YOR279C / RFM1

DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR279C / RFM1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.79|P-value:7.37E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-5.78|P-value:6.19E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.31|P-value:1.49E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:5.97|P-value:2.74E-7 ID:SGTC_320|Compound:4092-0846|FD-Score:4.75|P-value:3.40E-5 ID:SGTC_394|Compound:menadione|FD-Score:3.80|P-value:7.18E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.91|P-value:5.18E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.02|P-value:2.22E-7 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.89|P-value:5.46E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-4.64|P-value:5.05E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:3.86|P-value:5.95E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:4.33|P-value:1.42E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:5.24|P-value:5.50E-6 ID:SGTC_862|Compound:0452-0056|FD-Score:4.46|P-value:9.15E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:5.12|P-value:8.91E-6 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.16|P-value:2.44E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:4.18|P-value:2.27E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.84|P-value:2.43E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:5.21|P-value:6.28E-6 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.80|P-value:7.16E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:4.42|P-value:1.03E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.93|P-value:4.94E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:5.78|P-value:6.22E-7 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.25|P-value:1.79E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:4.61|P-value:5.48E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-4.45|P-value:9.58E-5 ID:SGTC_1663|Compound:st014140|FD-Score:3.74|P-value:8.49E-4 ID:SGTC_1664|Compound:st014217|FD-Score:5.36|P-value:3.51E-6 ID:SGTC_1750|Compound:st081859|FD-Score:3.88|P-value:5.67E-4 ID:SGTC_1763|Compound:st044482|FD-Score:4.69|P-value:4.17E-5 ID:SGTC_1767|Compound:st044992|FD-Score:4.01|P-value:3.81E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.94|P-value:4.74E-4 ID:SGTC_1807|Compound:st050092|FD-Score:6.41|P-value:3.74E-8 ID:SGTC_1814|Compound:st052110|FD-Score:4.16|P-value:2.39E-4 ID:SGTC_1825|Compound:st052143|FD-Score:7.10|P-value:1.29E-9 ID:SGTC_1827|Compound:berberine|FD-Score:5.58|P-value:1.41E-6 ID:SGTC_2382|Compound:9035899|FD-Score:6.25|P-value:7.96E-8 ID:SGTC_2461|Compound:5755302|FD-Score:-4.54|P-value:7.12E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.49|P-value:8.16E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.72|P-value:9.14E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.70|P-value:9.52E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:7.10|P-value:1.32E-9 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:7.26|P-value:5.70E-10 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-4.07|P-value:3.19E-4 ID:SGTC_2683|Compound:piperine|FD-Score:4.27|P-value:1.69E-4 ID:SGTC_2703|Compound:st077852|FD-Score:5.18|P-value:7.03E-6 ID:SGTC_2833|Compound:9001315|FD-Score:6.63|P-value:1.36E-8 ID:SGTC_2880|Compound:9042983|FD-Score:3.95|P-value:4.56E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.13|P-value:2.64E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.01|P-value:3.86E-4 ID:SGTC_2937|Compound:9044753|FD-Score:6.29|P-value:6.46E-8 ID:SGTC_2938|Compound:9059746|FD-Score:7.03|P-value:1.87E-9 ID:SGTC_3077|Compound:9117319|FD-Score:5.27|P-value:4.96E-6 ID:SGTC_3222|Compound:9128301|FD-Score:7.77|P-value:3.58E-11 ID:SGTC_3280|Compound:9140961|FD-Score:4.00|P-value:4.01E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.68|P-value:9.98E-4 ID:SGTC_3319|Compound:9138450|FD-Score:4.40|P-value:1.13E-4 ID:SGTC_3320|Compound:9137005|FD-Score:4.07|P-value:3.16E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.79|P-value:7.37E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-5.78|P-value:6.19E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.31|P-value:1.49E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:5.97|P-value:2.74E-7 ID:SGTC_320|Compound:4092-0846|FD-Score:4.75|P-value:3.40E-5 ID:SGTC_394|Compound:menadione|FD-Score:3.80|P-value:7.18E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.91|P-value:5.18E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.02|P-value:2.22E-7 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.89|P-value:5.46E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-4.64|P-value:5.05E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:3.86|P-value:5.95E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:4.33|P-value:1.42E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:5.24|P-value:5.50E-6 ID:SGTC_862|Compound:0452-0056|FD-Score:4.46|P-value:9.15E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:5.12|P-value:8.91E-6 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.16|P-value:2.44E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:4.18|P-value:2.27E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.84|P-value:2.43E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:5.21|P-value:6.28E-6 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.80|P-value:7.16E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:4.42|P-value:1.03E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.93|P-value:4.94E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:5.78|P-value:6.22E-7 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.25|P-value:1.79E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:4.61|P-value:5.48E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-4.45|P-value:9.58E-5 ID:SGTC_1663|Compound:st014140|FD-Score:3.74|P-value:8.49E-4 ID:SGTC_1664|Compound:st014217|FD-Score:5.36|P-value:3.51E-6 ID:SGTC_1750|Compound:st081859|FD-Score:3.88|P-value:5.67E-4 ID:SGTC_1763|Compound:st044482|FD-Score:4.69|P-value:4.17E-5 ID:SGTC_1767|Compound:st044992|FD-Score:4.01|P-value:3.81E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.94|P-value:4.74E-4 ID:SGTC_1807|Compound:st050092|FD-Score:6.41|P-value:3.74E-8 ID:SGTC_1814|Compound:st052110|FD-Score:4.16|P-value:2.39E-4 ID:SGTC_1825|Compound:st052143|FD-Score:7.10|P-value:1.29E-9 ID:SGTC_1827|Compound:berberine|FD-Score:5.58|P-value:1.41E-6 ID:SGTC_2382|Compound:9035899|FD-Score:6.25|P-value:7.96E-8 ID:SGTC_2461|Compound:5755302|FD-Score:-4.54|P-value:7.12E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.49|P-value:8.16E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.72|P-value:9.14E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.70|P-value:9.52E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:7.10|P-value:1.32E-9 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:7.26|P-value:5.70E-10 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-4.07|P-value:3.19E-4 ID:SGTC_2683|Compound:piperine|FD-Score:4.27|P-value:1.69E-4 ID:SGTC_2703|Compound:st077852|FD-Score:5.18|P-value:7.03E-6 ID:SGTC_2833|Compound:9001315|FD-Score:6.63|P-value:1.36E-8 ID:SGTC_2880|Compound:9042983|FD-Score:3.95|P-value:4.56E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.13|P-value:2.64E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.01|P-value:3.86E-4 ID:SGTC_2937|Compound:9044753|FD-Score:6.29|P-value:6.46E-8 ID:SGTC_2938|Compound:9059746|FD-Score:7.03|P-value:1.87E-9 ID:SGTC_3077|Compound:9117319|FD-Score:5.27|P-value:4.96E-6 ID:SGTC_3222|Compound:9128301|FD-Score:7.77|P-value:3.58E-11 ID:SGTC_3280|Compound:9140961|FD-Score:4.00|P-value:4.01E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.68|P-value:9.98E-4 ID:SGTC_3319|Compound:9138450|FD-Score:4.40|P-value:1.13E-4 ID:SGTC_3320|Compound:9137005|FD-Score:4.07|P-value:3.16E-4

Top fitness defect scores for YOR279C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3222 9128301 7.77 49.5 µM 3.58E-11 60S ribosome export 1 3.93E-15
2 SGTC_2566 crystal violet carbinol 7.26 226.0 nM 5.70E-10 8 1.95E-13
3 SGTC_1825 st052143 7.10 62.6 µM 1.29E-9 1 6.20E-13
4 SGTC_2563 tomatine 7.10 8.5 µM 1.32E-9 6 6.40E-13
5 SGTC_2938 9059746 7.03 27.3 µM 1.87E-9 fatty acid desaturase (OLE1) 9 1.04E-12
6 SGTC_2833 9001315 6.63 45.5 µM 1.36E-8 amide catabolism 12 1.72E-11
7 SGTC_1807 st050092 6.41 58.9 µM 3.74E-8 60S ribosome export 1 7.13E-11
8 SGTC_2937 9044753 6.29 11.3 µM 6.46E-8 60S ribosome export 5 1.54E-10
9 SGTC_2382 9035899 6.25 200.0 µM 7.96E-8 60S ribosome export 4 2.07E-10
10 SGTC_453 enantio-paf c16 6.02 10.0 µM 2.22E-7 48 8.73E-10
11 SGTC_312 4092-0653 5.97 6.8 µM 2.74E-7 ergosterol depletion effects on membrane 39 1.17E-9
12 SGTC_1311 1190-0148 5.78 100.0 µM 6.22E-7 azole & statin 10 3.73E-9
13 SGTC_1827 berberine 5.58 7.2 µM 1.41E-6 60S ribosome export 4 1.18E-8
14 SGTC_1664 st014217 5.36 9.0 µM 3.51E-6 60S ribosome export 4 4.25E-8
15 SGTC_3077 9117319 5.27 49.5 µM 4.96E-6 5 6.88E-8
16 SGTC_752 1896-0090 5.24 130.0 µM 5.50E-6 TSC3-RPN4 5 7.96E-8
17 SGTC_1070 indatraline 5.21 8.8 µM 6.28E-6 60S ribosome export 8 9.60E-8
18 SGTC_2703 st077852 5.18 53.4 µM 7.03E-6 4 1.12E-7
19 SGTC_953 1188-0045 5.12 9.7 µM 8.91E-6 60S ribosome export 6 1.57E-7
20 SGTC_1035 k081-0041 4.84 55.2 µM 2.43E-5 Golgi 13 6.40E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.192 4.34E-29 YGL099W LSG1 het Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
0.183 1.48E-26 YDR310C SUM1 hom Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint
0.158 5.20E-20 YHR170W NMD3 het Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
0.142 1.18E-16 YOR072W_d YOR072W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
0.133 8.86E-15 YLR359W ADE13 het Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.123 8.48E-13 YGL149W_d YGL149W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
0.117 8.78E-12 YGR244C LSC2 hom Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
0.117 1.13E-11 YJR023C_d YJR023C_d het Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
0.112 6.86E-11 YDL001W RMD1 hom Cytoplasmic protein required for sporulation
0.109 2.54E-10 YDR407C TRS120 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.107 4.90E-10 YBL010C_p YBL010C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.105 1.21E-9 YER112W LSM4 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress
0.099 8.03E-9 YDR132C YDR132C hom Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication
0.097 1.73E-8 YOL068C HST1 hom NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance
0.096 2.35E-8 YER180C-A SLO1 hom Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO