YOR275C / RIM20

Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR275C / RIM20

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:3.19|P-value:5.53E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:-3.80|P-value:5.62E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.30|P-value:3.60E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:6.10|P-value:2.34E-10 ID:SGTC_42|Compound:0133-0086|FD-Score:-5.30|P-value:3.53E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.30|P-value:5.99E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:-4.92|P-value:2.71E-7 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.18|P-value:5.74E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.49|P-value:1.97E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:5.26|P-value:3.79E-8 ID:SGTC_178|Compound:4092-0806|FD-Score:4.54|P-value:1.74E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:10.30|P-value:5.83E-26 ID:SGTC_278|Compound:4092-0821|FD-Score:3.14|P-value:6.65E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:5.04|P-value:1.29E-7 ID:SGTC_320|Compound:4092-0846|FD-Score:3.70|P-value:7.76E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:5.97|P-value:5.32E-10 ID:SGTC_346|Compound:4513-0042|FD-Score:3.90|P-value:3.40E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:4.09|P-value:1.46E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:7.12|P-value:1.72E-13 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.57|P-value:1.45E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.48|P-value:1.99E-4 ID:SGTC_447|Compound:ml7|FD-Score:3.70|P-value:7.66E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.36|P-value:4.10E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.24|P-value:4.92E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:4.38|P-value:3.82E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:4.47|P-value:2.42E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:8.48|P-value:2.46E-18 ID:SGTC_526|Compound:4469-0568|FD-Score:4.03|P-value:1.92E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:6.41|P-value:2.86E-11 ID:SGTC_576|Compound:1073-0113|FD-Score:4.60|P-value:1.30E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:4.35|P-value:4.36E-6 ID:SGTC_658|Compound:3253-0951|FD-Score:4.06|P-value:1.67E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:6.93|P-value:7.23E-13 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.79|P-value:5.80E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:4.67|P-value:9.13E-7 ID:SGTC_846|Compound:0335-0850|FD-Score:3.40|P-value:2.56E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:9.46|P-value:2.18E-22 ID:SGTC_875|Compound:0709-0210|FD-Score:4.45|P-value:2.66E-6 ID:SGTC_884|Compound:0851-0618|FD-Score:4.35|P-value:4.37E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:12.10|P-value:1.89E-35 ID:SGTC_916|Compound:4466-0038|FD-Score:3.60|P-value:1.14E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.18|P-value:5.76E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.66|P-value:8.93E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:6.19|P-value:1.28E-10 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.51|P-value:2.05E-6 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.92|P-value:2.99E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.19|P-value:5.86E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.64|P-value:9.92E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:4.64|P-value:1.03E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.50|P-value:1.75E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.96|P-value:2.53E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.19|P-value:5.48E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:11.80|P-value:7.13E-34 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.57|P-value:1.49E-6 ID:SGTC_1523|Compound:st012844|FD-Score:4.08|P-value:1.48E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:7.70|P-value:1.91E-15 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.22|P-value:4.91E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.08|P-value:8.64E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.26|P-value:4.20E-4 ID:SGTC_1687|Compound:st020778|FD-Score:5.08|P-value:1.06E-7 ID:SGTC_1712|Compound:st032288|FD-Score:4.73|P-value:6.71E-7 ID:SGTC_1754|Compound:st042065|FD-Score:4.92|P-value:2.43E-7 ID:SGTC_1760|Compound:st045453|FD-Score:6.18|P-value:1.38E-10 ID:SGTC_1788|Compound:fluconazole|FD-Score:9.37|P-value:5.39E-22 ID:SGTC_1800|Compound:st050079|FD-Score:6.51|P-value:1.48E-11 ID:SGTC_1801|Compound:st050089|FD-Score:7.43|P-value:1.64E-14 ID:SGTC_1803|Compound:st050068|FD-Score:7.33|P-value:3.57E-14 ID:SGTC_1818|Compound:st052136|FD-Score:3.18|P-value:5.71E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.60|P-value:1.29E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.55|P-value:1.43E-4 ID:SGTC_1884|Compound:5633444|FD-Score:7.17|P-value:1.25E-13 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.68|P-value:9.14E-5 ID:SGTC_2021|Compound:4019055|FD-Score:5.52|P-value:8.40E-9 ID:SGTC_2128|Compound:5255449|FD-Score:-5.63|P-value:5.11E-9 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.04|P-value:1.81E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.75|P-value:6.29E-5 ID:SGTC_2270|Compound:7924575|FD-Score:3.37|P-value:2.82E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.61|P-value:1.09E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.09|P-value:7.73E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:3.66|P-value:9.20E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.66|P-value:9.02E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.31|P-value:3.22E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.56|P-value:1.57E-6 ID:SGTC_2736|Compound:butenafine|FD-Score:3.15|P-value:6.34E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:6.85|P-value:1.29E-12 ID:SGTC_2756|Compound:carbadox|FD-Score:4.29|P-value:5.69E-6 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.04|P-value:1.77E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.32|P-value:3.42E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-3.12|P-value:7.75E-4 ID:SGTC_2790|Compound:5423970|FD-Score:6.41|P-value:2.85E-11 ID:SGTC_2805|Compound:7950783|FD-Score:5.65|P-value:3.92E-9 ID:SGTC_2809|Compound:7964133|FD-Score:3.22|P-value:4.90E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.04|P-value:1.81E-5 ID:SGTC_2839|Compound:9003951|FD-Score:3.33|P-value:3.28E-4 ID:SGTC_2843|Compound:9000894|FD-Score:3.07|P-value:8.25E-4 ID:SGTC_2847|Compound:9005661|FD-Score:3.31|P-value:3.59E-4 ID:SGTC_2991|Compound:9074669|FD-Score:5.15|P-value:6.98E-8 ID:SGTC_3018|Compound:9082602|FD-Score:7.02|P-value:3.73E-13 ID:SGTC_3037|Compound:9091026|FD-Score:4.06|P-value:1.65E-5 ID:SGTC_3152|Compound:9099253|FD-Score:5.33|P-value:2.56E-8 ID:SGTC_3210|Compound:9128157|FD-Score:3.59|P-value:1.19E-4 ID:SGTC_3297|Compound:9117502|FD-Score:3.03|P-value:9.79E-4 ID:SGTC_3308|Compound:9128332|FD-Score:5.73|P-value:2.41E-9 ID:SGTC_3|Compound:0833-0587|FD-Score:3.19|P-value:5.53E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:-3.80|P-value:5.62E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.30|P-value:3.60E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:6.10|P-value:2.34E-10 ID:SGTC_42|Compound:0133-0086|FD-Score:-5.30|P-value:3.53E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.30|P-value:5.99E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:-4.92|P-value:2.71E-7 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.18|P-value:5.74E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.49|P-value:1.97E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:5.26|P-value:3.79E-8 ID:SGTC_178|Compound:4092-0806|FD-Score:4.54|P-value:1.74E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:10.30|P-value:5.83E-26 ID:SGTC_278|Compound:4092-0821|FD-Score:3.14|P-value:6.65E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:5.04|P-value:1.29E-7 ID:SGTC_320|Compound:4092-0846|FD-Score:3.70|P-value:7.76E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:5.97|P-value:5.32E-10 ID:SGTC_346|Compound:4513-0042|FD-Score:3.90|P-value:3.40E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:4.09|P-value:1.46E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:7.12|P-value:1.72E-13 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.57|P-value:1.45E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.48|P-value:1.99E-4 ID:SGTC_447|Compound:ml7|FD-Score:3.70|P-value:7.66E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.36|P-value:4.10E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.24|P-value:4.92E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:4.38|P-value:3.82E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:4.47|P-value:2.42E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:8.48|P-value:2.46E-18 ID:SGTC_526|Compound:4469-0568|FD-Score:4.03|P-value:1.92E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:6.41|P-value:2.86E-11 ID:SGTC_576|Compound:1073-0113|FD-Score:4.60|P-value:1.30E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:4.35|P-value:4.36E-6 ID:SGTC_658|Compound:3253-0951|FD-Score:4.06|P-value:1.67E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:6.93|P-value:7.23E-13 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.79|P-value:5.80E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:4.67|P-value:9.13E-7 ID:SGTC_846|Compound:0335-0850|FD-Score:3.40|P-value:2.56E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:9.46|P-value:2.18E-22 ID:SGTC_875|Compound:0709-0210|FD-Score:4.45|P-value:2.66E-6 ID:SGTC_884|Compound:0851-0618|FD-Score:4.35|P-value:4.37E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:12.10|P-value:1.89E-35 ID:SGTC_916|Compound:4466-0038|FD-Score:3.60|P-value:1.14E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.18|P-value:5.76E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.66|P-value:8.93E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:6.19|P-value:1.28E-10 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.51|P-value:2.05E-6 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.92|P-value:2.99E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.19|P-value:5.86E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.64|P-value:9.92E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:4.64|P-value:1.03E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.50|P-value:1.75E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.96|P-value:2.53E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.19|P-value:5.48E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:11.80|P-value:7.13E-34 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.57|P-value:1.49E-6 ID:SGTC_1523|Compound:st012844|FD-Score:4.08|P-value:1.48E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:7.70|P-value:1.91E-15 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.22|P-value:4.91E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.08|P-value:8.64E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.26|P-value:4.20E-4 ID:SGTC_1687|Compound:st020778|FD-Score:5.08|P-value:1.06E-7 ID:SGTC_1712|Compound:st032288|FD-Score:4.73|P-value:6.71E-7 ID:SGTC_1754|Compound:st042065|FD-Score:4.92|P-value:2.43E-7 ID:SGTC_1760|Compound:st045453|FD-Score:6.18|P-value:1.38E-10 ID:SGTC_1788|Compound:fluconazole|FD-Score:9.37|P-value:5.39E-22 ID:SGTC_1800|Compound:st050079|FD-Score:6.51|P-value:1.48E-11 ID:SGTC_1801|Compound:st050089|FD-Score:7.43|P-value:1.64E-14 ID:SGTC_1803|Compound:st050068|FD-Score:7.33|P-value:3.57E-14 ID:SGTC_1818|Compound:st052136|FD-Score:3.18|P-value:5.71E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.60|P-value:1.29E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.55|P-value:1.43E-4 ID:SGTC_1884|Compound:5633444|FD-Score:7.17|P-value:1.25E-13 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.68|P-value:9.14E-5 ID:SGTC_2021|Compound:4019055|FD-Score:5.52|P-value:8.40E-9 ID:SGTC_2128|Compound:5255449|FD-Score:-5.63|P-value:5.11E-9 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.04|P-value:1.81E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.75|P-value:6.29E-5 ID:SGTC_2270|Compound:7924575|FD-Score:3.37|P-value:2.82E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.61|P-value:1.09E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.09|P-value:7.73E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:3.66|P-value:9.20E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.66|P-value:9.02E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.31|P-value:3.22E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.56|P-value:1.57E-6 ID:SGTC_2736|Compound:butenafine|FD-Score:3.15|P-value:6.34E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:6.85|P-value:1.29E-12 ID:SGTC_2756|Compound:carbadox|FD-Score:4.29|P-value:5.69E-6 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.04|P-value:1.77E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.32|P-value:3.42E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-3.12|P-value:7.75E-4 ID:SGTC_2790|Compound:5423970|FD-Score:6.41|P-value:2.85E-11 ID:SGTC_2805|Compound:7950783|FD-Score:5.65|P-value:3.92E-9 ID:SGTC_2809|Compound:7964133|FD-Score:3.22|P-value:4.90E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.04|P-value:1.81E-5 ID:SGTC_2839|Compound:9003951|FD-Score:3.33|P-value:3.28E-4 ID:SGTC_2843|Compound:9000894|FD-Score:3.07|P-value:8.25E-4 ID:SGTC_2847|Compound:9005661|FD-Score:3.31|P-value:3.59E-4 ID:SGTC_2991|Compound:9074669|FD-Score:5.15|P-value:6.98E-8 ID:SGTC_3018|Compound:9082602|FD-Score:7.02|P-value:3.73E-13 ID:SGTC_3037|Compound:9091026|FD-Score:4.06|P-value:1.65E-5 ID:SGTC_3152|Compound:9099253|FD-Score:5.33|P-value:2.56E-8 ID:SGTC_3210|Compound:9128157|FD-Score:3.59|P-value:1.19E-4 ID:SGTC_3297|Compound:9117502|FD-Score:3.03|P-value:9.79E-4 ID:SGTC_3308|Compound:9128332|FD-Score:5.73|P-value:2.41E-9

Top fitness defect scores for YOR275C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_902 1120-0002 12.10 2.1 µM 1.89E-35 azole & statin 2 4.18E-34
2 SGTC_1317 1273-0028 11.80 910.0 nM 7.13E-34 azole & statin 10 1.36E-32
3 SGTC_227 fluconazole 10.30 33.5 µM 5.83E-26 azole & statin 15 5.48E-25
4 SGTC_862 0452-0056 9.46 10.2 µM 2.18E-22 azole & statin 6 1.49E-21
5 SGTC_1788 fluconazole 9.37 20.0 µM 5.39E-22 azole & statin 12 3.54E-21
6 SGTC_525 k781-2675 8.48 26.7 µM 2.46E-18 redox potentiating 9 1.16E-17
7 SGTC_1525 8-methoxypsoralen 7.70 92.5 µM 1.91E-15 DNA damage response 2 6.98E-15
8 SGTC_1801 st050089 7.43 28.4 µM 1.64E-14 NEO1-PIK1 33 5.50E-14
9 SGTC_1803 st050068 7.33 52.4 µM 3.57E-14 NEO1-PIK1 51 1.16E-13
10 SGTC_1884 5633444 7.17 25.0 µM 1.25E-13 redox potentiating 21 3.86E-13
11 SGTC_363 0455-0021 7.12 3.1 µM 1.72E-13 azole & statin 22 5.25E-13
12 SGTC_3018 9082602 7.02 49.5 µM 3.73E-13 22 1.11E-12
13 SGTC_710 3448-4187 6.93 58.0 µM 7.23E-13 fatty acid desaturase (OLE1) 12 2.09E-12
14 SGTC_2752 diclazuril 6.85 33.1 µM 1.29E-12 50 3.63E-12
15 SGTC_1800 st050079 6.51 29.1 µM 1.48E-11 NEO1-PIK1 33 3.80E-11
16 SGTC_2790 5423970 6.41 71.4 µM 2.85E-11 endomembrane recycling 23 7.13E-11
17 SGTC_528 3492-0019 6.41 172.0 µM 2.86E-11 calcium & mitochondrial duress 112 7.16E-11
18 SGTC_1044 1222-0021 6.19 1.8 µM 1.28E-10 heme biosynthesis & mitochondrial translocase 13 3.03E-10
19 SGTC_1760 st045453 6.18 10.4 µM 1.38E-10 NEO1-PIK1 78 3.24E-10
20 SGTC_16 erodoxin 6.10 22.8 µM 2.34E-10 unfolded protein response 26 5.39E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.621 0 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.599 0 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.553 3.27E-268 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.553 3.57E-268 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.539 1.45E-252 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.468 1.17E-181 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.466 3.32E-180 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.339 3.96E-91 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.339 4.67E-91 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.327 2.49E-84 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.326 7.93E-84 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.320 1.07E-80 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.313 4.14E-77 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.301 4.81E-71 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.274 7.42E-59 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication