YOR245C / DGA1

Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR245C / DGA1

Click on Significant Values for Screen Details ID:SGTC_32|Compound:0928-0142|FD-Score:2.88|P-value:7.33E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-2.71|P-value:9.89E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:10.90|P-value:3.99E-34 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.24|P-value:1.13E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.89|P-value:7.92E-6 ID:SGTC_377|Compound:3970-0964|FD-Score:-2.95|P-value:3.86E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.15|P-value:2.53E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.05|P-value:3.71E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:2.88|P-value:7.30E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.19|P-value:2.06E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:-2.97|P-value:3.54E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.03|P-value:4.02E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.66|P-value:2.57E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.18|P-value:1.78E-6 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-2.82|P-value:6.47E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:4.28|P-value:1.01E-6 ID:SGTC_1880|Compound:MG-132|FD-Score:3.84|P-value:1.05E-5 ID:SGTC_2035|Compound:5154463|FD-Score:2.84|P-value:8.64E-4 ID:SGTC_2114|Compound:5491910|FD-Score:4.43|P-value:4.39E-7 ID:SGTC_2115|Compound:tiliquinol|FD-Score:4.56|P-value:2.10E-7 ID:SGTC_2117|Compound:5521686|FD-Score:3.78|P-value:1.41E-5 ID:SGTC_2326|Compound:6164455|FD-Score:3.15|P-value:2.49E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.00|P-value:4.56E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.48|P-value:5.93E-5 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.54|P-value:4.39E-5 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:3.49|P-value:5.64E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.26|P-value:1.57E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.62|P-value:2.96E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.45|P-value:6.65E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:3.29|P-value:1.37E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.03|P-value:4.03E-4 ID:SGTC_2880|Compound:9042983|FD-Score:4.86|P-value:3.32E-8 ID:SGTC_2905|Compound:7799065|FD-Score:3.06|P-value:3.61E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.20|P-value:1.39E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-2.72|P-value:9.55E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.77|P-value:1.45E-5 ID:SGTC_3148|Compound:9097893|FD-Score:3.52|P-value:4.86E-5 ID:SGTC_3154|Compound:9100113|FD-Score:3.73|P-value:1.81E-5 ID:SGTC_3187|Compound:9109394|FD-Score:-2.71|P-value:9.93E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.45|P-value:4.51E-5 ID:SGTC_3200|Compound:9114385|FD-Score:-3.88|P-value:5.42E-6 ID:SGTC_3269|Compound:9137823|FD-Score:-2.74|P-value:8.77E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:2.88|P-value:7.33E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-2.71|P-value:9.89E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:10.90|P-value:3.99E-34 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.24|P-value:1.13E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.89|P-value:7.92E-6 ID:SGTC_377|Compound:3970-0964|FD-Score:-2.95|P-value:3.86E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.15|P-value:2.53E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.05|P-value:3.71E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:2.88|P-value:7.30E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.19|P-value:2.06E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:-2.97|P-value:3.54E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.03|P-value:4.02E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.66|P-value:2.57E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.18|P-value:1.78E-6 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-2.82|P-value:6.47E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:4.28|P-value:1.01E-6 ID:SGTC_1880|Compound:MG-132|FD-Score:3.84|P-value:1.05E-5 ID:SGTC_2035|Compound:5154463|FD-Score:2.84|P-value:8.64E-4 ID:SGTC_2114|Compound:5491910|FD-Score:4.43|P-value:4.39E-7 ID:SGTC_2115|Compound:tiliquinol|FD-Score:4.56|P-value:2.10E-7 ID:SGTC_2117|Compound:5521686|FD-Score:3.78|P-value:1.41E-5 ID:SGTC_2326|Compound:6164455|FD-Score:3.15|P-value:2.49E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.00|P-value:4.56E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.48|P-value:5.93E-5 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.54|P-value:4.39E-5 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:3.49|P-value:5.64E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.26|P-value:1.57E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.62|P-value:2.96E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.45|P-value:6.65E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:3.29|P-value:1.37E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.03|P-value:4.03E-4 ID:SGTC_2880|Compound:9042983|FD-Score:4.86|P-value:3.32E-8 ID:SGTC_2905|Compound:7799065|FD-Score:3.06|P-value:3.61E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.20|P-value:1.39E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-2.72|P-value:9.55E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.77|P-value:1.45E-5 ID:SGTC_3148|Compound:9097893|FD-Score:3.52|P-value:4.86E-5 ID:SGTC_3154|Compound:9100113|FD-Score:3.73|P-value:1.81E-5 ID:SGTC_3187|Compound:9109394|FD-Score:-2.71|P-value:9.93E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.45|P-value:4.51E-5 ID:SGTC_3200|Compound:9114385|FD-Score:-3.88|P-value:5.42E-6 ID:SGTC_3269|Compound:9137823|FD-Score:-2.74|P-value:8.77E-4

Top fitness defect scores for YOR245C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_114 0364-0001 10.90 490.3 µM 3.99E-34 2 9.67E-28
2 SGTC_2880 9042983 4.86 58.4 µM 3.32E-8 fatty acid desaturase (OLE1) 12 5.88E-7
3 SGTC_2115 tiliquinol 4.56 12.8 µM 2.10E-7 5 2.61E-6
4 SGTC_2114 5491910 4.43 81.2 µM 4.39E-7 5 4.74E-6
5 SGTC_1876 myriocin 4.28 605.0 nM 1.01E-6 27 9.34E-6
6 SGTC_1456 k015-0012 4.18 13.0 µM 1.78E-6 27 1.47E-5
7 SGTC_278 4092-0821 3.89 23.9 µM 7.92E-6 plasma membrane duress 44 4.95E-5
8 SGTC_1880 MG-132 3.84 525.0 µM 1.05E-5 20 6.20E-5
9 SGTC_2117 5521686 3.78 200.0 µM 1.41E-5 18 7.88E-5
10 SGTC_3146 9095609 3.77 49.5 µM 1.45E-5 19 8.06E-5
11 SGTC_3154 9100113 3.73 49.5 µM 1.81E-5 37 9.66E-5
12 SGTC_1226 3909-7979 3.66 35.4 µM 2.57E-5 51 1.29E-4
13 SGTC_2716 st080858 3.62 38.6 µM 2.96E-5 60S ribosome export 25 1.44E-4
14 SGTC_2648 atorvastatin 3.54 78.7 µM 4.39E-5 azole & statin 28 1.99E-4
15 SGTC_3148 9097893 3.52 49.5 µM 4.86E-5 48 2.16E-4
16 SGTC_2656 pseudo-anisatin 3.49 100.0 µM 5.64E-5 5 2.44E-4
17 SGTC_2640 pentamidine 3.48 10.4 µM 5.93E-5 mitochondrial processes 47 2.54E-4
18 SGTC_2753 fluvastatin 3.45 17.1 µM 6.65E-5 azole & statin 55 2.79E-4
19 SGTC_2754 granisetron 3.29 64.0 µM 1.37E-4 62 5.02E-4
20 SGTC_2690 usnic acid 3.26 100.0 µM 1.57E-4 60 5.62E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.248 2.50E-48 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.175 1.37E-24 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.139 6.89E-16 YDR014W RAD61 hom Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin
0.124 6.05E-13 YGL126W SCS3 hom Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol
0.123 8.85E-13 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.123 1.04E-12 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
0.120 2.57E-12 YJR147W HMS2 hom Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication
0.119 5.44E-12 YLR381W CTF3 hom Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6
0.118 6.50E-12 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.117 1.17E-11 YOL158C ENB1 hom Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment
0.116 1.71E-11 YLL014W EMC6 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93
0.113 6.43E-11 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.108 4.21E-10 YGL085W_p LCL3_p hom Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS
0.107 4.31E-10 YJR016C ILV3 het Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
0.104 1.42E-9 YOR081C TGL5 hom Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate