YOR237W / HES1

Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); HES1 has a paralog, KES1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR237W / HES1

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:-3.15|P-value:3.79E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:5.73|P-value:1.95E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:3.46|P-value:2.15E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-5.02|P-value:5.14E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:3.29|P-value:4.06E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.67|P-value:8.92E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.75|P-value:6.48E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.16|P-value:6.57E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.98|P-value:2.39E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:4.93|P-value:2.09E-7 ID:SGTC_571|Compound:k831-0106|FD-Score:4.35|P-value:4.16E-6 ID:SGTC_616|Compound:4092-0450|FD-Score:3.52|P-value:1.64E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.68|P-value:8.08E-7 ID:SGTC_668|Compound:1682-0499|FD-Score:3.65|P-value:1.00E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.43|P-value:2.41E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.39|P-value:3.42E-6 ID:SGTC_972|Compound:1319-0219|FD-Score:3.61|P-value:1.15E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.00|P-value:2.21E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:7.80|P-value:3.96E-16 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.44|P-value:2.32E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.28|P-value:2.24E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.06|P-value:9.58E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.59|P-value:1.24E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.71|P-value:7.57E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.09|P-value:8.64E-4 ID:SGTC_1691|Compound:st019933|FD-Score:-3.15|P-value:3.70E-4 ID:SGTC_1743|Compound:st037606|FD-Score:4.05|P-value:1.71E-5 ID:SGTC_1791|Compound:st048313|FD-Score:3.26|P-value:4.64E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.52|P-value:1.66E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:4.53|P-value:1.69E-6 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.70|P-value:7.88E-5 ID:SGTC_2349|Compound:9023730|FD-Score:3.07|P-value:9.21E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-3.08|P-value:4.95E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.20|P-value:3.04E-4 ID:SGTC_2474|Compound:5321570|FD-Score:-3.10|P-value:4.60E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.09|P-value:1.43E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.63|P-value:4.36E-7 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.88|P-value:1.77E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-3.22|P-value:2.82E-4 ID:SGTC_2869|Compound:9037858|FD-Score:3.96|P-value:2.59E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.83|P-value:4.63E-5 ID:SGTC_2978|Compound:9011784|FD-Score:6.21|P-value:7.96E-11 ID:SGTC_2986|Compound:9022445|FD-Score:-3.89|P-value:1.67E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-3.65|P-value:4.91E-5 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.15|P-value:3.79E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:5.73|P-value:1.95E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:3.46|P-value:2.15E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-5.02|P-value:5.14E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:3.29|P-value:4.06E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.67|P-value:8.92E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.75|P-value:6.48E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.16|P-value:6.57E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.98|P-value:2.39E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:4.93|P-value:2.09E-7 ID:SGTC_571|Compound:k831-0106|FD-Score:4.35|P-value:4.16E-6 ID:SGTC_616|Compound:4092-0450|FD-Score:3.52|P-value:1.64E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.68|P-value:8.08E-7 ID:SGTC_668|Compound:1682-0499|FD-Score:3.65|P-value:1.00E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.43|P-value:2.41E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.39|P-value:3.42E-6 ID:SGTC_972|Compound:1319-0219|FD-Score:3.61|P-value:1.15E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.00|P-value:2.21E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:7.80|P-value:3.96E-16 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.44|P-value:2.32E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.28|P-value:2.24E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.06|P-value:9.58E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.59|P-value:1.24E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.71|P-value:7.57E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.09|P-value:8.64E-4 ID:SGTC_1691|Compound:st019933|FD-Score:-3.15|P-value:3.70E-4 ID:SGTC_1743|Compound:st037606|FD-Score:4.05|P-value:1.71E-5 ID:SGTC_1791|Compound:st048313|FD-Score:3.26|P-value:4.64E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.52|P-value:1.66E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:4.53|P-value:1.69E-6 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.70|P-value:7.88E-5 ID:SGTC_2349|Compound:9023730|FD-Score:3.07|P-value:9.21E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-3.08|P-value:4.95E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.20|P-value:3.04E-4 ID:SGTC_2474|Compound:5321570|FD-Score:-3.10|P-value:4.60E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.09|P-value:1.43E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.63|P-value:4.36E-7 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.88|P-value:1.77E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-3.22|P-value:2.82E-4 ID:SGTC_2869|Compound:9037858|FD-Score:3.96|P-value:2.59E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.83|P-value:4.63E-5 ID:SGTC_2978|Compound:9011784|FD-Score:6.21|P-value:7.96E-11 ID:SGTC_2986|Compound:9022445|FD-Score:-3.89|P-value:1.67E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-3.65|P-value:4.91E-5

Top fitness defect scores for YOR237W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1295 1013-0063 7.80 9.8 µM 3.96E-16 1 3.02E-15
2 SGTC_2978 9011784 6.21 43.0 µM 7.96E-11 4 2.60E-10
3 SGTC_55 0767-0285 5.73 6.6 µM 1.95E-9 17 5.14E-9
4 SGTC_566 0958-0068 4.93 16.5 µM 2.09E-7 RSC & ERG11 11 4.06E-7
5 SGTC_666 0272-0154 4.68 136.0 µM 8.08E-7 cell wall 36 1.44E-6
6 SGTC_2170 morpholine 4.53 200.0 µM 1.69E-6 6 2.88E-6
7 SGTC_770 0389-1121 4.39 67.2 µM 3.42E-6 RPP1 & pyrimidine depletion 16 5.56E-6
8 SGTC_571 k831-0106 4.35 44.2 µM 4.16E-6 9 6.70E-6
9 SGTC_2497 7-hydroxyflavone 4.09 100.0 µM 1.43E-5 19 2.14E-5
10 SGTC_1743 st037606 4.05 46.4 µM 1.71E-5 20 2.52E-5
11 SGTC_1063 disulfiram 4.00 1.8 µM 2.21E-5 21 3.21E-5
12 SGTC_437 s-farnesyl-l-cysteine methyl ester 3.98 6.7 µM 2.39E-5 12 3.45E-5
13 SGTC_2869 9037858 3.96 32.5 µM 2.59E-5 12 3.73E-5
14 SGTC_2966 9084041 3.83 48.0 µM 4.63E-5 39 6.44E-5
15 SGTC_263 alizarin 3.75 107.9 µM 6.48E-5 iron homeostasis 65 8.84E-5
16 SGTC_1619 st003326 3.71 88.7 µM 7.57E-5 60S ribosome export 23 1.02E-4
17 SGTC_2251 lansoprazole 3.70 556.0 µM 7.88E-5 27 1.06E-4
18 SGTC_251 melphalan 3.67 456.5 µM 8.92E-5 DNA damage response 36 1.19E-4
19 SGTC_668 1682-0499 3.65 62.6 µM 1.00E-4 29 1.33E-4
20 SGTC_972 1319-0219 3.61 195.0 µM 1.15E-4 43 1.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 6.94E-12 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.107 5.60E-10 YPL158C AIM44 hom Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.104 1.76E-9 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.103 2.17E-9 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.100 7.01E-9 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.095 3.85E-8 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.089 2.11E-7 YMR106C YKU80 hom Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
0.089 2.13E-7 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.086 6.97E-7 YNL274C GOR1 hom Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.086 7.04E-7 YLR444C_d YLR444C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.085 7.99E-7 YCR087C-A_p YCR087C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene
0.084 1.28E-6 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.081 2.55E-6 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.081 2.72E-6 YKL147C_d YKL147C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
0.080 3.24E-6 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain