YOR264W / DSE3

Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR264W / DSE3

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:-3.59|P-value:1.43E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.17|P-value:5.58E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.23|P-value:4.62E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.22|P-value:4.76E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.54|P-value:1.42E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.35|P-value:2.98E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.76|P-value:5.72E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.15|P-value:7.46E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.73|P-value:8.07E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:4.01|P-value:1.94E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:5.76|P-value:1.93E-9 ID:SGTC_817|Compound:1391-0715|FD-Score:3.15|P-value:6.18E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.04|P-value:9.00E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.08|P-value:7.72E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.05|P-value:8.61E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.07|P-value:8.20E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.27|P-value:4.83E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.22|P-value:4.72E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:7.78|P-value:9.10E-16 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.95|P-value:2.53E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.07|P-value:8.22E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.61|P-value:1.05E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.69|P-value:7.58E-5 ID:SGTC_1913|Compound:st060213|FD-Score:5.84|P-value:1.14E-9 ID:SGTC_1915|Compound:st067105|FD-Score:6.84|P-value:1.40E-12 ID:SGTC_1917|Compound:st066507|FD-Score:3.14|P-value:6.40E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.44|P-value:2.10E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-3.07|P-value:9.63E-4 ID:SGTC_2163|Compound:5671233|FD-Score:4.34|P-value:4.43E-6 ID:SGTC_2292|Compound:7671323|FD-Score:3.45|P-value:2.00E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.64|P-value:9.57E-5 ID:SGTC_2398|Compound:5228213|FD-Score:4.70|P-value:7.36E-7 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.20|P-value:5.15E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.47|P-value:1.86E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.10|P-value:8.80E-8 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:5.02|P-value:1.37E-7 ID:SGTC_2643|Compound:anethole|FD-Score:4.15|P-value:1.07E-5 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.37|P-value:2.67E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.61|P-value:1.06E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-3.45|P-value:2.42E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.50|P-value:2.02E-6 ID:SGTC_2845|Compound:9003024|FD-Score:3.70|P-value:7.31E-5 ID:SGTC_2973|Compound:9094665|FD-Score:3.12|P-value:6.67E-4 ID:SGTC_3119|Compound:9125183|FD-Score:3.09|P-value:7.64E-4 ID:SGTC_3252|Compound:9135871|FD-Score:5.10|P-value:9.12E-8 ID:SGTC_3332|Compound:9141069|FD-Score:3.72|P-value:6.92E-5 ID:SGTC_3344|Compound:9148862|FD-Score:3.29|P-value:3.70E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.14|P-value:6.30E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:-3.59|P-value:1.43E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.17|P-value:5.58E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.23|P-value:4.62E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.22|P-value:4.76E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.54|P-value:1.42E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.35|P-value:2.98E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.76|P-value:5.72E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.15|P-value:7.46E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.73|P-value:8.07E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:4.01|P-value:1.94E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:5.76|P-value:1.93E-9 ID:SGTC_817|Compound:1391-0715|FD-Score:3.15|P-value:6.18E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.04|P-value:9.00E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.08|P-value:7.72E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.05|P-value:8.61E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.07|P-value:8.20E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.27|P-value:4.83E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.22|P-value:4.72E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:7.78|P-value:9.10E-16 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.95|P-value:2.53E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.07|P-value:8.22E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.61|P-value:1.05E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.69|P-value:7.58E-5 ID:SGTC_1913|Compound:st060213|FD-Score:5.84|P-value:1.14E-9 ID:SGTC_1915|Compound:st067105|FD-Score:6.84|P-value:1.40E-12 ID:SGTC_1917|Compound:st066507|FD-Score:3.14|P-value:6.40E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.44|P-value:2.10E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-3.07|P-value:9.63E-4 ID:SGTC_2163|Compound:5671233|FD-Score:4.34|P-value:4.43E-6 ID:SGTC_2292|Compound:7671323|FD-Score:3.45|P-value:2.00E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.64|P-value:9.57E-5 ID:SGTC_2398|Compound:5228213|FD-Score:4.70|P-value:7.36E-7 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.20|P-value:5.15E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.47|P-value:1.86E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.10|P-value:8.80E-8 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:5.02|P-value:1.37E-7 ID:SGTC_2643|Compound:anethole|FD-Score:4.15|P-value:1.07E-5 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.37|P-value:2.67E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.61|P-value:1.06E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-3.45|P-value:2.42E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.50|P-value:2.02E-6 ID:SGTC_2845|Compound:9003024|FD-Score:3.70|P-value:7.31E-5 ID:SGTC_2973|Compound:9094665|FD-Score:3.12|P-value:6.67E-4 ID:SGTC_3119|Compound:9125183|FD-Score:3.09|P-value:7.64E-4 ID:SGTC_3252|Compound:9135871|FD-Score:5.10|P-value:9.12E-8 ID:SGTC_3332|Compound:9141069|FD-Score:3.72|P-value:6.92E-5 ID:SGTC_3344|Compound:9148862|FD-Score:3.29|P-value:3.70E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.14|P-value:6.30E-4

Top fitness defect scores for YOR264W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1326 1431-2094 7.78 10.8 µM 9.10E-16 tubulin folding & SWR complex 9 3.51E-15
2 SGTC_1915 st067105 6.84 30.6 µM 1.40E-12 RNA pol III & RNase P/MRP 6 4.08E-12
3 SGTC_1913 st060213 5.84 96.1 µM 1.14E-9 7 2.56E-9
4 SGTC_751 0833-0568 5.76 350.0 µM 1.93E-9 2 4.26E-9
5 SGTC_2582 agaric acid 5.10 100.0 µM 8.80E-8 redox potentiating 216 1.67E-7
6 SGTC_3252 9135871 5.10 49.5 µM 9.12E-8 3 1.73E-7
7 SGTC_2626 ethyl orsellinate 5.02 100.0 µM 1.37E-7 13 2.56E-7
8 SGTC_2398 5228213 4.70 48.8 µM 7.36E-7 iron homeostasis 21 1.29E-6
9 SGTC_2829 7992743 4.50 58.4 µM 2.02E-6 26 3.39E-6
10 SGTC_2163 5671233 4.34 125.0 µM 4.43E-6 14 7.22E-6
11 SGTC_2643 anethole 4.15 100.0 µM 1.07E-5 12 1.69E-5
12 SGTC_734 2023-0417 4.01 80.0 µM 1.94E-5 ergosterol biosynthesis 13 2.98E-5
13 SGTC_1338 1486-1223 3.95 76.0 µM 2.53E-5 21 3.84E-5
14 SGTC_694 1315-0438 3.76 43.2 µM 5.72E-5 13 8.43E-5
15 SGTC_3332 9141069 3.72 11.2 µM 6.92E-5 21 1.01E-4
16 SGTC_2845 9003024 3.70 43.0 µM 7.31E-5 amide catabolism 54 1.07E-4
17 SGTC_1742 st038235 3.69 28.9 µM 7.58E-5 mitochondrial stress 125 1.10E-4
18 SGTC_2320 7373003 3.64 200.0 µM 9.57E-5 38 1.38E-4
19 SGTC_1600 coumarin 106 3.61 71.1 µM 1.05E-4 35 1.50E-4
20 SGTC_2739 tacrine 3.61 100.9 µM 1.06E-4 heme requiring 26 1.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.75E-16 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.126 2.65E-13 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.121 1.74E-12 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.118 8.02E-12 YHR103W SBE22 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
0.110 1.85E-10 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.109 2.82E-10 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.106 7.85E-10 YBR082C UBC4 hom Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
0.104 1.41E-9 YLR085C ARP6 hom Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.101 5.00E-9 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.100 6.58E-9 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.100 6.97E-9 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.100 7.26E-9 YMR294W-A_d YMR294W-A_d hom Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents
0.099 8.54E-9 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.096 2.93E-8 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.094 4.18E-8 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus