HIPHOP chemogenomics database

YOR279C / RFM1

DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance

Zygosity: Homozygous strain

fixedexpanded
Profile for YOR279C / RFM1

Click on Significant Values for Screen Details

Top fitness defect scores for YOR279C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_3222	9128301	7.77	49.5 µM	3.58E-11	60S ribosome export	1	3.93E-15
2	SGTC_2566	crystal violet carbinol	7.26	226.0 nM	5.70E-10		8	1.95E-13
3	SGTC_1825	st052143	7.10	62.6 µM	1.29E-9		1	6.20E-13
4	SGTC_2563	tomatine	7.10	8.5 µM	1.32E-9		6	6.40E-13
5	SGTC_2938	9059746	7.03	27.3 µM	1.87E-9	fatty acid desaturase (OLE1)	9	1.04E-12
6	SGTC_2833	9001315	6.63	45.5 µM	1.36E-8	amide catabolism	12	1.72E-11
7	SGTC_1807	st050092	6.41	58.9 µM	3.74E-8	60S ribosome export	1	7.13E-11
8	SGTC_2937	9044753	6.29	11.3 µM	6.46E-8	60S ribosome export	5	1.54E-10
9	SGTC_2382	9035899	6.25	200.0 µM	7.96E-8	60S ribosome export	4	2.07E-10
10	SGTC_453	enantio-paf c16	6.02	10.0 µM	2.22E-7		48	8.73E-10
11	SGTC_312	4092-0653	5.97	6.8 µM	2.74E-7	ergosterol depletion effects on membrane	39	1.17E-9
12	SGTC_1311	1190-0148	5.78	100.0 µM	6.22E-7	azole & statin	10	3.73E-9
13	SGTC_1827	berberine	5.58	7.2 µM	1.41E-6	60S ribosome export	4	1.18E-8
14	SGTC_1664	st014217	5.36	9.0 µM	3.51E-6	60S ribosome export	4	4.25E-8
15	SGTC_3077	9117319	5.27	49.5 µM	4.96E-6		5	6.88E-8
16	SGTC_752	1896-0090	5.24	130.0 µM	5.50E-6	TSC3-RPN4	5	7.96E-8
17	SGTC_1070	indatraline	5.21	8.8 µM	6.28E-6	60S ribosome export	8	9.60E-8
18	SGTC_2703	st077852	5.18	53.4 µM	7.03E-6		4	1.12E-7
19	SGTC_953	1188-0045	5.12	9.7 µM	8.91E-6	60S ribosome export	6	1.57E-7
20	SGTC_1035	k081-0041	4.84	55.2 µM	2.43E-5	Golgi	13	6.40E-7

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.192	4.34E-29	YGL099W	LSG1	het	Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
0.183	1.48E-26	YDR310C	SUM1	hom	Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint
0.158	5.20E-20	YHR170W	NMD3	het	Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
0.142	1.18E-16	YOR072W_d	YOR072W_d	hom	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
0.133	8.86E-15	YLR359W	ADE13	het	Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.123	8.48E-13	YGL149W_d	YGL149W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
0.117	8.78E-12	YGR244C	LSC2	hom	Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
0.117	1.13E-11	YJR023C_d	YJR023C_d	het	Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
0.112	6.86E-11	YDL001W	RMD1	hom	Cytoplasmic protein required for sporulation
0.109	2.54E-10	YDR407C	TRS120	het	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.107	4.90E-10	YBL010C_p	YBL010C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.105	1.21E-9	YER112W	LSM4	het	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress
0.099	8.03E-9	YDR132C	YDR132C	hom	Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication
0.097	1.73E-8	YOL068C	HST1	hom	NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance
0.096	2.35E-8	YER180C-A	SLO1	hom	Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO