YOR272W / YTM1

Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR272W / YTM1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.40|P-value:2.55E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.62|P-value:1.09E-4 ID:SGTC_186|Compound:3455-3465|FD-Score:3.29|P-value:3.92E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.90|P-value:3.41E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.74|P-value:7.78E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:3.26|P-value:4.40E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.47|P-value:2.33E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.60|P-value:1.19E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.56|P-value:1.40E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.70|P-value:7.81E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.13|P-value:1.25E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.27|P-value:6.58E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:3.30|P-value:3.70E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.94|P-value:2.94E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.16|P-value:7.13E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.16|P-value:6.13E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.43|P-value:2.30E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.06|P-value:8.75E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.27|P-value:4.13E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.33|P-value:3.35E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.59|P-value:1.45E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.46|P-value:2.35E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.76|P-value:6.24E-5 ID:SGTC_2119|Compound:5528445|FD-Score:3.13|P-value:7.04E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.59|P-value:1.41E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.12|P-value:8.32E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-4.33|P-value:6.11E-6 ID:SGTC_2624|Compound:nerol|FD-Score:3.80|P-value:5.20E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:4.65|P-value:1.07E-6 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.22|P-value:5.01E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.08|P-value:8.30E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.41|P-value:2.91E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.27|P-value:4.24E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-5.31|P-value:3.96E-8 ID:SGTC_2948|Compound:9070189|FD-Score:-7.92|P-value:5.16E-16 ID:SGTC_2951|Compound:9072950|FD-Score:-6.38|P-value:5.35E-11 ID:SGTC_2952|Compound:9073731|FD-Score:9.77|P-value:1.33E-23 ID:SGTC_3089|Compound:9117425|FD-Score:3.55|P-value:1.42E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.27|P-value:4.84E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.05|P-value:1.82E-5 ID:SGTC_3192|Compound:9110362|FD-Score:3.86|P-value:4.05E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.40|P-value:2.55E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.62|P-value:1.09E-4 ID:SGTC_186|Compound:3455-3465|FD-Score:3.29|P-value:3.92E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.90|P-value:3.41E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.74|P-value:7.78E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:3.26|P-value:4.40E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.47|P-value:2.33E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.60|P-value:1.19E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.56|P-value:1.40E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.70|P-value:7.81E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.13|P-value:1.25E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.27|P-value:6.58E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:3.30|P-value:3.70E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.94|P-value:2.94E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.16|P-value:7.13E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.16|P-value:6.13E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.43|P-value:2.30E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.06|P-value:8.75E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.27|P-value:4.13E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.33|P-value:3.35E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.59|P-value:1.45E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.46|P-value:2.35E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.76|P-value:6.24E-5 ID:SGTC_2119|Compound:5528445|FD-Score:3.13|P-value:7.04E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.59|P-value:1.41E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.12|P-value:8.32E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-4.33|P-value:6.11E-6 ID:SGTC_2624|Compound:nerol|FD-Score:3.80|P-value:5.20E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:4.65|P-value:1.07E-6 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.22|P-value:5.01E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.08|P-value:8.30E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.41|P-value:2.91E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.27|P-value:4.24E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-5.31|P-value:3.96E-8 ID:SGTC_2948|Compound:9070189|FD-Score:-7.92|P-value:5.16E-16 ID:SGTC_2951|Compound:9072950|FD-Score:-6.38|P-value:5.35E-11 ID:SGTC_2952|Compound:9073731|FD-Score:9.77|P-value:1.33E-23 ID:SGTC_3089|Compound:9117425|FD-Score:3.55|P-value:1.42E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.27|P-value:4.84E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.05|P-value:1.82E-5 ID:SGTC_3192|Compound:9110362|FD-Score:3.86|P-value:4.05E-5

Top fitness defect scores for YOR272W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2952 9073731 9.77 13.8 µM 1.33E-23 tubulin folding & SWR complex 1 7.31E-23 2.12
2 SGTC_2654 protoveratrine a 4.65 100.0 µM 1.07E-6 2 1.68E-6 0.58
3 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.59 3.7 µM 1.41E-6 10 2.18E-6 0.01
4 SGTC_1071 trifluoperazine 4.27 6.3 µM 6.58E-6 6 9.70E-6 0.15
5 SGTC_1014 4130-3005 4.13 69.3 µM 1.25E-5 5 1.80E-5 0.14
6 SGTC_3143 9086658 4.05 49.5 µM 1.82E-5 13 2.60E-5 0.06
7 SGTC_1084 voriconazole 3.94 435.0 nM 2.94E-5 azole & statin 9 4.13E-5 0.03
8 SGTC_188 3229-0966 3.90 278.5 µM 3.41E-5 18 4.75E-5 0.02
9 SGTC_3192 9110362 3.86 49.5 µM 4.05E-5 mitochondrial processes 8 5.62E-5 0.08
10 SGTC_2624 nerol 3.80 100.0 µM 5.20E-5 2 7.15E-5 0.04
11 SGTC_1842 st055362 3.76 61.2 µM 6.24E-5 4 8.53E-5 0.44
12 SGTC_972 1319-0219 3.70 195.0 µM 7.81E-5 8 1.06E-4 0.08
13 SGTC_155 k072-0202 3.62 43.6 µM 1.09E-4 9 1.47E-4 0.05
14 SGTC_771 0250-0039 3.60 27.3 µM 1.19E-4 4 1.60E-4 0.14
15 SGTC_874 0599-0792 3.56 117.0 µM 1.40E-4 8 1.87E-4 0.03
16 SGTC_3089 9117425 3.55 49.5 µM 1.42E-4 3 1.89E-4 0.25
17 SGTC_1221 2958-7315 3.43 257.0 µM 2.30E-4 5 3.02E-4 0.11
18 SGTC_6 0844-0013 3.40 19.8 µM 2.55E-4 16 3.33E-4 0.02
19 SGTC_1352 1496-0991 3.33 99.0 µM 3.35E-4 tubulin folding & SWR complex 3 4.33E-4 0.28
20 SGTC_1081 sertraline 3.30 6.0 µM 3.70E-4 60S ribosome export 11 4.77E-4 0.19

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.181 2.97E-26 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.145 2.45E-17 YHR122W CIA2 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B
0.134 6.27E-15 YLR026C SED5 het cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
0.132 1.95E-14 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.120 2.59E-12 YLR398C SKI2 hom Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
0.117 1.06E-11 YLR319C BUD6 hom Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
0.116 1.55E-11 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.115 2.08E-11 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.111 1.37E-10 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.109 2.30E-10 YGL162W SUT1 hom Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.109 2.58E-10 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene
0.108 3.88E-10 YNL176C_p TDA7_p hom Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele
0.107 4.98E-10 YFL046W_p FMP32_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.103 2.08E-9 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.102 3.20E-9 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress