HIPHOP chemogenomics database
YOR270C / VPH1 
Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOR270C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.109 | 2.67E-10 | YMR126C_p | DLT1_p | hom | Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA) |
| 0.104 | 1.60E-9 | YAR007C | RFA1 | het | Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination |
| 0.088 | 3.19E-7 | YOR373W | NUD1 | het | Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance |
| 0.087 | 3.97E-7 | YPR153W | YPR153W | hom | Putative protein of unknown function |
| 0.085 | 9.20E-7 | YGR239C | PEX21 | hom | Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress |
| 0.085 | 9.22E-7 | YLR214W | FRE1 | hom | Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels |
| 0.082 | 2.11E-6 | YBR255W | MTC4 | hom | Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1 |
| 0.076 | 9.27E-6 | YDL081C | RPP1A | hom | Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component |
| 0.075 | 1.47E-5 | YML037C_p | YML037C_p | hom | Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene |
| 0.075 | 1.52E-5 | YER116C | SLX8 | hom | Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress |
| 0.074 | 1.63E-5 | YBL039W-B_p | YBL039W-B_p | hom | Putative protein of unknown function |
| 0.073 | 2.11E-5 | YLR434C_d | YLR434C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W |
| 0.072 | 3.02E-5 | YOL013W-B_d | YOL013W-B_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element |
| 0.072 | 3.18E-5 | YKL080W | VMA5 | hom | Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane |
| 0.071 | 3.57E-5 | YMR011W | HXT2 | hom | High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose |