YOR252W / TMA16

Protein of unknown function that associates with ribosomes

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR252W / TMA16

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-6.23|P-value:2.00E-11 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.56|P-value:7.95E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:-2.92|P-value:9.70E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.40|P-value:1.58E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.61|P-value:6.81E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.23|P-value:3.10E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.50|P-value:1.03E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.40|P-value:1.63E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-4.02|P-value:1.00E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-2.91|P-value:9.98E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.84|P-value:2.38E-5 ID:SGTC_537|Compound:1334-0398|FD-Score:-3.10|P-value:5.04E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.60|P-value:6.72E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.91|P-value:1.70E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.12|P-value:4.77E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.87|P-value:2.16E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.34|P-value:2.09E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:-2.96|P-value:8.46E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.36|P-value:1.81E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.01|P-value:7.22E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.08|P-value:5.52E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.88|P-value:2.02E-5 ID:SGTC_2007|Compound:4011539|FD-Score:4.20|P-value:4.50E-6 ID:SGTC_2098|Compound:5376439|FD-Score:3.04|P-value:6.50E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.52|P-value:9.84E-5 ID:SGTC_2289|Compound:7946404|FD-Score:-3.07|P-value:5.75E-4 ID:SGTC_2333|Compound:9017922|FD-Score:2.99|P-value:7.85E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.48|P-value:1.18E-4 ID:SGTC_2337|Compound:9009472|FD-Score:4.86|P-value:1.38E-7 ID:SGTC_2442|Compound:5158906|FD-Score:3.92|P-value:1.68E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.40|P-value:1.64E-6 ID:SGTC_2852|Compound:9023854|FD-Score:-3.06|P-value:5.80E-4 ID:SGTC_2905|Compound:7799065|FD-Score:3.35|P-value:2.00E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-3.34|P-value:1.99E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-3.17|P-value:3.92E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-3.43|P-value:1.35E-4 ID:SGTC_3092|Compound:9117248|FD-Score:2.95|P-value:9.12E-4 ID:SGTC_3114|Compound:9122766|FD-Score:-2.93|P-value:9.47E-4 ID:SGTC_3227|Compound:9130768|FD-Score:3.16|P-value:4.14E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.78|P-value:3.06E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-6.23|P-value:2.00E-11 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.56|P-value:7.95E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:-2.92|P-value:9.70E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.40|P-value:1.58E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.61|P-value:6.81E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.23|P-value:3.10E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.50|P-value:1.03E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.40|P-value:1.63E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-4.02|P-value:1.00E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-2.91|P-value:9.98E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.84|P-value:2.38E-5 ID:SGTC_537|Compound:1334-0398|FD-Score:-3.10|P-value:5.04E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.60|P-value:6.72E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.91|P-value:1.70E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.12|P-value:4.77E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.87|P-value:2.16E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.34|P-value:2.09E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:-2.96|P-value:8.46E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.36|P-value:1.81E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.01|P-value:7.22E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.08|P-value:5.52E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.88|P-value:2.02E-5 ID:SGTC_2007|Compound:4011539|FD-Score:4.20|P-value:4.50E-6 ID:SGTC_2098|Compound:5376439|FD-Score:3.04|P-value:6.50E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.52|P-value:9.84E-5 ID:SGTC_2289|Compound:7946404|FD-Score:-3.07|P-value:5.75E-4 ID:SGTC_2333|Compound:9017922|FD-Score:2.99|P-value:7.85E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.48|P-value:1.18E-4 ID:SGTC_2337|Compound:9009472|FD-Score:4.86|P-value:1.38E-7 ID:SGTC_2442|Compound:5158906|FD-Score:3.92|P-value:1.68E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.40|P-value:1.64E-6 ID:SGTC_2852|Compound:9023854|FD-Score:-3.06|P-value:5.80E-4 ID:SGTC_2905|Compound:7799065|FD-Score:3.35|P-value:2.00E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-3.34|P-value:1.99E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-3.17|P-value:3.92E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-3.43|P-value:1.35E-4 ID:SGTC_3092|Compound:9117248|FD-Score:2.95|P-value:9.12E-4 ID:SGTC_3114|Compound:9122766|FD-Score:-2.93|P-value:9.47E-4 ID:SGTC_3227|Compound:9130768|FD-Score:3.16|P-value:4.14E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.78|P-value:3.06E-5

Top fitness defect scores for YOR252W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2337 9009472 4.86 200.0 µM 1.38E-7 13 5.98E-7
2 SGTC_2621 lithochol-11-enic acid 4.40 100.0 µM 1.64E-6 14 5.49E-6
3 SGTC_2007 4011539 4.20 71.8 µM 4.50E-6 cell wall signaling 50 1.36E-5
4 SGTC_2442 5158906 3.92 48.5 µM 1.68E-5 22 4.42E-5
5 SGTC_1674 st016616 3.88 23.6 µM 2.02E-5 29 5.21E-5
6 SGTC_1370 2001-0092 3.87 44.6 µM 2.16E-5 37 5.54E-5
7 SGTC_480 am 92016 3.84 50.0 µM 2.38E-5 15 6.05E-5
8 SGTC_309 k408-0051 3.61 1.5 µM 6.81E-5 70 1.55E-4
9 SGTC_2102 5377816 3.52 72.8 µM 9.84E-5 36 2.16E-4
10 SGTC_2334 9017922 3.48 200.0 µM 1.18E-4 38 2.55E-4
11 SGTC_366 0181-0206 3.40 4.3 µM 1.63E-4 Golgi 68 3.40E-4
12 SGTC_2905 7799065 3.35 20.1 µM 2.00E-4 27 4.09E-4
13 SGTC_1378 2093-0007 3.34 380.0 nM 2.09E-4 44 4.26E-4
14 SGTC_3227 9130768 3.16 49.5 µM 4.14E-4 19 7.86E-4
15 SGTC_1130 3454-2858 3.12 15.9 µM 4.77E-4 NEO1 129 8.93E-4
16 SGTC_2098 5376439 3.04 882.5 nM 6.50E-4 42 0.00118
17 SGTC_1501 4491-0275 3.01 38.4 µM 7.22E-4 39 0.00130
18 SGTC_2333 9017922 2.99 200.0 µM 7.85E-4 71 0.00140
19 SGTC_3092 9117248 2.95 49.5 µM 9.12E-4 cell wall signaling 24 0.00160
20 SGTC_2338 7999974 2.87 200.0 µM 0.00119 76 0.00203

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.181 4.71E-26 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.176 9.47E-25 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.151 1.30E-18 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.149 3.38E-18 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.135 4.49E-15 YOR223W YOR223W hom Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3
0.131 2.13E-14 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.129 7.52E-14 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.125 3.32E-13 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.125 3.90E-13 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.124 5.71E-13 YGR100W MDR1 hom Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function
0.120 3.63E-12 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
0.117 1.26E-11 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.116 1.50E-11 YFR017C IGD1 hom Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication
0.115 2.02E-11 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.114 3.40E-11 YOR289W_p YOR289W_p hom Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus