YOR276W / CAF20

Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR276W / CAF20

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.74|P-value:7.93E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.09|P-value:9.00E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.41|P-value:4.12E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.31|P-value:5.91E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.56|P-value:1.61E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.59|P-value:1.45E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:6.95|P-value:1.61E-12 ID:SGTC_413|Compound:propylparaben|FD-Score:3.66|P-value:1.12E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:-3.34|P-value:5.28E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.52|P-value:2.73E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.08|P-value:1.99E-5 ID:SGTC_500|Compound:h-89|FD-Score:5.10|P-value:1.50E-7 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.49|P-value:3.03E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.26|P-value:6.95E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.11|P-value:8.29E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:4.36|P-value:5.61E-6 ID:SGTC_850|Compound:0388-0143|FD-Score:-3.46|P-value:3.37E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.62|P-value:1.28E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.92|P-value:3.85E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:-4.24|P-value:1.52E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.20|P-value:6.16E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.15|P-value:7.17E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.31|P-value:4.17E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.68|P-value:1.24E-6 ID:SGTC_1455|Compound:4262-0120|FD-Score:4.24|P-value:9.60E-6 ID:SGTC_1780|Compound:st038448|FD-Score:3.26|P-value:4.89E-4 ID:SGTC_1783|Compound:st039459|FD-Score:4.41|P-value:4.54E-6 ID:SGTC_1819|Compound:st053448|FD-Score:-3.88|P-value:6.77E-5 ID:SGTC_1862|Compound:st057513|FD-Score:3.52|P-value:1.87E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-3.41|P-value:4.04E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.07|P-value:9.39E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.12|P-value:1.68E-5 ID:SGTC_2288|Compound:7946289|FD-Score:3.18|P-value:6.46E-4 ID:SGTC_2380|Compound:9035439|FD-Score:4.05|P-value:2.24E-5 ID:SGTC_2384|Compound:9036245|FD-Score:3.69|P-value:9.97E-5 ID:SGTC_2391|Compound:6285546|FD-Score:3.29|P-value:4.44E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-4.22|P-value:1.68E-5 ID:SGTC_2891|Compound:9063876|FD-Score:3.07|P-value:9.64E-4 ID:SGTC_2899|Compound:9053889|FD-Score:4.80|P-value:6.85E-7 ID:SGTC_3206|Compound:9114350|FD-Score:-4.17|P-value:2.03E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.74|P-value:7.93E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.09|P-value:9.00E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.41|P-value:4.12E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.31|P-value:5.91E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.56|P-value:1.61E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.59|P-value:1.45E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:6.95|P-value:1.61E-12 ID:SGTC_413|Compound:propylparaben|FD-Score:3.66|P-value:1.12E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:-3.34|P-value:5.28E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.52|P-value:2.73E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.08|P-value:1.99E-5 ID:SGTC_500|Compound:h-89|FD-Score:5.10|P-value:1.50E-7 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.49|P-value:3.03E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.26|P-value:6.95E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.11|P-value:8.29E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:4.36|P-value:5.61E-6 ID:SGTC_850|Compound:0388-0143|FD-Score:-3.46|P-value:3.37E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.62|P-value:1.28E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.92|P-value:3.85E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:-4.24|P-value:1.52E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.20|P-value:6.16E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.15|P-value:7.17E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.31|P-value:4.17E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.68|P-value:1.24E-6 ID:SGTC_1455|Compound:4262-0120|FD-Score:4.24|P-value:9.60E-6 ID:SGTC_1780|Compound:st038448|FD-Score:3.26|P-value:4.89E-4 ID:SGTC_1783|Compound:st039459|FD-Score:4.41|P-value:4.54E-6 ID:SGTC_1819|Compound:st053448|FD-Score:-3.88|P-value:6.77E-5 ID:SGTC_1862|Compound:st057513|FD-Score:3.52|P-value:1.87E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-3.41|P-value:4.04E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.07|P-value:9.39E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.12|P-value:1.68E-5 ID:SGTC_2288|Compound:7946289|FD-Score:3.18|P-value:6.46E-4 ID:SGTC_2380|Compound:9035439|FD-Score:4.05|P-value:2.24E-5 ID:SGTC_2384|Compound:9036245|FD-Score:3.69|P-value:9.97E-5 ID:SGTC_2391|Compound:6285546|FD-Score:3.29|P-value:4.44E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-4.22|P-value:1.68E-5 ID:SGTC_2891|Compound:9063876|FD-Score:3.07|P-value:9.64E-4 ID:SGTC_2899|Compound:9053889|FD-Score:4.80|P-value:6.85E-7 ID:SGTC_3206|Compound:9114350|FD-Score:-4.17|P-value:2.03E-5

Top fitness defect scores for YOR276W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 6.95 1.1 µM 1.61E-12 mitochondrial stress 119 1.84E-12
2 SGTC_500 h-89 5.10 112.0 µM 1.50E-7 cell wall signaling 17 1.73E-7
3 SGTC_2899 9053889 4.80 58.4 µM 6.85E-7 3 7.89E-7
4 SGTC_1330 1469-0054 4.68 61.8 µM 1.24E-6 iron homeostasis 9 1.43E-6
5 SGTC_1783 st039459 4.41 87.5 µM 4.54E-6 Golgi 15 5.21E-6
6 SGTC_694 1315-0438 4.36 43.2 µM 5.61E-6 7 6.44E-6
7 SGTC_1455 4262-0120 4.24 131.0 µM 9.60E-6 plasma membrane duress 23 1.10E-5
8 SGTC_2130 NSC 7 4.12 2.5 µM 1.68E-5 copper-dependent oxidative stress 21 1.92E-5
9 SGTC_464 bw-b 70c 4.08 158.0 µM 1.99E-5 20 2.27E-5
10 SGTC_2380 9035439 4.05 200.0 µM 2.24E-5 endomembrane recycling 17 2.57E-5
11 SGTC_1004 4084-0029 3.92 199.0 µM 3.85E-5 17 4.40E-5
12 SGTC_58 0957-0393 3.74 9.0 µM 7.93E-5 cell wall 395 9.04E-5
13 SGTC_2384 9036245 3.69 200.0 µM 9.97E-5 37 1.14E-4
14 SGTC_413 propylparaben 3.66 100.0 µM 1.12E-4 amide catabolism 30 1.28E-4
15 SGTC_998 3996-0085 3.62 177.0 µM 1.28E-4 32 1.46E-4
16 SGTC_299 1273-0059 3.59 1.4 µM 1.45E-4 34 1.65E-4
17 SGTC_184 1494-0393 3.56 24.7 µM 1.61E-4 80 1.83E-4
18 SGTC_1862 st057513 3.52 3.8 µM 1.87E-4 24 2.12E-4
19 SGTC_1200 1643-0193 3.31 18.4 µM 4.17E-4 33 4.72E-4
20 SGTC_2391 6285546 3.29 200.0 µM 4.44E-4 41 5.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 3.35E-25 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.171 2.01E-23 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.150 2.45E-18 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.144 4.81E-17 YDR239C YDR239C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.133 1.19E-14 YML021C UNG1 hom Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
0.133 1.22E-14 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.132 1.43E-14 YLR412W BER1 hom Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene
0.130 4.32E-14 YMR282C AEP2 hom Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.124 5.58E-13 YMR267W PPA2 hom Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
0.123 8.77E-13 YDR003W RCR2 hom Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication
0.121 1.63E-12 YER028C MIG3 hom Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
0.119 5.10E-12 YBR042C CST26 hom Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication
0.118 6.07E-12 YPL179W PPQ1 hom Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors
0.116 1.73E-11 YAL017W PSK1 hom PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication
0.115 2.34E-11 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit