YOR257W / CDC31

Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR257W / CDC31

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.19|P-value:1.37E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:3.86|P-value:3.94E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.62|P-value:8.08E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:9.04|P-value:3.38E-15 ID:SGTC_212|Compound:3807-4682|FD-Score:3.78|P-value:4.98E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:15.30|P-value:1.12E-39 ID:SGTC_283|Compound:0987-0079|FD-Score:3.56|P-value:9.67E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:3.89|P-value:3.59E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.45|P-value:5.60E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:4.03|P-value:2.28E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.48|P-value:5.03E-5 ID:SGTC_509|Compound:pifithrin|FD-Score:3.60|P-value:8.45E-4 ID:SGTC_510|Compound:ag-490|FD-Score:3.87|P-value:3.82E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:7.19|P-value:2.72E-10 ID:SGTC_535|Compound:2293-4129|FD-Score:-5.52|P-value:1.54E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.65|P-value:7.35E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.85|P-value:1.30E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:6.28|P-value:2.82E-8 ID:SGTC_720|Compound:r052-1644|FD-Score:14.90|P-value:1.13E-37 ID:SGTC_780|Compound:0109-0199|FD-Score:-4.66|P-value:4.24E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:-4.55|P-value:6.29E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:-7.58|P-value:6.68E-11 ID:SGTC_792|Compound:4534-1957|FD-Score:-5.93|P-value:2.63E-7 ID:SGTC_806|Compound:3966-4455|FD-Score:5.34|P-value:1.90E-6 ID:SGTC_848|Compound:0368-0089|FD-Score:3.92|P-value:3.26E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:3.59|P-value:8.67E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.71|P-value:2.23E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:5.31|P-value:2.15E-6 ID:SGTC_974|Compound:1326-0144|FD-Score:4.89|P-value:1.10E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:3.69|P-value:6.54E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:-4.59|P-value:5.52E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.14|P-value:1.59E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:7.62|P-value:2.47E-11 ID:SGTC_1225|Compound:1216-0074|FD-Score:4.64|P-value:2.83E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:6.77|P-value:2.54E-9 ID:SGTC_1468|Compound:k284-1086|FD-Score:5.45|P-value:1.19E-6 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.27|P-value:1.05E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:5.58|P-value:6.81E-7 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-4.54|P-value:6.61E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.76|P-value:2.99E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:10.50|P-value:8.16E-20 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.83|P-value:1.41E-5 ID:SGTC_1915|Compound:st067105|FD-Score:12.60|P-value:1.00E-27 ID:SGTC_1953|Compound:st076800|FD-Score:5.90|P-value:1.67E-7 ID:SGTC_1961|Compound:st076550|FD-Score:-5.29|P-value:3.97E-6 ID:SGTC_1968|Compound:st069590|FD-Score:-5.06|P-value:9.68E-6 ID:SGTC_1997|Compound:st073024|FD-Score:3.62|P-value:8.03E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.76|P-value:8.03E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.99|P-value:2.58E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.97|P-value:2.76E-4 ID:SGTC_2149|Compound:5554786|FD-Score:4.03|P-value:2.30E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:14.80|P-value:2.15E-37 ID:SGTC_2268|Compound:7933382|FD-Score:21.80|P-value:2.64E-78 ID:SGTC_2273|Compound:7815444|FD-Score:3.78|P-value:4.98E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.58|P-value:9.14E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-4.74|P-value:3.23E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.62|P-value:8.03E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.65|P-value:7.43E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:5.69|P-value:4.22E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.39|P-value:6.94E-5 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.87|P-value:3.80E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:11.30|P-value:1.14E-22 ID:SGTC_2701|Compound:st077767|FD-Score:6.57|P-value:6.70E-9 ID:SGTC_2750|Compound:bromebric acid|FD-Score:5.34|P-value:1.87E-6 ID:SGTC_2784|Compound:7567673|FD-Score:5.75|P-value:3.22E-7 ID:SGTC_2812|Compound:7970281|FD-Score:6.44|P-value:1.29E-8 ID:SGTC_2956|Compound:9076196|FD-Score:3.84|P-value:4.18E-4 ID:SGTC_3118|Compound:9124250|FD-Score:5.69|P-value:4.25E-7 ID:SGTC_3192|Compound:9110362|FD-Score:3.97|P-value:2.76E-4 ID:SGTC_3285|Compound:9112818|FD-Score:4.78|P-value:1.72E-5 ID:SGTC_3308|Compound:9128332|FD-Score:-3.90|P-value:5.27E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.98|P-value:2.64E-4 ID:SGTC_3321|Compound:9137793|FD-Score:4.56|P-value:3.82E-5 ID:SGTC_3322|Compound:9139058|FD-Score:4.74|P-value:1.93E-5 ID:SGTC_3331|Compound:9141060|FD-Score:3.82|P-value:4.48E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.19|P-value:1.34E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.19|P-value:1.37E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:3.86|P-value:3.94E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.62|P-value:8.08E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:9.04|P-value:3.38E-15 ID:SGTC_212|Compound:3807-4682|FD-Score:3.78|P-value:4.98E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:15.30|P-value:1.12E-39 ID:SGTC_283|Compound:0987-0079|FD-Score:3.56|P-value:9.67E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:3.89|P-value:3.59E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.45|P-value:5.60E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:4.03|P-value:2.28E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.48|P-value:5.03E-5 ID:SGTC_509|Compound:pifithrin|FD-Score:3.60|P-value:8.45E-4 ID:SGTC_510|Compound:ag-490|FD-Score:3.87|P-value:3.82E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:7.19|P-value:2.72E-10 ID:SGTC_535|Compound:2293-4129|FD-Score:-5.52|P-value:1.54E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.65|P-value:7.35E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.85|P-value:1.30E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:6.28|P-value:2.82E-8 ID:SGTC_720|Compound:r052-1644|FD-Score:14.90|P-value:1.13E-37 ID:SGTC_780|Compound:0109-0199|FD-Score:-4.66|P-value:4.24E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:-4.55|P-value:6.29E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:-7.58|P-value:6.68E-11 ID:SGTC_792|Compound:4534-1957|FD-Score:-5.93|P-value:2.63E-7 ID:SGTC_806|Compound:3966-4455|FD-Score:5.34|P-value:1.90E-6 ID:SGTC_848|Compound:0368-0089|FD-Score:3.92|P-value:3.26E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:3.59|P-value:8.67E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.71|P-value:2.23E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:5.31|P-value:2.15E-6 ID:SGTC_974|Compound:1326-0144|FD-Score:4.89|P-value:1.10E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:3.69|P-value:6.54E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:-4.59|P-value:5.52E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.14|P-value:1.59E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:7.62|P-value:2.47E-11 ID:SGTC_1225|Compound:1216-0074|FD-Score:4.64|P-value:2.83E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:6.77|P-value:2.54E-9 ID:SGTC_1468|Compound:k284-1086|FD-Score:5.45|P-value:1.19E-6 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.27|P-value:1.05E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:5.58|P-value:6.81E-7 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-4.54|P-value:6.61E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.76|P-value:2.99E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:10.50|P-value:8.16E-20 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.83|P-value:1.41E-5 ID:SGTC_1915|Compound:st067105|FD-Score:12.60|P-value:1.00E-27 ID:SGTC_1953|Compound:st076800|FD-Score:5.90|P-value:1.67E-7 ID:SGTC_1961|Compound:st076550|FD-Score:-5.29|P-value:3.97E-6 ID:SGTC_1968|Compound:st069590|FD-Score:-5.06|P-value:9.68E-6 ID:SGTC_1997|Compound:st073024|FD-Score:3.62|P-value:8.03E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.76|P-value:8.03E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.99|P-value:2.58E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.97|P-value:2.76E-4 ID:SGTC_2149|Compound:5554786|FD-Score:4.03|P-value:2.30E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:14.80|P-value:2.15E-37 ID:SGTC_2268|Compound:7933382|FD-Score:21.80|P-value:2.64E-78 ID:SGTC_2273|Compound:7815444|FD-Score:3.78|P-value:4.98E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.58|P-value:9.14E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-4.74|P-value:3.23E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.62|P-value:8.03E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.65|P-value:7.43E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:5.69|P-value:4.22E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.39|P-value:6.94E-5 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.87|P-value:3.80E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:11.30|P-value:1.14E-22 ID:SGTC_2701|Compound:st077767|FD-Score:6.57|P-value:6.70E-9 ID:SGTC_2750|Compound:bromebric acid|FD-Score:5.34|P-value:1.87E-6 ID:SGTC_2784|Compound:7567673|FD-Score:5.75|P-value:3.22E-7 ID:SGTC_2812|Compound:7970281|FD-Score:6.44|P-value:1.29E-8 ID:SGTC_2956|Compound:9076196|FD-Score:3.84|P-value:4.18E-4 ID:SGTC_3118|Compound:9124250|FD-Score:5.69|P-value:4.25E-7 ID:SGTC_3192|Compound:9110362|FD-Score:3.97|P-value:2.76E-4 ID:SGTC_3285|Compound:9112818|FD-Score:4.78|P-value:1.72E-5 ID:SGTC_3308|Compound:9128332|FD-Score:-3.90|P-value:5.27E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.98|P-value:2.64E-4 ID:SGTC_3321|Compound:9137793|FD-Score:4.56|P-value:3.82E-5 ID:SGTC_3322|Compound:9139058|FD-Score:4.74|P-value:1.93E-5 ID:SGTC_3331|Compound:9141060|FD-Score:3.82|P-value:4.48E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.19|P-value:1.34E-4

Top fitness defect scores for YOR257W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2268 7933382 21.80 153.8 µM 2.64E-78 1 1.41E-105 14.50
2 SGTC_268 camptothecin 15.30 39.6 µM 1.12E-39 DNA damage response 3 5.00E-53 3.18
3 SGTC_720 r052-1644 14.90 49.9 µM 1.13E-37 TSC3-RPN4 1 2.64E-50 6.46
4 SGTC_2233 sulbentine 14.80 40.4 µM 2.15E-37 4 6.35E-50 1.05
5 SGTC_1915 st067105 12.60 30.6 µM 1.00E-27 RNA pol III & RNase P/MRP 5 8.51E-37 0.96
6 SGTC_2679 rapamycin 11.30 1.0 nM 1.14E-22 7 6.10E-30 0.80
7 SGTC_1844 rapamycin 10.50 4.0 nM 8.16E-20 9 4.51E-26 0.43
8 SGTC_157 1348-1695 9.04 65.8 µM 3.38E-15 iron homeostasis 9 7.94E-20 0.16
9 SGTC_1168 k815-0004 7.62 80.5 µM 2.47E-11 DNA damage response 4 1.30E-14 1.42
10 SGTC_525 k781-2675 7.19 26.7 µM 2.72E-10 redox potentiating 10 3.29E-13 0.04
11 SGTC_1422 4031-0024 6.77 15.5 µM 2.54E-9 iron homeostasis 4 6.64E-12 1.37
12 SGTC_2701 st077767 6.57 14.7 µM 6.70E-9 2 2.45E-11 0.78
13 SGTC_2812 7970281 6.44 58.4 µM 1.29E-8 2 5.90E-11 0.69
14 SGTC_612 0302-0167 6.28 22.4 µM 2.82E-8 copper-dependent oxidative stress 1 1.68E-10 0.69
15 SGTC_1953 st076800 5.90 12.1 µM 1.67E-7 1 1.84E-9 0.73
16 SGTC_2784 7567673 5.75 72.7 µM 3.22E-7 iron homeostasis 4 4.42E-9 0.48
17 SGTC_2561 acetosyringone 5.69 100.0 µM 4.22E-7 2 6.35E-9 0.35
18 SGTC_3118 9124250 5.69 49.5 µM 4.25E-7 2 6.41E-9 0.07
19 SGTC_1534 6-azauridine 5.58 81.6 µM 6.81E-7 RNA pol III & RNase P/MRP 3 1.20E-8 0.97
20 SGTC_1468 k284-1086 5.45 134.0 µM 1.19E-6 DNA intercalators 6 2.55E-8 1.34

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.401 4.53E-130 YOR256C TRE2 het Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication
0.203 1.09E-32 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.198 3.91E-31 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.178 2.39E-25 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.171 1.92E-23 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.170 3.03E-23 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.169 5.44E-23 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.167 1.87E-22 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.165 7.66E-22 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.161 8.09E-21 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.157 4.68E-20 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.155 2.47E-19 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.151 1.16E-18 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.150 2.38E-18 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.149 3.63E-18 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB