YOR255W / OSW1

Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR255W / OSW1

Click on Significant Values for Screen Details ID:SGTC_169|Compound:k015-0017|FD-Score:3.71|P-value:7.56E-5 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.15|P-value:6.57E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.12|P-value:7.31E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.54|P-value:1.51E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.16|P-value:6.38E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.54|P-value:1.49E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.23|P-value:4.71E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.10|P-value:7.48E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:3.59|P-value:1.26E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.68|P-value:8.69E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:4.27|P-value:6.37E-6 ID:SGTC_944|Compound:3370-0224|FD-Score:3.71|P-value:7.70E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.05|P-value:9.03E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.04|P-value:9.62E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.23|P-value:4.92E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.24|P-value:4.76E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:4.64|P-value:1.06E-6 ID:SGTC_1414|Compound:3917-0015|FD-Score:-3.19|P-value:5.50E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-3.45|P-value:2.07E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.14|P-value:6.60E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.49|P-value:1.87E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.41|P-value:2.43E-4 ID:SGTC_1634|Compound:st006576|FD-Score:-3.76|P-value:5.88E-5 ID:SGTC_1637|Compound:st007924|FD-Score:5.33|P-value:2.57E-8 ID:SGTC_1771|Compound:st048882|FD-Score:3.25|P-value:4.47E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.36|P-value:3.01E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.25|P-value:4.58E-4 ID:SGTC_1856|Compound:st057054|FD-Score:4.40|P-value:3.47E-6 ID:SGTC_1954|Compound:st077032|FD-Score:-3.87|P-value:3.82E-5 ID:SGTC_1999|Compound:st074831|FD-Score:-3.49|P-value:1.79E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.83|P-value:4.41E-5 ID:SGTC_2056|Compound:5235370|FD-Score:4.92|P-value:2.47E-7 ID:SGTC_2086|Compound:5274770|FD-Score:3.42|P-value:2.40E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.77|P-value:5.81E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.44|P-value:2.13E-4 ID:SGTC_2133|Compound:5320837|FD-Score:6.18|P-value:1.41E-10 ID:SGTC_2134|Compound:5324836|FD-Score:-3.17|P-value:5.95E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-4.55|P-value:1.65E-6 ID:SGTC_2255|Compound:7941087|FD-Score:-3.17|P-value:5.85E-4 ID:SGTC_2263|Compound:7948595|FD-Score:-3.07|P-value:8.39E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.36|P-value:2.92E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-3.16|P-value:6.18E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.34|P-value:3.25E-4 ID:SGTC_2300|Compound:7976697|FD-Score:4.50|P-value:2.19E-6 ID:SGTC_2303|Compound:7774051|FD-Score:-3.76|P-value:5.96E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.24|P-value:4.73E-4 ID:SGTC_2443|Compound:5493264|FD-Score:-3.34|P-value:3.16E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-3.12|P-value:7.03E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.36|P-value:3.05E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.18|P-value:5.94E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-5.70|P-value:2.80E-9 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.41|P-value:2.51E-4 ID:SGTC_2882|Compound:9058044|FD-Score:-3.16|P-value:6.21E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-4.24|P-value:7.37E-6 ID:SGTC_2911|Compound:7942208|FD-Score:3.45|P-value:2.18E-4 ID:SGTC_2941|Compound:9056145|FD-Score:7.05|P-value:3.10E-13 ID:SGTC_2950|Compound:9072895|FD-Score:3.16|P-value:6.33E-4 ID:SGTC_2957|Compound:9076800|FD-Score:8.42|P-value:3.85E-18 ID:SGTC_3000|Compound:9075062|FD-Score:3.17|P-value:6.04E-4 ID:SGTC_3008|Compound:9078912|FD-Score:5.08|P-value:1.09E-7 ID:SGTC_3055|Compound:9094636|FD-Score:3.06|P-value:8.96E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.88|P-value:3.78E-5 ID:SGTC_3083|Compound:9117465|FD-Score:-3.39|P-value:2.59E-4 ID:SGTC_3093|Compound:9117344|FD-Score:-4.51|P-value:1.97E-6 ID:SGTC_3137|Compound:9097352|FD-Score:3.11|P-value:7.48E-4 ID:SGTC_3171|Compound:9103192|FD-Score:3.19|P-value:5.70E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.04|P-value:9.45E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.66|P-value:9.23E-5 ID:SGTC_3326|Compound:9140064|FD-Score:3.18|P-value:5.87E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.71|P-value:7.56E-5 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.15|P-value:6.57E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.12|P-value:7.31E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.54|P-value:1.51E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.16|P-value:6.38E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.54|P-value:1.49E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.23|P-value:4.71E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.10|P-value:7.48E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:3.59|P-value:1.26E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.68|P-value:8.69E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:4.27|P-value:6.37E-6 ID:SGTC_944|Compound:3370-0224|FD-Score:3.71|P-value:7.70E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.05|P-value:9.03E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.04|P-value:9.62E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.23|P-value:4.92E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.24|P-value:4.76E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:4.64|P-value:1.06E-6 ID:SGTC_1414|Compound:3917-0015|FD-Score:-3.19|P-value:5.50E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-3.45|P-value:2.07E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.14|P-value:6.60E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.49|P-value:1.87E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.41|P-value:2.43E-4 ID:SGTC_1634|Compound:st006576|FD-Score:-3.76|P-value:5.88E-5 ID:SGTC_1637|Compound:st007924|FD-Score:5.33|P-value:2.57E-8 ID:SGTC_1771|Compound:st048882|FD-Score:3.25|P-value:4.47E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.36|P-value:3.01E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.25|P-value:4.58E-4 ID:SGTC_1856|Compound:st057054|FD-Score:4.40|P-value:3.47E-6 ID:SGTC_1954|Compound:st077032|FD-Score:-3.87|P-value:3.82E-5 ID:SGTC_1999|Compound:st074831|FD-Score:-3.49|P-value:1.79E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.83|P-value:4.41E-5 ID:SGTC_2056|Compound:5235370|FD-Score:4.92|P-value:2.47E-7 ID:SGTC_2086|Compound:5274770|FD-Score:3.42|P-value:2.40E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.77|P-value:5.81E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.44|P-value:2.13E-4 ID:SGTC_2133|Compound:5320837|FD-Score:6.18|P-value:1.41E-10 ID:SGTC_2134|Compound:5324836|FD-Score:-3.17|P-value:5.95E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-4.55|P-value:1.65E-6 ID:SGTC_2255|Compound:7941087|FD-Score:-3.17|P-value:5.85E-4 ID:SGTC_2263|Compound:7948595|FD-Score:-3.07|P-value:8.39E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.36|P-value:2.92E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-3.16|P-value:6.18E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.34|P-value:3.25E-4 ID:SGTC_2300|Compound:7976697|FD-Score:4.50|P-value:2.19E-6 ID:SGTC_2303|Compound:7774051|FD-Score:-3.76|P-value:5.96E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.24|P-value:4.73E-4 ID:SGTC_2443|Compound:5493264|FD-Score:-3.34|P-value:3.16E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-3.12|P-value:7.03E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.36|P-value:3.05E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.18|P-value:5.94E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-5.70|P-value:2.80E-9 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.41|P-value:2.51E-4 ID:SGTC_2882|Compound:9058044|FD-Score:-3.16|P-value:6.21E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-4.24|P-value:7.37E-6 ID:SGTC_2911|Compound:7942208|FD-Score:3.45|P-value:2.18E-4 ID:SGTC_2941|Compound:9056145|FD-Score:7.05|P-value:3.10E-13 ID:SGTC_2950|Compound:9072895|FD-Score:3.16|P-value:6.33E-4 ID:SGTC_2957|Compound:9076800|FD-Score:8.42|P-value:3.85E-18 ID:SGTC_3000|Compound:9075062|FD-Score:3.17|P-value:6.04E-4 ID:SGTC_3008|Compound:9078912|FD-Score:5.08|P-value:1.09E-7 ID:SGTC_3055|Compound:9094636|FD-Score:3.06|P-value:8.96E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.88|P-value:3.78E-5 ID:SGTC_3083|Compound:9117465|FD-Score:-3.39|P-value:2.59E-4 ID:SGTC_3093|Compound:9117344|FD-Score:-4.51|P-value:1.97E-6 ID:SGTC_3137|Compound:9097352|FD-Score:3.11|P-value:7.48E-4 ID:SGTC_3171|Compound:9103192|FD-Score:3.19|P-value:5.70E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.04|P-value:9.45E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.66|P-value:9.23E-5 ID:SGTC_3326|Compound:9140064|FD-Score:3.18|P-value:5.87E-4

Top fitness defect scores for YOR255W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2957 9076800 8.42 11.5 µM 3.85E-18 2 1.84E-17
2 SGTC_2941 9056145 7.05 11.2 µM 3.10E-13 3 9.27E-13
3 SGTC_2133 5320837 6.18 200.0 µM 1.41E-10 ERG2 3 3.28E-10
4 SGTC_1637 st007924 5.33 17.4 µM 2.57E-8 7 4.82E-8
5 SGTC_3008 9078912 5.08 71.4 µM 1.09E-7 3 1.94E-7
6 SGTC_2056 5235370 4.92 200.0 µM 2.47E-7 24 4.23E-7
7 SGTC_1405 3909-7894 4.64 12.0 µM 1.06E-6 60S ribosome export 4 1.72E-6
8 SGTC_2300 7976697 4.50 71.6 µM 2.19E-6 ERG2 19 3.44E-6
9 SGTC_1856 st057054 4.40 55.7 µM 3.47E-6 19 5.35E-6
10 SGTC_815 1582-0027 4.27 36.9 µM 6.37E-6 18 9.58E-6
11 SGTC_3080 9117754 3.88 49.5 µM 3.78E-5 19 5.29E-5
12 SGTC_2113 5491891 3.77 107.0 µM 5.81E-5 TSC3-RPN4 27 8.01E-5
13 SGTC_169 k015-0017 3.71 16.0 µM 7.56E-5 24 1.03E-4
14 SGTC_944 3370-0224 3.71 231.0 µM 7.70E-5 31 1.05E-4
15 SGTC_737 1950-0117 3.68 57.9 µM 8.69E-5 31 1.18E-4
16 SGTC_3222 9128301 3.66 49.5 µM 9.23E-5 60S ribosome export 34 1.25E-4
17 SGTC_395 anisomycin 3.59 6.2 µM 1.26E-4 16 1.68E-4
18 SGTC_265 mycophenolic acid 3.54 32.9 µM 1.51E-4 RPP1 & pyrimidine depletion 35 2.00E-4
19 SGTC_1601 4'-hydroxyflavanone 3.49 55.5 µM 1.87E-4 RPP1 & pyrimidine depletion 48 2.46E-4
20 SGTC_2911 7942208 3.45 15.6 µM 2.18E-4 mitochondrial response to ROS 25 2.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.29E-13 YML087C AIM33 hom Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
0.085 7.70E-7 YOR248W_d YOR248W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.078 5.81E-6 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.075 1.26E-5 YBL040C ERD2 het HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
0.073 2.47E-5 YHR033W_p YHR033W_p hom Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication
0.073 2.59E-5 YPR199C ARR1 hom Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds
0.071 3.72E-5 YJR133W XPT1 hom Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
0.068 7.38E-5 YJR140C HIR3 hom Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein
0.066 1.31E-4 YJL090C DPB11 het DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress
0.065 1.69E-4 YKL189W HYM1 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
0.065 1.70E-4 YLR173W_p YLR173W_p hom Putative protein of unknown function
0.064 1.98E-4 YHR143W DSE2 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
0.064 2.09E-4 YGR232W NAS6 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6
0.063 2.58E-4 YGR221C TOS2 hom Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p
0.063 2.82E-4 YDR329C PEX3 hom Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p