YOR270C / VPH1

Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR270C / VPH1

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:3.83|P-value:1.72E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:4.30|P-value:3.09E-5 ID:SGTC_323|Compound:4013-0906|FD-Score:4.14|P-value:5.66E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.53|P-value:1.22E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.32|P-value:9.45E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-4.13|P-value:9.72E-5 ID:SGTC_491|Compound:tetrandrine|FD-Score:-3.46|P-value:9.42E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:-3.79|P-value:3.27E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.87|P-value:2.44E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:-3.85|P-value:2.67E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.30|P-value:9.92E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:4.00|P-value:9.40E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:4.95|P-value:2.12E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:5.04|P-value:1.39E-6 ID:SGTC_686|Compound:1319-0111|FD-Score:-3.46|P-value:9.34E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.34|P-value:4.49E-5 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.64|P-value:5.25E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.69|P-value:2.84E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-4.10|P-value:1.08E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.37|P-value:4.02E-5 ID:SGTC_1735|Compound:st034310|FD-Score:-4.57|P-value:1.80E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.79|P-value:1.98E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.60|P-value:3.76E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.81|P-value:1.85E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.56|P-value:6.94E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.58|P-value:6.38E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.74|P-value:2.40E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.65|P-value:3.17E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.51|P-value:8.05E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.98|P-value:1.03E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.76|P-value:3.54E-4 ID:SGTC_2120|Compound:5538279|FD-Score:4.62|P-value:8.58E-6 ID:SGTC_2133|Compound:5320837|FD-Score:3.75|P-value:2.29E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.33|P-value:9.23E-4 ID:SGTC_2163|Compound:5671233|FD-Score:4.33|P-value:2.69E-5 ID:SGTC_2182|Compound:6325192|FD-Score:-3.71|P-value:4.26E-4 ID:SGTC_2321|Compound:7390090|FD-Score:4.60|P-value:9.24E-6 ID:SGTC_2324|Compound:6149169|FD-Score:-3.88|P-value:2.36E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.34|P-value:8.93E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.67|P-value:3.00E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.36|P-value:8.33E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.67|P-value:4.80E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.71|P-value:2.62E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:4.39|P-value:2.16E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.22|P-value:4.14E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.34|P-value:8.79E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-4.63|P-value:1.45E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:-4.49|P-value:2.50E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-5.48|P-value:3.42E-7 ID:SGTC_2837|Compound:9008476|FD-Score:3.94|P-value:1.18E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-4.75|P-value:8.84E-6 ID:SGTC_2939|Compound:9044578|FD-Score:3.91|P-value:1.31E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.44|P-value:9.98E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.50|P-value:5.34E-4 ID:SGTC_3019|Compound:9081971|FD-Score:-4.20|P-value:7.67E-5 ID:SGTC_3166|Compound:9102297|FD-Score:-3.86|P-value:2.56E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-5.08|P-value:2.16E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:3.83|P-value:1.72E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:4.30|P-value:3.09E-5 ID:SGTC_323|Compound:4013-0906|FD-Score:4.14|P-value:5.66E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.53|P-value:1.22E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.32|P-value:9.45E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-4.13|P-value:9.72E-5 ID:SGTC_491|Compound:tetrandrine|FD-Score:-3.46|P-value:9.42E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:-3.79|P-value:3.27E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.87|P-value:2.44E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:-3.85|P-value:2.67E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.30|P-value:9.92E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:4.00|P-value:9.40E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:4.95|P-value:2.12E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:5.04|P-value:1.39E-6 ID:SGTC_686|Compound:1319-0111|FD-Score:-3.46|P-value:9.34E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.34|P-value:4.49E-5 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.64|P-value:5.25E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.69|P-value:2.84E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-4.10|P-value:1.08E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.37|P-value:4.02E-5 ID:SGTC_1735|Compound:st034310|FD-Score:-4.57|P-value:1.80E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.79|P-value:1.98E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.60|P-value:3.76E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.81|P-value:1.85E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.56|P-value:6.94E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.58|P-value:6.38E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.74|P-value:2.40E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.65|P-value:3.17E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.51|P-value:8.05E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.98|P-value:1.03E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.76|P-value:3.54E-4 ID:SGTC_2120|Compound:5538279|FD-Score:4.62|P-value:8.58E-6 ID:SGTC_2133|Compound:5320837|FD-Score:3.75|P-value:2.29E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.33|P-value:9.23E-4 ID:SGTC_2163|Compound:5671233|FD-Score:4.33|P-value:2.69E-5 ID:SGTC_2182|Compound:6325192|FD-Score:-3.71|P-value:4.26E-4 ID:SGTC_2321|Compound:7390090|FD-Score:4.60|P-value:9.24E-6 ID:SGTC_2324|Compound:6149169|FD-Score:-3.88|P-value:2.36E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.34|P-value:8.93E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.67|P-value:3.00E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.36|P-value:8.33E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.67|P-value:4.80E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.71|P-value:2.62E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:4.39|P-value:2.16E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.22|P-value:4.14E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.34|P-value:8.79E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-4.63|P-value:1.45E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:-4.49|P-value:2.50E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-5.48|P-value:3.42E-7 ID:SGTC_2837|Compound:9008476|FD-Score:3.94|P-value:1.18E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-4.75|P-value:8.84E-6 ID:SGTC_2939|Compound:9044578|FD-Score:3.91|P-value:1.31E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.44|P-value:9.98E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.50|P-value:5.34E-4 ID:SGTC_3019|Compound:9081971|FD-Score:-4.20|P-value:7.67E-5 ID:SGTC_3166|Compound:9102297|FD-Score:-3.86|P-value:2.56E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-5.08|P-value:2.16E-6

Top fitness defect scores for YOR270C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_637 1181-0519 5.04 7.3 µM 1.39E-6 fatty acid desaturase (OLE1) 66 2.33E-7
2 SGTC_628 1636-0253 4.95 16.0 µM 2.12E-6 sphingolipid biosynthesis & PDR1 17 3.80E-7
3 SGTC_2120 5538279 4.62 152.0 µM 8.58E-6 9 1.94E-6
4 SGTC_2321 7390090 4.60 138.8 µM 9.24E-6 15 2.12E-6
5 SGTC_464 bw-b 70c 4.53 158.0 µM 1.22E-5 12 2.93E-6
6 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 4.39 100.0 µM 2.16E-5 12 5.67E-6
7 SGTC_2163 5671233 4.33 125.0 µM 2.69E-5 15 7.33E-6
8 SGTC_234 nsc-17383 4.30 10.7 µM 3.09E-5 ERG2 18 8.63E-6
9 SGTC_2640 pentamidine 4.22 10.4 µM 4.14E-5 mitochondrial processes 26 1.21E-5
10 SGTC_323 4013-0906 4.14 34.3 µM 5.66E-5 ERG2 10 1.74E-5
11 SGTC_626 0214-0009 4.00 33.0 µM 9.40E-5 copper-dependent oxidative stress 16 3.14E-5
12 SGTC_2109 5483026 3.98 200.0 µM 1.03E-4 RSC complex & mRNA processing 25 3.50E-5
13 SGTC_2837 9008476 3.94 45.5 µM 1.18E-4 32 4.09E-5
14 SGTC_2939 9044578 3.91 71.4 µM 1.31E-4 39 4.63E-5
15 SGTC_44 0929-0055 3.83 61.2 µM 1.72E-4 35 6.31E-5
16 SGTC_1848 st056003 3.81 16.4 µM 1.85E-4 19 6.90E-5
17 SGTC_1750 st081859 3.79 2.4 µM 1.98E-4 endomembrane recycling 201 7.43E-5
18 SGTC_2133 5320837 3.75 200.0 µM 2.29E-4 ERG2 31 8.80E-5
19 SGTC_1950 st077106 3.74 7.2 µM 2.40E-4 RNA processing & uracil transport 38 9.30E-5
20 SGTC_2615 purpurogallin-4-carboxylic acid 3.71 100.0 µM 2.62E-4 redox potentiating 71 1.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.67E-10 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.104 1.60E-9 YAR007C RFA1 het Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
0.088 3.19E-7 YOR373W NUD1 het Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance
0.087 3.97E-7 YPR153W YPR153W hom Putative protein of unknown function
0.085 9.20E-7 YGR239C PEX21 hom Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress
0.085 9.22E-7 YLR214W FRE1 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels
0.082 2.11E-6 YBR255W MTC4 hom Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
0.076 9.27E-6 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.075 1.47E-5 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.075 1.52E-5 YER116C SLX8 hom Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress
0.074 1.63E-5 YBL039W-B_p YBL039W-B_p hom Putative protein of unknown function
0.073 2.11E-5 YLR434C_d YLR434C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W
0.072 3.02E-5 YOL013W-B_d YOL013W-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element
0.072 3.18E-5 YKL080W VMA5 hom Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
0.071 3.57E-5 YMR011W HXT2 hom High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose