YOR250C / CLP1

Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR250C / CLP1

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:5.42|P-value:1.17E-6 ID:SGTC_50|Compound:0929-0078|FD-Score:4.28|P-value:9.66E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:8.25|P-value:3.17E-13 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.84|P-value:3.72E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-4.11|P-value:1.56E-4 ID:SGTC_264|Compound:promethazine|FD-Score:4.79|P-value:1.54E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:4.40|P-value:6.33E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.52|P-value:9.96E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.76|P-value:1.67E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.72|P-value:5.99E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:4.84|P-value:1.23E-5 ID:SGTC_512|Compound:prima-1|FD-Score:4.77|P-value:1.63E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:3.66|P-value:7.39E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:5.60|P-value:5.39E-7 ID:SGTC_697|Compound:0508-1955|FD-Score:3.72|P-value:6.04E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.70|P-value:5.90E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:4.45|P-value:5.36E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.92|P-value:3.27E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:4.03|P-value:2.27E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:4.28|P-value:9.86E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.91|P-value:3.06E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:-7.18|P-value:1.65E-10 ID:SGTC_1218|Compound:1348-1416|FD-Score:4.27|P-value:9.96E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:-3.82|P-value:3.99E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.06|P-value:2.08E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:-4.43|P-value:5.14E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:-5.70|P-value:2.92E-7 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.90|P-value:3.14E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:5.57|P-value:6.13E-7 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.14|P-value:3.83E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.15|P-value:1.50E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-5.39|P-value:1.17E-6 ID:SGTC_1574|Compound:spiramycin|FD-Score:-5.12|P-value:3.58E-6 ID:SGTC_1606|Compound:st000094|FD-Score:3.96|P-value:2.84E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:-4.26|P-value:9.29E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-4.17|P-value:1.27E-4 ID:SGTC_1745|Compound:st081495|FD-Score:5.56|P-value:6.49E-7 ID:SGTC_1768|Compound:st044301|FD-Score:4.57|P-value:3.53E-5 ID:SGTC_1780|Compound:st038448|FD-Score:-4.08|P-value:1.76E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.67|P-value:7.05E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.67|P-value:7.07E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.64|P-value:7.63E-4 ID:SGTC_1950|Compound:st077106|FD-Score:4.50|P-value:4.41E-5 ID:SGTC_1975|Compound:st070967|FD-Score:4.74|P-value:1.87E-5 ID:SGTC_2003|Compound:4023581|FD-Score:5.11|P-value:4.29E-6 ID:SGTC_2005|Compound:4024620|FD-Score:-3.94|P-value:2.71E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.86|P-value:3.54E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-4.55|P-value:3.27E-5 ID:SGTC_2114|Compound:5491910|FD-Score:3.85|P-value:3.99E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:4.23|P-value:1.17E-4 ID:SGTC_2238|Compound:6671620|FD-Score:5.30|P-value:1.99E-6 ID:SGTC_2240|Compound:6690706|FD-Score:5.58|P-value:5.79E-7 ID:SGTC_2342|Compound:7990637|FD-Score:6.94|P-value:7.20E-10 ID:SGTC_2517|Compound:totarol|FD-Score:-3.87|P-value:3.47E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-5.35|P-value:1.37E-6 ID:SGTC_2544|Compound:sphondin|FD-Score:3.97|P-value:2.78E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:4.21|P-value:1.25E-4 ID:SGTC_2551|Compound:apiole|FD-Score:3.94|P-value:3.00E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-9.02|P-value:1.46E-15 ID:SGTC_2619|Compound:obliquin|FD-Score:3.69|P-value:6.75E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.68|P-value:2.33E-5 ID:SGTC_2802|Compound:7925815|FD-Score:-4.13|P-value:1.44E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.56|P-value:9.74E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.96|P-value:2.88E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:5.42|P-value:1.17E-6 ID:SGTC_50|Compound:0929-0078|FD-Score:4.28|P-value:9.66E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:8.25|P-value:3.17E-13 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.84|P-value:3.72E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-4.11|P-value:1.56E-4 ID:SGTC_264|Compound:promethazine|FD-Score:4.79|P-value:1.54E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:4.40|P-value:6.33E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.52|P-value:9.96E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.76|P-value:1.67E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.72|P-value:5.99E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:4.84|P-value:1.23E-5 ID:SGTC_512|Compound:prima-1|FD-Score:4.77|P-value:1.63E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:3.66|P-value:7.39E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:5.60|P-value:5.39E-7 ID:SGTC_697|Compound:0508-1955|FD-Score:3.72|P-value:6.04E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.70|P-value:5.90E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:4.45|P-value:5.36E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.92|P-value:3.27E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:4.03|P-value:2.27E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:4.28|P-value:9.86E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.91|P-value:3.06E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:-7.18|P-value:1.65E-10 ID:SGTC_1218|Compound:1348-1416|FD-Score:4.27|P-value:9.96E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:-3.82|P-value:3.99E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.06|P-value:2.08E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:-4.43|P-value:5.14E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:-5.70|P-value:2.92E-7 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.90|P-value:3.14E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:5.57|P-value:6.13E-7 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.14|P-value:3.83E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.15|P-value:1.50E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-5.39|P-value:1.17E-6 ID:SGTC_1574|Compound:spiramycin|FD-Score:-5.12|P-value:3.58E-6 ID:SGTC_1606|Compound:st000094|FD-Score:3.96|P-value:2.84E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:-4.26|P-value:9.29E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-4.17|P-value:1.27E-4 ID:SGTC_1745|Compound:st081495|FD-Score:5.56|P-value:6.49E-7 ID:SGTC_1768|Compound:st044301|FD-Score:4.57|P-value:3.53E-5 ID:SGTC_1780|Compound:st038448|FD-Score:-4.08|P-value:1.76E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.67|P-value:7.05E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.67|P-value:7.07E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.64|P-value:7.63E-4 ID:SGTC_1950|Compound:st077106|FD-Score:4.50|P-value:4.41E-5 ID:SGTC_1975|Compound:st070967|FD-Score:4.74|P-value:1.87E-5 ID:SGTC_2003|Compound:4023581|FD-Score:5.11|P-value:4.29E-6 ID:SGTC_2005|Compound:4024620|FD-Score:-3.94|P-value:2.71E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.86|P-value:3.54E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-4.55|P-value:3.27E-5 ID:SGTC_2114|Compound:5491910|FD-Score:3.85|P-value:3.99E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:4.23|P-value:1.17E-4 ID:SGTC_2238|Compound:6671620|FD-Score:5.30|P-value:1.99E-6 ID:SGTC_2240|Compound:6690706|FD-Score:5.58|P-value:5.79E-7 ID:SGTC_2342|Compound:7990637|FD-Score:6.94|P-value:7.20E-10 ID:SGTC_2517|Compound:totarol|FD-Score:-3.87|P-value:3.47E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-5.35|P-value:1.37E-6 ID:SGTC_2544|Compound:sphondin|FD-Score:3.97|P-value:2.78E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:4.21|P-value:1.25E-4 ID:SGTC_2551|Compound:apiole|FD-Score:3.94|P-value:3.00E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-9.02|P-value:1.46E-15 ID:SGTC_2619|Compound:obliquin|FD-Score:3.69|P-value:6.75E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.68|P-value:2.33E-5 ID:SGTC_2802|Compound:7925815|FD-Score:-4.13|P-value:1.44E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.56|P-value:9.74E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.96|P-value:2.88E-4

Top fitness defect scores for YOR250C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_53 0973-0023 8.25 40.0 µM 3.17E-13 RNA processing & uracil transport 1 7.93E-17 1.83
2 SGTC_2342 7990637 6.94 118.9 µM 7.20E-10 RNA processing & uracil transport 2 1.93E-12 2.19
3 SGTC_612 0302-0167 5.60 22.4 µM 5.39E-7 copper-dependent oxidative stress 3 1.08E-8 0.69
4 SGTC_2240 6690706 5.58 185.9 µM 5.79E-7 2 1.19E-8 0.75
5 SGTC_1391 3442-0225 5.57 151.0 µM 6.13E-7 1 1.28E-8 0.98
6 SGTC_1745 st081495 5.56 74.0 µM 6.49E-7 RNA processing & uracil transport 15 1.38E-8 0.06
7 SGTC_47 0149-0135 5.42 24.2 µM 1.17E-6 TSC3-RPN4 2 2.96E-8 0.63
8 SGTC_2238 6671620 5.30 73.2 µM 1.99E-6 1 5.94E-8 0.55
9 SGTC_1511 0906-3109 5.14 28.5 µM 3.83E-6 excess fatty acid 4 1.39E-7 0.16
10 SGTC_2003 4023581 5.11 200.0 µM 4.29E-6 cell wall signaling 2 1.61E-7 0.13
11 SGTC_474 dl-dihydrosphingosine 4.84 5.0 µM 1.23E-5 3 6.34E-7 0.72
12 SGTC_264 promethazine 4.79 12.5 mM 1.54E-5 DNA intercalators 15 8.46E-7 0.06
13 SGTC_512 prima-1 4.77 270.0 µM 1.63E-5 DNA intercalators 8 9.16E-7 0.26
14 SGTC_423 5-fluorouracil 4.76 457.0 µM 1.67E-5 exosome 17 9.45E-7 0.01
15 SGTC_1975 st070967 4.74 30.8 µM 1.87E-5 6 1.09E-6 0.01
16 SGTC_2620 irigenin 4.68 100.0 µM 2.33E-5 7 1.46E-6 0.05
17 SGTC_1768 st044301 4.57 37.2 µM 3.53E-5 2 2.49E-6 0.13
18 SGTC_1950 st077106 4.50 7.2 µM 4.41E-5 RNA processing & uracil transport 4 3.33E-6 0.22
19 SGTC_875 0709-0210 4.45 25.7 µM 5.36E-5 fatty acid desaturase (OLE1) 9 4.29E-6 0.25
20 SGTC_368 fentichlor 4.40 4.6 µM 6.33E-5 5 5.33E-6 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.090 1.60E-7 YGL215W CLG1 hom Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
0.083 1.36E-6 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.081 2.54E-6 YPR143W RRP15 het Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
0.080 3.78E-6 YGR109C CLB6 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1
0.078 5.77E-6 YBR301W PAU24 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.076 9.14E-6 YNL255C GIS2 hom Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2
0.075 1.23E-5 YDR290W_d YDR290W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103
0.074 1.62E-5 YNL338W_d YNL338W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
0.074 1.67E-5 YBR253W SRB6 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.073 2.51E-5 YLR073C RFU1 hom Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes
0.072 3.00E-5 YDR289C RTT103 hom Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
0.071 3.73E-5 YKR073C_d YKR073C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.071 3.89E-5 YPL066W RGL1 hom Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source
0.070 4.89E-5 YGL255W ZRT1 hom High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
0.070 5.18E-5 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm