YOR244W / ESA1

Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR244W / ESA1

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.18|P-value:1.00E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:3.22|P-value:5.16E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.28|P-value:4.12E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.35|P-value:3.17E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.32|P-value:3.55E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.94|P-value:2.31E-7 ID:SGTC_545|Compound:4218-0007|FD-Score:-3.37|P-value:2.92E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:-4.09|P-value:1.51E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:3.79|P-value:5.46E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.40|P-value:2.63E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.47|P-value:2.04E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:3.14|P-value:6.70E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.25|P-value:7.43E-6 ID:SGTC_775|Compound:4577-0580|FD-Score:-3.25|P-value:4.59E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.62|P-value:1.11E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:-3.09|P-value:8.08E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.29|P-value:4.03E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.19|P-value:5.63E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.30|P-value:3.83E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:-3.08|P-value:8.44E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.29|P-value:3.92E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.31|P-value:5.44E-6 ID:SGTC_1835|Compound:st008666|FD-Score:3.23|P-value:4.88E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.25|P-value:4.54E-4 ID:SGTC_1908|Compound:st060353|FD-Score:6.01|P-value:4.38E-10 ID:SGTC_1936|Compound:st074407|FD-Score:3.07|P-value:8.83E-4 ID:SGTC_1974|Compound:st069448|FD-Score:-3.10|P-value:7.70E-4 ID:SGTC_2049|Compound:5262831|FD-Score:4.17|P-value:1.07E-5 ID:SGTC_2089|Compound:5281248|FD-Score:4.93|P-value:2.53E-7 ID:SGTC_2105|Compound:5350118|FD-Score:3.51|P-value:1.74E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.37|P-value:2.89E-4 ID:SGTC_2188|Compound:6126565|FD-Score:3.57|P-value:1.35E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.56|P-value:1.43E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.98|P-value:2.44E-5 ID:SGTC_2383|Compound:9036125|FD-Score:-3.50|P-value:1.75E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.22|P-value:5.03E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.47|P-value:2.54E-6 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.50|P-value:1.79E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.69|P-value:8.52E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.85|P-value:3.77E-7 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.04|P-value:9.42E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.27|P-value:4.17E-4 ID:SGTC_2932|Compound:9016711|FD-Score:5.27|P-value:3.77E-8 ID:SGTC_3029|Compound:9088683|FD-Score:3.08|P-value:8.51E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.18|P-value:1.00E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:3.22|P-value:5.16E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.28|P-value:4.12E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.35|P-value:3.17E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.32|P-value:3.55E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.94|P-value:2.31E-7 ID:SGTC_545|Compound:4218-0007|FD-Score:-3.37|P-value:2.92E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:-4.09|P-value:1.51E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:3.79|P-value:5.46E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.40|P-value:2.63E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.47|P-value:2.04E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:3.14|P-value:6.70E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.25|P-value:7.43E-6 ID:SGTC_775|Compound:4577-0580|FD-Score:-3.25|P-value:4.59E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.62|P-value:1.11E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:-3.09|P-value:8.08E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.29|P-value:4.03E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.19|P-value:5.63E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.30|P-value:3.83E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:-3.08|P-value:8.44E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.29|P-value:3.92E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.31|P-value:5.44E-6 ID:SGTC_1835|Compound:st008666|FD-Score:3.23|P-value:4.88E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.25|P-value:4.54E-4 ID:SGTC_1908|Compound:st060353|FD-Score:6.01|P-value:4.38E-10 ID:SGTC_1936|Compound:st074407|FD-Score:3.07|P-value:8.83E-4 ID:SGTC_1974|Compound:st069448|FD-Score:-3.10|P-value:7.70E-4 ID:SGTC_2049|Compound:5262831|FD-Score:4.17|P-value:1.07E-5 ID:SGTC_2089|Compound:5281248|FD-Score:4.93|P-value:2.53E-7 ID:SGTC_2105|Compound:5350118|FD-Score:3.51|P-value:1.74E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.37|P-value:2.89E-4 ID:SGTC_2188|Compound:6126565|FD-Score:3.57|P-value:1.35E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.56|P-value:1.43E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.98|P-value:2.44E-5 ID:SGTC_2383|Compound:9036125|FD-Score:-3.50|P-value:1.75E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.22|P-value:5.03E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.47|P-value:2.54E-6 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.50|P-value:1.79E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.69|P-value:8.52E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.85|P-value:3.77E-7 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.04|P-value:9.42E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.27|P-value:4.17E-4 ID:SGTC_2932|Compound:9016711|FD-Score:5.27|P-value:3.77E-8 ID:SGTC_3029|Compound:9088683|FD-Score:3.08|P-value:8.51E-4

Top fitness defect scores for YOR244W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1908 st060353 6.01 56.5 µM 4.38E-10 RPP1 & pyrimidine depletion 4 9.27E-10 1.05
2 SGTC_2932 9016711 5.27 44.5 µM 3.77E-8 3 6.73E-8 0.18
3 SGTC_495 decylubiquinone 4.94 155.0 µM 2.31E-7 copper-dependent oxidative stress 1 3.85E-7 1.24
4 SGTC_2089 5281248 4.93 129.7 µM 2.53E-7 superoxide 7 4.20E-7 0.26
5 SGTC_2526 patulin 4.47 37.6 µM 2.54E-6 9 3.87E-6 0.14
6 SGTC_1712 st032288 4.31 53.4 µM 5.44E-6 calcium & mitochondrial duress 33 8.06E-6 0.02
7 SGTC_682 0kpi-0099 4.25 17.0 µM 7.43E-6 25 1.09E-5 0.10
8 SGTC_45 0kpi-0036 4.18 14.9 µM 1.00E-5 excess fatty acid 7 1.45E-5 0.69
9 SGTC_2049 5262831 4.17 67.2 µM 1.07E-5 5 1.54E-5 0.27
10 SGTC_2312 7706453 3.98 155.7 µM 2.44E-5 11 3.42E-5 0.06
11 SGTC_571 k831-0106 3.79 44.2 µM 5.46E-5 6 7.42E-5 0.17
12 SGTC_2581 avocatin a 3.69 64.0 µM 8.52E-5 sphingolipid biosynthesis & PDR1 10 1.14E-4 0.23
13 SGTC_2188 6126565 3.57 140.7 µM 1.35E-4 mitochondrial processes 8 1.78E-4 0.02
14 SGTC_2311 7694451 3.56 200.0 µM 1.43E-4 15 1.87E-4 0.01
15 SGTC_2105 5350118 3.51 200.0 µM 1.74E-4 10 2.27E-4 0.18
16 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 3.50 92.6 µM 1.79E-4 13 2.33E-4 0.06
17 SGTC_662 k832-1615 3.47 104.0 µM 2.04E-4 8 2.64E-4 0.18
18 SGTC_600 1495-0418 3.40 41.6 µM 2.63E-4 RPP1 & pyrimidine depletion 11 3.37E-4 0.12
19 SGTC_2156 5649887 3.37 115.0 µM 2.89E-4 RPP1 & pyrimidine depletion 24 3.70E-4 0.13
20 SGTC_369 0957-0393 3.35 4.5 µM 3.17E-4 cell wall signaling 13 4.04E-4 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.76E-19 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.115 2.72E-11 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.104 1.56E-9 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.103 1.98E-9 YGL227W VID30 hom Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm
0.103 2.26E-9 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.096 2.18E-8 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.094 4.35E-8 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.092 9.55E-8 YDR420W HKR1 hom Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
0.092 1.09E-7 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress
0.091 1.42E-7 YFR012W DCV1 hom Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication
0.090 1.62E-7 YOL017W ESC8 hom Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication
0.087 4.35E-7 YKL052C ASK1 het Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; protein abundance increases in response to DNA replication stress
0.087 4.94E-7 YDR156W RPA14 hom RNA polymerase I subunit A14
0.086 5.98E-7 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.085 7.19E-7 YER005W YND1 hom Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity