YOR271C_p / FSF1

Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR271C / FSF1

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-3.95|P-value:3.82E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.24|P-value:5.92E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.20|P-value:6.90E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:-4.06|P-value:2.30E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:3.58|P-value:1.30E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.67|P-value:8.73E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.39|P-value:3.87E-6 ID:SGTC_373|Compound:0844-0104|FD-Score:3.84|P-value:4.40E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:3.54|P-value:1.51E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.46|P-value:2.66E-6 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.20|P-value:5.28E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.29|P-value:3.88E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.11|P-value:1.35E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-13.60|P-value:2.34E-43 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.54|P-value:1.49E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:-3.37|P-value:3.79E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:-4.55|P-value:2.43E-6 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.97|P-value:3.48E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.50|P-value:2.31E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.79|P-value:5.48E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.74|P-value:9.11E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.54|P-value:2.00E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.28|P-value:3.93E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.55|P-value:1.45E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.54|P-value:1.48E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.62|P-value:1.11E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.85|P-value:3.89E-7 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.38|P-value:3.55E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.72|P-value:7.33E-5 ID:SGTC_1642|Compound:st009582|FD-Score:3.45|P-value:2.12E-4 ID:SGTC_1652|Compound:st011932|FD-Score:6.27|P-value:9.20E-11 ID:SGTC_1689|Compound:st020265|FD-Score:3.28|P-value:3.98E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.91|P-value:3.26E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.37|P-value:2.89E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.47|P-value:2.60E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-4.35|P-value:6.33E-6 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.35|P-value:3.12E-4 ID:SGTC_2201|Compound:6605497|FD-Score:4.05|P-value:1.82E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-3.31|P-value:4.70E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-4.06|P-value:2.35E-5 ID:SGTC_2390|Compound:9097792|FD-Score:4.18|P-value:1.02E-5 ID:SGTC_2836|Compound:9010338|FD-Score:-4.39|P-value:5.31E-6 ID:SGTC_2841|Compound:9004761|FD-Score:-4.31|P-value:7.57E-6 ID:SGTC_3016|Compound:9080866|FD-Score:3.03|P-value:9.76E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.95|P-value:3.82E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.24|P-value:5.92E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.20|P-value:6.90E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:-4.06|P-value:2.30E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:3.58|P-value:1.30E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.67|P-value:8.73E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.39|P-value:3.87E-6 ID:SGTC_373|Compound:0844-0104|FD-Score:3.84|P-value:4.40E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:3.54|P-value:1.51E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.46|P-value:2.66E-6 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.20|P-value:5.28E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.29|P-value:3.88E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.11|P-value:1.35E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-13.60|P-value:2.34E-43 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.54|P-value:1.49E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:-3.37|P-value:3.79E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:-4.55|P-value:2.43E-6 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.97|P-value:3.48E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.50|P-value:2.31E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.79|P-value:5.48E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.74|P-value:9.11E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.54|P-value:2.00E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.28|P-value:3.93E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.55|P-value:1.45E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.54|P-value:1.48E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.62|P-value:1.11E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.85|P-value:3.89E-7 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.38|P-value:3.55E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.72|P-value:7.33E-5 ID:SGTC_1642|Compound:st009582|FD-Score:3.45|P-value:2.12E-4 ID:SGTC_1652|Compound:st011932|FD-Score:6.27|P-value:9.20E-11 ID:SGTC_1689|Compound:st020265|FD-Score:3.28|P-value:3.98E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.91|P-value:3.26E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.37|P-value:2.89E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.47|P-value:2.60E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-4.35|P-value:6.33E-6 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.35|P-value:3.12E-4 ID:SGTC_2201|Compound:6605497|FD-Score:4.05|P-value:1.82E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-3.31|P-value:4.70E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-4.06|P-value:2.35E-5 ID:SGTC_2390|Compound:9097792|FD-Score:4.18|P-value:1.02E-5 ID:SGTC_2836|Compound:9010338|FD-Score:-4.39|P-value:5.31E-6 ID:SGTC_2841|Compound:9004761|FD-Score:-4.31|P-value:7.57E-6 ID:SGTC_3016|Compound:9080866|FD-Score:3.03|P-value:9.76E-4

Top fitness defect scores for YOR271C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1652 st011932 6.27 78.0 µM 9.20E-11 RSC complex & mRNA processing 3 1.85E-10
2 SGTC_1514 1189-1591 4.85 158.0 µM 3.89E-7 22 6.21E-7
3 SGTC_387 norethindrone acetate 4.46 66.7 µM 2.66E-6 4 4.03E-6
4 SGTC_310 1273-0058 4.39 1.1 µM 3.87E-6 mitochondrial stress 219 5.78E-6
5 SGTC_2390 9097792 4.18 176.6 µM 1.02E-5 12 1.49E-5
6 SGTC_676 falcarinol 4.11 140.0 µM 1.35E-5 49 1.95E-5
7 SGTC_2201 6605497 4.05 169.9 µM 1.82E-5 ergosterol biosynthesis 7 2.60E-5
8 SGTC_1698 5-fluorocytosine 3.91 1.1 µM 3.26E-5 exosome 9 4.58E-5
9 SGTC_373 0844-0104 3.84 25.9 µM 4.40E-5 ERAD & cell cycle 50 6.13E-5
10 SGTC_1279 0874-0590 3.79 65.2 µM 5.48E-5 36 7.58E-5
11 SGTC_1522 st012842 3.72 45.6 µM 7.33E-5 RNA pol III & RNase P/MRP 36 1.01E-4
12 SGTC_136 0097-0015 3.67 404.5 µM 8.73E-5 60S ribosome export 23 1.19E-4
13 SGTC_1503 4585-0012 3.62 61.3 µM 1.11E-4 25 1.50E-4
14 SGTC_134 0269-0018 3.58 6.9 µM 1.30E-4 152 1.75E-4
15 SGTC_1444 4112-3581 3.55 28.0 µM 1.45E-4 21 1.96E-4
16 SGTC_1500 4488-1866 3.54 171.0 µM 1.48E-4 RPP1 & pyrimidine depletion 31 1.98E-4
17 SGTC_1049 3226-0134 3.54 66.0 µM 1.49E-4 46 2.01E-4
18 SGTC_374 0880-0231 3.54 82.3 µM 1.51E-4 iron homeostasis 36 2.02E-4
19 SGTC_1642 st009582 3.45 77.7 µM 2.12E-4 RPP1 & pyrimidine depletion 29 2.82E-4
20 SGTC_1730 st033808 3.37 45.1 µM 2.89E-4 67 3.80E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.301 2.90E-71 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.282 1.56E-62 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.272 4.57E-58 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.268 2.69E-56 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.254 1.08E-50 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.231 1.09E-41 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.229 4.74E-41 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.218 1.57E-37 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.218 2.43E-37 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.208 5.94E-34 YDR242W AMD2 hom Putative amidase
0.203 1.37E-32 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.196 3.26E-30 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.193 2.03E-29 YPL113C_p YPL113C_p hom Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene
0.187 1.17E-27 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.181 4.44E-26 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p