YOR277C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR277C / YOR277C

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:4.14|P-value:6.41E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:-4.74|P-value:5.15E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:3.57|P-value:4.80E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:6.46|P-value:1.14E-9 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.54|P-value:5.40E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.53|P-value:5.58E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.93|P-value:1.41E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.38|P-value:9.00E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.32|P-value:3.29E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:4.41|P-value:2.29E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.92|P-value:1.46E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.65|P-value:3.72E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:6.18|P-value:5.38E-9 ID:SGTC_1314|Compound:1222-0010|FD-Score:5.93|P-value:2.04E-8 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.54|P-value:5.33E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.99|P-value:1.14E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.61|P-value:4.21E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:4.31|P-value:3.39E-5 ID:SGTC_1656|Compound:st012921|FD-Score:5.33|P-value:4.05E-7 ID:SGTC_1767|Compound:st044992|FD-Score:4.41|P-value:2.30E-5 ID:SGTC_1809|Compound:st050081|FD-Score:3.55|P-value:5.23E-4 ID:SGTC_2053|Compound:5265679|FD-Score:4.50|P-value:1.61E-5 ID:SGTC_2098|Compound:5376439|FD-Score:3.66|P-value:3.55E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-3.85|P-value:1.69E-4 ID:SGTC_2278|Compound:7948257|FD-Score:-3.44|P-value:6.88E-4 ID:SGTC_2375|Compound:9072683|FD-Score:-3.66|P-value:3.29E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.83|P-value:1.97E-4 ID:SGTC_2393|Compound:9031399|FD-Score:4.71|P-value:6.54E-6 ID:SGTC_2402|Compound:5553605|FD-Score:-4.35|P-value:2.62E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.68|P-value:7.58E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.68|P-value:3.11E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.49|P-value:6.29E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.94|P-value:1.34E-4 ID:SGTC_2908|Compound:7930301|FD-Score:4.16|P-value:5.97E-5 ID:SGTC_2992|Compound:9074591|FD-Score:3.40|P-value:8.39E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:4.14|P-value:6.41E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:-4.74|P-value:5.15E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:3.57|P-value:4.80E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:6.46|P-value:1.14E-9 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.54|P-value:5.40E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.53|P-value:5.58E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.93|P-value:1.41E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.38|P-value:9.00E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.32|P-value:3.29E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:4.41|P-value:2.29E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.92|P-value:1.46E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.65|P-value:3.72E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:6.18|P-value:5.38E-9 ID:SGTC_1314|Compound:1222-0010|FD-Score:5.93|P-value:2.04E-8 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.54|P-value:5.33E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.99|P-value:1.14E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.61|P-value:4.21E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:4.31|P-value:3.39E-5 ID:SGTC_1656|Compound:st012921|FD-Score:5.33|P-value:4.05E-7 ID:SGTC_1767|Compound:st044992|FD-Score:4.41|P-value:2.30E-5 ID:SGTC_1809|Compound:st050081|FD-Score:3.55|P-value:5.23E-4 ID:SGTC_2053|Compound:5265679|FD-Score:4.50|P-value:1.61E-5 ID:SGTC_2098|Compound:5376439|FD-Score:3.66|P-value:3.55E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-3.85|P-value:1.69E-4 ID:SGTC_2278|Compound:7948257|FD-Score:-3.44|P-value:6.88E-4 ID:SGTC_2375|Compound:9072683|FD-Score:-3.66|P-value:3.29E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.83|P-value:1.97E-4 ID:SGTC_2393|Compound:9031399|FD-Score:4.71|P-value:6.54E-6 ID:SGTC_2402|Compound:5553605|FD-Score:-4.35|P-value:2.62E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.68|P-value:7.58E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.68|P-value:3.11E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.49|P-value:6.29E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.94|P-value:1.34E-4 ID:SGTC_2908|Compound:7930301|FD-Score:4.16|P-value:5.97E-5 ID:SGTC_2992|Compound:9074591|FD-Score:3.40|P-value:8.39E-4

Top fitness defect scores for YOR277C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_374 0880-0231 6.46 82.3 µM 1.14E-9 iron homeostasis 4 5.39E-11
2 SGTC_1227 3909-8010 6.18 46.6 µM 5.38E-9 3 3.26E-10
3 SGTC_1314 1222-0010 5.93 41.1 µM 2.04E-8 2 1.53E-9
4 SGTC_1656 st012921 5.33 11.0 µM 4.05E-7 17 4.89E-8
5 SGTC_2393 9031399 4.71 185.9 µM 6.54E-6 RNA processing & uracil transport 15 1.23E-6
6 SGTC_2582 agaric acid 4.68 100.0 µM 7.58E-6 redox potentiating 246 1.46E-6
7 SGTC_2053 5265679 4.50 138.0 µM 1.61E-5 13 3.47E-6
8 SGTC_1194 1488-0194 4.41 225.0 µM 2.29E-5 22 5.24E-6
9 SGTC_1767 st044992 4.41 70.3 µM 2.30E-5 13 5.26E-6
10 SGTC_1028 k015-0029 4.32 4.8 µM 3.29E-5 14 7.97E-6
11 SGTC_1546 5-methoxyflavanone 4.31 78.7 µM 3.39E-5 8 8.25E-6
12 SGTC_2908 7930301 4.16 100.0 µM 5.97E-5 21 1.59E-5
13 SGTC_71 0417-1750 4.14 47.8 µM 6.41E-5 Golgi 40 1.72E-5
14 SGTC_1474 0330-0125 3.99 5.3 µM 1.14E-4 30 3.34E-5
15 SGTC_2802 7925815 3.94 54.5 µM 1.34E-4 44 4.04E-5
16 SGTC_815 1582-0027 3.93 36.9 µM 1.41E-4 27 4.28E-5
17 SGTC_1199 1638-0010 3.92 4.5 µM 1.46E-4 endomembrane recycling 25 4.45E-5
18 SGTC_2386 9075165 3.83 157.4 µM 1.97E-4 10 6.33E-5
19 SGTC_2098 5376439 3.66 882.5 nM 3.55E-4 17 1.25E-4
20 SGTC_1220 1838-0075 3.65 193.0 µM 3.72E-4 20 1.32E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 8.34E-16 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.125 3.21E-13 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.117 1.30E-11 YPR078C_p YPR078C_p hom Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
0.114 4.09E-11 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.107 4.81E-10 YLR238W FAR10 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
0.102 2.92E-9 YDR066C RTR2 hom Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication
0.102 3.26E-9 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.100 7.04E-9 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.098 1.23E-8 YJL090C DPB11 het DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress
0.098 1.24E-8 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.097 1.71E-8 YDL207W GLE1 het Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
0.096 2.55E-8 YLR154C RNH203 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome
0.096 2.82E-8 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.094 5.01E-8 YDL048C STP4 hom Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p; predicted to be a transcription factor; relative distribution to the nucleus increases upon DNA replication stress
0.093 7.64E-8 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress