YOR262W / GPN2

Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR262W / GPN2

Click on Significant Values for Screen Details ID:SGTC_210|Compound:3551-0445|FD-Score:4.22|P-value:1.76E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:3.35|P-value:4.98E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:4.49|P-value:5.36E-6 ID:SGTC_446|Compound:go6976|FD-Score:3.82|P-value:8.75E-5 ID:SGTC_462|Compound:ag-879|FD-Score:3.17|P-value:9.34E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.79|P-value:1.01E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:6.07|P-value:1.31E-9 ID:SGTC_619|Compound:1652-1634|FD-Score:-3.26|P-value:7.20E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:4.88|P-value:8.42E-7 ID:SGTC_639|Compound:0833-0042|FD-Score:4.24|P-value:1.60E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:3.27|P-value:6.58E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:7.13|P-value:1.42E-12 ID:SGTC_879|Compound:0831-1030|FD-Score:4.50|P-value:5.10E-6 ID:SGTC_885|Compound:0865-0106|FD-Score:3.70|P-value:1.43E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:4.60|P-value:3.19E-6 ID:SGTC_906|Compound:1165-0455|FD-Score:3.79|P-value:1.01E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-5.68|P-value:1.39E-8 ID:SGTC_1000|Compound:4048-0884|FD-Score:9.08|P-value:2.72E-19 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.60|P-value:2.05E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:9.05|P-value:3.62E-19 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-3.70|P-value:1.51E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:-3.42|P-value:4.18E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.85|P-value:7.96E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:-3.25|P-value:7.53E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.48|P-value:3.19E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.64|P-value:1.80E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.39|P-value:4.46E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.96|P-value:5.08E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:7.87|P-value:6.26E-15 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.92|P-value:6.83E-7 ID:SGTC_1604|Compound:st002052|FD-Score:3.71|P-value:1.36E-4 ID:SGTC_1643|Compound:st009866|FD-Score:4.26|P-value:1.48E-5 ID:SGTC_1773|Compound:st048542|FD-Score:5.43|P-value:4.98E-8 ID:SGTC_1801|Compound:st050089|FD-Score:3.65|P-value:1.68E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.65|P-value:1.73E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.78|P-value:1.04E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.50|P-value:2.98E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.99|P-value:4.54E-5 ID:SGTC_1974|Compound:st069448|FD-Score:3.61|P-value:2.01E-4 ID:SGTC_1978|Compound:st071761|FD-Score:3.25|P-value:7.21E-4 ID:SGTC_2004|Compound:4023728|FD-Score:12.20|P-value:3.65E-33 ID:SGTC_2017|Compound:5132927|FD-Score:3.62|P-value:1.88E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-3.24|P-value:7.91E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.23|P-value:7.64E-4 ID:SGTC_2067|Compound:5224629|FD-Score:3.50|P-value:2.97E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.23|P-value:7.69E-4 ID:SGTC_2090|Compound:5301565|FD-Score:6.27|P-value:4.04E-10 ID:SGTC_2093|Compound:5331342|FD-Score:4.74|P-value:1.69E-6 ID:SGTC_2172|Compound:5754775|FD-Score:-3.93|P-value:6.08E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:5.53|P-value:2.92E-8 ID:SGTC_2360|Compound:9040895|FD-Score:-4.14|P-value:2.60E-5 ID:SGTC_2389|Compound:9091542|FD-Score:-3.31|P-value:6.16E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.91|P-value:6.15E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.68|P-value:1.54E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:4.58|P-value:3.52E-6 ID:SGTC_2516|Compound:gossypol|FD-Score:3.38|P-value:4.61E-4 ID:SGTC_2534|Compound:helenine|FD-Score:5.69|P-value:1.24E-8 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.41|P-value:4.13E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.63|P-value:1.85E-4 ID:SGTC_2646|Compound:retinol|FD-Score:-5.97|P-value:2.71E-9 ID:SGTC_2650|Compound:prasterone|FD-Score:-3.27|P-value:6.92E-4 ID:SGTC_2671|Compound:danthron|FD-Score:4.26|P-value:1.50E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:-4.00|P-value:4.73E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.32|P-value:5.93E-4 ID:SGTC_2692|Compound:st077426|FD-Score:-3.59|P-value:2.26E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-3.55|P-value:2.60E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.44|P-value:3.67E-4 ID:SGTC_2921|Compound:7974240|FD-Score:8.33|P-value:1.56E-16 ID:SGTC_2925|Compound:9010536|FD-Score:-4.84|P-value:1.10E-6 ID:SGTC_2947|Compound:9072639|FD-Score:3.97|P-value:4.84E-5 ID:SGTC_3055|Compound:9094636|FD-Score:3.30|P-value:5.94E-4 ID:SGTC_3143|Compound:9086658|FD-Score:5.89|P-value:3.86E-9 ID:SGTC_3145|Compound:9085516|FD-Score:3.89|P-value:6.63E-5 ID:SGTC_3211|Compound:9128781|FD-Score:4.94|P-value:6.27E-7 ID:SGTC_3288|Compound:9119690|FD-Score:3.50|P-value:3.00E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-8.67|P-value:1.09E-17 ID:SGTC_210|Compound:3551-0445|FD-Score:4.22|P-value:1.76E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:3.35|P-value:4.98E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:4.49|P-value:5.36E-6 ID:SGTC_446|Compound:go6976|FD-Score:3.82|P-value:8.75E-5 ID:SGTC_462|Compound:ag-879|FD-Score:3.17|P-value:9.34E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.79|P-value:1.01E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:6.07|P-value:1.31E-9 ID:SGTC_619|Compound:1652-1634|FD-Score:-3.26|P-value:7.20E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:4.88|P-value:8.42E-7 ID:SGTC_639|Compound:0833-0042|FD-Score:4.24|P-value:1.60E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:3.27|P-value:6.58E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:7.13|P-value:1.42E-12 ID:SGTC_879|Compound:0831-1030|FD-Score:4.50|P-value:5.10E-6 ID:SGTC_885|Compound:0865-0106|FD-Score:3.70|P-value:1.43E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:4.60|P-value:3.19E-6 ID:SGTC_906|Compound:1165-0455|FD-Score:3.79|P-value:1.01E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-5.68|P-value:1.39E-8 ID:SGTC_1000|Compound:4048-0884|FD-Score:9.08|P-value:2.72E-19 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.60|P-value:2.05E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:9.05|P-value:3.62E-19 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-3.70|P-value:1.51E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:-3.42|P-value:4.18E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.85|P-value:7.96E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:-3.25|P-value:7.53E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.48|P-value:3.19E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.64|P-value:1.80E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.39|P-value:4.46E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.96|P-value:5.08E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:7.87|P-value:6.26E-15 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.92|P-value:6.83E-7 ID:SGTC_1604|Compound:st002052|FD-Score:3.71|P-value:1.36E-4 ID:SGTC_1643|Compound:st009866|FD-Score:4.26|P-value:1.48E-5 ID:SGTC_1773|Compound:st048542|FD-Score:5.43|P-value:4.98E-8 ID:SGTC_1801|Compound:st050089|FD-Score:3.65|P-value:1.68E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.65|P-value:1.73E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.78|P-value:1.04E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.50|P-value:2.98E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.99|P-value:4.54E-5 ID:SGTC_1974|Compound:st069448|FD-Score:3.61|P-value:2.01E-4 ID:SGTC_1978|Compound:st071761|FD-Score:3.25|P-value:7.21E-4 ID:SGTC_2004|Compound:4023728|FD-Score:12.20|P-value:3.65E-33 ID:SGTC_2017|Compound:5132927|FD-Score:3.62|P-value:1.88E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-3.24|P-value:7.91E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.23|P-value:7.64E-4 ID:SGTC_2067|Compound:5224629|FD-Score:3.50|P-value:2.97E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.23|P-value:7.69E-4 ID:SGTC_2090|Compound:5301565|FD-Score:6.27|P-value:4.04E-10 ID:SGTC_2093|Compound:5331342|FD-Score:4.74|P-value:1.69E-6 ID:SGTC_2172|Compound:5754775|FD-Score:-3.93|P-value:6.08E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:5.53|P-value:2.92E-8 ID:SGTC_2360|Compound:9040895|FD-Score:-4.14|P-value:2.60E-5 ID:SGTC_2389|Compound:9091542|FD-Score:-3.31|P-value:6.16E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.91|P-value:6.15E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.68|P-value:1.54E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:4.58|P-value:3.52E-6 ID:SGTC_2516|Compound:gossypol|FD-Score:3.38|P-value:4.61E-4 ID:SGTC_2534|Compound:helenine|FD-Score:5.69|P-value:1.24E-8 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.41|P-value:4.13E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.63|P-value:1.85E-4 ID:SGTC_2646|Compound:retinol|FD-Score:-5.97|P-value:2.71E-9 ID:SGTC_2650|Compound:prasterone|FD-Score:-3.27|P-value:6.92E-4 ID:SGTC_2671|Compound:danthron|FD-Score:4.26|P-value:1.50E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:-4.00|P-value:4.73E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.32|P-value:5.93E-4 ID:SGTC_2692|Compound:st077426|FD-Score:-3.59|P-value:2.26E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-3.55|P-value:2.60E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.44|P-value:3.67E-4 ID:SGTC_2921|Compound:7974240|FD-Score:8.33|P-value:1.56E-16 ID:SGTC_2925|Compound:9010536|FD-Score:-4.84|P-value:1.10E-6 ID:SGTC_2947|Compound:9072639|FD-Score:3.97|P-value:4.84E-5 ID:SGTC_3055|Compound:9094636|FD-Score:3.30|P-value:5.94E-4 ID:SGTC_3143|Compound:9086658|FD-Score:5.89|P-value:3.86E-9 ID:SGTC_3145|Compound:9085516|FD-Score:3.89|P-value:6.63E-5 ID:SGTC_3211|Compound:9128781|FD-Score:4.94|P-value:6.27E-7 ID:SGTC_3288|Compound:9119690|FD-Score:3.50|P-value:3.00E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-8.67|P-value:1.09E-17

Top fitness defect scores for YOR262W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2004 4023728 12.20 41.9 µM 3.65E-33 5 1.82E-34 1.70
2 SGTC_1000 4048-0884 9.08 8.7 µM 2.72E-19 copper-dependent oxidative stress 1 5.19E-20 1.83
3 SGTC_1069 diphenylcyclopropenone 9.05 8.5 µM 3.62E-19 3 6.99E-20 3.36
4 SGTC_2921 7974240 8.33 10.7 µM 1.56E-16 3 3.88E-17 1.48
5 SGTC_1367 1812-0510 7.87 76.9 µM 6.26E-15 3 1.81E-15 3.31
6 SGTC_820 1582-0060 7.13 59.9 µM 1.42E-12 4 5.16E-13 0.08
7 SGTC_2090 5301565 6.27 104.5 µM 4.04E-10 TSC3-RPN4 2 1.85E-10 1.30
8 SGTC_611 3453-1652 6.07 23.7 µM 1.31E-9 8 6.30E-10 0.19
9 SGTC_3143 9086658 5.89 49.5 µM 3.86E-9 4 1.94E-9 0.78
10 SGTC_2534 helenine 5.69 20.1 µM 1.24E-8 RSC complex & mRNA processing 14 6.49E-9 0.17
11 SGTC_2233 sulbentine 5.53 40.4 µM 2.92E-8 24 1.59E-8 0.13
12 SGTC_1773 st048542 5.43 73.6 µM 4.98E-8 13 2.77E-8 0.13
13 SGTC_3211 9128781 4.94 49.5 µM 6.27E-7 10 3.86E-7 0.42
14 SGTC_1585 2',4'-dihydroxychalcone 4.92 10.4 µM 6.83E-7 5 4.22E-7 0.01
15 SGTC_630 4356-0227 4.88 183.0 µM 8.42E-7 2 5.25E-7 0.45
16 SGTC_2093 5331342 4.74 194.4 µM 1.69E-6 3 1.08E-6 0.70
17 SGTC_897 1000-0139 4.60 31.4 µM 3.19E-6 8 2.10E-6 0.69
18 SGTC_2510 benzyl isothiocyanate 4.58 8.3 µM 3.52E-6 17 2.32E-6 0.05
19 SGTC_879 0831-1030 4.50 162.0 µM 5.10E-6 16 3.41E-6 0.01
20 SGTC_428 3448-4153 4.49 16.5 µM 5.36E-6 TSC3-RPN4 7 3.60E-6 0.40

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.458 2.37E-173 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.339 3.42E-91 YMR185W RTP1 het Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene
0.282 2.42E-62 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.216 8.66E-37 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.195 3.94E-30 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.194 7.04E-30 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.184 7.31E-27 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.171 1.70E-23 YML124C TUB3 hom Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.166 3.38E-22 YNL148C ALF1 hom Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
0.145 3.51E-17 YER107C GLE2 hom RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1
0.142 1.73E-16 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.133 1.17E-14 YBR058C-A TSC3 hom Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
0.132 1.83E-14 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.123 7.61E-13 YNL216W RAP1 het Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain)
0.117 1.24E-11 YFL023W BUD27 hom Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP