YOR282W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR282W / YOR282W

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.18|P-value:4.06E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.17|P-value:4.24E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.93|P-value:1.73E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:3.50|P-value:1.16E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-4.25|P-value:3.40E-6 ID:SGTC_424|Compound:splitomicin|FD-Score:3.07|P-value:6.22E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.01|P-value:7.05E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.16|P-value:4.46E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:4.14|P-value:6.45E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:3.18|P-value:4.01E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.29|P-value:2.47E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.45|P-value:1.34E-6 ID:SGTC_742|Compound:0kpi-0133|FD-Score:-3.17|P-value:3.89E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.31|P-value:2.31E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.92|P-value:1.78E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.12|P-value:7.05E-6 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.66|P-value:5.83E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.12|P-value:5.12E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.35|P-value:2.09E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.13|P-value:4.84E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.12|P-value:5.13E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.36|P-value:1.99E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.04|P-value:6.83E-4 ID:SGTC_1891|Compound:st059073|FD-Score:5.33|P-value:9.50E-9 ID:SGTC_1892|Compound:st058411|FD-Score:5.17|P-value:2.48E-8 ID:SGTC_1935|Compound:st074532|FD-Score:4.08|P-value:8.38E-6 ID:SGTC_2081|Compound:5214970|FD-Score:-3.17|P-value:3.86E-4 ID:SGTC_2102|Compound:5377816|FD-Score:2.99|P-value:8.33E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.18|P-value:4.11E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.48|P-value:1.25E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:38.50|P-value:0 ID:SGTC_2444|Compound:5485484|FD-Score:3.74|P-value:4.07E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.44|P-value:1.42E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.45|P-value:1.30E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.28|P-value:2.75E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.22|P-value:3.49E-4 ID:SGTC_2784|Compound:7567673|FD-Score:2.95|P-value:9.61E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-2.94|P-value:9.25E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.06|P-value:6.45E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.08|P-value:5.92E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-3.69|P-value:4.73E-5 ID:SGTC_3187|Compound:9109394|FD-Score:4.77|P-value:2.46E-7 ID:SGTC_3216|Compound:9129716|FD-Score:4.54|P-value:8.36E-7 ID:SGTC_3236|Compound:9132701|FD-Score:3.36|P-value:2.00E-4 ID:SGTC_3240|Compound:9133527|FD-Score:3.51|P-value:1.07E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.18|P-value:4.06E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.17|P-value:4.24E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.93|P-value:1.73E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:3.50|P-value:1.16E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-4.25|P-value:3.40E-6 ID:SGTC_424|Compound:splitomicin|FD-Score:3.07|P-value:6.22E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.01|P-value:7.05E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.16|P-value:4.46E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:4.14|P-value:6.45E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:3.18|P-value:4.01E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.29|P-value:2.47E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.45|P-value:1.34E-6 ID:SGTC_742|Compound:0kpi-0133|FD-Score:-3.17|P-value:3.89E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.31|P-value:2.31E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.92|P-value:1.78E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.12|P-value:7.05E-6 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.66|P-value:5.83E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.12|P-value:5.12E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.35|P-value:2.09E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.13|P-value:4.84E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.12|P-value:5.13E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.36|P-value:1.99E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.04|P-value:6.83E-4 ID:SGTC_1891|Compound:st059073|FD-Score:5.33|P-value:9.50E-9 ID:SGTC_1892|Compound:st058411|FD-Score:5.17|P-value:2.48E-8 ID:SGTC_1935|Compound:st074532|FD-Score:4.08|P-value:8.38E-6 ID:SGTC_2081|Compound:5214970|FD-Score:-3.17|P-value:3.86E-4 ID:SGTC_2102|Compound:5377816|FD-Score:2.99|P-value:8.33E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.18|P-value:4.11E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.48|P-value:1.25E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:38.50|P-value:0 ID:SGTC_2444|Compound:5485484|FD-Score:3.74|P-value:4.07E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.44|P-value:1.42E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.45|P-value:1.30E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.28|P-value:2.75E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.22|P-value:3.49E-4 ID:SGTC_2784|Compound:7567673|FD-Score:2.95|P-value:9.61E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-2.94|P-value:9.25E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.06|P-value:6.45E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.08|P-value:5.92E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-3.69|P-value:4.73E-5 ID:SGTC_3187|Compound:9109394|FD-Score:4.77|P-value:2.46E-7 ID:SGTC_3216|Compound:9129716|FD-Score:4.54|P-value:8.36E-7 ID:SGTC_3236|Compound:9132701|FD-Score:3.36|P-value:2.00E-4 ID:SGTC_3240|Compound:9133527|FD-Score:3.51|P-value:1.07E-4

Top fitness defect scores for YOR282W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2405 ticlatone 38.50 3.5 µM 0 1 0 27.90
2 SGTC_1891 st059073 5.33 26.2 µM 9.50E-9 TSC3-RPN4 1 4.89E-8 0.64
3 SGTC_1892 st058411 5.17 7.4 µM 2.48E-8 2 1.16E-7 0.44
4 SGTC_3187 9109394 4.77 49.5 µM 2.46E-7 Golgi 2 9.15E-7 0.23
5 SGTC_3216 9129716 4.54 49.5 µM 8.36E-7 RPP1 & pyrimidine depletion 5 2.76E-6 0.09
6 SGTC_679 0422-0091 4.45 41.4 µM 1.34E-6 Golgi 9 4.23E-6 0.30
7 SGTC_662 k832-1615 4.14 104.0 µM 6.45E-6 3 1.75E-5 0.13
8 SGTC_1094 duloxetine 4.12 25.4 µM 7.05E-6 RPP1 & pyrimidine depletion 3 1.89E-5 0.15
9 SGTC_1935 st074532 4.08 41.6 µM 8.38E-6 6 2.21E-5 0.46
10 SGTC_68 0986-0284 3.93 82.8 µM 1.73E-5 11 4.25E-5 0.11
11 SGTC_1002 4049-0206 3.92 172.0 µM 1.78E-5 5 4.36E-5 0.07
12 SGTC_2444 5485484 3.74 36.4 µM 4.07E-5 10 9.20E-5 0.07
13 SGTC_1106 tegaserod maleate 3.66 11.7 µM 5.83E-5 6 1.27E-4 0.20
14 SGTC_3240 9133527 3.51 49.5 µM 1.07E-4 2 2.21E-4 0.49
15 SGTC_152 4469-0003 3.50 551.2 µM 1.16E-4 19 2.36E-4 0.06
16 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 3.48 200.0 µM 1.25E-4 10 2.54E-4 0.09
17 SGTC_2555 cholic acid 3.44 100.0 µM 1.42E-4 3 2.86E-4 0.37
18 SGTC_1721 st082152 3.36 9.3 µM 1.99E-4 60S ribosome export 15 3.87E-4 0.08
19 SGTC_3236 9132701 3.36 49.5 µM 2.00E-4 TSC3-RPN4 6 3.89E-4 0.10
20 SGTC_1271 0832-2808 3.35 169.0 µM 2.09E-4 14 4.03E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.321 6.76E-81 YKL090W CUE2 hom Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
0.318 2.71E-79 YER074W RPS24A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
0.288 6.79E-65 YHR193C EGD2 hom Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
0.247 1.09E-47 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.219 1.73E-37 YNL069C RPL16B hom Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication
0.213 1.43E-35 YCR001W_d YCR001W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene
0.208 1.07E-33 YBL087C RPL23A hom Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication
0.205 4.09E-33 YGR134W CAF130 hom Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
0.201 5.97E-32 YBR040W FIG1 hom Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating
0.184 8.91E-27 YMR042W ARG80 hom Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p
0.184 7.96E-27 YHR029C YHI9 hom Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production
0.182 3.18E-26 YPL091W GLR1 hom Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress
0.176 1.44E-24 YFR036W CDC26 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.171 2.26E-23 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.170 5.34E-23 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication