YOR256C / TRE2

Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR256C / TRE2

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:3.75|P-value:1.92E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.83|P-value:1.44E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.84|P-value:4.06E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:13.20|P-value:2.40E-35 ID:SGTC_168|Compound:3970-0862|FD-Score:3.52|P-value:4.33E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:6.53|P-value:3.95E-10 ID:SGTC_313|Compound:3474-0040|FD-Score:3.56|P-value:3.76E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:4.01|P-value:7.46E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:-4.14|P-value:6.90E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:3.66|P-value:2.65E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:5.65|P-value:5.16E-8 ID:SGTC_374|Compound:0880-0231|FD-Score:6.92|P-value:3.76E-11 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:5.98|P-value:8.99E-9 ID:SGTC_404|Compound:fumagillin|FD-Score:3.83|P-value:1.46E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.67|P-value:4.56E-8 ID:SGTC_525|Compound:k781-2675|FD-Score:5.95|P-value:1.05E-8 ID:SGTC_612|Compound:0302-0167|FD-Score:4.84|P-value:2.43E-6 ID:SGTC_720|Compound:r052-1644|FD-Score:3.52|P-value:4.30E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:5.59|P-value:6.87E-8 ID:SGTC_848|Compound:0368-0089|FD-Score:3.26|P-value:9.96E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:4.96|P-value:1.44E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-4.90|P-value:3.00E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:3.67|P-value:2.53E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:-3.83|P-value:2.15E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.42|P-value:8.52E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:-4.33|P-value:3.35E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:4.71|P-value:4.32E-6 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.96|P-value:8.85E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.68|P-value:2.47E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:5.05|P-value:9.71E-7 ID:SGTC_1674|Compound:st016616|FD-Score:-3.45|P-value:7.68E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.61|P-value:1.05E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.21|P-value:2.54E-9 ID:SGTC_1884|Compound:5633444|FD-Score:4.57|P-value:8.07E-6 ID:SGTC_1915|Compound:st067105|FD-Score:7.52|P-value:7.82E-13 ID:SGTC_1998|Compound:st075797|FD-Score:-4.07|P-value:8.96E-5 ID:SGTC_2029|Compound:5175081|FD-Score:3.95|P-value:9.46E-5 ID:SGTC_2030|Compound:5175110|FD-Score:4.23|P-value:3.17E-5 ID:SGTC_2069|Compound:5228469|FD-Score:4.25|P-value:2.99E-5 ID:SGTC_2078|Compound:5212016|FD-Score:4.01|P-value:7.57E-5 ID:SGTC_2160|Compound:5660466|FD-Score:3.58|P-value:3.54E-4 ID:SGTC_2216|Compound:7189485|FD-Score:3.62|P-value:3.01E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:11.60|P-value:7.43E-28 ID:SGTC_2253|Compound:7938677|FD-Score:3.37|P-value:6.91E-4 ID:SGTC_2268|Compound:7933382|FD-Score:5.68|P-value:4.31E-8 ID:SGTC_2317|Compound:5986382|FD-Score:3.41|P-value:6.15E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.28|P-value:9.23E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.33|P-value:8.05E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.84|P-value:1.40E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.79|P-value:1.65E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.38|P-value:6.77E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:5.31|P-value:2.79E-7 ID:SGTC_2586|Compound:curcumin|FD-Score:5.91|P-value:1.29E-8 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-6.23|P-value:4.11E-9 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.99|P-value:8.72E-9 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-6.57|P-value:5.97E-10 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.88|P-value:2.06E-6 ID:SGTC_2750|Compound:bromebric acid|FD-Score:11.50|P-value:2.43E-27 ID:SGTC_2759|Compound:disulfiram|FD-Score:9.43|P-value:4.33E-19 ID:SGTC_2846|Compound:9008642|FD-Score:4.79|P-value:3.13E-6 ID:SGTC_2854|Compound:9024559|FD-Score:-3.92|P-value:1.52E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-3.52|P-value:6.10E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-7.85|P-value:1.77E-13 ID:SGTC_3161|Compound:9100388|FD-Score:4.26|P-value:2.81E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.47|P-value:7.20E-4 ID:SGTC_3285|Compound:9112818|FD-Score:5.45|P-value:1.40E-7 ID:SGTC_3288|Compound:9119690|FD-Score:5.05|P-value:9.59E-7 ID:SGTC_52|Compound:0329-0193|FD-Score:3.75|P-value:1.92E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.83|P-value:1.44E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.84|P-value:4.06E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:13.20|P-value:2.40E-35 ID:SGTC_168|Compound:3970-0862|FD-Score:3.52|P-value:4.33E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:6.53|P-value:3.95E-10 ID:SGTC_313|Compound:3474-0040|FD-Score:3.56|P-value:3.76E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:4.01|P-value:7.46E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:-4.14|P-value:6.90E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:3.66|P-value:2.65E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:5.65|P-value:5.16E-8 ID:SGTC_374|Compound:0880-0231|FD-Score:6.92|P-value:3.76E-11 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:5.98|P-value:8.99E-9 ID:SGTC_404|Compound:fumagillin|FD-Score:3.83|P-value:1.46E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.67|P-value:4.56E-8 ID:SGTC_525|Compound:k781-2675|FD-Score:5.95|P-value:1.05E-8 ID:SGTC_612|Compound:0302-0167|FD-Score:4.84|P-value:2.43E-6 ID:SGTC_720|Compound:r052-1644|FD-Score:3.52|P-value:4.30E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:5.59|P-value:6.87E-8 ID:SGTC_848|Compound:0368-0089|FD-Score:3.26|P-value:9.96E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:4.96|P-value:1.44E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-4.90|P-value:3.00E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:3.67|P-value:2.53E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:-3.83|P-value:2.15E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.42|P-value:8.52E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:-4.33|P-value:3.35E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:4.71|P-value:4.32E-6 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.96|P-value:8.85E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.68|P-value:2.47E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:5.05|P-value:9.71E-7 ID:SGTC_1674|Compound:st016616|FD-Score:-3.45|P-value:7.68E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.61|P-value:1.05E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.21|P-value:2.54E-9 ID:SGTC_1884|Compound:5633444|FD-Score:4.57|P-value:8.07E-6 ID:SGTC_1915|Compound:st067105|FD-Score:7.52|P-value:7.82E-13 ID:SGTC_1998|Compound:st075797|FD-Score:-4.07|P-value:8.96E-5 ID:SGTC_2029|Compound:5175081|FD-Score:3.95|P-value:9.46E-5 ID:SGTC_2030|Compound:5175110|FD-Score:4.23|P-value:3.17E-5 ID:SGTC_2069|Compound:5228469|FD-Score:4.25|P-value:2.99E-5 ID:SGTC_2078|Compound:5212016|FD-Score:4.01|P-value:7.57E-5 ID:SGTC_2160|Compound:5660466|FD-Score:3.58|P-value:3.54E-4 ID:SGTC_2216|Compound:7189485|FD-Score:3.62|P-value:3.01E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:11.60|P-value:7.43E-28 ID:SGTC_2253|Compound:7938677|FD-Score:3.37|P-value:6.91E-4 ID:SGTC_2268|Compound:7933382|FD-Score:5.68|P-value:4.31E-8 ID:SGTC_2317|Compound:5986382|FD-Score:3.41|P-value:6.15E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.28|P-value:9.23E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.33|P-value:8.05E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.84|P-value:1.40E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.79|P-value:1.65E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.38|P-value:6.77E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:5.31|P-value:2.79E-7 ID:SGTC_2586|Compound:curcumin|FD-Score:5.91|P-value:1.29E-8 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-6.23|P-value:4.11E-9 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.99|P-value:8.72E-9 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-6.57|P-value:5.97E-10 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.88|P-value:2.06E-6 ID:SGTC_2750|Compound:bromebric acid|FD-Score:11.50|P-value:2.43E-27 ID:SGTC_2759|Compound:disulfiram|FD-Score:9.43|P-value:4.33E-19 ID:SGTC_2846|Compound:9008642|FD-Score:4.79|P-value:3.13E-6 ID:SGTC_2854|Compound:9024559|FD-Score:-3.92|P-value:1.52E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-3.52|P-value:6.10E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-7.85|P-value:1.77E-13 ID:SGTC_3161|Compound:9100388|FD-Score:4.26|P-value:2.81E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.47|P-value:7.20E-4 ID:SGTC_3285|Compound:9112818|FD-Score:5.45|P-value:1.40E-7 ID:SGTC_3288|Compound:9119690|FD-Score:5.05|P-value:9.59E-7

Top fitness defect scores for YOR256C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_157 1348-1695 13.20 65.8 µM 2.40E-35 iron homeostasis 2 5.61E-40 2.96
2 SGTC_2233 sulbentine 11.60 40.4 µM 7.43E-28 7 2.02E-31 0.57
3 SGTC_2750 bromebric acid 11.50 70.2 µM 2.43E-27 1 7.82E-31 6.15
4 SGTC_2759 disulfiram 9.43 3.4 µM 4.33E-19 2 2.03E-21 1.12
5 SGTC_1915 st067105 7.52 30.6 µM 7.82E-13 RNA pol III & RNase P/MRP 14 2.72E-14 0.22
6 SGTC_374 0880-0231 6.92 82.3 µM 3.76E-11 iron homeostasis 2 2.22E-12 0.47
7 SGTC_268 camptothecin 6.53 39.6 µM 3.95E-10 DNA damage response 20 3.22E-11 0.42
8 SGTC_1844 rapamycin 6.21 4.0 nM 2.54E-9 21 2.66E-10 0.28
9 SGTC_2612 dictamnine 5.99 15.5 µM 8.72E-9 RNA pol III & RNase P/MRP 19 1.08E-9 0.20
10 SGTC_402 epigallocatechin gallate 5.98 10.0 µM 8.99E-9 3 1.12E-9 1.76
11 SGTC_525 k781-2675 5.95 26.7 µM 1.05E-8 redox potentiating 21 1.33E-9 0.01
12 SGTC_2586 curcumin 5.91 80.0 µM 1.29E-8 iron homeostasis 3 1.68E-9 1.10
13 SGTC_2268 7933382 5.68 153.8 µM 4.31E-8 4 6.61E-9 0.60
14 SGTC_514 4466-0038 5.67 2.6 nM 4.56E-8 cell wall 20 7.06E-9 0.08
15 SGTC_351 caspofungin 5.65 25.0 nM 5.16E-8 cell wall 15 8.12E-9 0.11
16 SGTC_815 1582-0027 5.59 36.9 µM 6.87E-8 2 1.12E-8 1.00
17 SGTC_3285 9112818 5.45 20.9 µM 1.40E-7 cell wall 6 2.52E-8 0.29
18 SGTC_2584 androsterone 5.31 48.7 µM 2.79E-7 cell wall 16 5.49E-8 0.11
19 SGTC_3288 9119690 5.05 36.2 µM 9.59E-7 16 2.22E-7 0.97
20 SGTC_1599 8-chlro-1-tetrahydronorharmanone 5.05 90.6 µM 9.71E-7 5 2.25E-7 0.51

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.401 4.53E-130 YOR257W CDC31 het Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
0.193 1.61E-29 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.163 2.42E-21 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.160 1.20E-20 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.157 5.88E-20 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.148 6.03E-18 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.143 1.03E-16 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.142 1.20E-16 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.141 2.06E-16 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.135 3.81E-15 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.134 7.01E-15 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.127 1.72E-13 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.123 8.10E-13 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.123 9.01E-13 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.117 1.22E-11 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex