YOR242C / SSP2

Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR242C / SSP2

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:3.05|P-value:4.04E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.03|P-value:4.27E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:3.26|P-value:1.73E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:4.06|P-value:4.07E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:3.06|P-value:3.88E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:2.87|P-value:8.05E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:-4.20|P-value:1.87E-6 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.13|P-value:2.78E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.01|P-value:4.60E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.99|P-value:5.86E-6 ID:SGTC_884|Compound:0851-0618|FD-Score:2.91|P-value:7.10E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.02|P-value:4.52E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.58|P-value:4.18E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.04|P-value:4.53E-6 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.64|P-value:3.14E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.09|P-value:3.45E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.30|P-value:1.46E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.50|P-value:6.05E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.02|P-value:4.62E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.99|P-value:5.21E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.25|P-value:1.81E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.29|P-value:1.51E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.30|P-value:1.44E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.15|P-value:2.73E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.02|P-value:4.63E-4 ID:SGTC_2003|Compound:4023581|FD-Score:6.70|P-value:9.14E-14 ID:SGTC_2024|Compound:5144227|FD-Score:2.93|P-value:6.41E-4 ID:SGTC_2083|Compound:5306046|FD-Score:-2.88|P-value:7.45E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.43|P-value:8.14E-5 ID:SGTC_2187|Compound:6125751|FD-Score:3.64|P-value:3.28E-5 ID:SGTC_2380|Compound:9035439|FD-Score:4.24|P-value:1.59E-6 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.60|P-value:3.66E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:2.84|P-value:9.00E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.44|P-value:7.66E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.46|P-value:6.99E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-2.86|P-value:8.14E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.11|P-value:3.26E-4 ID:SGTC_2866|Compound:9034245|FD-Score:3.23|P-value:1.95E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-3.08|P-value:3.45E-4 ID:SGTC_3039|Compound:9090270|FD-Score:3.23|P-value:1.97E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.23|P-value:1.96E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.05|P-value:4.04E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.03|P-value:4.27E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:3.26|P-value:1.73E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:4.06|P-value:4.07E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:3.06|P-value:3.88E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:2.87|P-value:8.05E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:-4.20|P-value:1.87E-6 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.13|P-value:2.78E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.01|P-value:4.60E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.99|P-value:5.86E-6 ID:SGTC_884|Compound:0851-0618|FD-Score:2.91|P-value:7.10E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.02|P-value:4.52E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.58|P-value:4.18E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.04|P-value:4.53E-6 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.64|P-value:3.14E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.09|P-value:3.45E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.30|P-value:1.46E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.50|P-value:6.05E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.02|P-value:4.62E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.99|P-value:5.21E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.25|P-value:1.81E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.29|P-value:1.51E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.30|P-value:1.44E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.15|P-value:2.73E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.02|P-value:4.63E-4 ID:SGTC_2003|Compound:4023581|FD-Score:6.70|P-value:9.14E-14 ID:SGTC_2024|Compound:5144227|FD-Score:2.93|P-value:6.41E-4 ID:SGTC_2083|Compound:5306046|FD-Score:-2.88|P-value:7.45E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.43|P-value:8.14E-5 ID:SGTC_2187|Compound:6125751|FD-Score:3.64|P-value:3.28E-5 ID:SGTC_2380|Compound:9035439|FD-Score:4.24|P-value:1.59E-6 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.60|P-value:3.66E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:2.84|P-value:9.00E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.44|P-value:7.66E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.46|P-value:6.99E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-2.86|P-value:8.14E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.11|P-value:3.26E-4 ID:SGTC_2866|Compound:9034245|FD-Score:3.23|P-value:1.95E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-3.08|P-value:3.45E-4 ID:SGTC_3039|Compound:9090270|FD-Score:3.23|P-value:1.97E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.23|P-value:1.96E-4

Top fitness defect scores for YOR242C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2003 4023581 6.70 200.0 µM 9.14E-14 cell wall signaling 10 1.05E-11
2 SGTC_2380 9035439 4.24 200.0 µM 1.59E-6 endomembrane recycling 12 1.11E-5
3 SGTC_331 k048-0133 4.06 24.5 µM 4.07E-6 RSC & ERG11 7 2.43E-5
4 SGTC_1132 3456-3614 4.04 2.5 µM 4.53E-6 tubulin folding & SWR complex 40 2.66E-5
5 SGTC_572 0960-0087 3.99 17.7 µM 5.86E-6 26 3.29E-5
6 SGTC_1148 3909-7663 3.64 27.7 µM 3.14E-5 22 1.34E-4
7 SGTC_2187 6125751 3.64 200.0 µM 3.28E-5 RSC complex & mRNA processing 25 1.39E-4
8 SGTC_1103 duloxetine 3.58 36.1 µM 4.18E-5 47 1.70E-4
9 SGTC_1235 benzylparaben 3.50 21.5 µM 6.05E-5 21 2.32E-4
10 SGTC_2094 5332512 3.43 191.7 µM 8.14E-5 42 2.97E-4
11 SGTC_1792 st045773 3.30 43.6 µM 1.44E-4 52 4.78E-4
12 SGTC_1215 3852-0577 3.30 11.2 µM 1.46E-4 34 4.85E-4
13 SGTC_1788 fluconazole 3.29 20.0 µM 1.51E-4 azole & statin 88 4.99E-4
14 SGTC_194 1486-1323 3.26 56.9 µM 1.73E-4 38 5.57E-4
15 SGTC_1726 st035556 3.25 14.6 µM 1.81E-4 72 5.80E-4
16 SGTC_2866 9034245 3.23 58.4 µM 1.95E-4 23 6.17E-4
17 SGTC_3354 9151612 3.23 71.4 µM 1.96E-4 37 6.20E-4
18 SGTC_3039 9090270 3.23 49.5 µM 1.97E-4 RPP1 & pyrimidine depletion 27 6.22E-4
19 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 3.15 62.6 µM 2.73E-4 TSC3-RPN4 34 8.19E-4
20 SGTC_2854 9024559 3.11 71.4 µM 3.26E-4 65 9.51E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 1.26E-13 YGL140C_p YGL140C_p hom Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
0.101 4.96E-9 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.099 8.23E-9 YML070W DAK1 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.097 2.10E-8 YEL055C POL5 het DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA
0.095 3.80E-8 YPL208W RKM1 hom SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp)
0.092 8.42E-8 YGL209W MIG2 hom Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication
0.092 8.99E-8 YDL101C DUN1 hom Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
0.087 4.51E-7 YDL051W LHP1 hom RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen
0.086 6.81E-7 YBR153W RIB7 het Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway
0.084 1.15E-6 YNL270C ALP1 hom Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication
0.081 2.73E-6 YAL022C FUN26 hom Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis
0.080 3.61E-6 YPR156C TPO3 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication
0.079 4.34E-6 YNL093W YPT53 hom Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication
0.078 5.72E-6 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.076 1.02E-5 YPL110C GDE1 hom Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes