YOR283W

Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR283W / YOR283W

Click on Significant Values for Screen Details ID:SGTC_32|Compound:0928-0142|FD-Score:3.59|P-value:1.55E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.41|P-value:3.60E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.54|P-value:1.83E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.45|P-value:2.58E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.68|P-value:1.27E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-3.63|P-value:1.58E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.99|P-value:3.65E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.97|P-value:3.34E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:5.35|P-value:3.87E-8 ID:SGTC_962|Compound:1254-0300|FD-Score:5.93|P-value:1.31E-9 ID:SGTC_1060|Compound:3448-7350|FD-Score:-4.58|P-value:2.68E-6 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.61|P-value:1.41E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.76|P-value:1.09E-6 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.46|P-value:2.54E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:-3.15|P-value:8.99E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.60|P-value:1.49E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:5.73|P-value:4.45E-9 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.99|P-value:3.05E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.14|P-value:7.77E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.22|P-value:5.96E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.40|P-value:3.12E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.48|P-value:2.71E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-3.96|P-value:4.15E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.50|P-value:2.17E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.88|P-value:5.96E-7 ID:SGTC_1958|Compound:st076513|FD-Score:-3.23|P-value:6.77E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.12|P-value:8.28E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.51|P-value:2.08E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.48|P-value:2.29E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-4.85|P-value:7.00E-7 ID:SGTC_2823|Compound:7987624|FD-Score:4.24|P-value:1.01E-5 ID:SGTC_2826|Compound:7992541|FD-Score:3.23|P-value:5.71E-4 ID:SGTC_3077|Compound:9117319|FD-Score:3.55|P-value:1.77E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.33|P-value:3.97E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.50|P-value:2.51E-4 ID:SGTC_3258|Compound:9138477|FD-Score:3.45|P-value:2.63E-4 ID:SGTC_3335|Compound:9143315|FD-Score:5.17|P-value:1.04E-7 ID:SGTC_3338|Compound:9144300|FD-Score:-3.51|P-value:2.49E-4 ID:SGTC_3352|Compound:9151559|FD-Score:-3.44|P-value:3.15E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:3.59|P-value:1.55E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.41|P-value:3.60E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.54|P-value:1.83E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.45|P-value:2.58E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.68|P-value:1.27E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-3.63|P-value:1.58E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.99|P-value:3.65E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.97|P-value:3.34E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:5.35|P-value:3.87E-8 ID:SGTC_962|Compound:1254-0300|FD-Score:5.93|P-value:1.31E-9 ID:SGTC_1060|Compound:3448-7350|FD-Score:-4.58|P-value:2.68E-6 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.61|P-value:1.41E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.76|P-value:1.09E-6 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.46|P-value:2.54E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:-3.15|P-value:8.99E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.60|P-value:1.49E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:5.73|P-value:4.45E-9 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.99|P-value:3.05E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.14|P-value:7.77E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.22|P-value:5.96E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.40|P-value:3.12E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.48|P-value:2.71E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-3.96|P-value:4.15E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.50|P-value:2.17E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.88|P-value:5.96E-7 ID:SGTC_1958|Compound:st076513|FD-Score:-3.23|P-value:6.77E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.12|P-value:8.28E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.51|P-value:2.08E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.48|P-value:2.29E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-4.85|P-value:7.00E-7 ID:SGTC_2823|Compound:7987624|FD-Score:4.24|P-value:1.01E-5 ID:SGTC_2826|Compound:7992541|FD-Score:3.23|P-value:5.71E-4 ID:SGTC_3077|Compound:9117319|FD-Score:3.55|P-value:1.77E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.33|P-value:3.97E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.50|P-value:2.51E-4 ID:SGTC_3258|Compound:9138477|FD-Score:3.45|P-value:2.63E-4 ID:SGTC_3335|Compound:9143315|FD-Score:5.17|P-value:1.04E-7 ID:SGTC_3338|Compound:9144300|FD-Score:-3.51|P-value:2.49E-4 ID:SGTC_3352|Compound:9151559|FD-Score:-3.44|P-value:3.15E-4

Top fitness defect scores for YOR283W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_962 1254-0300 5.93 21.5 µM 1.31E-9 6 1.49E-9
2 SGTC_1165 k072-0275 5.73 30.3 µM 4.45E-9 13 5.02E-9
3 SGTC_931 2812-0076 5.35 566.0 µM 3.87E-8 6 4.34E-8
4 SGTC_3335 9143315 5.17 29.6 µM 1.04E-7 fatty acid desaturase (OLE1) 1 1.16E-7
5 SGTC_2823 7987624 4.24 58.4 µM 1.01E-5 23 1.11E-5
6 SGTC_1170 0310-0127 3.99 64.8 µM 3.05E-5 27 3.33E-5
7 SGTC_799 1310-0557 3.97 151.0 µM 3.34E-5 superoxide 21 3.66E-5
8 SGTC_1071 trifluoperazine 3.61 6.3 µM 1.41E-4 37 1.53E-4
9 SGTC_1159 4092-0538 3.60 61.2 µM 1.49E-4 42 1.62E-4
10 SGTC_32 0928-0142 3.59 34.1 µM 1.55E-4 TSC3-RPN4 10 1.68E-4
11 SGTC_3077 9117319 3.55 49.5 µM 1.77E-4 24 1.92E-4
12 SGTC_78 0336-0123 3.54 156.8 µM 1.83E-4 31 1.99E-4
13 SGTC_2080 5212524 3.51 12.4 µM 2.08E-4 copper-dependent oxidative stress 27 2.25E-4
14 SGTC_1587 estradiol valerate 3.50 56.1 µM 2.17E-4 21 2.35E-4
15 SGTC_2423 st077119 3.48 87.2 µM 2.29E-4 23 2.48E-4
16 SGTC_1109 tnp00067 3.46 928.3 nM 2.54E-4 30 2.75E-4
17 SGTC_358 0075-0058 3.45 9.4 µM 2.58E-4 89 2.80E-4
18 SGTC_3258 9138477 3.45 49.5 µM 2.63E-4 12 2.85E-4
19 SGTC_1377 2944-0135 3.40 198.0 µM 3.12E-4 calcium & mitochondrial duress 57 3.37E-4
20 SGTC_3175 9106517 3.33 49.5 µM 3.97E-4 iron homeostasis 33 4.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.158 3.26E-20 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.157 6.18E-20 YLR026C SED5 het cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
0.152 8.12E-19 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.149 3.84E-18 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.146 1.80E-17 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.145 3.26E-17 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.140 3.42E-16 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.136 2.82E-15 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.133 9.33E-15 YKR039W GAP1 hom General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth
0.131 2.10E-14 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.125 3.27E-13 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.124 5.12E-13 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.117 9.92E-12 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.116 1.46E-11 YNL042W BOP3 hom Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury
0.116 1.67E-11 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia