YOR273C / TPO4

Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR273C / TPO4

Click on Significant Values for Screen Details ID:SGTC_120|Compound:rhodamine 6G|FD-Score:5.31|P-value:2.19E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:5.95|P-value:6.27E-9 ID:SGTC_156|Compound:3474-0145|FD-Score:3.36|P-value:9.37E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:5.39|P-value:1.44E-7 ID:SGTC_208|Compound:k072-0098|FD-Score:3.92|P-value:1.23E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.37|P-value:9.03E-4 ID:SGTC_277|Compound:nystatin|FD-Score:4.37|P-value:1.92E-5 ID:SGTC_288|Compound:1315-0019|FD-Score:4.18|P-value:4.35E-5 ID:SGTC_291|Compound:4130-1278|FD-Score:5.43|P-value:1.16E-7 ID:SGTC_296|Compound:1222-0039|FD-Score:3.45|P-value:6.98E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.93|P-value:1.45E-6 ID:SGTC_398|Compound:bronopol|FD-Score:4.47|P-value:1.24E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:5.38|P-value:1.52E-7 ID:SGTC_496|Compound:calpeptin|FD-Score:3.89|P-value:1.40E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.99|P-value:9.47E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:5.82|P-value:1.33E-8 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.68|P-value:3.08E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:4.43|P-value:1.50E-5 ID:SGTC_703|Compound:3875-0075|FD-Score:4.15|P-value:4.92E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:4.52|P-value:1.00E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:6.29|P-value:8.24E-10 ID:SGTC_860|Compound:0443-0016|FD-Score:3.35|P-value:9.65E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:4.40|P-value:1.70E-5 ID:SGTC_929|Compound:2805-0021|FD-Score:4.55|P-value:8.71E-6 ID:SGTC_981|Compound:1488-1094|FD-Score:3.91|P-value:1.27E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.47|P-value:6.44E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.28|P-value:2.79E-5 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.43|P-value:7.48E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.54|P-value:9.34E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.08|P-value:4.51E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:7.39|P-value:5.14E-13 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.38|P-value:8.81E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.44|P-value:7.06E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.89|P-value:1.36E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.84|P-value:1.64E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.54|P-value:5.07E-4 ID:SGTC_1688|Compound:st021091|FD-Score:4.45|P-value:1.35E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:6.24|P-value:1.12E-9 ID:SGTC_1717|Compound:st033143|FD-Score:-3.59|P-value:6.51E-5 ID:SGTC_1752|Compound:st044819|FD-Score:4.28|P-value:2.82E-5 ID:SGTC_1775|Compound:st081588|FD-Score:3.58|P-value:4.42E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-3.32|P-value:1.86E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.63|P-value:3.69E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.65|P-value:3.39E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.51|P-value:5.67E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.57|P-value:4.54E-4 ID:SGTC_1947|Compound:st076332|FD-Score:4.49|P-value:1.14E-5 ID:SGTC_2163|Compound:5671233|FD-Score:4.66|P-value:5.41E-6 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.80|P-value:1.96E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.70|P-value:2.83E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:-2.85|P-value:9.95E-4 ID:SGTC_2266|Compound:7929956|FD-Score:4.52|P-value:1.02E-5 ID:SGTC_2267|Compound:7931562|FD-Score:4.24|P-value:3.43E-5 ID:SGTC_2268|Compound:7933382|FD-Score:9.70|P-value:1.96E-21 ID:SGTC_2282|Compound:7944268|FD-Score:7.39|P-value:4.94E-13 ID:SGTC_2283|Compound:7944793|FD-Score:5.44|P-value:1.10E-7 ID:SGTC_2284|Compound:7945075|FD-Score:6.00|P-value:4.66E-9 ID:SGTC_2357|Compound:9067248|FD-Score:3.49|P-value:6.00E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.68|P-value:3.02E-4 ID:SGTC_2456|Compound:5770359|FD-Score:4.43|P-value:1.46E-5 ID:SGTC_2475|Compound:5812728|FD-Score:6.59|P-value:1.21E-10 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.99|P-value:1.13E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.80|P-value:1.97E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.14|P-value:3.57E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:4.55|P-value:8.61E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:4.59|P-value:7.44E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.91|P-value:1.28E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:5.63|P-value:3.90E-8 ID:SGTC_2712|Compound:st079126|FD-Score:4.45|P-value:1.37E-5 ID:SGTC_2783|Compound:7738165|FD-Score:5.09|P-value:6.75E-7 ID:SGTC_2790|Compound:5423970|FD-Score:4.77|P-value:3.24E-6 ID:SGTC_2869|Compound:9037858|FD-Score:6.26|P-value:1.00E-9 ID:SGTC_2897|Compound:9048598|FD-Score:4.01|P-value:8.46E-5 ID:SGTC_2900|Compound:5328528|FD-Score:10.00|P-value:1.04E-22 ID:SGTC_2936|Compound:9038235|FD-Score:5.15|P-value:5.05E-7 ID:SGTC_2966|Compound:9084041|FD-Score:4.46|P-value:1.32E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.91|P-value:1.30E-4 ID:SGTC_3089|Compound:9117425|FD-Score:5.34|P-value:1.89E-7 ID:SGTC_3093|Compound:9117344|FD-Score:3.69|P-value:2.90E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.56|P-value:4.78E-4 ID:SGTC_3280|Compound:9140961|FD-Score:3.91|P-value:1.29E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.47|P-value:6.43E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:5.31|P-value:2.19E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:5.95|P-value:6.27E-9 ID:SGTC_156|Compound:3474-0145|FD-Score:3.36|P-value:9.37E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:5.39|P-value:1.44E-7 ID:SGTC_208|Compound:k072-0098|FD-Score:3.92|P-value:1.23E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.37|P-value:9.03E-4 ID:SGTC_277|Compound:nystatin|FD-Score:4.37|P-value:1.92E-5 ID:SGTC_288|Compound:1315-0019|FD-Score:4.18|P-value:4.35E-5 ID:SGTC_291|Compound:4130-1278|FD-Score:5.43|P-value:1.16E-7 ID:SGTC_296|Compound:1222-0039|FD-Score:3.45|P-value:6.98E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.93|P-value:1.45E-6 ID:SGTC_398|Compound:bronopol|FD-Score:4.47|P-value:1.24E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:5.38|P-value:1.52E-7 ID:SGTC_496|Compound:calpeptin|FD-Score:3.89|P-value:1.40E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.99|P-value:9.47E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:5.82|P-value:1.33E-8 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.68|P-value:3.08E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:4.43|P-value:1.50E-5 ID:SGTC_703|Compound:3875-0075|FD-Score:4.15|P-value:4.92E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:4.52|P-value:1.00E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:6.29|P-value:8.24E-10 ID:SGTC_860|Compound:0443-0016|FD-Score:3.35|P-value:9.65E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:4.40|P-value:1.70E-5 ID:SGTC_929|Compound:2805-0021|FD-Score:4.55|P-value:8.71E-6 ID:SGTC_981|Compound:1488-1094|FD-Score:3.91|P-value:1.27E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.47|P-value:6.44E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.28|P-value:2.79E-5 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.43|P-value:7.48E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.54|P-value:9.34E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.08|P-value:4.51E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:7.39|P-value:5.14E-13 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.38|P-value:8.81E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.44|P-value:7.06E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.89|P-value:1.36E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.84|P-value:1.64E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.54|P-value:5.07E-4 ID:SGTC_1688|Compound:st021091|FD-Score:4.45|P-value:1.35E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:6.24|P-value:1.12E-9 ID:SGTC_1717|Compound:st033143|FD-Score:-3.59|P-value:6.51E-5 ID:SGTC_1752|Compound:st044819|FD-Score:4.28|P-value:2.82E-5 ID:SGTC_1775|Compound:st081588|FD-Score:3.58|P-value:4.42E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-3.32|P-value:1.86E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.63|P-value:3.69E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.65|P-value:3.39E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.51|P-value:5.67E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.57|P-value:4.54E-4 ID:SGTC_1947|Compound:st076332|FD-Score:4.49|P-value:1.14E-5 ID:SGTC_2163|Compound:5671233|FD-Score:4.66|P-value:5.41E-6 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.80|P-value:1.96E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.70|P-value:2.83E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:-2.85|P-value:9.95E-4 ID:SGTC_2266|Compound:7929956|FD-Score:4.52|P-value:1.02E-5 ID:SGTC_2267|Compound:7931562|FD-Score:4.24|P-value:3.43E-5 ID:SGTC_2268|Compound:7933382|FD-Score:9.70|P-value:1.96E-21 ID:SGTC_2282|Compound:7944268|FD-Score:7.39|P-value:4.94E-13 ID:SGTC_2283|Compound:7944793|FD-Score:5.44|P-value:1.10E-7 ID:SGTC_2284|Compound:7945075|FD-Score:6.00|P-value:4.66E-9 ID:SGTC_2357|Compound:9067248|FD-Score:3.49|P-value:6.00E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.68|P-value:3.02E-4 ID:SGTC_2456|Compound:5770359|FD-Score:4.43|P-value:1.46E-5 ID:SGTC_2475|Compound:5812728|FD-Score:6.59|P-value:1.21E-10 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.99|P-value:1.13E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.80|P-value:1.97E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.14|P-value:3.57E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:4.55|P-value:8.61E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:4.59|P-value:7.44E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.91|P-value:1.28E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:5.63|P-value:3.90E-8 ID:SGTC_2712|Compound:st079126|FD-Score:4.45|P-value:1.37E-5 ID:SGTC_2783|Compound:7738165|FD-Score:5.09|P-value:6.75E-7 ID:SGTC_2790|Compound:5423970|FD-Score:4.77|P-value:3.24E-6 ID:SGTC_2869|Compound:9037858|FD-Score:6.26|P-value:1.00E-9 ID:SGTC_2897|Compound:9048598|FD-Score:4.01|P-value:8.46E-5 ID:SGTC_2900|Compound:5328528|FD-Score:10.00|P-value:1.04E-22 ID:SGTC_2936|Compound:9038235|FD-Score:5.15|P-value:5.05E-7 ID:SGTC_2966|Compound:9084041|FD-Score:4.46|P-value:1.32E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.91|P-value:1.30E-4 ID:SGTC_3089|Compound:9117425|FD-Score:5.34|P-value:1.89E-7 ID:SGTC_3093|Compound:9117344|FD-Score:3.69|P-value:2.90E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.56|P-value:4.78E-4 ID:SGTC_3280|Compound:9140961|FD-Score:3.91|P-value:1.29E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.47|P-value:6.43E-4

Top fitness defect scores for YOR273C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2900 5328528 10.00 85.3 µM 1.04E-22 Golgi 1 7.33E-24
2 SGTC_2268 7933382 9.70 153.8 µM 1.96E-21 1 1.50E-22
3 SGTC_2282 7944268 7.39 200.0 µM 4.94E-13 RPP1 & pyrimidine depletion 1 7.18E-14
4 SGTC_1212 0520-0165 7.39 585.0 µM 5.14E-13 3 7.48E-14
5 SGTC_2475 5812728 6.59 15.0 µM 1.21E-10 mitochondrial processes 3 2.18E-11
6 SGTC_825 1988-2224 6.29 89.6 µM 8.24E-10 cell wall signaling 13 1.61E-10
7 SGTC_2869 9037858 6.26 32.5 µM 1.00E-9 1 1.98E-10
8 SGTC_1693 xanthone 6.24 101.9 µM 1.12E-9 DNA damage response 1 2.22E-10
9 SGTC_2284 7945075 6.00 39.2 µM 4.66E-9 mitochondrial processes 3 9.84E-10
10 SGTC_137 0438-0332 5.95 85.4 µM 6.27E-9 ubiquinone biosynthesis & proteasome 64 1.34E-9
11 SGTC_674 0498-0004 5.82 451.0 µM 1.33E-8 heme requiring 4 2.93E-9
12 SGTC_2652 actinonin 5.63 100.0 µM 3.90E-8 1 9.07E-9
13 SGTC_2283 7944793 5.44 200.0 µM 1.10E-7 13 2.68E-8
14 SGTC_291 4130-1278 5.43 35.5 µM 1.16E-7 Golgi 5 2.84E-8
15 SGTC_157 1348-1695 5.39 65.8 µM 1.44E-7 iron homeostasis 27 3.57E-8
16 SGTC_423 5-fluorouracil 5.38 457.0 µM 1.52E-7 exosome 5 3.77E-8
17 SGTC_3089 9117425 5.34 49.5 µM 1.89E-7 5 4.75E-8
18 SGTC_120 rhodamine 6G 5.31 52.3 µM 2.19E-7 mitochondrial processes 12 5.54E-8
19 SGTC_2936 9038235 5.15 15.6 µM 5.05E-7 6 1.33E-7
20 SGTC_2783 7738165 5.09 71.4 µM 6.75E-7 10 1.81E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 3.28E-9 YBR053C_p YBR053C_p hom Putative protein of unknown function; induced by cell wall perturbation
0.098 1.38E-8 YOR257W CDC31 het Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
0.092 9.60E-8 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.089 2.68E-7 YBL044W_p YBL044W_p hom Putative protein of unknown function; YBL044W is not an essential protein
0.085 7.73E-7 YBR034C HMT1 hom Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region.
0.077 7.58E-6 YIL161W_p YIL161W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene
0.075 1.37E-5 YHR031C RRM3 hom DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
0.073 2.60E-5 YNL285W_d YNL285W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.072 3.18E-5 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.069 6.68E-5 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.067 9.65E-5 YDL071C_d YDL071C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W
0.067 1.08E-4 YJL015C_d YJL015C_d het Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W
0.065 1.61E-4 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.064 1.99E-4 YBL087C RPL23A hom Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication
0.064 2.03E-4 YDR141C DOP1 het Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies