YOR247W / SRL1

Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR247W / SRL1

Click on Significant Values for Screen Details ID:SGTC_355|Compound:1311-2252|FD-Score:3.90|P-value:7.16E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.61|P-value:3.56E-6 ID:SGTC_432|Compound:NS 1619|FD-Score:-4.28|P-value:1.57E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:-4.20|P-value:2.22E-5 ID:SGTC_540|Compound:1187-0821|FD-Score:3.72|P-value:1.46E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-3.44|P-value:4.09E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:-3.33|P-value:5.94E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.22|P-value:8.47E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:6.49|P-value:1.28E-10 ID:SGTC_787|Compound:4152-0075|FD-Score:3.49|P-value:3.42E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:-3.54|P-value:2.90E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.55|P-value:4.57E-6 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.80|P-value:1.08E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.39|P-value:4.84E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.41|P-value:4.45E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.88|P-value:7.92E-5 ID:SGTC_1964|Compound:st076914|FD-Score:7.25|P-value:8.56E-13 ID:SGTC_1967|Compound:st070177|FD-Score:-4.51|P-value:5.63E-6 ID:SGTC_1972|Compound:st070201|FD-Score:-5.18|P-value:2.34E-7 ID:SGTC_1973|Compound:st070275|FD-Score:-3.85|P-value:8.91E-5 ID:SGTC_2049|Compound:5262831|FD-Score:4.94|P-value:7.34E-7 ID:SGTC_2058|Compound:5236698|FD-Score:4.30|P-value:1.38E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.63|P-value:2.04E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.75|P-value:1.27E-4 ID:SGTC_2143|Compound:5623677|FD-Score:-3.41|P-value:4.61E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.48|P-value:3.47E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.60|P-value:2.26E-4 ID:SGTC_2317|Compound:5986382|FD-Score:6.77|P-value:2.15E-11 ID:SGTC_2399|Compound:5884133|FD-Score:3.41|P-value:4.40E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-4.03|P-value:4.40E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.53|P-value:3.02E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-3.36|P-value:5.38E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.73|P-value:2.02E-6 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.76|P-value:1.73E-6 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.19|P-value:9.33E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.84|P-value:1.21E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.25|P-value:7.79E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.83|P-value:9.38E-5 ID:SGTC_2710|Compound:st078562|FD-Score:3.59|P-value:2.38E-4 ID:SGTC_2863|Compound:9028737|FD-Score:-3.87|P-value:8.43E-5 ID:SGTC_2867|Compound:9039098|FD-Score:3.75|P-value:1.28E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.24|P-value:8.03E-4 ID:SGTC_2950|Compound:9072895|FD-Score:6.03|P-value:2.08E-9 ID:SGTC_2952|Compound:9073731|FD-Score:5.02|P-value:4.98E-7 ID:SGTC_2965|Compound:9082772|FD-Score:-4.67|P-value:2.75E-6 ID:SGTC_3077|Compound:9117319|FD-Score:3.36|P-value:5.37E-4 ID:SGTC_3126|Compound:9127922|FD-Score:5.35|P-value:9.42E-8 ID:SGTC_3179|Compound:9107801|FD-Score:-3.81|P-value:1.05E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.69|P-value:1.65E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-3.30|P-value:6.58E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.90|P-value:7.16E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.61|P-value:3.56E-6 ID:SGTC_432|Compound:NS 1619|FD-Score:-4.28|P-value:1.57E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:-4.20|P-value:2.22E-5 ID:SGTC_540|Compound:1187-0821|FD-Score:3.72|P-value:1.46E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-3.44|P-value:4.09E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:-3.33|P-value:5.94E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.22|P-value:8.47E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:6.49|P-value:1.28E-10 ID:SGTC_787|Compound:4152-0075|FD-Score:3.49|P-value:3.42E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:-3.54|P-value:2.90E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.55|P-value:4.57E-6 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.80|P-value:1.08E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.39|P-value:4.84E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.41|P-value:4.45E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.88|P-value:7.92E-5 ID:SGTC_1964|Compound:st076914|FD-Score:7.25|P-value:8.56E-13 ID:SGTC_1967|Compound:st070177|FD-Score:-4.51|P-value:5.63E-6 ID:SGTC_1972|Compound:st070201|FD-Score:-5.18|P-value:2.34E-7 ID:SGTC_1973|Compound:st070275|FD-Score:-3.85|P-value:8.91E-5 ID:SGTC_2049|Compound:5262831|FD-Score:4.94|P-value:7.34E-7 ID:SGTC_2058|Compound:5236698|FD-Score:4.30|P-value:1.38E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.63|P-value:2.04E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.75|P-value:1.27E-4 ID:SGTC_2143|Compound:5623677|FD-Score:-3.41|P-value:4.61E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.48|P-value:3.47E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.60|P-value:2.26E-4 ID:SGTC_2317|Compound:5986382|FD-Score:6.77|P-value:2.15E-11 ID:SGTC_2399|Compound:5884133|FD-Score:3.41|P-value:4.40E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-4.03|P-value:4.40E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.53|P-value:3.02E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-3.36|P-value:5.38E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.73|P-value:2.02E-6 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.76|P-value:1.73E-6 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.19|P-value:9.33E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.84|P-value:1.21E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.25|P-value:7.79E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.83|P-value:9.38E-5 ID:SGTC_2710|Compound:st078562|FD-Score:3.59|P-value:2.38E-4 ID:SGTC_2863|Compound:9028737|FD-Score:-3.87|P-value:8.43E-5 ID:SGTC_2867|Compound:9039098|FD-Score:3.75|P-value:1.28E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.24|P-value:8.03E-4 ID:SGTC_2950|Compound:9072895|FD-Score:6.03|P-value:2.08E-9 ID:SGTC_2952|Compound:9073731|FD-Score:5.02|P-value:4.98E-7 ID:SGTC_2965|Compound:9082772|FD-Score:-4.67|P-value:2.75E-6 ID:SGTC_3077|Compound:9117319|FD-Score:3.36|P-value:5.37E-4 ID:SGTC_3126|Compound:9127922|FD-Score:5.35|P-value:9.42E-8 ID:SGTC_3179|Compound:9107801|FD-Score:-3.81|P-value:1.05E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.69|P-value:1.65E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-3.30|P-value:6.58E-4

Top fitness defect scores for YOR247W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1964 st076914 7.25 61.0 µM 8.56E-13 RPP1 & pyrimidine depletion 1 2.16E-13
2 SGTC_2317 5986382 6.77 200.0 µM 2.15E-11 1 6.42E-12
3 SGTC_612 0302-0167 6.49 22.4 µM 1.28E-10 copper-dependent oxidative stress 7 4.23E-11
4 SGTC_2950 9072895 6.03 21.5 µM 2.08E-9 7 7.96E-10
5 SGTC_3126 9127922 5.35 49.5 µM 9.42E-8 fatty acid desaturase (OLE1) 20 4.41E-8
6 SGTC_2952 9073731 5.02 13.8 µM 4.98E-7 tubulin folding & SWR complex 14 2.55E-7
7 SGTC_2049 5262831 4.94 67.2 µM 7.34E-7 13 3.83E-7
8 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 4.84 92.6 µM 1.21E-6 13 6.47E-7
9 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 4.76 63.6 µM 1.73E-6 24 9.48E-7
10 SGTC_2526 patulin 4.73 37.6 µM 2.02E-6 52 1.11E-6
11 SGTC_421 streptovitacin 4.61 30.0 mM 3.56E-6 12 2.02E-6
12 SGTC_1260 0700-1617 4.55 7.8 µM 4.57E-6 calcium & mitochondrial duress 19 2.63E-6
13 SGTC_2058 5236698 4.30 133.0 µM 1.38E-5 20 8.42E-6
14 SGTC_355 1311-2252 3.90 105.0 µM 7.16E-5 18 4.75E-5
15 SGTC_1702 st027038 3.88 51.0 µM 7.92E-5 12 5.28E-5
16 SGTC_2606 farnesol 3.83 9.8 µM 9.38E-5 20 6.31E-5
17 SGTC_1429 4049-0205 3.80 9.5 µM 1.08E-4 14 7.31E-5
18 SGTC_2137 5261020 3.75 140.0 µM 1.27E-4 42 8.69E-5
19 SGTC_2867 9039098 3.75 71.4 µM 1.28E-4 iron homeostasis 43 8.78E-5
20 SGTC_540 1187-0821 3.72 17.3 µM 1.46E-4 20 1.00E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 4.63E-16 YOR233W KIN4 hom Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.101 4.82E-9 YJL105W SET4 hom Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication
0.097 1.85E-8 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.086 6.27E-7 YDL102W POL3 het Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
0.085 7.82E-7 YNL010W_p YNL010W_p hom Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation
0.084 1.09E-6 YGL232W TAN1 hom Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress
0.084 1.16E-6 YNR030W ALG12 hom Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation
0.082 1.87E-6 YOL139C CDC33 het mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth
0.080 3.95E-6 YKR022C NTR2 het Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
0.079 4.18E-6 YOR244W ESA1 het Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy
0.078 5.75E-6 YGL169W SUA5 het Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family
0.078 5.98E-6 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.076 1.14E-5 YMR020W FMS1 hom Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
0.073 2.65E-5 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.071 3.67E-5 YKL012W PRP40 het U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex