-36 RSC complex & mRNA processing 4 5.90E-39 0.37
3 SGTC_138 0850-0259 12.50 40.9 µM 2.75E-33 cell wall 10 3.82E-36 1.97
4 SGTC_22 0964-0034 10.80 14.5 µM 2.12E-25 unfolded protein response 3 1.61E-27 2.81
5 SGTC_245 methotrexate 9.97 289.6 µM 6.71E-22 1 1.08E-23 1.43
6 SGTC_3347 9188721 9.46 44.7 µM 6.19E-20 5 1.52E-21 2.08
7 SGTC_871 0574-0004 9.12 149.0 µM 1.19E-18 7 3.82E-20 0.07
8 SGTC_2192 5915882 8.98 198.5 µM 3.92E-18 RNA processing & uracil transport 2 1.41E-19 0.19
9 SGTC_580 1123-0028 8.75 41.0 µM 2.53E-17 DNA damage response 2 1.08E-18 0.35
10 SGTC_1374 2889-5571 8.72 141.0 µM 3.09E-17 RSC complex & mRNA processing 16 1.34E-18 1.32
11 SGTC_1313 1220-0047 8.66 237.0 µM 5.02E-17 1 2.28E-18 2.25
12 SGTC_227 fluconazole 8.55 33.5 µM 1.25E-16 azole & statin 17 6.18E-18 0.24
13 SGTC_58 0957-0393 8.39 9.0 µM 4.39E-16 cell wall 14 2.44E-17 0.11
14 SGTC_2912 7964298 8.01 10.9 µM 7.81E-15 cell wall 17 5.65E-16 0.05
15 SGTC_829 1635-0120 7.92 117.0 µM 1.59E-14 DNA damage response 17 1.23E-15 0.04
16 SGTC_332 4112-0506 7.75 40.9 µM 5.46E-14 4 4.71E-15 0.16
17 SGTC_839 0122-0028 7.65 230.0 µM 1.06E-13 RSC complex & mRNA processing 3 9.70E-15 0.16
18 SGTC_1818 st052136 7.63 56.3 µM 1.22E-13 NEO1-PIK1 2 1.14E-14 0.20
19 SGTC_354 2783-3500 7.28 4.9 µM 1.41E-12 cell wall 7 1.64E-13 0.09
20 SGTC_576 1073-0113 7.26 22.7 µM 1.69E-12 redox potentiating 13 2.00E-13 0.43

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.649 0 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.575 2.22E-294 YBL092W RPL32 het Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog
0.558 2.76E-274 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.463 8.06E-178 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.458 9.01E-174 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.370 1.01E-109 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.353 5.96E-99 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.348 6.17E-96 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.343 3.06E-93 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.340 9.86E-92 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.330 3.28E-86 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.329 2.35E-85 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.316 1.34E-78 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.308 1.78E-74 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.306 1.69E-73 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients