YOR246C / ENV9

Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR246C / ENV9

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:6.32|P-value:8.93E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.69|P-value:2.24E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:9.73|P-value:1.03E-20 ID:SGTC_67|Compound:0335-0847|FD-Score:8.22|P-value:2.48E-15 ID:SGTC_72|Compound:0744-0168|FD-Score:7.09|P-value:7.37E-12 ID:SGTC_86|Compound:0417-1630|FD-Score:18.60|P-value:1.19E-70 ID:SGTC_103|Compound:0844-0104|FD-Score:27.70|P-value:1.30E-153 ID:SGTC_137|Compound:0438-0332|FD-Score:8.22|P-value:2.48E-15 ID:SGTC_141|Compound:0443-0274|FD-Score:11.20|P-value:8.42E-27 ID:SGTC_142|Compound:0335-0849|FD-Score:18.40|P-value:1.00E-68 ID:SGTC_143|Compound:4032-1194|FD-Score:8.19|P-value:3.08E-15 ID:SGTC_153|Compound:4077-0274|FD-Score:8.19|P-value:3.22E-15 ID:SGTC_165|Compound:k038-0023|FD-Score:12.40|P-value:1.57E-32 ID:SGTC_167|Compound:3672-0051|FD-Score:8.03|P-value:1.09E-14 ID:SGTC_200|Compound:k038-0079|FD-Score:9.45|P-value:1.18E-19 ID:SGTC_209|Compound:4077-0173|FD-Score:12.60|P-value:2.11E-33 ID:SGTC_216|Compound:k038-0035|FD-Score:7.48|P-value:5.44E-13 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.84|P-value:3.70E-11 ID:SGTC_294|Compound:k038-0071|FD-Score:4.28|P-value:2.31E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.52|P-value:4.12E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:5.67|P-value:3.41E-8 ID:SGTC_336|Compound:4111-0029|FD-Score:7.10|P-value:6.77E-12 ID:SGTC_340|Compound:k038-0059|FD-Score:5.05|P-value:7.61E-7 ID:SGTC_352|Compound:k048-0007|FD-Score:11.00|P-value:5.90E-26 ID:SGTC_367|Compound:0335-0881|FD-Score:6.39|P-value:5.97E-10 ID:SGTC_373|Compound:0844-0104|FD-Score:6.73|P-value:7.25E-11 ID:SGTC_384|Compound:k007-0144|FD-Score:7.29|P-value:1.95E-12 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.53|P-value:8.04E-6 ID:SGTC_446|Compound:go6976|FD-Score:3.46|P-value:4.90E-4 ID:SGTC_458|Compound:nppb|FD-Score:-3.46|P-value:5.01E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.32|P-value:7.88E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.50|P-value:4.28E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.36|P-value:7.00E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:10.40|P-value:2.80E-23 ID:SGTC_639|Compound:0833-0042|FD-Score:4.79|P-value:2.60E-6 ID:SGTC_642|Compound:0335-0876|FD-Score:5.62|P-value:4.43E-8 ID:SGTC_660|Compound:4031-1742|FD-Score:5.97|P-value:6.74E-9 ID:SGTC_696|Compound:1560-0013|FD-Score:4.79|P-value:2.60E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:23.60|P-value:2.20E-112 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.47|P-value:4.79E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.35|P-value:7.11E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:15.90|P-value:3.31E-52 ID:SGTC_848|Compound:0368-0089|FD-Score:5.22|P-value:3.27E-7 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:6.43|P-value:4.57E-10 ID:SGTC_942|Compound:3253-1115|FD-Score:5.44|P-value:1.13E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.53|P-value:6.92E-8 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.91|P-value:1.50E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.39|P-value:6.18E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:15.20|P-value:1.32E-47 ID:SGTC_1171|Compound:0368-0077|FD-Score:7.36|P-value:1.22E-12 ID:SGTC_1235|Compound:benzylparaben|FD-Score:5.47|P-value:9.39E-8 ID:SGTC_1240|Compound:0356-0016|FD-Score:6.96|P-value:1.71E-11 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.66|P-value:2.44E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:5.26|P-value:2.74E-7 ID:SGTC_1320|Compound:1313-0481|FD-Score:5.11|P-value:5.71E-7 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.25|P-value:9.93E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:4.53|P-value:8.13E-6 ID:SGTC_1427|Compound:4048-4900|FD-Score:4.66|P-value:4.52E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:6.04|P-value:4.35E-9 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.30|P-value:2.12E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:7.02|P-value:1.18E-11 ID:SGTC_1647|Compound:st011722|FD-Score:6.01|P-value:5.33E-9 ID:SGTC_1750|Compound:st081859|FD-Score:9.70|P-value:1.37E-20 ID:SGTC_1754|Compound:st042065|FD-Score:3.94|P-value:8.89E-5 ID:SGTC_1764|Compound:st044502|FD-Score:3.29|P-value:8.57E-4 ID:SGTC_1767|Compound:st044992|FD-Score:6.12|P-value:2.83E-9 ID:SGTC_1774|Compound:st048371|FD-Score:3.53|P-value:3.93E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:13.70|P-value:6.09E-39 ID:SGTC_1803|Compound:st050068|FD-Score:4.27|P-value:2.38E-5 ID:SGTC_1899|Compound:st063254|FD-Score:4.19|P-value:3.26E-5 ID:SGTC_1953|Compound:st076800|FD-Score:5.71|P-value:2.65E-8 ID:SGTC_2154|Compound:5570129|FD-Score:10.30|P-value:6.91E-23 ID:SGTC_2167|Compound:5876490|FD-Score:-3.38|P-value:6.60E-4 ID:SGTC_2210|Compound:7115885|FD-Score:6.75|P-value:6.47E-11 ID:SGTC_2308|Compound:7584454|FD-Score:3.67|P-value:2.39E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.97|P-value:7.90E-5 ID:SGTC_2322|Compound:7413319|FD-Score:9.55|P-value:4.77E-20 ID:SGTC_2371|Compound:9071574|FD-Score:6.01|P-value:5.23E-9 ID:SGTC_2385|Compound:9074692|FD-Score:9.34|P-value:3.05E-19 ID:SGTC_2413|Compound:inermin|FD-Score:41.90|P-value:0 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.54|P-value:7.76E-6 ID:SGTC_2469|Compound:5655019|FD-Score:4.62|P-value:5.48E-6 ID:SGTC_2471|Compound:5466956|FD-Score:3.31|P-value:8.22E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.56|P-value:7.20E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.38|P-value:6.42E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:5.57|P-value:5.68E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:4.01|P-value:6.77E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:6.47|P-value:3.76E-10 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:5.35|P-value:1.72E-7 ID:SGTC_2710|Compound:st078562|FD-Score:6.61|P-value:1.57E-10 ID:SGTC_2805|Compound:7950783|FD-Score:4.38|P-value:1.55E-5 ID:SGTC_2812|Compound:7970281|FD-Score:-3.94|P-value:8.80E-5 ID:SGTC_2817|Compound:7995342|FD-Score:3.37|P-value:6.72E-4 ID:SGTC_2941|Compound:9056145|FD-Score:5.22|P-value:3.29E-7 ID:SGTC_2966|Compound:9084041|FD-Score:3.28|P-value:9.02E-4 ID:SGTC_2967|Compound:9089538|FD-Score:24.50|P-value:1.56E-120 ID:SGTC_3090|Compound:9117696|FD-Score:8.67|P-value:7.85E-17 ID:SGTC_3141|Compound:9094609|FD-Score:3.95|P-value:8.38E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.40|P-value:6.03E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.48|P-value:9.82E-6 ID:SGTC_3205|Compound:9113483|FD-Score:4.54|P-value:7.85E-6 ID:SGTC_3209|Compound:9113616|FD-Score:4.26|P-value:2.54E-5 ID:SGTC_3283|Compound:9109332|FD-Score:7.09|P-value:7.40E-12 ID:SGTC_3290|Compound:9121031|FD-Score:3.66|P-value:2.44E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.75|P-value:1.81E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:6.32|P-value:8.93E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.69|P-value:2.24E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:9.73|P-value:1.03E-20 ID:SGTC_67|Compound:0335-0847|FD-Score:8.22|P-value:2.48E-15 ID:SGTC_72|Compound:0744-0168|FD-Score:7.09|P-value:7.37E-12 ID:SGTC_86|Compound:0417-1630|FD-Score:18.60|P-value:1.19E-70 ID:SGTC_103|Compound:0844-0104|FD-Score:27.70|P-value:1.30E-153 ID:SGTC_137|Compound:0438-0332|FD-Score:8.22|P-value:2.48E-15 ID:SGTC_141|Compound:0443-0274|FD-Score:11.20|P-value:8.42E-27 ID:SGTC_142|Compound:0335-0849|FD-Score:18.40|P-value:1.00E-68 ID:SGTC_143|Compound:4032-1194|FD-Score:8.19|P-value:3.08E-15 ID:SGTC_153|Compound:4077-0274|FD-Score:8.19|P-value:3.22E-15 ID:SGTC_165|Compound:k038-0023|FD-Score:12.40|P-value:1.57E-32 ID:SGTC_167|Compound:3672-0051|FD-Score:8.03|P-value:1.09E-14 ID:SGTC_200|Compound:k038-0079|FD-Score:9.45|P-value:1.18E-19 ID:SGTC_209|Compound:4077-0173|FD-Score:12.60|P-value:2.11E-33 ID:SGTC_216|Compound:k038-0035|FD-Score:7.48|P-value:5.44E-13 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.84|P-value:3.70E-11 ID:SGTC_294|Compound:k038-0071|FD-Score:4.28|P-value:2.31E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.52|P-value:4.12E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:5.67|P-value:3.41E-8 ID:SGTC_336|Compound:4111-0029|FD-Score:7.10|P-value:6.77E-12 ID:SGTC_340|Compound:k038-0059|FD-Score:5.05|P-value:7.61E-7 ID:SGTC_352|Compound:k048-0007|FD-Score:11.00|P-value:5.90E-26 ID:SGTC_367|Compound:0335-0881|FD-Score:6.39|P-value:5.97E-10 ID:SGTC_373|Compound:0844-0104|FD-Score:6.73|P-value:7.25E-11 ID:SGTC_384|Compound:k007-0144|FD-Score:7.29|P-value:1.95E-12 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.53|P-value:8.04E-6 ID:SGTC_446|Compound:go6976|FD-Score:3.46|P-value:4.90E-4 ID:SGTC_458|Compound:nppb|FD-Score:-3.46|P-value:5.01E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.32|P-value:7.88E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.50|P-value:4.28E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.36|P-value:7.00E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:10.40|P-value:2.80E-23 ID:SGTC_639|Compound:0833-0042|FD-Score:4.79|P-value:2.60E-6 ID:SGTC_642|Compound:0335-0876|FD-Score:5.62|P-value:4.43E-8 ID:SGTC_660|Compound:4031-1742|FD-Score:5.97|P-value:6.74E-9 ID:SGTC_696|Compound:1560-0013|FD-Score:4.79|P-value:2.60E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:23.60|P-value:2.20E-112 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.47|P-value:4.79E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.35|P-value:7.11E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:15.90|P-value:3.31E-52 ID:SGTC_848|Compound:0368-0089|FD-Score:5.22|P-value:3.27E-7 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:6.43|P-value:4.57E-10 ID:SGTC_942|Compound:3253-1115|FD-Score:5.44|P-value:1.13E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.53|P-value:6.92E-8 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.91|P-value:1.50E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.39|P-value:6.18E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:15.20|P-value:1.32E-47 ID:SGTC_1171|Compound:0368-0077|FD-Score:7.36|P-value:1.22E-12 ID:SGTC_1235|Compound:benzylparaben|FD-Score:5.47|P-value:9.39E-8 ID:SGTC_1240|Compound:0356-0016|FD-Score:6.96|P-value:1.71E-11 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.66|P-value:2.44E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:5.26|P-value:2.74E-7 ID:SGTC_1320|Compound:1313-0481|FD-Score:5.11|P-value:5.71E-7 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.25|P-value:9.93E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:4.53|P-value:8.13E-6 ID:SGTC_1427|Compound:4048-4900|FD-Score:4.66|P-value:4.52E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:6.04|P-value:4.35E-9 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.30|P-value:2.12E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:7.02|P-value:1.18E-11 ID:SGTC_1647|Compound:st011722|FD-Score:6.01|P-value:5.33E-9 ID:SGTC_1750|Compound:st081859|FD-Score:9.70|P-value:1.37E-20 ID:SGTC_1754|Compound:st042065|FD-Score:3.94|P-value:8.89E-5 ID:SGTC_1764|Compound:st044502|FD-Score:3.29|P-value:8.57E-4 ID:SGTC_1767|Compound:st044992|FD-Score:6.12|P-value:2.83E-9 ID:SGTC_1774|Compound:st048371|FD-Score:3.53|P-value:3.93E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:13.70|P-value:6.09E-39 ID:SGTC_1803|Compound:st050068|FD-Score:4.27|P-value:2.38E-5 ID:SGTC_1899|Compound:st063254|FD-Score:4.19|P-value:3.26E-5 ID:SGTC_1953|Compound:st076800|FD-Score:5.71|P-value:2.65E-8 ID:SGTC_2154|Compound:5570129|FD-Score:10.30|P-value:6.91E-23 ID:SGTC_2167|Compound:5876490|FD-Score:-3.38|P-value:6.60E-4 ID:SGTC_2210|Compound:7115885|FD-Score:6.75|P-value:6.47E-11 ID:SGTC_2308|Compound:7584454|FD-Score:3.67|P-value:2.39E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.97|P-value:7.90E-5 ID:SGTC_2322|Compound:7413319|FD-Score:9.55|P-value:4.77E-20 ID:SGTC_2371|Compound:9071574|FD-Score:6.01|P-value:5.23E-9 ID:SGTC_2385|Compound:9074692|FD-Score:9.34|P-value:3.05E-19 ID:SGTC_2413|Compound:inermin|FD-Score:41.90|P-value:0 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.54|P-value:7.76E-6 ID:SGTC_2469|Compound:5655019|FD-Score:4.62|P-value:5.48E-6 ID:SGTC_2471|Compound:5466956|FD-Score:3.31|P-value:8.22E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.56|P-value:7.20E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.38|P-value:6.42E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:5.57|P-value:5.68E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:4.01|P-value:6.77E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:6.47|P-value:3.76E-10 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:5.35|P-value:1.72E-7 ID:SGTC_2710|Compound:st078562|FD-Score:6.61|P-value:1.57E-10 ID:SGTC_2805|Compound:7950783|FD-Score:4.38|P-value:1.55E-5 ID:SGTC_2812|Compound:7970281|FD-Score:-3.94|P-value:8.80E-5 ID:SGTC_2817|Compound:7995342|FD-Score:3.37|P-value:6.72E-4 ID:SGTC_2941|Compound:9056145|FD-Score:5.22|P-value:3.29E-7 ID:SGTC_2966|Compound:9084041|FD-Score:3.28|P-value:9.02E-4 ID:SGTC_2967|Compound:9089538|FD-Score:24.50|P-value:1.56E-120 ID:SGTC_3090|Compound:9117696|FD-Score:8.67|P-value:7.85E-17 ID:SGTC_3141|Compound:9094609|FD-Score:3.95|P-value:8.38E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.40|P-value:6.03E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.48|P-value:9.82E-6 ID:SGTC_3205|Compound:9113483|FD-Score:4.54|P-value:7.85E-6 ID:SGTC_3209|Compound:9113616|FD-Score:4.26|P-value:2.54E-5 ID:SGTC_3283|Compound:9109332|FD-Score:7.09|P-value:7.40E-12 ID:SGTC_3290|Compound:9121031|FD-Score:3.66|P-value:2.44E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.75|P-value:1.81E-4

Top fitness defect scores for YOR246C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2413 inermin 41.90 26.1 µM 0 1 0
2 SGTC_103 0844-0104 27.70 51.8 µM 1.30E-153 ERAD & cell cycle 1 2.49E-169
3 SGTC_2967 9089538 24.50 49.9 µM 1.56E-120 1 8.12E-133
4 SGTC_733 4069-0007 23.60 56.1 µM 2.20E-112 ERAD & cell cycle 2 8.01E-124
5 SGTC_86 0417-1630 18.60 471.9 µM 1.19E-70 ubiquinone biosynthesis & proteasome 6 9.22E-78
6 SGTC_142 0335-0849 18.40 62.7 µM 1.00E-68 ubiquinone biosynthesis & proteasome 8 1.23E-75
7 SGTC_805 3852-0218 15.90 479.0 µM 3.31E-52 ERAD & cell cycle 1 2.08E-57
8 SGTC_1161 k007-0610 15.20 110.0 µM 1.32E-47 ERAD & cell cycle 6 2.49E-52
9 SGTC_1789 tunicamycin 13.70 25.0 nM 6.09E-39 unfolded protein response 1 9.03E-43
10 SGTC_209 4077-0173 12.60 175.6 µM 2.11E-33 1 1.17E-36
11 SGTC_165 k038-0023 12.40 64.4 µM 1.57E-32 ubiquinone biosynthesis & proteasome 3 1.06E-35
12 SGTC_141 0443-0274 11.20 32.3 µM 8.42E-27 mitochondrial response to ROS 4 2.23E-29
13 SGTC_352 k048-0007 11.00 5.1 µM 5.90E-26 ERAD & cell cycle 6 1.91E-28
14 SGTC_635 k038-0028 10.40 24.7 µM 2.80E-23 ubiquinone biosynthesis & proteasome 3 1.71E-25
15 SGTC_2154 5570129 10.30 200.0 µM 6.91E-23 1 4.63E-25
16 SGTC_64 000l-0018 9.73 272.1 µM 1.03E-20 ubiquinone biosynthesis & proteasome 39 1.15E-22
17 SGTC_1750 st081859 9.70 2.4 µM 1.37E-20 endomembrane recycling 46 1.57E-22
18 SGTC_2322 7413319 9.55 38.2 µM 4.77E-20 ERAD & cell cycle 21 6.26E-22
19 SGTC_200 k038-0079 9.45 37.5 µM 1.18E-19 ubiquinone biosynthesis & proteasome 9 1.71E-21
20 SGTC_2385 9074692 9.34 200.0 µM 3.05E-19 3 4.85E-21

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.407 1.19E-133 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.363 4.41E-105 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.352 2.62E-98 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.346 7.08E-95 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.343 5.80E-93 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.340 1.13E-91 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.339 4.32E-91 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.337 9.68E-90 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.335 1.32E-88 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.333 1.64E-87 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.326 1.66E-83 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.321 3.14E-81 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.315 4.91E-78 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.310 1.11E-75 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.309 2.66E-75 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity