YOR253W / NAT5

Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR253W / NAT5

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:4.38|P-value:3.90E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:3.78|P-value:5.72E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:5.33|P-value:2.55E-8 ID:SGTC_53|Compound:0973-0023|FD-Score:3.05|P-value:9.38E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.60|P-value:1.19E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.64|P-value:1.00E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.56|P-value:1.38E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.34|P-value:3.22E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.60|P-value:1.18E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.14|P-value:6.74E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:3.56|P-value:1.41E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.10|P-value:7.73E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.80|P-value:5.25E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:5.29|P-value:3.23E-8 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.28|P-value:4.10E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:-3.14|P-value:6.02E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.75|P-value:6.53E-5 ID:SGTC_1663|Compound:st014140|FD-Score:3.90|P-value:3.47E-5 ID:SGTC_1779|Compound:st039427|FD-Score:-3.44|P-value:1.97E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.56|P-value:1.58E-6 ID:SGTC_1991|Compound:st073000|FD-Score:-4.15|P-value:9.57E-6 ID:SGTC_2016|Compound:5121758|FD-Score:3.39|P-value:2.68E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.11|P-value:7.54E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.22|P-value:5.08E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-6.80|P-value:1.35E-12 ID:SGTC_2323|Compound:6148992|FD-Score:-6.22|P-value:7.84E-11 ID:SGTC_2325|Compound:6158266|FD-Score:9.93|P-value:1.34E-24 ID:SGTC_2327|Compound:6189656|FD-Score:-4.92|P-value:2.03E-7 ID:SGTC_2399|Compound:5884133|FD-Score:3.36|P-value:3.02E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.05|P-value:1.74E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.06|P-value:1.67E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.16|P-value:6.29E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.50|P-value:1.74E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.07|P-value:8.75E-4 ID:SGTC_2797|Compound:7859098|FD-Score:4.46|P-value:2.62E-6 ID:SGTC_2867|Compound:9039098|FD-Score:3.07|P-value:8.73E-4 ID:SGTC_2877|Compound:9040724|FD-Score:-3.34|P-value:2.86E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.08|P-value:8.25E-4 ID:SGTC_3182|Compound:9108849|FD-Score:-4.27|P-value:5.56E-6 ID:SGTC_17|Compound:0960-0276|FD-Score:4.38|P-value:3.90E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:3.78|P-value:5.72E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:5.33|P-value:2.55E-8 ID:SGTC_53|Compound:0973-0023|FD-Score:3.05|P-value:9.38E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.60|P-value:1.19E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.64|P-value:1.00E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.56|P-value:1.38E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.34|P-value:3.22E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.60|P-value:1.18E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.14|P-value:6.74E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:3.56|P-value:1.41E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.10|P-value:7.73E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.80|P-value:5.25E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:5.29|P-value:3.23E-8 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.28|P-value:4.10E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:-3.14|P-value:6.02E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.75|P-value:6.53E-5 ID:SGTC_1663|Compound:st014140|FD-Score:3.90|P-value:3.47E-5 ID:SGTC_1779|Compound:st039427|FD-Score:-3.44|P-value:1.97E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.56|P-value:1.58E-6 ID:SGTC_1991|Compound:st073000|FD-Score:-4.15|P-value:9.57E-6 ID:SGTC_2016|Compound:5121758|FD-Score:3.39|P-value:2.68E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.11|P-value:7.54E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.22|P-value:5.08E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-6.80|P-value:1.35E-12 ID:SGTC_2323|Compound:6148992|FD-Score:-6.22|P-value:7.84E-11 ID:SGTC_2325|Compound:6158266|FD-Score:9.93|P-value:1.34E-24 ID:SGTC_2327|Compound:6189656|FD-Score:-4.92|P-value:2.03E-7 ID:SGTC_2399|Compound:5884133|FD-Score:3.36|P-value:3.02E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.05|P-value:1.74E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.06|P-value:1.67E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.16|P-value:6.29E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.50|P-value:1.74E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.07|P-value:8.75E-4 ID:SGTC_2797|Compound:7859098|FD-Score:4.46|P-value:2.62E-6 ID:SGTC_2867|Compound:9039098|FD-Score:3.07|P-value:8.73E-4 ID:SGTC_2877|Compound:9040724|FD-Score:-3.34|P-value:2.86E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.08|P-value:8.25E-4 ID:SGTC_3182|Compound:9108849|FD-Score:-4.27|P-value:5.56E-6

Top fitness defect scores for YOR253W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2325 6158266 9.93 200.0 µM 1.34E-24 1 1.50E-23
2 SGTC_44 0929-0055 5.33 61.2 µM 2.55E-8 15 4.96E-8
3 SGTC_1253 0550-0034 5.29 176.0 µM 3.23E-8 6 6.22E-8
4 SGTC_1952 st077036 4.56 64.1 µM 1.58E-6 18 2.55E-6
5 SGTC_2797 7859098 4.46 81.8 µM 2.62E-6 20 4.15E-6
6 SGTC_17 0960-0276 4.38 49.8 µM 3.90E-6 19 6.06E-6
7 SGTC_2630 antimycin a 4.06 100.0 µM 1.67E-5 mitochondrial processes 35 2.43E-5
8 SGTC_2552 juarezic acid 4.05 87.0 µM 1.74E-5 TSC3-RPN4 34 2.54E-5
9 SGTC_1663 st014140 3.90 55.4 µM 3.47E-5 60S ribosome export 17 4.90E-5
10 SGTC_1091 telmisartan 3.80 47.6 µM 5.25E-5 19 7.28E-5
11 SGTC_22 0964-0034 3.78 14.5 µM 5.72E-5 unfolded protein response 52 7.91E-5
12 SGTC_1446 4239-0190 3.75 62.0 µM 6.53E-5 45 8.98E-5
13 SGTC_137 0438-0332 3.64 85.4 µM 1.00E-4 ubiquinone biosynthesis & proteasome 143 1.36E-4
14 SGTC_427 1354-0053 3.60 47.3 µM 1.18E-4 32 1.59E-4
15 SGTC_128 0906-2981 3.60 13.4 µM 1.19E-4 22 1.59E-4
16 SGTC_176 1486-1328 3.56 72.8 µM 1.38E-4 74 1.84E-4
17 SGTC_858 0438-0351 3.56 2.8 µM 1.41E-4 copper-dependent oxidative stress 33 1.87E-4
18 SGTC_2678 equilin 3.50 100.0 µM 1.74E-4 33 2.29E-4
19 SGTC_2016 5121758 3.39 140.0 µM 2.68E-4 redox potentiating 78 3.47E-4
20 SGTC_2399 5884133 3.36 200.0 µM 3.02E-4 cell wall signaling 105 3.88E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 3.78E-10 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.091 1.29E-7 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.087 4.53E-7 YFL048C EMP47 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.086 6.06E-7 YGR295C COS6 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.086 6.71E-7 YMR103C_d YMR103C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.084 9.61E-7 YDR152W GIR2 hom Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein
0.083 1.68E-6 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.081 2.44E-6 YPL172C COX10 hom Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders
0.080 3.29E-6 YHR195W NVJ1 hom Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)
0.080 4.00E-6 YOR024W_d YOR024W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.079 4.88E-6 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.076 1.07E-5 YLR425W TUS1 hom Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
0.075 1.32E-5 YCL042W_p YCL042W_p hom Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
0.074 1.64E-5 YDR418W RPL12B hom Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication
0.074 1.75E-5 YPR182W SMX3 het Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F