YOR280C / FSH3

Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR280C / FSH3

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:-4.78|P-value:5.52E-7 ID:SGTC_51|Compound:1013-0126|FD-Score:3.81|P-value:5.42E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.81|P-value:5.29E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-5.50|P-value:1.08E-8 ID:SGTC_544|Compound:k015-0020|FD-Score:3.59|P-value:1.28E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.14|P-value:6.95E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.09|P-value:8.31E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.26|P-value:4.55E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:-3.15|P-value:6.61E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.14|P-value:7.03E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:-3.81|P-value:5.22E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.33|P-value:3.47E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.16|P-value:6.43E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.22|P-value:5.20E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.17|P-value:6.25E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:4.05|P-value:1.90E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:3.28|P-value:4.21E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.28|P-value:4.20E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.09|P-value:8.32E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.25|P-value:4.66E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.14|P-value:7.06E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.10|P-value:8.08E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.87|P-value:4.18E-5 ID:SGTC_1667|Compound:st014849|FD-Score:3.31|P-value:3.74E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.85|P-value:4.11E-7 ID:SGTC_1734|Compound:st037168|FD-Score:-3.38|P-value:2.87E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.68|P-value:9.26E-5 ID:SGTC_1792|Compound:st045773|FD-Score:3.66|P-value:9.75E-5 ID:SGTC_1808|Compound:st050063|FD-Score:-3.32|P-value:3.60E-4 ID:SGTC_1825|Compound:st052143|FD-Score:4.07|P-value:1.73E-5 ID:SGTC_1900|Compound:st060200|FD-Score:5.21|P-value:5.92E-8 ID:SGTC_1919|Compound:st067113|FD-Score:-5.27|P-value:4.12E-8 ID:SGTC_1999|Compound:st074831|FD-Score:4.30|P-value:6.08E-6 ID:SGTC_2012|Compound:4023501|FD-Score:-3.10|P-value:7.90E-4 ID:SGTC_2047|Compound:4141938|FD-Score:4.29|P-value:6.37E-6 ID:SGTC_2128|Compound:5255449|FD-Score:4.11|P-value:1.47E-5 ID:SGTC_2277|Compound:7947813|FD-Score:3.16|P-value:6.55E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.84|P-value:4.62E-5 ID:SGTC_2313|Compound:7726885|FD-Score:-3.47|P-value:2.03E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.24|P-value:4.95E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.48|P-value:1.96E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.17|P-value:6.37E-4 ID:SGTC_2413|Compound:inermin|FD-Score:-3.40|P-value:2.68E-4 ID:SGTC_2415|Compound:st077333|FD-Score:6.51|P-value:1.72E-11 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.08|P-value:8.54E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:4.35|P-value:4.82E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.98|P-value:2.01E-7 ID:SGTC_2605|Compound:digitonin|FD-Score:5.45|P-value:1.45E-8 ID:SGTC_2610|Compound:ononetin|FD-Score:6.66|P-value:5.98E-12 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:6.21|P-value:1.36E-10 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.08|P-value:1.69E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.08|P-value:8.79E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:5.21|P-value:5.64E-8 ID:SGTC_2678|Compound:equilin|FD-Score:4.52|P-value:2.16E-6 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.93|P-value:2.59E-7 ID:SGTC_2797|Compound:7859098|FD-Score:3.13|P-value:7.38E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.71|P-value:8.25E-7 ID:SGTC_2833|Compound:9001315|FD-Score:-3.79|P-value:5.78E-5 ID:SGTC_3047|Compound:9092122|FD-Score:3.63|P-value:1.11E-4 ID:SGTC_3058|Compound:9093861|FD-Score:-6.09|P-value:2.81E-10 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.92|P-value:2.82E-7 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.91|P-value:2.90E-7 ID:SGTC_3214|Compound:9129694|FD-Score:3.14|P-value:7.13E-4 ID:SGTC_3222|Compound:9128301|FD-Score:6.33|P-value:6.12E-11 ID:SGTC_3307|Compound:9126885|FD-Score:5.13|P-value:8.76E-8 ID:SGTC_48|Compound:0382-0018|FD-Score:-4.78|P-value:5.52E-7 ID:SGTC_51|Compound:1013-0126|FD-Score:3.81|P-value:5.42E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.81|P-value:5.29E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-5.50|P-value:1.08E-8 ID:SGTC_544|Compound:k015-0020|FD-Score:3.59|P-value:1.28E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.14|P-value:6.95E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.09|P-value:8.31E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.26|P-value:4.55E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:-3.15|P-value:6.61E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.14|P-value:7.03E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:-3.81|P-value:5.22E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.33|P-value:3.47E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.16|P-value:6.43E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.22|P-value:5.20E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.17|P-value:6.25E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:4.05|P-value:1.90E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:3.28|P-value:4.21E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.28|P-value:4.20E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.09|P-value:8.32E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.25|P-value:4.66E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.14|P-value:7.06E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.10|P-value:8.08E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.87|P-value:4.18E-5 ID:SGTC_1667|Compound:st014849|FD-Score:3.31|P-value:3.74E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.85|P-value:4.11E-7 ID:SGTC_1734|Compound:st037168|FD-Score:-3.38|P-value:2.87E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.68|P-value:9.26E-5 ID:SGTC_1792|Compound:st045773|FD-Score:3.66|P-value:9.75E-5 ID:SGTC_1808|Compound:st050063|FD-Score:-3.32|P-value:3.60E-4 ID:SGTC_1825|Compound:st052143|FD-Score:4.07|P-value:1.73E-5 ID:SGTC_1900|Compound:st060200|FD-Score:5.21|P-value:5.92E-8 ID:SGTC_1919|Compound:st067113|FD-Score:-5.27|P-value:4.12E-8 ID:SGTC_1999|Compound:st074831|FD-Score:4.30|P-value:6.08E-6 ID:SGTC_2012|Compound:4023501|FD-Score:-3.10|P-value:7.90E-4 ID:SGTC_2047|Compound:4141938|FD-Score:4.29|P-value:6.37E-6 ID:SGTC_2128|Compound:5255449|FD-Score:4.11|P-value:1.47E-5 ID:SGTC_2277|Compound:7947813|FD-Score:3.16|P-value:6.55E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.84|P-value:4.62E-5 ID:SGTC_2313|Compound:7726885|FD-Score:-3.47|P-value:2.03E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.24|P-value:4.95E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.48|P-value:1.96E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.17|P-value:6.37E-4 ID:SGTC_2413|Compound:inermin|FD-Score:-3.40|P-value:2.68E-4 ID:SGTC_2415|Compound:st077333|FD-Score:6.51|P-value:1.72E-11 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.08|P-value:8.54E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:4.35|P-value:4.82E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.98|P-value:2.01E-7 ID:SGTC_2605|Compound:digitonin|FD-Score:5.45|P-value:1.45E-8 ID:SGTC_2610|Compound:ononetin|FD-Score:6.66|P-value:5.98E-12 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:6.21|P-value:1.36E-10 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.08|P-value:1.69E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.08|P-value:8.79E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:5.21|P-value:5.64E-8 ID:SGTC_2678|Compound:equilin|FD-Score:4.52|P-value:2.16E-6 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.93|P-value:2.59E-7 ID:SGTC_2797|Compound:7859098|FD-Score:3.13|P-value:7.38E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.71|P-value:8.25E-7 ID:SGTC_2833|Compound:9001315|FD-Score:-3.79|P-value:5.78E-5 ID:SGTC_3047|Compound:9092122|FD-Score:3.63|P-value:1.11E-4 ID:SGTC_3058|Compound:9093861|FD-Score:-6.09|P-value:2.81E-10 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.92|P-value:2.82E-7 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.91|P-value:2.90E-7 ID:SGTC_3214|Compound:9129694|FD-Score:3.14|P-value:7.13E-4 ID:SGTC_3222|Compound:9128301|FD-Score:6.33|P-value:6.12E-11 ID:SGTC_3307|Compound:9126885|FD-Score:5.13|P-value:8.76E-8

Top fitness defect scores for YOR280C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2610 ononetin 6.66 44.2 µM 5.98E-12 5 1.33E-11
2 SGTC_2415 st077333 6.51 57.7 µM 1.72E-11 8 3.69E-11
3 SGTC_3222 9128301 6.33 49.5 µM 6.12E-11 60S ribosome export 4 1.26E-10
4 SGTC_2614 arthonioic acid 6.21 13.4 µM 1.36E-10 3 2.73E-10
5 SGTC_2605 digitonin 5.45 300.0 nM 1.45E-8 7 2.49E-8
6 SGTC_2663 amphotericin b 5.21 100.0 µM 5.64E-8 2 9.24E-8
7 SGTC_1900 st060200 5.21 72.8 µM 5.92E-8 7 9.68E-8
8 SGTC_3307 9126885 5.13 69.3 µM 8.76E-8 14 1.41E-7
9 SGTC_2567 aureobasidin a 4.98 60.0 nM 2.01E-7 58 3.15E-7
10 SGTC_2759 disulfiram 4.93 3.4 µM 2.59E-7 14 4.04E-7
11 SGTC_3059 1327-0034 4.92 3.0 µM 2.82E-7 37 4.38E-7
12 SGTC_3060 1327-0027 4.91 12.5 µM 2.90E-7 25 4.51E-7
13 SGTC_1679 4130-1276 4.85 6.7 µM 4.11E-7 Golgi 37 6.31E-7
14 SGTC_2829 7992743 4.71 58.4 µM 8.25E-7 21 1.24E-6
15 SGTC_2678 equilin 4.52 100.0 µM 2.16E-6 16 3.13E-6
16 SGTC_2549 cedrol 4.35 20.9 µM 4.82E-6 9 6.81E-6
17 SGTC_1999 st074831 4.30 12.5 µM 6.08E-6 plasma membrane duress 20 8.53E-6
18 SGTC_2047 4141938 4.29 200.0 µM 6.37E-6 4 8.93E-6
19 SGTC_2128 5255449 4.11 168.5 µM 1.47E-5 32 2.00E-5
20 SGTC_2628 lathosterol 4.08 100.0 µM 1.69E-5 29 2.29E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 6.26E-17 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.103 2.09E-9 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.102 3.41E-9 YNL249C MPA43 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.099 8.86E-9 YDR130C FIN1 hom Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress
0.098 1.14E-8 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.097 1.67E-8 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.097 1.77E-8 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.086 5.38E-7 YNR046W TRM112 het Protein involved in methylation of tRNA, rRNA, and translation factors; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; interacts with and stabilizes 18S rRNA methyltransferase Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin; relative distribution to the nucleus increases upon DNA replication stress
0.085 7.56E-7 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.083 1.36E-6 YBR146W MRPS9 hom Mitochondrial ribosomal protein of the small subunit
0.083 1.54E-6 YDR224C HTB1 het Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
0.083 1.65E-6 YGL065C ALG2 het Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol
0.079 4.78E-6 YMR013W-A_d YMR013W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73
0.078 5.63E-6 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.076 9.66E-6 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene