YOR263C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR263C / YOR263C

Click on Significant Values for Screen Details ID:SGTC_183|Compound:3914-0051|FD-Score:3.28|P-value:6.19E-4 ID:SGTC_199|Compound:4063-0024|FD-Score:3.68|P-value:1.46E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.26|P-value:6.55E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.29|P-value:6.05E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.84|P-value:9.69E-7 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.90|P-value:6.64E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.26|P-value:1.41E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:3.29|P-value:6.06E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.51|P-value:2.77E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.54|P-value:2.43E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.25|P-value:1.42E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.46|P-value:3.24E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:4.37|P-value:8.48E-6 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.13|P-value:2.44E-5 ID:SGTC_1413|Compound:3910-0535|FD-Score:4.12|P-value:2.47E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:5.51|P-value:3.07E-8 ID:SGTC_1713|Compound:st033146|FD-Score:3.58|P-value:2.12E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.15|P-value:9.70E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-3.44|P-value:3.72E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.13|P-value:2.37E-5 ID:SGTC_2255|Compound:7941087|FD-Score:3.32|P-value:5.38E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-3.19|P-value:8.90E-4 ID:SGTC_2387|Compound:9077560|FD-Score:4.34|P-value:9.85E-6 ID:SGTC_2391|Compound:6285546|FD-Score:4.98|P-value:4.93E-7 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.88|P-value:6.83E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.44|P-value:3.61E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.41|P-value:4.00E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.95|P-value:5.03E-5 ID:SGTC_2791|Compound:5663188|FD-Score:-3.93|P-value:5.80E-5 ID:SGTC_2907|Compound:7721985|FD-Score:3.63|P-value:1.76E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.95|P-value:5.35E-5 ID:SGTC_3148|Compound:9097893|FD-Score:4.08|P-value:2.95E-5 ID:SGTC_3328|Compound:9140624|FD-Score:-4.24|P-value:1.61E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:3.28|P-value:6.19E-4 ID:SGTC_199|Compound:4063-0024|FD-Score:3.68|P-value:1.46E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.26|P-value:6.55E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.29|P-value:6.05E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.84|P-value:9.69E-7 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.90|P-value:6.64E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.26|P-value:1.41E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:3.29|P-value:6.06E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.51|P-value:2.77E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.54|P-value:2.43E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.25|P-value:1.42E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.46|P-value:3.24E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:4.37|P-value:8.48E-6 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.13|P-value:2.44E-5 ID:SGTC_1413|Compound:3910-0535|FD-Score:4.12|P-value:2.47E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:5.51|P-value:3.07E-8 ID:SGTC_1713|Compound:st033146|FD-Score:3.58|P-value:2.12E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.15|P-value:9.70E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-3.44|P-value:3.72E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.13|P-value:2.37E-5 ID:SGTC_2255|Compound:7941087|FD-Score:3.32|P-value:5.38E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-3.19|P-value:8.90E-4 ID:SGTC_2387|Compound:9077560|FD-Score:4.34|P-value:9.85E-6 ID:SGTC_2391|Compound:6285546|FD-Score:4.98|P-value:4.93E-7 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.88|P-value:6.83E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.44|P-value:3.61E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.41|P-value:4.00E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.95|P-value:5.03E-5 ID:SGTC_2791|Compound:5663188|FD-Score:-3.93|P-value:5.80E-5 ID:SGTC_2907|Compound:7721985|FD-Score:3.63|P-value:1.76E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.95|P-value:5.35E-5 ID:SGTC_3148|Compound:9097893|FD-Score:4.08|P-value:2.95E-5 ID:SGTC_3328|Compound:9140624|FD-Score:-4.24|P-value:1.61E-5

Top fitness defect scores for YOR263C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1576 erythromycin ethylsuccinate 5.51 23.2 µM 3.07E-8 5 1.83E-8
2 SGTC_2391 6285546 4.98 200.0 µM 4.93E-7 4 3.24E-7
3 SGTC_402 epigallocatechin gallate 4.84 10.0 µM 9.69E-7 7 6.52E-7
4 SGTC_1261 0712-0010 4.37 12.7 µM 8.48E-6 RNA processing & uracil transport 16 6.14E-6
5 SGTC_2387 9077560 4.34 195.1 µM 9.85E-6 11 7.17E-6
6 SGTC_669 0108-0021 4.26 26.2 µM 1.41E-5 fatty acid desaturase (OLE1) 65 1.04E-5
7 SGTC_1080 nisoldipine 4.25 24.4 µM 1.42E-5 TSC3-RPN4 21 1.05E-5
8 SGTC_2052 5265182 4.13 7.1 µM 2.37E-5 26 1.78E-5
9 SGTC_1402 3909-7673 4.13 35.9 µM 2.44E-5 20 1.83E-5
10 SGTC_1413 3910-0535 4.12 34.4 µM 2.47E-5 9 1.86E-5
11 SGTC_3148 9097893 4.08 49.5 µM 2.95E-5 35 2.23E-5
12 SGTC_2772 vinpocetine 3.95 57.1 µM 5.03E-5 24 3.87E-5
13 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 3.88 200.0 µM 6.83E-5 15 5.31E-5
14 SGTC_199 4063-0024 3.68 41.6 µM 1.46E-4 7 1.17E-4
15 SGTC_2907 7721985 3.63 69.9 µM 1.76E-4 32 1.41E-4
16 SGTC_1713 st033146 3.58 12.8 µM 2.12E-4 40 1.71E-4
17 SGTC_1074 carmofur 3.54 3.8 µM 2.43E-4 exosome 32 1.97E-4
18 SGTC_1036 k216-0215 3.51 33.5 µM 2.77E-4 mitochondrial response to ROS 69 2.26E-4
19 SGTC_1165 k072-0275 3.46 30.3 µM 3.24E-4 58 2.65E-4
20 SGTC_2411 st077133 3.44 39.9 µM 3.61E-4 RNA pol III & RNase P/MRP 54 2.96E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 4.18E-10 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.107 4.72E-10 YDR420W HKR1 hom Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
0.102 3.78E-9 YPL267W ACM1 hom Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein
0.096 2.76E-8 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.090 1.86E-7 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.088 3.28E-7 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.083 1.52E-6 YNL318C HXT14 hom Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.083 1.69E-6 YDR112W_d IRC2_d hom Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
0.081 2.73E-6 YKL049C CSE4 het Centromere protein that resembles histone H3; required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p; Cse4p marks a subset of open chromatin; associated with promoters, accessible chromatin and RNA polymerase II-bound regions
0.079 4.03E-6 YBR129C OPY1 hom Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.079 4.18E-6 YPR168W NUT2 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress
0.079 4.51E-6 YJL049W_p YJL049W_p hom Putative protein of unknown function; YJL049W is a non-essential gene
0.078 6.10E-6 YOR156C NFI1 hom SUMO E3 ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; primary E3 ligase for Sir4p; sumoylates Yku70p/Yku80p and Sir4p in vivo to promote chromatin anchoring; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length
0.077 8.78E-6 YCL001W RER1 hom Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER
0.076 1.05E-5 YNL260C LTO1 het Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species